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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for RELA
Z-value: 4.71
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Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg38_v1_chr11_-_65662780_65662928 | 0.93 | 2.0e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_76023489 Show fit | 78.16 |
ENST00000306602.3
|
C-X-C motif chemokine ligand 10 |
|
| chr6_-_31582415 Show fit | 58.00 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr11_+_102317492 Show fit | 54.56 |
ENST00000673846.1
|
baculoviral IAP repeat containing 3 |
|
| chr6_-_29559724 Show fit | 46.65 |
ENST00000377050.5
|
ubiquitin D |
|
| chr6_+_137867241 Show fit | 45.59 |
ENST00000612899.5
ENST00000420009.5 |
TNF alpha induced protein 3 |
|
| chr6_+_137867414 Show fit | 44.98 |
ENST00000237289.8
ENST00000433680.1 |
TNF alpha induced protein 3 |
|
| chr19_+_45001430 Show fit | 44.20 |
ENST00000625761.2
ENST00000505236.1 ENST00000221452.13 |
RELB proto-oncogene, NF-kB subunit |
|
| chr11_+_102317542 Show fit | 40.40 |
ENST00000532808.5
|
baculoviral IAP repeat containing 3 |
|
| chr10_+_102394488 Show fit | 39.71 |
ENST00000369966.8
|
nuclear factor kappa B subunit 2 |
|
| chr6_-_142946312 Show fit | 39.64 |
ENST00000367604.6
|
HIVEP zinc finger 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 133.5 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 3.9 | 132.9 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 9.8 | 108.0 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 8.5 | 93.0 | GO:0042090 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 30.2 | 90.6 | GO:0034147 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) |
| 9.0 | 63.0 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 15.1 | 60.2 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 14.3 | 57.2 | GO:1902228 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 13.5 | 54.1 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 7.7 | 53.6 | GO:0000255 | allantoin metabolic process(GO:0000255) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 223.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 161.6 | GO:0045121 | membrane raft(GO:0045121) |
| 0.3 | 109.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 9.9 | 89.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 83.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 74.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 15.1 | 60.2 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 9.5 | 57.2 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.9 | 54.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.3 | 48.6 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 144.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 13.5 | 134.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 2.7 | 127.9 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 21.9 | 109.3 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 1.5 | 72.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.0 | 66.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.2 | 64.7 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 8.2 | 57.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 7.1 | 56.7 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.3 | 56.1 | GO:0004896 | cytokine receptor activity(GO:0004896) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 349.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.4 | 178.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.6 | 135.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 2.2 | 88.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.9 | 79.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 2.0 | 74.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.8 | 57.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 1.0 | 49.6 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 1.1 | 47.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 43.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 288.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 5.7 | 285.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.0 | 100.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 4.1 | 90.4 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 3.5 | 74.1 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 2.0 | 56.7 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.7 | 32.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.7 | 31.3 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 3.2 | 28.4 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.6 | 27.6 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |