ISMARA results: REL

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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for REL

Z-value: 2.49

Motif logo

Transcription factors associated with REL

Gene Symbol	Gene ID	Gene Info
REL Ensembl NCBI GeneCards UniProt	ENSG00000162924.15	REL

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
REL	hg38_v1_chr2_+_60881553_60881619, hg38_v1_chr2_+_60881515_60881552	0.15	4.6e-01	Click!

Activity profile of REL motif

Sorted Z-values of REL motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

View svg image
View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr6_+_137867241 Show fit	22.09	ENST00000612899.5 ENST00000420009.5	TNFAIP3 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 3
chr6_+_137867414 Show fit	21.98	ENST00000237289.8 ENST00000433680.1	TNFAIP3 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 3
chr11_+_102317492 Show fit	21.89	ENST00000673846.1	BIRC3 Ensembl NCBI GeneCards UniProt Show fit	baculoviral IAP repeat containing 3
chr6_-_29559724 Show fit	21.33	ENST00000377050.5	UBD Ensembl NCBI GeneCards UniProt Show fit	ubiquitin D
chr4_+_73836667 Show fit	19.93	ENST00000226317.10	CXCL6 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 6
chr6_-_31582415 Show fit	19.64	ENST00000429299.3 ENST00000446745.2	LTB Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin beta
chr2_+_227813834 Show fit	16.07	ENST00000358813.5 ENST00000409189.7	CCL20 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 20
chr11_+_102317542 Show fit	15.93	ENST00000532808.5	BIRC3 Ensembl NCBI GeneCards UniProt Show fit	baculoviral IAP repeat containing 3
chr11_+_102317450 Show fit	15.53	ENST00000615299.4 ENST00000527309.2 ENST00000526421.6 ENST00000263464.9	BIRC3 Ensembl NCBI GeneCards UniProt Show fit	baculoviral IAP repeat containing 3
chr6_-_142946312 Show fit	15.52	ENST00000367604.6	HIVEP2 Ensembl NCBI GeneCards UniProt Show fit	HIVEP zinc finger 2
chr10_+_102395693 Show fit	15.04	ENST00000652277.1 ENST00000189444.11 ENST00000661543.1	NFKB2 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor kappa B subunit 2
chr14_+_103123452 Show fit	14.72	ENST00000558056.1 ENST00000560869.6	TNFAIP2 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 2
chr1_-_169734064 Show fit	14.49	ENST00000333360.12	SELE Ensembl NCBI GeneCards UniProt Show fit	selectin E
chr4_-_76036060 Show fit	13.08	ENST00000306621.8	CXCL11 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 11
chr4_-_73998669 Show fit	12.14	ENST00000296027.5	CXCL5 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 5
chr19_+_4229502 Show fit	11.41	ENST00000221847.6	EBI3 Ensembl NCBI GeneCards UniProt Show fit	Epstein-Barr virus induced 3
chr5_-_151087131 Show fit	10.63	ENST00000315050.11 ENST00000523338.5 ENST00000522100.5	TNIP1 Ensembl NCBI GeneCards UniProt Show fit	TNFAIP3 interacting protein 1
chr1_+_109910485 Show fit	10.31	ENST00000525659.5	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1
chr4_+_73869385 Show fit	10.14	ENST00000395761.4	CXCL1 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 1
chr1_-_7940825 Show fit	10.02	ENST00000377507.8	TNFRSF9 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 9
chr5_+_10564064 Show fit	9.71	ENST00000296657.7	ANKRD33B Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat domain 33B
chr11_-_8810635 Show fit	9.55	ENST00000527510.5 ENST00000528527.5 ENST00000313726.11 ENST00000528523.5	DENND2B Ensembl NCBI GeneCards UniProt Show fit	DENN domain containing 2B
chr1_+_109910840 Show fit	8.99	ENST00000329608.11 ENST00000488198.5	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1
chr10_+_102394488 Show fit	8.46	ENST00000369966.8	NFKB2 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor kappa B subunit 2
chr12_-_9760893 Show fit	8.35	ENST00000228434.7 ENST00000536709.1	CD69 Ensembl NCBI GeneCards UniProt Show fit	CD69 molecule
chr4_-_74038681 Show fit	8.31	ENST00000296026.4	CXCL3 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 3
chr8_-_47738153 Show fit	8.06	ENST00000408965.4	CEBPD Ensembl NCBI GeneCards UniProt Show fit	CCAAT enhancer binding protein delta
chr4_-_74099187 Show fit	7.93	ENST00000508487.3	CXCL2 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 2
chr12_+_101877571 Show fit	7.70	ENST00000258534.13	DRAM1 Ensembl NCBI GeneCards UniProt Show fit	DNA damage regulated autophagy modulator 1
chr11_-_72781858 Show fit	7.25	ENST00000537947.5	STARD10 Ensembl NCBI GeneCards UniProt Show fit	StAR related lipid transfer domain containing 10
chr12_-_57110284 Show fit	7.12	ENST00000543873.6 ENST00000554663.5 ENST00000557635.5	STAT6 Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 6
chr6_+_14117764 Show fit	7.08	ENST00000379153.4	CD83 Ensembl NCBI GeneCards UniProt Show fit	CD83 molecule
chr20_+_46118300 Show fit	6.96	ENST00000372285.8 ENST00000372276.7	CD40 Ensembl NCBI GeneCards UniProt Show fit	CD40 molecule
chr8_+_85245451 Show fit	6.44	ENST00000321764.4	CA13 Ensembl NCBI GeneCards UniProt Show fit	carbonic anhydrase 13
chr9_-_133479075 Show fit	6.36	ENST00000414172.1 ENST00000371897.8 ENST00000371899.9	SLC2A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 2 member 6
chr11_-_128522285 Show fit	6.31	ENST00000319397.6 ENST00000535549.5	ETS1 Ensembl NCBI GeneCards UniProt Show fit	ETS proto-oncogene 1, transcription factor
chr20_+_46118277 Show fit	6.29	ENST00000620709.4	CD40 Ensembl NCBI GeneCards UniProt Show fit	CD40 molecule
chr20_-_45348414 Show fit	6.28	ENST00000372733.3	SDC4 Ensembl NCBI GeneCards UniProt Show fit	syndecan 4
chr11_-_128522264 Show fit	6.27	ENST00000531611.5	ETS1 Ensembl NCBI GeneCards UniProt Show fit	ETS proto-oncogene 1, transcription factor
chr19_-_47231191 Show fit	6.22	ENST00000439096.3	BBC3 Ensembl NCBI GeneCards UniProt Show fit	BCL2 binding component 3
chr2_-_162318475 Show fit	6.20	ENST00000648433.1	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr11_-_128522189 Show fit	6.04	ENST00000526145.6	ETS1 Ensembl NCBI GeneCards UniProt Show fit	ETS proto-oncogene 1, transcription factor
chr11_-_72781833 Show fit	5.79	ENST00000535054.1 ENST00000545082.5	STARD10 Ensembl NCBI GeneCards UniProt Show fit	StAR related lipid transfer domain containing 10
chr2_+_161160420 Show fit	5.73	ENST00000392749.7 ENST00000405852.5	TANK Ensembl NCBI GeneCards UniProt Show fit	TRAF family member associated NFKB activator
chr6_+_29100609 Show fit	5.66	ENST00000377171.3	OR2J1 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor family 2 subfamily J member 1
chr2_+_161160299 Show fit	5.55	ENST00000440506.5 ENST00000429217.5 ENST00000406287.5 ENST00000402568.5	TANK Ensembl NCBI GeneCards UniProt Show fit	TRAF family member associated NFKB activator
chr12_-_76878985 Show fit	5.40	ENST00000547435.1 ENST00000552330.5 ENST00000311083.10 ENST00000546966.5	CSRP2 Ensembl NCBI GeneCards UniProt Show fit	cysteine and glycine rich protein 2
chr6_+_32854179 Show fit	5.13	ENST00000374859.3	PSMB9 Ensembl NCBI GeneCards UniProt Show fit	proteasome 20S subunit beta 9
chr22_-_19525369 Show fit	5.13	ENST00000403084.1 ENST00000413119.2	CLDN5 Ensembl NCBI GeneCards UniProt Show fit	claudin 5
chr21_+_33403391 Show fit	4.86	ENST00000290219.11 ENST00000381995.5	IFNGR2 Ensembl NCBI GeneCards UniProt Show fit	interferon gamma receptor 2
chr2_-_203535253 Show fit	4.59	ENST00000457812.5 ENST00000319170.10 ENST00000630330.2 ENST00000308091.8 ENST00000453034.5 ENST00000420371.2	RAPH1 Ensembl NCBI GeneCards UniProt Show fit	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr10_+_30434176 Show fit	4.51	ENST00000263056.6 ENST00000375322.2	MAP3K8 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase 8
chr2_+_108377947 Show fit	4.48	ENST00000272452.7	SULT1C4 Ensembl NCBI GeneCards UniProt Show fit	sulfotransferase family 1C member 4
chr19_-_4338786 Show fit	4.41	ENST00000601482.1 ENST00000600324.5 ENST00000594605.6	STAP2 Ensembl NCBI GeneCards UniProt Show fit	signal transducing adaptor family member 2
chr1_-_204411804 Show fit	4.30	ENST00000367188.5	PPP1R15B Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1 regulatory subunit 15B
chr2_-_162318613 Show fit	4.14	ENST00000649979.2 ENST00000421365.2	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr16_+_50696999 Show fit	4.13	ENST00000300589.6	NOD2 Ensembl NCBI GeneCards UniProt Show fit	nucleotide binding oligomerization domain containing 2
chr9_+_70043840 Show fit	4.11	ENST00000377182.5	MAMDC2 Ensembl NCBI GeneCards UniProt Show fit	MAM domain containing 2
chr7_-_99144053 Show fit	4.04	ENST00000361125.1 ENST00000361368.7	SMURF1 Ensembl NCBI GeneCards UniProt Show fit	SMAD specific E3 ubiquitin protein ligase 1
chr16_-_75464364 Show fit	4.03	ENST00000569540.5 ENST00000566594.1	TMEM170A Ensembl NCBI GeneCards UniProt Show fit ENSG00000261717.5 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 170A novel TMEM170A-CFDP1 readthrough protein
chr21_+_33403466 Show fit	3.98	ENST00000405436.5	IFNGR2 Ensembl NCBI GeneCards UniProt Show fit	interferon gamma receptor 2
chr10_+_88990621 Show fit	3.95	ENST00000352159.8	FAS Ensembl NCBI GeneCards UniProt Show fit	Fas cell surface death receptor
chr4_-_145180496 Show fit	3.93	ENST00000447906.8	OTUD4 Ensembl NCBI GeneCards UniProt Show fit	OTU deubiquitinase 4
chr10_+_30434021 Show fit	3.93	ENST00000542547.5	MAP3K8 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase 8
chr10_+_88990531 Show fit	3.89	ENST00000355740.7	FAS Ensembl NCBI GeneCards UniProt Show fit	Fas cell surface death receptor
chr6_+_144150492 Show fit	3.81	ENST00000367568.5	STX11 Ensembl NCBI GeneCards UniProt Show fit	syntaxin 11
chr11_-_441964 Show fit	3.77	ENST00000332826.7	ANO9 Ensembl NCBI GeneCards UniProt Show fit	anoctamin 9
chr8_-_118951876 Show fit	3.76	ENST00000297350.9	TNFRSF11B Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 11b
chr1_-_209651291 Show fit	3.69	ENST00000391911.5 ENST00000415782.1	LAMB3 Ensembl NCBI GeneCards UniProt Show fit	laminin subunit beta 3
chr1_+_206470463 Show fit	3.63	ENST00000581977.7 ENST00000578328.6 ENST00000584998.5 ENST00000579827.6	IKBKE Ensembl NCBI GeneCards UniProt Show fit	inhibitor of nuclear factor kappa B kinase subunit epsilon
chr15_-_39920248 Show fit	3.55	ENST00000561100.2	GPR176 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 176
chr2_-_96505345 Show fit	3.41	ENST00000310865.7 ENST00000451794.6	NEURL3 Ensembl NCBI GeneCards UniProt Show fit	neuralized E3 ubiquitin protein ligase 3
chr4_-_184474518 Show fit	3.35	ENST00000393593.8	IRF2 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 2
chr16_+_27313879 Show fit	3.33	ENST00000562142.5 ENST00000561742.5 ENST00000543915.6 ENST00000395762.7 ENST00000563002.5	IL4R Ensembl NCBI GeneCards UniProt Show fit	interleukin 4 receptor
chr15_-_75455767 Show fit	3.23	ENST00000360439.8	SIN3A Ensembl NCBI GeneCards UniProt Show fit	SIN3 transcription regulator family member A
chr10_+_88990736 Show fit	3.15	ENST00000357339.6 ENST00000652046.1 ENST00000355279.2	FAS Ensembl NCBI GeneCards UniProt Show fit	Fas cell surface death receptor
chr1_+_24745396 Show fit	3.13	ENST00000374379.9	CLIC4 Ensembl NCBI GeneCards UniProt Show fit	chloride intracellular channel 4
chr8_-_23854796 Show fit	3.11	ENST00000290271.7	STC1 Ensembl NCBI GeneCards UniProt Show fit	stanniocalcin 1
chr3_+_101827982 Show fit	3.01	ENST00000461724.5 ENST00000483180.5 ENST00000394054.6	NFKBIZ Ensembl NCBI GeneCards UniProt Show fit	NFKB inhibitor zeta
chr17_+_42288429 Show fit	3.01	ENST00000676631.1 ENST00000677893.1	STAT5A Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 5A
chr2_-_175005357 Show fit	2.98	ENST00000409156.7 ENST00000444573.2 ENST00000409900.9	CHN1 Ensembl NCBI GeneCards UniProt Show fit	chimerin 1
chr17_+_42288464 Show fit	2.96	ENST00000590726.7 ENST00000678903.1 ENST00000590949.6 ENST00000676585.1 ENST00000588868.5	STAT5A Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 5A
chr10_-_94362925 Show fit	2.94	ENST00000371361.3	NOC3L Ensembl NCBI GeneCards UniProt Show fit	NOC3 like DNA replication regulator
chr5_+_134648772 Show fit	2.83	ENST00000398844.7 ENST00000322887.8	SEC24A Ensembl NCBI GeneCards UniProt Show fit	SEC24 homolog A, COPII coat complex component
chr16_-_75464655 Show fit	2.83	ENST00000569276.1 ENST00000357613.8 ENST00000561878.2 ENST00000566980.1 ENST00000567194.5	TMEM170A Ensembl NCBI GeneCards UniProt Show fit ENSG00000261717.5 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 170A novel TMEM170A-CFDP1 readthrough protein
chr10_-_98268186 Show fit	2.79	ENST00000260702.4	LOXL4 Ensembl NCBI GeneCards UniProt Show fit	lysyl oxidase like 4
chr1_+_16440700 Show fit	2.79	ENST00000504551.6 ENST00000457722.6 ENST00000337132.10 ENST00000443980.6	NECAP2 Ensembl NCBI GeneCards UniProt Show fit	NECAP endocytosis associated 2
chr1_-_159924529 Show fit	2.77	ENST00000320307.8	TAGLN2 Ensembl NCBI GeneCards UniProt Show fit	transgelin 2
chr19_+_38899680 Show fit	2.73	ENST00000576510.5 ENST00000392079.7	NFKBIB Ensembl NCBI GeneCards UniProt Show fit	NFKB inhibitor beta
chr1_-_159925496 Show fit	2.73	ENST00000368097.9	TAGLN2 Ensembl NCBI GeneCards UniProt Show fit	transgelin 2
chr15_+_70853239 Show fit	2.70	ENST00000544974.6 ENST00000558546.5	LRRC49 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 49
chr1_-_64966488 Show fit	2.62	ENST00000342505.5 ENST00000673254.1	JAK1 Ensembl NCBI GeneCards UniProt Show fit	Janus kinase 1
chr6_+_150721073 Show fit	2.57	ENST00000358517.6	PLEKHG1 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology and RhoGEF domain containing G1
chr2_+_68467544 Show fit	2.37	ENST00000303795.9	APLF Ensembl NCBI GeneCards UniProt Show fit	aprataxin and PNKP like factor
chr14_-_35404650 Show fit	2.30	ENST00000553342.1 ENST00000557140.5 ENST00000216797.10	NFKBIA Ensembl NCBI GeneCards UniProt Show fit	NFKB inhibitor alpha
chr10_+_13100075 Show fit	2.25	ENST00000378747.8 ENST00000378757.6 ENST00000378752.7 ENST00000378748.7	OPTN Ensembl NCBI GeneCards UniProt Show fit	optineurin
chr17_-_7687427 Show fit	2.24	ENST00000514944.5 ENST00000503591.1 ENST00000610292.4 ENST00000420246.6 ENST00000455263.6 ENST00000610538.4 ENST00000622645.4 ENST00000445888.6 ENST00000619485.4 ENST00000509690.5 ENST00000604348.5 ENST00000269305.9 ENST00000620739.4	TP53 Ensembl NCBI GeneCards UniProt Show fit	tumor protein p53
chr19_+_38899946 Show fit	2.24	ENST00000572515.5 ENST00000313582.6 ENST00000575359.5	NFKBIB Ensembl NCBI GeneCards UniProt Show fit	NFKB inhibitor beta
chr12_+_11649666 Show fit	2.23	ENST00000396373.9	ETV6 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 6
chr7_+_150368189 Show fit	2.22	ENST00000519397.1 ENST00000479668.5	REPIN1 Ensembl NCBI GeneCards UniProt Show fit	replication initiator 1
chr2_+_207529731 Show fit	2.22	ENST00000430624.5	CREB1 Ensembl NCBI GeneCards UniProt Show fit	cAMP responsive element binding protein 1
chr14_-_24188787 Show fit	2.22	ENST00000625289.1 ENST00000354464.11	IPO4 Ensembl NCBI GeneCards UniProt Show fit	importin 4
chr1_-_27490045 Show fit	2.15	ENST00000536657.1	WASF2 Ensembl NCBI GeneCards UniProt Show fit	WASP family member 2
chr19_-_17847962 Show fit	2.11	ENST00000458235.7 ENST00000534444.1	JAK3 Ensembl NCBI GeneCards UniProt Show fit	Janus kinase 3
chr15_+_44427793 Show fit	1.96	ENST00000558966.5 ENST00000559793.5 ENST00000558968.1	CTDSPL2 Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like 2
chr19_+_33373694 Show fit	1.96	ENST00000284000.9	CEBPG Ensembl NCBI GeneCards UniProt Show fit	CCAAT enhancer binding protein gamma
chr15_-_50765656 Show fit	1.94	ENST00000261854.10	SPPL2A Ensembl NCBI GeneCards UniProt Show fit	signal peptide peptidase like 2A
chr6_-_30742486 Show fit	1.90	ENST00000438162.5 ENST00000454845.1	FLOT1 Ensembl NCBI GeneCards UniProt Show fit	flotillin 1
chr1_+_6206077 Show fit	1.89	ENST00000377939.5	RNF207 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 207
chr7_-_19145306 Show fit	1.89	ENST00000275461.3	FERD3L Ensembl NCBI GeneCards UniProt Show fit	Fer3 like bHLH transcription factor
chr14_+_102777461 Show fit	1.88	ENST00000560371.5 ENST00000347662.8	TRAF3 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor associated factor 3
chr2_+_90114838 Show fit	1.86	ENST00000417279.3	IGKV3D-15 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3D-15
chr1_-_205943449 Show fit	1.85	ENST00000367135.8 ENST00000367134.2	SLC26A9 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 26 member 9
chr12_+_57216779 Show fit	1.85	ENST00000349394.6	NXPH4 Ensembl NCBI GeneCards UniProt Show fit	neurexophilin 4
chr7_-_82443715 Show fit	1.84	ENST00000356253.9 ENST00000423588.1	CACNA2D1 Ensembl NCBI GeneCards UniProt Show fit	calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr1_-_112707314 Show fit	1.82	ENST00000369642.7	RHOC Ensembl NCBI GeneCards UniProt Show fit	ras homolog family member C
chrX_-_48897747 Show fit	1.80	ENST00000490755.2 ENST00000465150.6 ENST00000495490.6	TIMM17B Ensembl NCBI GeneCards UniProt Show fit	translocase of inner mitochondrial membrane 17B
chr8_-_12755457 Show fit	1.77	ENST00000398246.8	LONRF1 Ensembl NCBI GeneCards UniProt Show fit	LON peptidase N-terminal domain and ring finger 1
chr19_+_41219235 Show fit	1.62	ENST00000359092.7	AXL Ensembl NCBI GeneCards UniProt Show fit	AXL receptor tyrosine kinase
chr15_+_52019206 Show fit	1.60	ENST00000681888.1 ENST00000261845.7 ENST00000680066.1 ENST00000680777.1 ENST00000680652.1	MAPK6 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase 6
chr14_+_102777433 Show fit	1.59	ENST00000392745.8	TRAF3 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor associated factor 3
chr12_+_55818033 Show fit	1.55	ENST00000552672.5 ENST00000243045.10 ENST00000550836.1	ORMDL2 Ensembl NCBI GeneCards UniProt Show fit	ORMDL sphingolipid biosynthesis regulator 2
chr14_+_102777555 Show fit	1.53	ENST00000539721.5 ENST00000560463.5	TRAF3 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor associated factor 3
chr3_-_196287649 Show fit	1.53	ENST00000441879.5 ENST00000292823.6 ENST00000431016.6 ENST00000411591.5	PCYT1A Ensembl NCBI GeneCards UniProt Show fit	phosphate cytidylyltransferase 1, choline, alpha
chrX_+_48897900 Show fit	1.48	ENST00000376566.8 ENST00000376563.5	PQBP1 Ensembl NCBI GeneCards UniProt Show fit	polyglutamine binding protein 1
chr4_-_102828048 Show fit	1.46	ENST00000508249.1	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr22_-_27919199 Show fit	1.45	ENST00000634017.1 ENST00000436663.1 ENST00000320996.14 ENST00000335272.10 ENST00000455418.7	PITPNB Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol transfer protein beta
chr22_+_22195753 Show fit	1.40	ENST00000390285.4	IGLV6-57 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 6-57
chr1_-_155991198 Show fit	1.38	ENST00000673475.1	ARHGEF2 Ensembl NCBI GeneCards UniProt Show fit	Rho/Rac guanine nucleotide exchange factor 2
chr9_-_115118198 Show fit	1.37	ENST00000534839.1 ENST00000535648.5	TNC Ensembl NCBI GeneCards UniProt Show fit	tenascin C
chr15_-_89334794 Show fit	1.34	ENST00000268124.11 ENST00000442287.6	POLG Ensembl NCBI GeneCards UniProt Show fit	DNA polymerase gamma, catalytic subunit
chr1_+_109910892 Show fit	1.33	ENST00000369802.7 ENST00000420111.6	CSF1 Ensembl NCBI GeneCards UniProt Show fit	colony stimulating factor 1
chr1_-_27490130 Show fit	1.28	ENST00000618852.5	WASF2 Ensembl NCBI GeneCards UniProt Show fit	WASP family member 2
chr11_+_65712231 Show fit	1.27	ENST00000530446.5 ENST00000534104.5 ENST00000341318.9 ENST00000530605.5 ENST00000528198.5 ENST00000531880.1 ENST00000534650.5	KAT5 Ensembl NCBI GeneCards UniProt Show fit	lysine acetyltransferase 5
chr10_+_12349533 Show fit	1.26	ENST00000619168.5	CAMK1D Ensembl NCBI GeneCards UniProt Show fit	calcium/calmodulin dependent protein kinase ID
chr5_-_59768631 Show fit	1.24	ENST00000502575.1 ENST00000507116.5	PDE4D Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 4D
chr9_-_115118145 Show fit	1.24	ENST00000350763.9	TNC Ensembl NCBI GeneCards UniProt Show fit	tenascin C
chr7_-_103074816 Show fit	1.23	ENST00000379305.7 ENST00000379308.7	FBXL13 Ensembl NCBI GeneCards UniProt Show fit	F-box and leucine rich repeat protein 13
chr11_+_114296347 Show fit	1.18	ENST00000299964.4	NNMT Ensembl NCBI GeneCards UniProt Show fit	nicotinamide N-methyltransferase
chr3_-_179604628 Show fit	1.17	ENST00000476781.6 ENST00000259038.6	MRPL47 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L47
chr3_+_42160160 Show fit	1.17	ENST00000341421.7 ENST00000396175.5	TRAK1 Ensembl NCBI GeneCards UniProt Show fit	trafficking kinesin protein 1
chr12_+_51239278 Show fit	1.16	ENST00000551313.1	DAZAP2 Ensembl NCBI GeneCards UniProt Show fit	DAZ associated protein 2
chr15_-_89211803 Show fit	1.16	ENST00000563254.1	RLBP1 Ensembl NCBI GeneCards UniProt Show fit	retinaldehyde binding protein 1
chr6_+_112236806 Show fit	1.16	ENST00000588837.5 ENST00000590293.5 ENST00000585450.5 ENST00000629766.2 ENST00000590804.5 ENST00000590584.4 ENST00000628122.2 ENST00000627025.1 ENST00000590673.5 ENST00000585611.5 ENST00000587816.2	LAMA4-AS1 Ensembl NCBI GeneCards UniProt Show fit ENSG00000281613.2 Ensembl NCBI GeneCards UniProt Show fit	LAMA4 antisense RNA 1 novel ret finger protein-like 4B
chr10_+_87659839 Show fit	1.16	ENST00000456849.2	PAPSS2 Ensembl NCBI GeneCards UniProt Show fit	3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr9_-_133129395 Show fit	1.16	ENST00000393157.8	RALGDS Ensembl NCBI GeneCards UniProt Show fit	ral guanine nucleotide dissociation stimulator
chr6_+_135181268 Show fit	1.15	ENST00000341911.10 ENST00000442647.7 ENST00000618728.4 ENST00000316528.12 ENST00000616088.4	MYB Ensembl NCBI GeneCards UniProt Show fit	MYB proto-oncogene, transcription factor
chr11_+_65711991 Show fit	1.14	ENST00000377046.7 ENST00000352980.8	KAT5 Ensembl NCBI GeneCards UniProt Show fit	lysine acetyltransferase 5
chr3_-_179604648 Show fit	1.13	ENST00000392659.2	MRPL47 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L47
chr22_-_37984534 Show fit	1.13	ENST00000396884.8	SOX10 Ensembl NCBI GeneCards UniProt Show fit	SRY-box transcription factor 10
chr3_+_153162196 Show fit	1.12	ENST00000323534.5	RAP2B Ensembl NCBI GeneCards UniProt Show fit	RAP2B, member of RAS oncogene family
chr6_+_31715339 Show fit	1.12	ENST00000375824.1 ENST00000375825.7	LY6G6D Ensembl NCBI GeneCards UniProt Show fit	lymphocyte antigen 6 family member G6D
chr18_+_36297661 Show fit	1.11	ENST00000257209.8 ENST00000590592.5 ENST00000359247.8	FHOD3 Ensembl NCBI GeneCards UniProt Show fit	formin homology 2 domain containing 3
chr13_+_87671354 Show fit	1.11	ENST00000683689.1	SLITRK5 Ensembl NCBI GeneCards UniProt Show fit	SLIT and NTRK like family member 5
chr12_-_122500520 Show fit	1.09	ENST00000540586.1 ENST00000543897.5	ZCCHC8 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCHC-type containing 8
chr16_+_84176067 Show fit	1.08	ENST00000564928.1	DNAAF1 Ensembl NCBI GeneCards UniProt Show fit	dynein axonemal assembly factor 1
chr19_+_55654994 Show fit	1.08	ENST00000308924.9	U2AF2 Ensembl NCBI GeneCards UniProt Show fit	U2 small nuclear RNA auxiliary factor 2
chr2_-_89085787 Show fit	1.06	ENST00000390252.2	IGKV3-15 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 3-15
chr9_+_6328363 Show fit	1.03	ENST00000344545.6 ENST00000381428.1 ENST00000314556.4	TPD52L3 Ensembl NCBI GeneCards UniProt Show fit	TPD52 like 3
chr1_-_35193135 Show fit	1.02	ENST00000357214.6	SFPQ Ensembl NCBI GeneCards UniProt Show fit	splicing factor proline and glutamine rich
chr16_-_66925526 Show fit	1.02	ENST00000299759.11 ENST00000420652.5	RRAD Ensembl NCBI GeneCards UniProt Show fit	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
chr4_-_175812746 Show fit	1.00	ENST00000393658.6	GPM6A Ensembl NCBI GeneCards UniProt Show fit	glycoprotein M6A
chr4_-_102827723 Show fit	0.96	ENST00000349311.12	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr6_+_10694916 Show fit	0.96	ENST00000379568.4	PAK1IP1 Ensembl NCBI GeneCards UniProt Show fit	PAK1 interacting protein 1
chr11_-_65614195 Show fit	0.94	ENST00000309100.8 ENST00000529839.1 ENST00000526293.1	MAP3K11 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase 11
chr4_+_168497044 Show fit	0.93	ENST00000505667.6	PALLD Ensembl NCBI GeneCards UniProt Show fit	palladin, cytoskeletal associated protein
chr13_-_37869723 Show fit	0.92	ENST00000426868.6 ENST00000379705.8 ENST00000338947.9 ENST00000355779.6 ENST00000358477.6 ENST00000379673.2	TRPC4 Ensembl NCBI GeneCards UniProt Show fit	transient receptor potential cation channel subfamily C member 4
chr16_+_67537439 Show fit	0.91	ENST00000428437.6 ENST00000569253.5	RIPOR1 Ensembl NCBI GeneCards UniProt Show fit	RHO family interacting cell polarization regulator 1
chr11_-_61967127 Show fit	0.91	ENST00000532601.1	FTH1 Ensembl NCBI GeneCards UniProt Show fit	ferritin heavy chain 1
chr20_+_44355692 Show fit	0.91	ENST00000316673.8 ENST00000609795.5 ENST00000457232.5 ENST00000609262.5	HNF4A Ensembl NCBI GeneCards UniProt Show fit	hepatocyte nuclear factor 4 alpha
chr21_-_41953997 Show fit	0.89	ENST00000380486.4	C2CD2 Ensembl NCBI GeneCards UniProt Show fit	C2 calcium dependent domain containing 2
chr15_+_92904447 Show fit	0.87	ENST00000626782.2	CHD2 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 2
chr4_+_168497066 Show fit	0.87	ENST00000261509.10	PALLD Ensembl NCBI GeneCards UniProt Show fit	palladin, cytoskeletal associated protein
chr15_+_44427591 Show fit	0.86	ENST00000558791.5 ENST00000260327.9	CTDSPL2 Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like 2
chr11_+_72114840 Show fit	0.86	ENST00000622388.4	FOLR3 Ensembl NCBI GeneCards UniProt Show fit	folate receptor gamma
chr12_-_66678934 Show fit	0.86	ENST00000545666.5 ENST00000398016.7 ENST00000359742.9 ENST00000538211.5	GRIP1 Ensembl NCBI GeneCards UniProt Show fit	glutamate receptor interacting protein 1
chr17_+_42833390 Show fit	0.85	ENST00000590720.6 ENST00000586114.5 ENST00000585805.5 ENST00000441946.6 ENST00000591152.5 ENST00000589469.5 ENST00000293362.7 ENST00000592169.2	PSME3 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 3
chr12_-_96400067 Show fit	0.83	ENST00000542666.5	CDK17 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase 17
chr1_+_95117324 Show fit	0.82	ENST00000370203.9 ENST00000456991.5	TLCD4 Ensembl NCBI GeneCards UniProt Show fit	TLC domain containing 4
chr6_+_31946086 Show fit	0.82	ENST00000425368.7	CFB Ensembl NCBI GeneCards UniProt Show fit	complement factor B
chrX_-_40735476 Show fit	0.81	ENST00000324817.6	MED14 Ensembl NCBI GeneCards UniProt Show fit	mediator complex subunit 14
chr12_-_6607397 Show fit	0.81	ENST00000645005.1 ENST00000646806.1	CHD4 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 4
chr20_-_35284715 Show fit	0.76	ENST00000374436.7 ENST00000675032.1	EIF6 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 6
chr2_+_15940537 Show fit	0.76	ENST00000281043.4 ENST00000638417.1	MYCN Ensembl NCBI GeneCards UniProt Show fit	MYCN proto-oncogene, bHLH transcription factor
chr15_-_73368951 Show fit	0.76	ENST00000261917.4	HCN4 Ensembl NCBI GeneCards UniProt Show fit	hyperpolarization activated cyclic nucleotide gated potassium channel 4
chr3_-_58587033 Show fit	0.75	ENST00000447756.2	FAM107A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 107 member A
chr2_-_74465162 Show fit	0.73	ENST00000649854.1 ENST00000650523.1 ENST00000649601.1 ENST00000448666.7 ENST00000409065.5 ENST00000414701.1 ENST00000452063.7 ENST00000649075.1 ENST00000648810.1 ENST00000462443.2	MOGS Ensembl NCBI GeneCards UniProt Show fit	mannosyl-oligosaccharide glucosidase
chr3_+_52685995 Show fit	0.73	ENST00000394799.6 ENST00000418458.6	GNL3 Ensembl NCBI GeneCards UniProt Show fit	G protein nucleolar 3
chr14_+_24147474 Show fit	0.73	ENST00000324103.11 ENST00000559260.5	RNF31 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 31
chr19_-_48746797 Show fit	0.73	ENST00000602105.1 ENST00000332955.7	IZUMO1 Ensembl NCBI GeneCards UniProt Show fit	izumo sperm-egg fusion 1
chr3_+_178807293 Show fit	0.73	ENST00000358316.7 ENST00000617329.1	KCNMB2 Ensembl NCBI GeneCards UniProt Show fit	potassium calcium-activated channel subfamily M regulatory beta subunit 2
chr17_+_36211055 Show fit	0.71	ENST00000617405.5 ENST00000617416.4 ENST00000613173.4 ENST00000620732.4 ENST00000620098.4 ENST00000620576.4 ENST00000620055.4 ENST00000610565.4 ENST00000620250.1	CCL4L2 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 4 like 2
chr4_-_102828022 Show fit	0.71	ENST00000502690.5	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr19_+_2096960 Show fit	0.70	ENST00000588003.5	IZUMO4 Ensembl NCBI GeneCards UniProt Show fit	IZUMO family member 4
chr4_+_133149307 Show fit	0.69	ENST00000618019.1	PCDH10 Ensembl NCBI GeneCards UniProt Show fit	protocadherin 10
chr20_-_35284745 Show fit	0.68	ENST00000374443.7 ENST00000374450.8	EIF6 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 6
chr10_-_6062290 Show fit	0.67	ENST00000256876.10 ENST00000379954.5	IL2RA Ensembl NCBI GeneCards UniProt Show fit	interleukin 2 receptor subunit alpha
chr10_-_107164692 Show fit	0.66	ENST00000263054.11	SORCS1 Ensembl NCBI GeneCards UniProt Show fit	sortilin related VPS10 domain containing receptor 1
chr7_+_107744134 Show fit	0.66	ENST00000222597.6 ENST00000440859.8 ENST00000415884.6	CBLL1 Ensembl NCBI GeneCards UniProt Show fit	Cbl proto-oncogene like 1
chr12_+_51238724 Show fit	0.66	ENST00000449723.7 ENST00000549555.5 ENST00000439799.6 ENST00000412716.8 ENST00000425012.6	DAZAP2 Ensembl NCBI GeneCards UniProt Show fit	DAZ associated protein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
14.7	44.1	GO:0034148	regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
5.9	23.5	GO:0002268	follicular dendritic cell differentiation(GO:0002268)
5.4	16.1	GO:0045360	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
5.2	20.6	GO:1903971	positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
3.8	53.3	GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
3.5	10.6	GO:0044501	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
3.3	13.3	GO:0033590	response to cobalamin(GO:0033590)
2.8	11.3	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
2.8	19.6	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
2.7	21.3	GO:0070842	aggresome assembly(GO:0070842)
2.1	10.3	GO:0034344	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
2.1	4.1	GO:1902523	positive regulation of protein K63-linked ubiquitination(GO:1902523)
1.8	7.1	GO:0002296	T-helper 1 cell lineage commitment(GO:0002296)
1.7	18.6	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
1.7	10.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
1.6	56.6	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
1.6	11.0	GO:0097527	necroptotic signaling pathway(GO:0097527)
1.4	5.4	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
1.3	12.5	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
1.2	2.3	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
1.1	2.2	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
1.1	3.2	GO:1901675	negative regulation of histone H3-K27 acetylation(GO:1901675)
1.0	6.3	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
1.0	13.0	GO:0032782	bile acid secretion(GO:0032782)
1.0	15.2	GO:0051601	exocyst localization(GO:0051601)
0.9	3.8	GO:2001226	negative regulation of anion channel activity(GO:0010360) negative regulation of chloride transport(GO:2001226)
0.9	7.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.9	2.6	GO:0060739	mesenchymal-epithelial cell signaling involved in prostate gland development(GO:0060739)
0.9	6.0	GO:0000255	allantoin metabolic process(GO:0000255)
0.8	13.4	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.8	6.3	GO:0061734	parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.6	1.9	GO:1903947	positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of atrial cardiac muscle cell action potential(GO:1903949) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033)
0.6	1.8	GO:0086048	membrane depolarization during bundle of His cell action potential(GO:0086048)
0.6	5.1	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.6	13.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.5	5.0	GO:0008063	Toll signaling pathway(GO:0008063)
0.5	6.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.5	4.3	GO:1903912	negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.5	3.8	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.4	1.5	GO:0090156	cellular sphingolipid homeostasis(GO:0090156)
0.4	1.9	GO:0071802	negative regulation of podosome assembly(GO:0071802)
0.4	1.2	GO:0000103	sulfate assimilation(GO:0000103)
0.4	1.2	GO:1990922	regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.4	3.7	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.4	2.2	GO:0007296	vitellogenesis(GO:0007296)
0.4	1.8	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
0.3	1.2	GO:0034670	chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.3	1.2	GO:0098957	anterograde axonal transport of mitochondrion(GO:0098957)
0.3	1.4	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.3	6.9	GO:0051292	nuclear pore complex assembly(GO:0051292) endoplasmic reticulum tubular network organization(GO:0071786)
0.3	0.5	GO:2000669	negative regulation of dendritic cell apoptotic process(GO:2000669)
0.3	1.0	GO:1901842	negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2	2.2	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2	2.4	GO:0051106	positive regulation of DNA ligation(GO:0051106)
0.2	1.9	GO:0033504	floor plate development(GO:0033504)
0.2	1.1	GO:0071393	cellular response to progesterone stimulus(GO:0071393)
0.2	1.3	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.2	1.9	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway(GO:0034141) positive regulation of cell adhesion molecule production(GO:0060355)
0.2	1.6	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.2	1.7	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.2	2.9	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.2	4.5	GO:0006068	ethanol catabolic process(GO:0006068)
0.2	0.5	GO:0021849	neuroblast division in subventricular zone(GO:0021849)
0.2	6.4	GO:1904659	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2	4.2	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1	0.7	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.1	1.5	GO:0006657	CDP-choline pathway(GO:0006657)
0.1	3.8	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	1.4	GO:0072553	terminal button organization(GO:0072553)
0.1	1.0	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.1	0.6	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.1	1.2	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1	0.5	GO:1900535	medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1	0.1	GO:0021784	postganglionic parasympathetic fiber development(GO:0021784)
0.1	0.9	GO:0006880	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1	3.4	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
0.1	4.7	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1	0.8	GO:0071321	cellular response to cGMP(GO:0071321)
0.1	6.4	GO:0006730	one-carbon metabolic process(GO:0006730)
0.1	3.9	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.1	2.8	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.3	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	1.8	GO:0003334	keratinocyte development(GO:0003334)
0.1	0.3	GO:1990022	RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1	1.9	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.1	0.3	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
0.1	1.8	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.1	2.4	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.1	0.9	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	2.8	GO:0060334	regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1	4.0	GO:0035666	TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.1	8.3	GO:0035690	cellular response to drug(GO:0035690)
0.1	0.2	GO:1904397	positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1	0.2	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1	0.6	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1	0.5	GO:0070269	ectopic germ cell programmed cell death(GO:0035234) pyroptosis(GO:0070269)
0.1	1.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.1	0.3	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1	1.2	GO:0006776	vitamin A metabolic process(GO:0006776)
0.1	3.0	GO:0008045	motor neuron axon guidance(GO:0008045)
0.1	0.8	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	4.5	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1	0.5	GO:2000074	regulation of type B pancreatic cell development(GO:2000074) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1	0.9	GO:0014051	gamma-aminobutyric acid secretion(GO:0014051)
0.1	5.5	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1	0.7	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.1	1.2	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1	6.0	GO:0031295	T cell costimulation(GO:0031295)
0.1	3.3	GO:0007622	rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.1	0.9	GO:0015884	folic acid transport(GO:0015884)
0.0	0.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.9	GO:0051683	establishment of Golgi localization(GO:0051683)
0.0	0.4	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.0	0.5	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	1.1	GO:0021756	striatum development(GO:0021756)
0.0	1.1	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	0.6	GO:0035855	megakaryocyte development(GO:0035855)
0.0	4.6	GO:0048675	axon extension(GO:0048675)
0.0	1.1	GO:1903831	acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0	5.7	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	1.0	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.5	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.5	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.0	3.3	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	0.5	GO:0010818	T cell chemotaxis(GO:0010818)
0.0	1.1	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0	0.3	GO:0014901	regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0	1.5	GO:0048814	regulation of dendrite morphogenesis(GO:0048814)
0.0	0.7	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
0.0	6.4	GO:0048839	inner ear development(GO:0048839)
0.0	1.6	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.5	GO:1904776	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0	0.5	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	2.2	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.0	0.1	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.2	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.1	GO:1902527	positive regulation of protein monoubiquitination(GO:1902527)
0.0	1.5	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.2	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.7	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.3	GO:0050901	leukocyte tethering or rolling(GO:0050901)
0.0	0.2	GO:0036301	interleukin-21 production(GO:0032625) macrophage colony-stimulating factor production(GO:0036301) interleukin-21 secretion(GO:0072619) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.0	1.9	GO:0071222	cellular response to lipopolysaccharide(GO:0071222)
0.0	0.0	GO:0038158	granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.0	1.3	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.4	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.9	GO:0060021	palate development(GO:0060021)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.9	23.5	GO:0033257	Bcl3/NF-kappaB2 complex(GO:0033257)
3.4	20.6	GO:1990682	CSF1-CSF1R complex(GO:1990682)
1.7	13.3	GO:0043196	varicosity(GO:0043196)
0.9	13.0	GO:0046581	intercellular canaliculus(GO:0046581)
0.6	5.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.6	2.3	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.5	3.8	GO:0005610	laminin-5 complex(GO:0005610)
0.5	15.2	GO:0000145	exocyst(GO:0000145)
0.4	1.3	GO:0005760	gamma DNA polymerase complex(GO:0005760)
0.3	7.7	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.3	21.3	GO:0016235	aggresome(GO:0016235)
0.3	1.9	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.3	5.0	GO:0035631	CD40 receptor complex(GO:0035631)
0.3	1.5	GO:0035339	SPOTS complex(GO:0035339)
0.3	1.5	GO:0042587	glycogen granule(GO:0042587)
0.3	2.4	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3	4.1	GO:0031209	SCAR complex(GO:0031209)
0.3	0.8	GO:0098855	HCN channel complex(GO:0098855)
0.2	1.5	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.2	4.3	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.2	1.2	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
0.2	0.9	GO:0070288	intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.2	0.9	GO:0008537	proteasome activator complex(GO:0008537)
0.2	1.1	GO:0089701	U2AF(GO:0089701)
0.2	2.9	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	81.3	GO:0045121	membrane raft(GO:0045121)
0.1	3.2	GO:0016580	Sin3 complex(GO:0016580)
0.1	1.8	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1	0.5	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.1	1.0	GO:0042382	paraspeckles(GO:0042382)
0.1	1.8	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	2.8	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	5.7	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	2.8	GO:0030125	clathrin vesicle coat(GO:0030125)
0.1	22.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	0.2	GO:0031905	early endosome lumen(GO:0031905)
0.1	0.7	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1	3.1	GO:0005902	microvillus(GO:0005902)
0.1	5.4	GO:0030175	filopodium(GO:0030175)
0.1	1.4	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	49.2	GO:0000323	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1	1.8	GO:0098858	actin-based cell projection(GO:0098858)
0.0	2.4	GO:0002102	podosome(GO:0002102)
0.0	84.0	GO:0005615	extracellular space(GO:0005615)
0.0	2.2	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	1.6	GO:0008180	COP9 signalosome(GO:0008180)
0.0	1.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	2.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	15.5	GO:0005667	transcription factor complex(GO:0005667)
0.0	2.3	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.7	GO:0002080	acrosomal membrane(GO:0002080)
0.0	1.7	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.1	GO:0005865	striated muscle thin filament(GO:0005865)
0.0	1.2	GO:1904115	axon cytoplasm(GO:1904115)
0.0	3.1	GO:0016605	PML body(GO:0016605)
0.0	0.7	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.0	2.2	GO:0005643	nuclear pore(GO:0005643)
0.0	0.1	GO:0044305	calyx of Held(GO:0044305)
0.0	3.2	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.0	1.7	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0	0.3	GO:0005922	connexon complex(GO:0005922)
0.0	2.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	2.9	GO:0005578	proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.4	16.1	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
4.8	71.5	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
2.9	20.6	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
2.3	43.6	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
2.2	8.8	GO:0004906	interferon-gamma receptor activity(GO:0004906)
1.9	11.3	GO:0035800	deubiquitinase activator activity(GO:0035800)
1.8	11.0	GO:0043120	tumor necrosis factor binding(GO:0043120)
1.2	14.5	GO:0033691	sialic acid binding(GO:0033691)
1.0	53.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.0	2.9	GO:0008384	IkappaB kinase activity(GO:0008384)
0.9	27.0	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.9	21.3	GO:0070628	proteasome binding(GO:0070628)
0.5	6.3	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.4	6.4	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.4	1.1	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.4	17.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.3	6.4	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.3	20.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.3	1.5	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3	2.6	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.3	2.6	GO:0045545	syndecan binding(GO:0045545)
0.3	1.9	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2	4.1	GO:0050700	CARD domain binding(GO:0050700)
0.2	9.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.2	1.2	GO:0005502	11-cis retinal binding(GO:0005502)
0.2	1.8	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2	4.5	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.2	10.6	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.2	4.0	GO:0048185	activin binding(GO:0048185) I-SMAD binding(GO:0070411)
0.2	5.1	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2	3.8	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.2	0.9	GO:0061133	endopeptidase activator activity(GO:0061133)
0.2	1.1	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.2	0.8	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.1	1.4	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	0.4	GO:0008336	gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1	2.8	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1	0.9	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	1.8	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1	4.5	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.1	1.2	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1	2.4	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1	0.3	GO:0098640	integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1	4.8	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1	4.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.1	7.4	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	0.2	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.1	11.8	GO:0043021	ribonucleoprotein complex binding(GO:0043021)
0.1	0.9	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	4.0	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	10.6	GO:0000149	SNARE binding(GO:0000149)
0.1	2.0	GO:0008301	DNA binding, bending(GO:0008301)
0.1	3.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.1	3.0	GO:0046875	ephrin receptor binding(GO:0046875)
0.1	1.1	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.1	1.6	GO:0004707	MAP kinase activity(GO:0004707)
0.1	25.2	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1	1.8	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	9.6	GO:0004896	cytokine receptor activity(GO:0004896)
0.1	0.5	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1	2.4	GO:0070491	repressing transcription factor binding(GO:0070491)
0.1	0.5	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.1	0.4	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.1	0.9	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.5	GO:0042731	PH domain binding(GO:0042731)
0.0	1.9	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	5.9	GO:0051117	ATPase binding(GO:0051117)
0.0	1.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	1.6	GO:0070840	dynein complex binding(GO:0070840)
0.0	1.8	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	1.3	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.7	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.9	GO:0005542	folic acid binding(GO:0005542)
0.0	0.5	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	5.7	GO:0004984	olfactory receptor activity(GO:0004984)
0.0	4.6	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	1.2	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.5	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.4	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	2.1	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.4	GO:0015926	glucosidase activity(GO:0015926)
0.0	0.9	GO:0071889	14-3-3 protein binding(GO:0071889)
0.0	0.8	GO:0001848	complement binding(GO:0001848)
0.0	1.3	GO:0001046	core promoter sequence-specific DNA binding(GO:0001046)
0.0	0.3	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.0	3.1	GO:0005179	hormone activity(GO:0005179)
0.0	7.6	GO:0030246	carbohydrate binding(GO:0030246)
0.0	0.5	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	1.4	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.7	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	3.9	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	1.0	GO:0001047	core promoter binding(GO:0001047)
0.0	0.4	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.4	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.8	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	8.2	GO:0044212	transcription regulatory region DNA binding(GO:0044212)
0.0	1.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	0.8	GO:0019003	GDP binding(GO:0019003)
0.0	1.5	GO:0005262	calcium channel activity(GO:0005262)
0.0	0.0	GO:0052815	medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.1	128.2	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.6	20.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.6	10.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5	8.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.5	24.9	PID CD40 PATHWAY	CD40/CD40L signaling
0.4	5.2	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.4	10.1	PID IL23 PATHWAY	IL23-mediated signaling events
0.3	8.1	PID IL27 PATHWAY	IL27-mediated signaling events
0.3	7.9	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3	15.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.3	20.6	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	7.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	7.2	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.2	86.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	3.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	8.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	9.1	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	8.9	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	2.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	6.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	0.8	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	2.4	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	7.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	2.9	PID REELIN PATHWAY	Reelin signaling pathway
0.1	4.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	1.2	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	1.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	2.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	100.9	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
1.7	5.0	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
1.4	30.8	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
1.3	88.1	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.1	10.3	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.6	18.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.5	10.7	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	6.4	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.3	7.6	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.3	6.4	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.3	7.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	8.4	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.2	5.6	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.2	6.3	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	3.5	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.2	8.1	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	3.8	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	13.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	5.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	0.9	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.1	1.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	4.7	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	1.2	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	1.5	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.8	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.7	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0	4.0	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.0	4.3	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	1.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	4.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	1.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	2.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.1	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.7	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.6	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	4.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.9	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.5	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	1.2	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.0	0.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.7	REACTOME PI METABOLISM	Genes involved in PI Metabolism

Results for REL

Z-value: 2.49

Motif logo

Transcription factors associated with REL

Activity-expression correlation:

Activity profile of REL motif

Sorted Z-values of REL motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: