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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for POU4F2

Z-value: 0.42

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
ENSG00000151615.3 POU4F2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg38_v1_chr4_+_146638890_146638894-0.125.5e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr21_-_30487436 0.72 ENST00000334055.5
keratin associated protein 19-2
chr1_-_182672232 0.58 ENST00000508450.5
regulator of G protein signaling 8
chr19_+_45498439 0.43 ENST00000451287.7
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
chr8_-_18684033 0.41 ENST00000614430.3
pleckstrin and Sec7 domain containing 3
chr8_-_18684093 0.40 ENST00000428502.6
pleckstrin and Sec7 domain containing 3
chr12_-_52385649 0.39 ENST00000257951.3
keratin 84
chr1_-_44017296 0.38 ENST00000357730.6
ENST00000360584.6
ENST00000528803.1
solute carrier family 6 member 9
chr8_-_18683932 0.36 ENST00000615573.4
pleckstrin and Sec7 domain containing 3
chr3_-_79767987 0.27 ENST00000464233.6
roundabout guidance receptor 1
chr9_+_74615582 0.25 ENST00000396204.2
RAR related orphan receptor B
chrX_+_30235894 0.23 ENST00000620842.1
MAGE family member B3
chr6_-_89217339 0.22 ENST00000454853.7
gamma-aminobutyric acid type A receptor subunit rho1
chr5_+_90640718 0.22 ENST00000640403.1
adhesion G protein-coupled receptor V1
chr4_+_158521937 0.21 ENST00000343542.9
ENST00000470033.2
relaxin family peptide receptor 1
chr2_-_70553440 0.21 ENST00000450929.5
transforming growth factor alpha
chr12_-_30735014 0.21 ENST00000433722.6
caprin family member 2
chr6_+_39792298 0.20 ENST00000633794.1
ENST00000274867.9
dishevelled associated activator of morphogenesis 2
chr4_+_75556048 0.20 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
odontogenesis associated phosphoprotein
chr10_+_97584314 0.19 ENST00000370647.8
4-hydroxy-2-oxoglutarate aldolase 1
chr18_-_28036585 0.19 ENST00000399380.7
cadherin 2
chr14_+_21887848 0.19 ENST00000390437.2
T cell receptor alpha variable 12-2
chr21_-_30492008 0.18 ENST00000334063.6
keratin associated protein 19-3
chr11_-_31509569 0.17 ENST00000526776.5
inner mitochondrial membrane peptidase subunit 1
chr17_+_70104848 0.16 ENST00000392670.5
potassium inwardly rectifying channel subfamily J member 16
chr6_-_25874212 0.16 ENST00000361703.10
ENST00000397060.8
solute carrier family 17 member 3
chr9_+_122371036 0.15 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
prostaglandin-endoperoxide synthase 1
chr5_-_135578983 0.15 ENST00000512158.6
C-X-C motif chemokine ligand 14
chr14_+_31561376 0.15 ENST00000550649.5
ENST00000281081.12
nucleotide binding protein like
chr3_-_51875597 0.15 ENST00000446461.2
IQ motif containing F5
chr2_-_49973939 0.13 ENST00000630656.1
neurexin 1
chr5_-_58999885 0.13 ENST00000317118.12
phosphodiesterase 4D
chr4_-_122621011 0.12 ENST00000611104.2
ENST00000648588.1
interleukin 21
chrX_-_100732100 0.12 ENST00000372981.1
ENST00000263033.9
synaptotagmin like 4
chr3_-_58627567 0.12 ENST00000649301.1
family with sequence similarity 107 member A
chr4_-_168480477 0.11 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DExD/H-box 60 like
chr12_-_7444139 0.11 ENST00000416109.2
ENST00000313599.8
CD163 molecule like 1
chr1_+_198638968 0.11 ENST00000348564.11
ENST00000530727.5
ENST00000442510.8
ENST00000645247.1
ENST00000367367.8
ENST00000367364.5
ENST00000413409.6
protein tyrosine phosphatase receptor type C
chr17_+_18183052 0.11 ENST00000541285.1
alkB homolog 5, RNA demethylase
chr17_+_18183803 0.11 ENST00000399138.5
alkB homolog 5, RNA demethylase
chr5_+_155013755 0.11 ENST00000435029.6
kinesin family member 4B
chr7_-_81770122 0.10 ENST00000423064.7
hepatocyte growth factor
chr11_-_41459592 0.10 ENST00000528697.6
ENST00000530763.5
leucine rich repeat containing 4C
chr7_+_143284930 0.10 ENST00000409244.5
ENST00000409541.5
ENST00000410004.1
ENST00000359333.8
transmembrane protein 139
chr8_+_22999535 0.10 ENST00000251822.7
Rho related BTB domain containing 2
chr4_-_47981535 0.09 ENST00000402813.9
cyclic nucleotide gated channel subunit alpha 1
chr12_-_118359639 0.09 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr6_+_130018565 0.09 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr16_-_20404731 0.09 ENST00000302451.9
protein disulfide isomerase like, testis expressed
chr11_-_125680831 0.09 ENST00000315608.7
ENST00000530048.5
ENST00000533904.6
acrosomal vesicle protein 1
chr9_+_122370523 0.09 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr5_+_135579193 0.08 ENST00000646290.1
solute carrier family 25 member 48
chrX_+_134796758 0.08 ENST00000414371.6
PABIR family member 3
chr14_+_19743571 0.08 ENST00000642117.2
olfactory receptor family 4 subfamily Q member 3
chr9_+_122371014 0.07 ENST00000362012.7
prostaglandin-endoperoxide synthase 1
chr15_-_37101205 0.07 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
Meis homeobox 2
chr11_-_125680869 0.07 ENST00000527795.1
acrosomal vesicle protein 1
chr4_+_158521714 0.06 ENST00000613319.4
ENST00000423548.5
ENST00000448688.6
relaxin family peptide receptor 1
chr8_+_49911604 0.06 ENST00000642164.1
ENST00000644093.1
ENST00000643999.1
ENST00000647073.1
ENST00000646880.1
syntrophin gamma 1
chr15_+_45252228 0.06 ENST00000560438.5
ENST00000347644.8
solute carrier family 28 member 2
chrX_-_106903331 0.06 ENST00000411805.1
ENST00000276173.5
ripply transcriptional repressor 1
chr17_-_66229380 0.06 ENST00000205948.11
apolipoprotein H
chr12_-_118359105 0.05 ENST00000541186.5
ENST00000539872.5
TAO kinase 3
chr8_-_48921419 0.05 ENST00000020945.4
snail family transcriptional repressor 2
chr21_-_30813270 0.05 ENST00000329621.6
keratin associated protein 8-1
chr4_+_158521872 0.05 ENST00000307765.10
relaxin family peptide receptor 1
chr7_-_81770039 0.05 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
hepatocyte growth factor
chr20_+_57561103 0.05 ENST00000319441.6
phosphoenolpyruvate carboxykinase 1
chr15_-_34583592 0.05 ENST00000683415.1
golgin A8 family member B
chr17_-_41467386 0.05 ENST00000225899.4
keratin 32
chr2_-_157444044 0.04 ENST00000264192.8
cytohesin 1 interacting protein
chr8_-_7486400 0.04 ENST00000335479.2
defensin beta 106B
chr11_+_118304721 0.04 ENST00000361763.9
CD3e molecule
chr3_+_122055355 0.04 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86 molecule
chr7_-_42152444 0.04 ENST00000479210.1
GLI family zinc finger 3
chr17_-_10469558 0.04 ENST00000255381.2
myosin heavy chain 4
chr2_+_210477676 0.04 ENST00000673510.1
ENST00000673630.1
ENST00000430249.7
carbamoyl-phosphate synthase 1
chr2_+_210477708 0.04 ENST00000673711.1
carbamoyl-phosphate synthase 1
chr8_+_7825137 0.03 ENST00000335186.3
defensin beta 106A
chr12_+_109139397 0.03 ENST00000377854.9
ENST00000377848.7
acetyl-CoA carboxylase beta
chr3_+_108822759 0.03 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr18_+_31318144 0.03 ENST00000257192.5
desmoglein 1
chr7_-_25228485 0.03 ENST00000222674.2
neuropeptide VF precursor
chr3_+_63443076 0.03 ENST00000295894.9
synaptoporin
chr1_+_40040720 0.03 ENST00000414893.5
ENST00000372792.7
ENST00000372805.8
ENST00000414281.5
ENST00000420216.5
ENST00000372798.5
ENST00000340450.7
ENST00000435719.5
ENST00000427843.5
ENST00000417287.5
ENST00000424977.1
cyclase associated actin cytoskeleton regulatory protein 1
chr17_-_7929793 0.03 ENST00000303790.3
potassium voltage-gated channel subfamily A regulatory beta subunit 3
chr20_-_51802433 0.03 ENST00000395997.3
spalt like transcription factor 4
chr3_+_108822778 0.03 ENST00000295756.11
T cell receptor associated transmembrane adaptor 1
chr17_+_7407838 0.03 ENST00000302926.7
neuroligin 2
chr1_+_50108856 0.03 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAV like RNA binding protein 4
chr1_-_31919093 0.03 ENST00000602683.5
ENST00000470404.5
protein tyrosine phosphatase 4A2
chr16_+_28494634 0.03 ENST00000564831.6
ENST00000431282.2
apolipoprotein B receptor
chr7_-_42152396 0.03 ENST00000642432.1
ENST00000647255.1
ENST00000677288.1
GLI family zinc finger 3
chr10_+_93612532 0.03 ENST00000371447.4
phosphodiesterase 6C
chr2_-_69643152 0.02 ENST00000606389.7
AP2 associated kinase 1
chr1_-_193059489 0.02 ENST00000367455.8
ENST00000421683.1
ubiquitin C-terminal hydrolase L5
chr17_+_50165990 0.02 ENST00000262018.8
ENST00000344627.10
ENST00000682109.1
ENST00000504073.2
sarcoglycan alpha
chr19_-_35228699 0.02 ENST00000324675.3
family with sequence similarity 187 member B
chr1_+_193059587 0.02 ENST00000400968.7
ENST00000415442.2
ENST00000506303.1
Ro60, Y RNA binding protein
chrX_-_134797134 0.02 ENST00000370790.5
ENST00000493333.5
ENST00000611027.2
ENST00000343004.10
ENST00000298090.10
PABIR family member 2
chr1_-_182671853 0.02 ENST00000367556.5
regulator of G protein signaling 8
chrX_+_69616067 0.02 ENST00000338901.4
ENST00000525810.5
ENST00000527388.5
ENST00000374553.6
ENST00000374552.9
ENST00000524573.5
ectodysplasin A
chr1_+_193059448 0.02 ENST00000432079.5
Ro60, Y RNA binding protein
chr1_-_182671902 0.02 ENST00000483095.6
regulator of G protein signaling 8
chr17_-_10026265 0.02 ENST00000437099.6
ENST00000396115.6
growth arrest specific 7
chr17_-_81656532 0.02 ENST00000331056.10
phosphodiesterase 6G
chr6_+_118548289 0.02 ENST00000357525.6
phospholamban
chrX_+_103585478 0.01 ENST00000468024.5
ENST00000415568.2
ENST00000472484.6
ENST00000613326.4
ENST00000490644.5
ENST00000459722.1
ENST00000472745.1
ENST00000494801.5
ENST00000434216.2
transcription elongation factor A like 4
chr14_-_70416994 0.01 ENST00000621525.4
ENST00000256366.6
SYNJ2BP-COX16 readthrough
synaptojanin 2 binding protein
chr6_-_138987640 0.01 ENST00000529597.5
ENST00000415951.6
ENST00000367663.8
ENST00000409812.6
RALBP1 associated Eps domain containing 1
chr6_-_73521783 0.01 ENST00000331523.7
ENST00000356303.7
eukaryotic translation elongation factor 1 alpha 1
chr11_-_31509588 0.01 ENST00000534812.5
ENST00000529749.5
ENST00000532287.6
ENST00000278200.5
ENST00000530023.5
ENST00000533642.1
inner mitochondrial membrane peptidase subunit 1
chr10_+_97446137 0.01 ENST00000370854.7
ENST00000393760.6
ENST00000414567.5
zinc finger DHHC-type palmitoyltransferase 16
chr6_-_111483700 0.01 ENST00000435970.5
ENST00000358835.7
REV3 like, DNA directed polymerase zeta catalytic subunit
chr10_+_18260715 0.01 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
calcium voltage-gated channel auxiliary subunit beta 2
chr17_+_58169401 0.01 ENST00000641866.1
olfactory receptor family 4 subfamily D member 2
chr12_+_53454819 0.01 ENST00000562264.5
poly(rC) binding protein 2
chr10_+_97446194 0.01 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
zinc finger DHHC-type palmitoyltransferase 16
chr10_-_97445850 0.00 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
exosome component 1
chr12_+_53454764 0.00 ENST00000439930.7
ENST00000548933.5
poly(rC) binding protein 2
chr12_+_56116623 0.00 ENST00000546591.6
ribosomal protein L41
chr12_+_53454718 0.00 ENST00000552819.5
ENST00000455667.7
poly(rC) binding protein 2
chr12_+_53954870 0.00 ENST00000243103.4
homeobox C12
chr12_+_56116584 0.00 ENST00000501597.3
ribosomal protein L41
chr1_-_244862381 0.00 ENST00000640001.1
ENST00000639628.1
heterogeneous nuclear ribonucleoprotein U

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.3 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925)
0.1 0.2 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.0 1.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.1 GO:1903717 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0060873 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
0.0 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.0 0.0 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.0 GO:0043016 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.2 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.0 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.0 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.1 GO:0005415 nucleoside:sodium symporter activity(GO:0005415)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac