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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for POU5F1_POU2F3
Z-value: 1.54
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU5F1 | hg38_v1_chr6_-_31170620_31170698 | 0.49 | 1.2e-02 | Click! |
| POU2F3 | hg38_v1_chr11_+_120236635_120236642, hg38_v1_chr11_+_120240135_120240199 | 0.11 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_185812209 Show fit | 9.98 |
ENST00000393523.6
ENST00000393528.7 ENST00000449407.6 |
sorbin and SH3 domain containing 2 |
|
| chr1_+_228458095 Show fit | 9.33 |
ENST00000620438.1
|
H2B.U histone 1 |
|
| chr1_+_61077219 Show fit | 7.52 |
ENST00000407417.7
|
nuclear factor I A |
|
| chr1_+_61082398 Show fit | 7.51 |
ENST00000664149.1
|
nuclear factor I A |
|
| chr1_+_61081728 Show fit | 7.41 |
ENST00000371189.8
|
nuclear factor I A |
|
| chr19_+_14583076 Show fit | 5.18 |
ENST00000547437.5
ENST00000417570.6 |
C-type lectin domain containing 17A |
|
| chr4_+_125314918 Show fit | 5.06 |
ENST00000674496.2
ENST00000394329.9 |
FAT atypical cadherin 4 |
|
| chr4_+_41612892 Show fit | 5.05 |
ENST00000509454.5
ENST00000396595.7 ENST00000381753.8 |
LIM and calponin homology domains 1 |
|
| chr18_+_75210755 Show fit | 4.95 |
ENST00000322038.5
|
teashirt zinc finger homeobox 1 |
|
| chr4_+_133149278 Show fit | 4.76 |
ENST00000264360.7
|
protocadherin 10 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.7 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 15.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 10.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.2 | 9.6 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 9.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.4 | 8.7 | GO:0060023 | soft palate development(GO:0060023) |
| 0.7 | 7.9 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 1.5 | 7.7 | GO:2000690 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.5 | 7.4 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 1.3 | 6.7 | GO:0019075 | virus maturation(GO:0019075) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 10.8 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 8.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 8.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.9 | 7.9 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.4 | 6.7 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 6.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 5.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 4.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 4.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 23.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.6 | 13.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 10.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.3 | 10.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 8.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.5 | 7.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 5.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 1.1 | 5.5 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.9 | 5.2 | GO:0042806 | fucose binding(GO:0042806) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 10.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 8.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.6 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.2 | 6.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 3.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 2.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 7.4 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 6.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 6.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 5.1 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 5.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 4.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 3.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 3.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 3.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |