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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for POU6F1

Z-value: 0.51

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.17 POU6F1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg38_v1_chr12_-_51217671_51217827-0.125.7e-01Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_127822455 1.67 ENST00000265052.10
MGLL
monoglyceride lipase
chr2_-_201698628 1.33 ENST00000602867.1
ENST00000409474.8
MPP4
membrane palmitoylated protein 4
chr2_-_201697993 1.32 ENST00000428900.6
MPP4
membrane palmitoylated protein 4
chr2_-_201698692 1.30 ENST00000315506.11
ENST00000359962.9
ENST00000620095.4
MPP4
membrane palmitoylated protein 4
chr2_-_201698040 1.28 ENST00000396886.7
ENST00000409143.5
MPP4
membrane palmitoylated protein 4
chr18_+_63887698 0.95 ENST00000457692.5
ENST00000299502.9
ENST00000413956.5
SERPINB2
serpin family B member 2
chr20_+_59940362 0.90 ENST00000360816.8
FAM217B
family with sequence similarity 217 member B
chr12_-_30735014 0.65 ENST00000433722.6
CAPRIN2
caprin family member 2
chr20_+_59628609 0.50 ENST00000541461.5
PHACTR3
phosphatase and actin regulator 3
chr14_+_22515623 0.48 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr5_+_68290637 0.47 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr20_-_59940289 0.46 ENST00000370996.5
PPP1R3D
protein phosphatase 1 regulatory subunit 3D
chr4_-_168480477 0.38 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DDX60L
DExD/H-box 60 like
chr2_-_216694794 0.37 ENST00000449583.1
IGFBP5
insulin like growth factor binding protein 5
chr1_-_197146688 0.37 ENST00000294732.11
ASPM
assembly factor for spindle microtubules
chr11_+_124241095 0.37 ENST00000641972.1
OR8G1
olfactory receptor family 8 subfamily G member 1
chr5_+_132873660 0.36 ENST00000296877.3
LEAP2
liver enriched antimicrobial peptide 2
chr2_+_202073282 0.35 ENST00000459709.5
KIAA2012
KIAA2012
chr13_+_97960192 0.35 ENST00000496368.6
ENST00000421861.7
ENST00000357602.7
IPO5
importin 5
chr2_+_202073249 0.34 ENST00000498697.3
KIAA2012
KIAA2012
chr1_-_197146620 0.34 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chr1_+_107141022 0.31 ENST00000370067.5
ENST00000370068.6
NTNG1
netrin G1
chr2_+_190180835 0.30 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr20_-_56497608 0.27 ENST00000617620.1
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr2_-_99301195 0.26 ENST00000308528.9
LYG1
lysozyme g1
chr11_+_89924064 0.26 ENST00000623787.3
TRIM49D2
tripartite motif containing 49D2
chr8_+_117135259 0.26 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr19_+_51573171 0.26 ENST00000436511.2
ZNF175
zinc finger protein 175
chr6_-_47042306 0.25 ENST00000371253.7
ADGRF1
adhesion G protein-coupled receptor F1
chr17_-_42185452 0.24 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr21_-_31160904 0.23 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr3_+_46354072 0.23 ENST00000445132.3
ENST00000421659.1
CCR2
C-C motif chemokine receptor 2
chr8_+_117134989 0.23 ENST00000456015.7
SLC30A8
solute carrier family 30 member 8
chr12_-_7444139 0.22 ENST00000416109.2
ENST00000313599.8
CD163L1
CD163 molecule like 1
chr9_-_86947496 0.21 ENST00000298743.9
GAS1
growth arrest specific 1
chr1_-_153150884 0.20 ENST00000368748.5
SPRR2G
small proline rich protein 2G
chr8_-_89984609 0.20 ENST00000519426.5
ENST00000265433.8
NBN
nibrin
chr19_-_3786254 0.19 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chrX_-_100874209 0.19 ENST00000372964.5
ENST00000217885.5
NOX1
NADPH oxidase 1
chr1_-_161038907 0.18 ENST00000318289.14
ENST00000368023.7
ENST00000423014.3
ENST00000368024.5
TSTD1
thiosulfate sulfurtransferase like domain containing 1
chr6_-_132659178 0.18 ENST00000275216.3
TAAR1
trace amine associated receptor 1
chr14_+_94026314 0.18 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr19_-_3786408 0.17 ENST00000395040.6
MATK
megakaryocyte-associated tyrosine kinase
chr11_+_2301987 0.17 ENST00000612299.4
ENST00000182290.9
TSPAN32
tetraspanin 32
chr6_+_151325665 0.16 ENST00000354675.10
AKAP12
A-kinase anchoring protein 12
chrX_+_120604084 0.16 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr20_+_6007245 0.16 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr5_+_163437569 0.16 ENST00000512163.5
ENST00000393929.5
ENST00000510097.5
ENST00000340828.7
ENST00000511490.4
ENST00000510664.5
CCNG1
cyclin G1
chr19_-_3786363 0.16 ENST00000310132.11
MATK
megakaryocyte-associated tyrosine kinase
chr16_-_58684707 0.15 ENST00000564100.5
ENST00000570101.5
ENST00000562397.5
ENST00000219320.9
ENST00000564010.5
ENST00000570214.5
ENST00000563196.5
SLC38A7
solute carrier family 38 member 7
chr11_+_2302119 0.15 ENST00000381121.7
TSPAN32
tetraspanin 32
chr11_-_4393650 0.14 ENST00000254436.8
TRIM21
tripartite motif containing 21
chr9_+_101028721 0.14 ENST00000374874.8
PLPPR1
phospholipid phosphatase related 1
chr6_+_63521738 0.14 ENST00000648894.1
ENST00000639568.2
PTP4A1
protein tyrosine phosphatase 4A1
chr16_+_19410723 0.13 ENST00000381414.8
ENST00000396229.6
TMC5
transmembrane channel like 5
chr12_+_48904105 0.13 ENST00000266984.9
CCDC65
coiled-coil domain containing 65
chr16_+_19410480 0.13 ENST00000541464.5
TMC5
transmembrane channel like 5
chr9_-_128881922 0.12 ENST00000320665.10
ENST00000436267.7
ENST00000302586.8
ENST00000651925.1
KYAT1
ENSG00000286112.1
kynurenine aminotransferase 1
kynurenine aminotransferase 1
chr11_+_31650024 0.12 ENST00000638317.1
ELP4
elongator acetyltransferase complex subunit 4
chr2_-_197675578 0.12 ENST00000295049.9
RFTN2
raftlin family member 2
chr6_+_29306626 0.11 ENST00000377160.4
OR14J1
olfactory receptor family 14 subfamily J member 1
chr4_+_105710809 0.11 ENST00000360505.9
ENST00000510865.5
ENST00000509336.5
GSTCD
glutathione S-transferase C-terminal domain containing
chr2_-_178651500 0.11 ENST00000446966.1
ENST00000426232.5
TTN
titin
chr15_+_44736556 0.10 ENST00000338264.8
TRIM69
tripartite motif containing 69
chr15_+_44736522 0.10 ENST00000329464.9
ENST00000558329.5
ENST00000560442.5
ENST00000561043.5
TRIM69
tripartite motif containing 69
chr9_-_110337808 0.10 ENST00000374510.8
ENST00000374507.4
ENST00000423740.7
ENST00000374511.7
TXNDC8
thioredoxin domain containing 8
chr22_+_31122923 0.10 ENST00000620191.4
ENST00000412277.6
ENST00000412985.5
ENST00000331075.10
ENST00000420017.5
ENST00000400294.6
ENST00000405300.5
ENST00000404390.7
INPP5J
inositol polyphosphate-5-phosphatase J
chr20_-_51802433 0.10 ENST00000395997.3
SALL4
spalt like transcription factor 4
chr17_+_7407838 0.09 ENST00000302926.7
NLGN2
neuroligin 2
chr1_+_224929648 0.09 ENST00000430092.5
ENST00000366850.7
ENST00000400952.7
ENST00000682510.1
ENST00000366849.5
DNAH14
dynein axonemal heavy chain 14
chr7_+_148590760 0.09 ENST00000307003.3
C7orf33
chromosome 7 open reading frame 33
chr19_-_35228699 0.08 ENST00000324675.3
FAM187B
family with sequence similarity 187 member B
chr6_+_50818857 0.08 ENST00000393655.4
TFAP2B
transcription factor AP-2 beta
chr12_+_48904116 0.08 ENST00000552942.5
ENST00000320516.5
CCDC65
coiled-coil domain containing 65
chr6_+_25754699 0.08 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr9_-_114806031 0.08 ENST00000374045.5
TNFSF15
TNF superfamily member 15
chr3_+_77039836 0.08 ENST00000461745.5
ROBO2
roundabout guidance receptor 2
chr2_+_190180930 0.08 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chrX_-_123622809 0.07 ENST00000441692.5
THOC2
THO complex 2
chr2_+_11539833 0.07 ENST00000263834.9
GREB1
growth regulating estrogen receptor binding 1
chr2_-_165203870 0.07 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr1_+_224952670 0.06 ENST00000366848.5
ENST00000439375.6
DNAH14
dynein axonemal heavy chain 14
chr2_-_165204042 0.06 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chrX_-_100874332 0.06 ENST00000372960.8
NOX1
NADPH oxidase 1
chr22_-_21952827 0.06 ENST00000397495.8
ENST00000263212.10
PPM1F
protein phosphatase, Mg2+/Mn2+ dependent 1F
chrX_-_100874351 0.06 ENST00000372966.8
NOX1
NADPH oxidase 1
chrX_-_123623155 0.06 ENST00000618150.4
THOC2
THO complex 2
chr11_+_71833200 0.06 ENST00000328698.2
DEFB108B
defensin beta 108B
chr6_-_111483700 0.05 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr3_+_109136707 0.05 ENST00000622536.6
C3orf85
chromosome 3 open reading frame 85
chr1_+_50106265 0.05 ENST00000357083.8
ELAVL4
ELAV like RNA binding protein 4
chr1_+_50105666 0.04 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr12_+_10307818 0.04 ENST00000350274.9
ENST00000336164.9
KLRD1
killer cell lectin like receptor D1
chr8_-_18683932 0.03 ENST00000615573.4
PSD3
pleckstrin and Sec7 domain containing 3
chrX_+_43656289 0.03 ENST00000338702.4
MAOA
monoamine oxidase A
chr15_+_58987652 0.03 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr17_-_28645108 0.02 ENST00000528896.7
KIAA0100
KIAA0100
chr20_-_51802509 0.02 ENST00000371539.7
ENST00000217086.9
SALL4
spalt like transcription factor 4
chr11_-_89490715 0.02 ENST00000528341.5
NOX4
NADPH oxidase 4
chr9_-_4666495 0.01 ENST00000475086.5
SPATA6L
spermatogenesis associated 6 like
chr2_+_127645864 0.01 ENST00000544369.5
GPR17
G protein-coupled receptor 17
chr1_+_176463164 0.01 ENST00000367661.7
ENST00000367662.5
PAPPA2
pappalysin 2
chr8_+_91249307 0.01 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr1_-_151459471 0.01 ENST00000271715.7
POGZ
pogo transposable element derived with ZNF domain

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.7 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.3 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.3 GO:1990451 cellular stress response to acidic pH(GO:1990451)
0.1 0.2 GO:0090264 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439)
0.1 0.2 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 0.3 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1 0.2 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.5 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.3 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174) telomeric 3' overhang formation(GO:0031860)
0.0 0.9 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.2 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.0 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:0033227 dsRNA transport(GO:0033227)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.7 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.5 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0047804 cysteine-S-conjugate beta-lyase activity(GO:0047804) L-phenylalanine aminotransferase activity(GO:0070546)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.5 GO:0005549 odorant binding(GO:0005549)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)