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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for REL
Z-value: 2.49
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Transcription factors associated with REL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REL | hg38_v1_chr2_+_60881553_60881619, hg38_v1_chr2_+_60881515_60881552 | 0.15 | 4.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of REL
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_137867241 Show fit | 22.09 |
ENST00000612899.5
ENST00000420009.5 |
TNF alpha induced protein 3 |
|
| chr6_+_137867414 Show fit | 21.98 |
ENST00000237289.8
ENST00000433680.1 |
TNF alpha induced protein 3 |
|
| chr11_+_102317492 Show fit | 21.89 |
ENST00000673846.1
|
baculoviral IAP repeat containing 3 |
|
| chr6_-_29559724 Show fit | 21.33 |
ENST00000377050.5
|
ubiquitin D |
|
| chr4_+_73836667 Show fit | 19.93 |
ENST00000226317.10
|
C-X-C motif chemokine ligand 6 |
|
| chr6_-_31582415 Show fit | 19.64 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr2_+_227813834 Show fit | 16.07 |
ENST00000358813.5
ENST00000409189.7 |
C-C motif chemokine ligand 20 |
|
| chr11_+_102317542 Show fit | 15.93 |
ENST00000532808.5
|
baculoviral IAP repeat containing 3 |
|
| chr11_+_102317450 Show fit | 15.53 |
ENST00000615299.4
ENST00000527309.2 ENST00000526421.6 ENST00000263464.9 |
baculoviral IAP repeat containing 3 |
|
| chr6_-_142946312 Show fit | 15.52 |
ENST00000367604.6
|
HIVEP zinc finger 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 56.6 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 3.8 | 53.3 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 14.7 | 44.1 | GO:0034148 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) |
| 5.9 | 23.5 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 2.7 | 21.3 | GO:0070842 | aggresome assembly(GO:0070842) |
| 5.2 | 20.6 | GO:1903971 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 2.8 | 19.6 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 1.7 | 18.6 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996) |
| 5.4 | 16.1 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 1.0 | 15.2 | GO:0051601 | exocyst localization(GO:0051601) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 84.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 81.3 | GO:0045121 | membrane raft(GO:0045121) |
| 0.1 | 49.2 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 5.9 | 23.5 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 22.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 21.3 | GO:0016235 | aggresome(GO:0016235) |
| 3.4 | 20.6 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 15.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.5 | 15.2 | GO:0000145 | exocyst(GO:0000145) |
| 1.7 | 13.3 | GO:0043196 | varicosity(GO:0043196) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 71.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.0 | 53.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 2.3 | 43.6 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.9 | 27.0 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 25.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.9 | 21.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 2.9 | 20.6 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.3 | 20.3 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.4 | 17.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 5.4 | 16.1 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 128.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 86.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 24.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.6 | 20.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 20.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.3 | 15.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.6 | 10.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.4 | 10.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 9.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 8.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 100.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.3 | 88.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.4 | 30.8 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.6 | 18.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 13.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.5 | 10.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 1.1 | 10.3 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.2 | 8.4 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.2 | 8.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 7.7 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |