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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for PRDM4

Z-value: 0.34

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.12 PRDM4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg38_v1_chr12_-_107761113_1077611760.291.6e-01Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_-_124500986 0.73 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5 group A member 1
chr11_-_441964 0.66 ENST00000332826.7
ANO9
anoctamin 9
chr15_-_35085295 0.53 ENST00000528386.4
NANOGP8
Nanog homeobox retrogene P8
chr16_-_67936808 0.52 ENST00000358514.9
PSMB10
proteasome 20S subunit beta 10
chr19_+_42220283 0.51 ENST00000301215.8
ENST00000597945.1
ZNF526
zinc finger protein 526
chr7_+_143381907 0.36 ENST00000392910.6
ZYX
zyxin
chr7_+_143381561 0.35 ENST00000354434.8
ZYX
zyxin
chr8_+_144477975 0.31 ENST00000435887.2
PPP1R16A
protein phosphatase 1 regulatory subunit 16A
chr10_+_86968432 0.22 ENST00000416348.1
ENST00000372013.8
ADIRF
adipogenesis regulatory factor
chr1_+_172533104 0.22 ENST00000616058.4
ENST00000263688.4
ENST00000610051.5
SUCO
SUN domain containing ossification factor
chr19_-_48868454 0.21 ENST00000355496.9
PLEKHA4
pleckstrin homology domain containing A4
chr7_-_5423826 0.20 ENST00000430969.6
TNRC18
trinucleotide repeat containing 18
chr10_+_102226293 0.19 ENST00000370005.4
ELOVL3
ELOVL fatty acid elongase 3
chr19_-_48868590 0.19 ENST00000263265.11
PLEKHA4
pleckstrin homology domain containing A4
chr17_-_35487739 0.18 ENST00000628453.3
ENSG00000205045.11
schlafen family member 12 like
chr1_+_171781635 0.17 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr2_+_218399838 0.17 ENST00000273062.7
CTDSP1
CTD small phosphatase 1
chr6_-_32192630 0.16 ENST00000375040.8
GPSM3
G protein signaling modulator 3
chr20_-_51023081 0.16 ENST00000433903.5
ENST00000424171.5
ENST00000371571.5
ENST00000439216.5
KCNG1
potassium voltage-gated channel modifier subfamily G member 1
chr20_+_31968141 0.16 ENST00000562532.3
XKR7
XK related 7
chr7_+_91264426 0.15 ENST00000287934.4
FZD1
frizzled class receptor 1
chr5_-_103120097 0.14 ENST00000508629.5
ENST00000399004.7
GIN1
gypsy retrotransposon integrase 1
chr10_+_122163590 0.14 ENST00000368999.5
TACC2
transforming acidic coiled-coil containing protein 2
chrX_+_15790446 0.13 ENST00000380308.7
ENST00000307771.8
ZRSR2
zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
chr6_-_32192845 0.13 ENST00000487761.5
GPSM3
G protein signaling modulator 3
chr1_+_6451304 0.13 ENST00000636644.1
ESPN
espin
chr13_+_51861963 0.12 ENST00000242819.7
CCDC70
coiled-coil domain containing 70
chr12_-_10723307 0.12 ENST00000279550.11
ENST00000228251.9
YBX3
Y-box binding protein 3
chr5_-_181261078 0.10 ENST00000611618.1
TRIM52
tripartite motif containing 52
chr1_-_211492111 0.10 ENST00000367002.5
ENST00000680073.1
RD3
RD3 regulator of GUCY2D
chr14_+_23555983 0.08 ENST00000404535.3
THTPA
thiamine triphosphatase
chr22_-_21002081 0.08 ENST00000215742.9
ENST00000399133.2
THAP7
THAP domain containing 7
chrX_+_49235460 0.07 ENST00000376227.4
CCDC22
coiled-coil domain containing 22
chr1_-_161199044 0.07 ENST00000367995.3
ENST00000367996.6
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif 4
chr12_+_15322480 0.07 ENST00000674188.1
ENST00000281171.9
ENST00000543886.6
PTPRO
protein tyrosine phosphatase receptor type O
chr22_+_38468036 0.06 ENST00000409006.3
ENST00000216014.9
KDELR3
KDEL endoplasmic reticulum protein retention receptor 3
chr1_-_42766978 0.06 ENST00000372526.2
ENST00000236040.8
ENST00000296388.10
ENST00000397054.7
P3H1
prolyl 3-hydroxylase 1
chr14_+_31561376 0.06 ENST00000550649.5
ENST00000281081.12
NUBPL
nucleotide binding protein like
chr1_+_6451578 0.05 ENST00000434576.2
ENST00000477679.2
ESPN
espin
chr2_+_233388146 0.05 ENST00000409813.7
DGKD
diacylglycerol kinase delta
chr9_+_136665745 0.04 ENST00000371698.3
EGFL7
EGF like domain multiple 7
chr1_+_26788166 0.03 ENST00000374145.6
ENST00000431541.6
ENST00000674273.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr1_+_42767241 0.03 ENST00000372525.7
C1orf50
chromosome 1 open reading frame 50
chr4_-_82373946 0.03 ENST00000352301.8
ENST00000509107.1
ENST00000353341.8
ENST00000313899.12
HNRNPD
heterogeneous nuclear ribonucleoprotein D
chr19_-_11529094 0.03 ENST00000588998.5
ENST00000586149.1
ECSIT
ECSIT signaling integrator
chr21_+_33403391 0.03 ENST00000290219.11
ENST00000381995.5
IFNGR2
interferon gamma receptor 2
chr15_-_66504832 0.02 ENST00000569438.2
ENST00000569696.5
ENST00000307961.11
RPL4
ribosomal protein L4
chrX_+_116436599 0.02 ENST00000598581.3
SLC6A14
solute carrier family 6 member 14
chr1_+_26787667 0.02 ENST00000674335.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr17_+_44557476 0.02 ENST00000315323.5
FZD2
frizzled class receptor 2
chr4_+_673518 0.02 ENST00000506838.5
MYL5
myosin light chain 5
chr1_+_26787926 0.01 ENST00000674202.1
ENST00000674222.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr5_+_159916475 0.01 ENST00000306675.5
ADRA1B
adrenoceptor alpha 1B
chr15_+_66504959 0.01 ENST00000535141.6
ENST00000613446.4
ENST00000446801.6
ZWILCH
zwilch kinetochore protein
chr12_+_15322529 0.01 ENST00000348962.7
PTPRO
protein tyrosine phosphatase receptor type O
chr15_+_45023137 0.01 ENST00000674211.1
ENST00000267814.14
SORD
sorbitol dehydrogenase
chr17_+_7884783 0.01 ENST00000380358.9
CHD3
chromodomain helicase DNA binding protein 3
chr2_+_203706475 0.00 ENST00000374481.7
ENST00000458610.6
CD28
CD28 molecule
chr1_+_218345326 0.00 ENST00000366930.9
TGFB2
transforming growth factor beta 2
chr6_+_26045374 0.00 ENST00000612966.3
H3C3
H3 clustered histone 3
chr5_+_145937793 0.00 ENST00000511217.1
SH3RF2
SH3 domain containing ring finger 2
chr20_+_59721210 0.00 ENST00000395636.6
ENST00000361300.4
PHACTR3
phosphatase and actin regulator 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0007538 primary sex determination(GO:0007538)
0.2 0.7 GO:2001226 negative regulation of anion channel activity(GO:0010360) negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.2 GO:0072719 cellular response to cisplatin(GO:0072719)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.2 GO:0030046 parallel actin filament bundle assembly(GO:0030046)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes