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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for PPARD

Z-value: 0.39

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.14 PPARD

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg38_v1_chr6_+_35342614_35342633-0.038.8e-01Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_-_109625161 0.42 ENST00000372101.3
KCNE5
potassium voltage-gated channel subfamily E regulatory subunit 5
chr19_+_10086787 0.35 ENST00000590378.5
ENST00000397881.7
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chr3_-_126517764 0.34 ENST00000290868.7
UROC1
urocanate hydratase 1
chr19_+_10086305 0.32 ENST00000253110.16
ENST00000591813.5
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chr14_+_74084947 0.29 ENST00000674221.1
ENST00000554938.2
LIN52
lin-52 DREAM MuvB core complex component
chr17_+_4950147 0.29 ENST00000522301.5
ENO3
enolase 3
chr11_-_45918014 0.24 ENST00000525192.5
PEX16
peroxisomal biogenesis factor 16
chr4_+_158672237 0.23 ENST00000682734.1
ETFDH
electron transfer flavoprotein dehydrogenase
chr17_+_7580442 0.23 ENST00000584180.1
CD68
CD68 molecule
chr17_-_36017953 0.23 ENST00000612516.4
ENST00000615050.2
CCL23
C-C motif chemokine ligand 23
chr20_+_45857607 0.21 ENST00000255152.3
ZSWIM3
zinc finger SWIM-type containing 3
chr7_+_7182526 0.20 ENST00000436587.7
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
chr4_+_158672266 0.20 ENST00000684622.1
ENST00000683483.1
ENST00000684641.1
ENST00000682456.1
ENST00000684627.1
ENST00000511912.6
ENST00000684505.1
ENST00000683305.1
ENST00000684036.1
ENST00000683751.1
ENST00000684129.1
ENST00000307738.5
ETFDH
electron transfer flavoprotein dehydrogenase
chr12_-_6556034 0.18 ENST00000619571.5
ENST00000336604.8
ENST00000396840.6
ENST00000356896.8
IFFO1
intermediate filament family orphan 1
chr3_+_46497970 0.18 ENST00000296142.4
RTP3
receptor transporter protein 3
chr2_+_108449178 0.18 ENST00000309863.11
ENST00000409821.5
GCC2
GRIP and coiled-coil domain containing 2
chr17_-_7219813 0.18 ENST00000399510.8
ENST00000648172.8
DLG4
discs large MAGUK scaffold protein 4
chr1_-_161069666 0.17 ENST00000368016.7
ARHGAP30
Rho GTPase activating protein 30
chr2_-_64019367 0.17 ENST00000272322.9
VPS54
VPS54 subunit of GARP complex
chr1_+_202348687 0.17 ENST00000608999.6
ENST00000391959.5
ENST00000480184.5
PPP1R12B
protein phosphatase 1 regulatory subunit 12B
chr9_+_112380080 0.16 ENST00000398803.1
ENST00000398805.8
HSDL2
hydroxysteroid dehydrogenase like 2
chr1_-_109426410 0.16 ENST00000271308.9
PSMA5
proteasome 20S subunit alpha 5
chr22_-_50578417 0.16 ENST00000312108.12
ENST00000395650.6
CPT1B
carnitine palmitoyltransferase 1B
chr2_-_218568291 0.15 ENST00000418019.5
ENST00000454775.5
ENST00000338465.5
ENST00000415516.5
ENST00000258399.8
USP37
ubiquitin specific peptidase 37
chr17_-_35943707 0.15 ENST00000615905.5
LYZL6
lysozyme like 6
chr17_-_35943662 0.15 ENST00000618542.4
LYZL6
lysozyme like 6
chr6_+_33204645 0.15 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr3_+_19148500 0.14 ENST00000328405.7
KCNH8
potassium voltage-gated channel subfamily H member 8
chr11_-_45917867 0.14 ENST00000378750.10
PEX16
peroxisomal biogenesis factor 16
chr3_-_50567646 0.14 ENST00000426034.5
ENST00000441239.5
C3orf18
chromosome 3 open reading frame 18
chr20_-_63499074 0.14 ENST00000217182.6
ENST00000642899.1
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr19_-_10577231 0.13 ENST00000589348.1
ENST00000592285.1
ENST00000587069.5
AP1M2
adaptor related protein complex 1 subunit mu 2
chr3_+_186666003 0.13 ENST00000232003.5
HRG
histidine rich glycoprotein
chr17_+_39737923 0.13 ENST00000577695.5
ENST00000309156.9
GRB7
growth factor receptor bound protein 7
chr1_+_6451304 0.13 ENST00000636644.1
ESPN
espin
chr16_-_4351283 0.13 ENST00000318059.8
PAM16
presequence translocase associated motor 16
chr16_-_4351257 0.12 ENST00000577031.5
PAM16
presequence translocase associated motor 16
chr15_-_82262660 0.11 ENST00000557844.1
ENST00000359445.7
ENST00000268206.12
EFL1
elongation factor like GTPase 1
chr2_-_158456702 0.11 ENST00000409889.1
ENST00000283233.10
CCDC148
coiled-coil domain containing 148
chr11_-_45917823 0.11 ENST00000533151.5
ENST00000241041.7
PEX16
peroxisomal biogenesis factor 16
chr17_-_36001549 0.11 ENST00000617897.2
CCL15
C-C motif chemokine ligand 15
chr7_+_101020073 0.10 ENST00000306151.9
MUC17
mucin 17, cell surface associated
chr1_-_119768892 0.10 ENST00000369406.8
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2
chr17_+_50532713 0.10 ENST00000503690.5
ENST00000514874.5
ENST00000268933.8
EPN3
epsin 3
chr7_+_17299234 0.10 ENST00000637807.1
ENSG00000283321.1
novel protein
chrX_+_2828921 0.10 ENST00000398806.8
GYG2
glycogenin 2
chr3_+_48465811 0.10 ENST00000433541.1
ENST00000444177.1
TREX1
three prime repair exonuclease 1
chr2_+_218568865 0.10 ENST00000295701.9
CNOT9
CCR4-NOT transcription complex subunit 9
chr9_-_33402551 0.10 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
AQP7
aquaporin 7
chr16_-_74774812 0.09 ENST00000219368.8
FA2H
fatty acid 2-hydroxylase
chr12_+_130953898 0.09 ENST00000261654.10
ADGRD1
adhesion G protein-coupled receptor D1
chr18_-_49813869 0.09 ENST00000586485.5
ENST00000587994.5
ENST00000586100.1
ACAA2
acetyl-CoA acyltransferase 2
chr1_+_54641754 0.09 ENST00000339553.9
ENST00000421030.7
MROH7
maestro heat like repeat family member 7
chr1_+_8945858 0.09 ENST00000549778.5
ENST00000377443.7
ENST00000480186.7
ENST00000377436.6
ENST00000377442.3
CA6
carbonic anhydrase 6
chr1_+_54641806 0.08 ENST00000409996.5
MROH7
maestro heat like repeat family member 7
chr18_-_49813512 0.08 ENST00000285093.15
ACAA2
acetyl-CoA acyltransferase 2
chr2_-_99255107 0.08 ENST00000333017.6
ENST00000626374.2
ENST00000409679.5
ENST00000423306.1
LYG2
lysozyme g2
chr6_-_33580229 0.08 ENST00000374467.4
ENST00000442998.6
ENST00000360661.9
BAK1
BCL2 antagonist/killer 1
chr1_+_201739864 0.08 ENST00000367295.5
NAV1
neuron navigator 1
chr1_+_61952036 0.08 ENST00000646453.1
ENST00000635137.1
PATJ
PATJ crumbs cell polarity complex component
chr2_+_218419114 0.08 ENST00000454069.5
ENST00000392114.6
ENST00000248444.10
VIL1
villin 1
chr5_-_16508858 0.07 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr14_-_24576240 0.07 ENST00000216336.3
CTSG
cathepsin G
chr20_+_41340780 0.07 ENST00000373257.8
LPIN3
lipin 3
chr20_+_41340878 0.07 ENST00000632009.1
LPIN3
lipin 3
chr5_-_16508951 0.07 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr2_+_95274439 0.07 ENST00000317620.14
ENST00000403131.6
ENST00000317668.8
PROM2
prominin 2
chrX_+_2828808 0.07 ENST00000381163.7
GYG2
glycogenin 2
chr6_-_87589961 0.06 ENST00000369536.10
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr5_-_16508812 0.06 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr3_-_125375249 0.06 ENST00000484491.5
ENST00000492394.5
ENST00000471196.1
ENST00000468369.5
ENST00000485866.5
ENST00000360647.9
ZNF148
zinc finger protein 148
chr11_+_64306227 0.06 ENST00000405666.5
ENST00000468670.2
ESRRA
estrogen related receptor alpha
chr1_+_165895564 0.06 ENST00000469256.6
UCK2
uridine-cytidine kinase 2
chrX_+_38352573 0.06 ENST00000039007.5
OTC
ornithine transcarbamylase
chr6_+_32038382 0.06 ENST00000478281.5
ENST00000471671.4
ENST00000435122.3
ENST00000644719.2
CYP21A2
cytochrome P450 family 21 subfamily A member 2
chr10_-_92291063 0.06 ENST00000265997.5
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr19_+_1205761 0.06 ENST00000326873.12
ENST00000586243.5
STK11
serine/threonine kinase 11
chr7_+_24285107 0.06 ENST00000405982.1
NPY
neuropeptide Y
chr22_+_22822658 0.06 ENST00000620395.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr12_-_95073490 0.06 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2 group C member 1
chr6_+_31670167 0.06 ENST00000375864.4
LY6G5B
lymphocyte antigen 6 family member G5B
chr12_+_95858928 0.06 ENST00000266735.9
ENST00000553192.5
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr6_+_87590067 0.05 ENST00000546266.5
ENST00000257789.4
ENST00000392844.8
ORC3
origin recognition complex subunit 3
chr1_-_197067234 0.05 ENST00000367412.2
F13B
coagulation factor XIII B chain
chr9_+_124011738 0.05 ENST00000373615.9
LHX2
LIM homeobox 2
chr1_-_29181809 0.05 ENST00000466448.4
ENST00000373795.7
SRSF4
serine and arginine rich splicing factor 4
chr11_+_17260353 0.05 ENST00000530527.5
NUCB2
nucleobindin 2
chr8_+_95024977 0.05 ENST00000396124.9
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr1_+_165895583 0.05 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr15_+_82262781 0.05 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000682753.1
ENST00000566861.5
ENST00000565432.1
SAXO2
stabilizer of axonemal microtubules 2
chr20_-_45857196 0.04 ENST00000457981.5
ENST00000426915.1
ENST00000217455.9
ACOT8
acyl-CoA thioesterase 8
chr10_-_95069489 0.04 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
CYP2C8
cytochrome P450 family 2 subfamily C member 8
chr5_-_157166262 0.04 ENST00000302938.4
FAM71B
family with sequence similarity 71 member B
chr2_+_206159884 0.04 ENST00000392222.7
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_+_206159580 0.03 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr2_+_197500371 0.03 ENST00000409468.1
ENST00000233893.10
HSPE1
heat shock protein family E (Hsp10) member 1
chr2_-_177392673 0.03 ENST00000447413.1
ENST00000397057.6
ENST00000456746.5
ENST00000464747.5
ENSG00000213963.6
NFE2L2
novel transcript
nuclear factor, erythroid 2 like 2
chr10_-_72954790 0.03 ENST00000373032.4
PLA2G12B
phospholipase A2 group XIIB
chr5_-_16508788 0.03 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr3_-_187291882 0.03 ENST00000392470.6
ENST00000169293.10
ENST00000439271.1
ENST00000392472.6
ENST00000392475.2
MASP1
mannan binding lectin serine peptidase 1
chr2_+_227325349 0.03 ENST00000436237.5
ENST00000443428.6
ENST00000418961.5
MFF
mitochondrial fission factor
chr1_+_43389874 0.03 ENST00000372450.8
SZT2
SZT2 subunit of KICSTOR complex
chr1_-_161069857 0.03 ENST00000368013.8
ARHGAP30
Rho GTPase activating protein 30
chr2_+_73214233 0.03 ENST00000389501.9
ENST00000629411.2
SMYD5
SMYD family member 5
chr12_-_52926459 0.03 ENST00000552150.5
KRT8
keratin 8
chr1_+_6451578 0.03 ENST00000434576.2
ENST00000477679.2
ESPN
espin
chr2_+_158795309 0.02 ENST00000309950.8
ENST00000621326.4
ENST00000409042.5
DAPL1
death associated protein like 1
chr3_+_50273119 0.02 ENST00000456560.6
ENST00000418576.3
SEMA3B
semaphorin 3B
chr10_-_50251500 0.02 ENST00000682911.1
ASAH2
N-acylsphingosine amidohydrolase 2
chr3_-_58537283 0.02 ENST00000459701.6
ACOX2
acyl-CoA oxidase 2
chr21_-_25735570 0.02 ENST00000400090.7
ENST00000400087.7
ENST00000400093.3
ATP5PF
ATP synthase peripheral stalk subunit F6
chr5_-_16508990 0.02 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr3_-_58537181 0.02 ENST00000302819.10
ACOX2
acyl-CoA oxidase 2
chr19_+_4153616 0.02 ENST00000078445.7
ENST00000595923.5
ENST00000602257.5
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3 like 3
chr5_-_177554545 0.02 ENST00000514747.6
FAM193B
family with sequence similarity 193 member B
chr4_+_173168800 0.02 ENST00000512285.5
ENST00000265000.9
GALNT7
polypeptide N-acetylgalactosaminyltransferase 7
chr1_+_43389889 0.02 ENST00000562955.2
ENST00000634258.3
SZT2
SZT2 subunit of KICSTOR complex
chr21_-_25734887 0.02 ENST00000400094.5
ENST00000284971.8
ATP5PF
ATP synthase peripheral stalk subunit F6
chr2_-_206159410 0.02 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr1_-_161069962 0.01 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30
chr2_+_197500398 0.01 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr21_-_25735026 0.01 ENST00000400099.5
ENST00000457143.6
ATP5PF
ATP synthase peripheral stalk subunit F6
chr6_+_142147162 0.01 ENST00000452973.6
ENST00000620996.4
ENST00000367621.1
ENST00000367630.9
VTA1
vesicle trafficking 1
chr6_+_30327259 0.01 ENST00000376659.9
ENST00000428555.1
TRIM39
tripartite motif containing 39
chr20_+_48921701 0.01 ENST00000371917.5
ARFGEF2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr2_-_25342475 0.01 ENST00000264709.7
ENST00000406659.3
DNMT3A
DNA methyltransferase 3 alpha
chr8_-_80030232 0.01 ENST00000518271.1
ENST00000276585.9
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr6_+_43298254 0.01 ENST00000372585.10
ENST00000449231.5
ENST00000372589.7
SLC22A7
solute carrier family 22 member 7
chr6_+_30626842 0.00 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
ATAT1
alpha tubulin acetyltransferase 1
chr15_+_75201873 0.00 ENST00000394987.5
C15orf39
chromosome 15 open reading frame 39
chr4_-_7068033 0.00 ENST00000264954.5
GRPEL1
GrpE like 1, mitochondrial
chr3_-_53844617 0.00 ENST00000481668.5
ENST00000467802.1
CHDH
choline dehydrogenase
chr10_+_92291155 0.00 ENST00000358935.3
MARCHF5
membrane associated ring-CH-type finger 5
chr20_+_43558968 0.00 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.3 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.2 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.0 0.4 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.3 GO:0061709 reticulophagy(GO:0061709)
0.0 0.1 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.0 0.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0002339 B cell selection(GO:0002339)
0.0 0.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.2 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 0.1 GO:0097272 ammonia homeostasis(GO:0097272)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.1 GO:0060327 cytoplasmic actin-based contraction involved in cell motility(GO:0060327)
0.0 0.1 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0000938 GARP complex(GO:0000938)
0.0 0.1 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 0.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.4 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.2 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.0 0.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.4 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.4 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.0 0.2 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0 0.0 GO:0052816 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)