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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for RBPJ
Z-value: 1.22
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Transcription factors associated with RBPJ
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RBPJ | hg38_v1_chr4_+_26320975_26321030 | -0.62 | 8.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RBPJ
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_155667654 Show fit | 16.83 |
ENST00000513574.1
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155667198 Show fit | 11.41 |
ENST00000296518.11
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155667096 Show fit | 8.41 |
ENST00000393832.7
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr7_+_94394886 Show fit | 4.27 |
ENST00000297268.11
ENST00000620463.1 |
collagen type I alpha 2 chain |
|
| chr6_-_75493629 Show fit | 3.71 |
ENST00000393004.6
|
filamin A interacting protein 1 |
|
| chr1_+_61404076 Show fit | 3.49 |
ENST00000357977.5
|
nuclear factor I A |
|
| chr12_-_48865863 Show fit | 3.25 |
ENST00000309739.6
|
Rho family GTPase 1 |
|
| chr6_-_75493773 Show fit | 3.00 |
ENST00000237172.12
|
filamin A interacting protein 1 |
|
| chr8_+_67952028 Show fit | 2.70 |
ENST00000288368.5
|
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 |
|
| chr3_-_142029108 Show fit | 2.58 |
ENST00000497579.5
|
transcription factor Dp-2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.0 | GO:1904835 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.3 | 4.6 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 1.4 | 4.2 | GO:0061027 | umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027) |
| 0.4 | 3.5 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 3.5 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 3.3 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.1 | 2.9 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.7 | 2.8 | GO:0032765 | positive regulation of mast cell cytokine production(GO:0032765) |
| 0.0 | 2.7 | GO:0042752 | regulation of circadian rhythm(GO:0042752) |
| 0.3 | 2.6 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.7 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.5 | 5.0 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.3 | 4.3 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.3 | 3.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 2.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 2.2 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 2.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.1 | 2.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 1.7 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 1.1 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 1.1 | 4.4 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.4 | 4.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.6 | 3.5 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 2.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 2.6 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 2.5 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 2.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 1.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.6 | 1.7 | GO:0035375 | zymogen binding(GO:0035375) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 5.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 4.3 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 3.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.8 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 2.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.3 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 5.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 4.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 2.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.8 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.0 | 1.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.1 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.9 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |