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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for PRDM1
Z-value: 2.15
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Transcription factors associated with PRDM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM1 | hg38_v1_chr6_+_106098933_106098958 | 0.52 | 7.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29559724 Show fit | 24.21 |
ENST00000377050.5
|
ubiquitin D |
|
| chr22_-_36160773 Show fit | 13.57 |
ENST00000531095.1
ENST00000349314.6 ENST00000397293.6 |
apolipoprotein L3 |
|
| chr10_-_5978022 Show fit | 12.63 |
ENST00000525219.6
|
interleukin 15 receptor subunit alpha |
|
| chr4_+_141636923 Show fit | 11.87 |
ENST00000529613.5
|
interleukin 15 |
|
| chr4_+_141636611 Show fit | 11.61 |
ENST00000514653.5
|
interleukin 15 |
|
| chr6_+_32854179 Show fit | 11.48 |
ENST00000374859.3
|
proteasome 20S subunit beta 9 |
|
| chr10_-_5977589 Show fit | 10.98 |
ENST00000620345.4
ENST00000397251.7 ENST00000397248.6 ENST00000622442.4 ENST00000620865.4 |
interleukin 15 receptor subunit alpha |
|
| chr10_-_5977535 Show fit | 10.87 |
ENST00000379977.8
|
interleukin 15 receptor subunit alpha |
|
| chr17_+_43006740 Show fit | 10.64 |
ENST00000438323.2
ENST00000415816.7 |
interferon induced protein 35 |
|
| chr16_+_50742110 Show fit | 9.73 |
ENST00000566679.6
ENST00000564634.5 ENST00000398568.6 |
CYLD lysine 63 deubiquitinase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.1 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 10.9 | 32.7 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 6.7 | 27.0 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 3.0 | 24.2 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.0 | 23.7 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 5.6 | 22.5 | GO:1903974 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.1 | 17.2 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.6 | 15.2 | GO:1900116 | extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 3.4 | 13.5 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 1.9 | 9.7 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 27.0 | GO:0097542 | ciliary tip(GO:0097542) |
| 3.3 | 26.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.4 | 24.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 23.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 3.7 | 22.5 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 2.8 | 19.9 | GO:0042825 | TAP complex(GO:0042825) |
| 3.2 | 12.8 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.7 | 9.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 6.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 38.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 1.5 | 27.0 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.8 | 24.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.0 | 24.2 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 23.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 3.2 | 22.5 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 4.0 | 19.9 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 5.1 | 15.2 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 1.6 | 12.8 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 10.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 27.0 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.6 | 22.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 16.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 11.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 7.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.5 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 6.4 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 4.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 4.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 41.5 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.5 | 27.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 15.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 9.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 7.3 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 6.6 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.4 | 6.4 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.2 | 6.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.3 | 5.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 4.8 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |