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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for REST

Z-value: 0.82

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.19 REST

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg38_v1_chr4_+_56908894_56909016,
hg38_v1_chr4_+_56907876_56907947		0.252.2e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_93430927 2.47 ENST00000393151.6
UNC79
unc-79 homolog, NALCN channel complex subunit
chr11_-_72781833 2.00 ENST00000535054.1
ENST00000545082.5
STARD10
StAR related lipid transfer domain containing 10
chr10_+_97849824 1.88 ENST00000370602.6
GOLGA7B
golgin A7 family member B
chr14_+_93430853 1.60 ENST00000553484.5
UNC79
unc-79 homolog, NALCN channel complex subunit
chr4_+_95091462 1.26 ENST00000264568.8
BMPR1B
bone morphogenetic protein receptor type 1B
chr4_+_8580387 1.24 ENST00000382487.5
GPR78
G protein-coupled receptor 78
chr9_+_132582581 1.15 ENST00000263610.7
BARHL1
BarH like homeobox 1
chr2_-_51032151 1.12 ENST00000628515.2
NRXN1
neurexin 1
chr20_+_31968141 1.10 ENST00000562532.3
XKR7
XK related 7
chr18_+_59899988 1.00 ENST00000316660.7
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_-_40218339 0.95 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr12_+_66755 0.84 ENST00000538872.6
IQSEC3
IQ motif and Sec7 domain ArfGEF 3
chr12_+_112791738 0.81 ENST00000389385.9
RPH3A
rabphilin 3A
chr12_+_112791933 0.79 ENST00000551052.5
ENST00000415485.7
RPH3A
rabphilin 3A
chr12_-_12684490 0.77 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr5_+_33936386 0.74 ENST00000330120.5
RXFP3
relaxin family peptide receptor 3
chr6_+_43635832 0.74 ENST00000372171.5
MAD2L1BP
MAD2L1 binding protein
chr6_+_25652201 0.73 ENST00000612225.4
ENST00000377961.3
SCGN
secretagogin, EF-hand calcium binding protein
chr9_-_136205122 0.71 ENST00000371748.10
LHX3
LIM homeobox 3
chr15_-_82709886 0.70 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
AP3B2
adaptor related protein complex 3 subunit beta 2
chr9_-_133609325 0.69 ENST00000673969.1
FAM163B
family with sequence similarity 163 member B
chr8_-_144336451 0.69 ENST00000569446.3
SCRT1
scratch family transcriptional repressor 1
chr6_+_154039480 0.66 ENST00000229768.9
ENST00000419506.6
ENST00000524163.5
ENST00000414028.6
ENST00000435918.6
ENST00000337049.8
OPRM1
opioid receptor mu 1
chr22_+_22711689 0.64 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr15_-_31870651 0.61 ENST00000307050.6
ENST00000560598.2
OTUD7A
OTU deubiquitinase 7A
chr6_+_154039416 0.61 ENST00000452687.6
OPRM1
opioid receptor mu 1
chr3_-_8644782 0.60 ENST00000544814.6
SSUH2
ssu-2 homolog
chr6_+_154039333 0.58 ENST00000428397.6
OPRM1
opioid receptor mu 1
chrX_-_153971810 0.57 ENST00000310441.12
HCFC1
host cell factor C1
chr6_+_35805347 0.56 ENST00000360215.3
LHFPL5
LHFPL tetraspan subfamily member 5
chr8_-_56445941 0.55 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chrX_-_153875847 0.55 ENST00000361699.8
ENST00000361981.7
L1CAM
L1 cell adhesion molecule
chr20_-_45515612 0.54 ENST00000217428.7
SPINT3
serine peptidase inhibitor, Kunitz type 3
chr14_-_74426102 0.53 ENST00000554953.1
ENST00000331628.8
SYNDIG1L
synapse differentiation inducing 1 like
chr3_+_75906666 0.53 ENST00000487694.7
ENST00000602589.5
ROBO2
roundabout guidance receptor 2
chr20_+_46029206 0.52 ENST00000243964.7
SLC12A5
solute carrier family 12 member 5
chr5_+_71719267 0.50 ENST00000296777.5
CARTPT
CART prepropeptide
chr15_-_82709859 0.50 ENST00000542200.2
ENST00000535359.6
ENST00000668990.2
ENST00000652847.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chr5_-_151924824 0.50 ENST00000455880.2
GLRA1
glycine receptor alpha 1
chr5_-_136365476 0.49 ENST00000378459.7
ENST00000502753.4
ENST00000513104.6
ENST00000352189.8
TRPC7
transient receptor potential cation channel subfamily C member 7
chr11_+_125903320 0.48 ENST00000525943.1
DDX25
DEAD-box helicase 25
chr5_-_151924846 0.47 ENST00000274576.9
GLRA1
glycine receptor alpha 1
chr16_+_24256313 0.47 ENST00000005284.4
CACNG3
calcium voltage-gated channel auxiliary subunit gamma 3
chr20_+_46029165 0.47 ENST00000616201.4
ENST00000616202.4
ENST00000616933.4
ENST00000626937.2
SLC12A5
solute carrier family 12 member 5
chr18_-_43277482 0.46 ENST00000255224.8
ENST00000590752.5
ENST00000596867.1
SYT4
synaptotagmin 4
chr10_+_59177161 0.46 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein like
chr1_-_241357085 0.44 ENST00000366564.5
RGS7
regulator of G protein signaling 7
chr4_-_174829212 0.43 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr1_-_151716782 0.43 ENST00000420342.1
ENST00000290583.9
CELF3
CUGBP Elav-like family member 3
chr9_-_71446835 0.43 ENST00000357533.6
TRPM3
transient receptor potential cation channel subfamily M member 3
chr1_+_212432891 0.41 ENST00000366988.5
NENF
neudesin neurotrophic factor
chr20_+_63696643 0.40 ENST00000369996.3
TNFRSF6B
TNF receptor superfamily member 6b
chr1_-_241357171 0.40 ENST00000440928.6
RGS7
regulator of G protein signaling 7
chrX_-_49200174 0.40 ENST00000472598.5
ENST00000263233.9
ENST00000479808.5
SYP
synaptophysin
chr9_+_137139481 0.39 ENST00000371546.8
ENST00000371550.8
ENST00000371553.7
ENST00000371555.8
ENST00000371559.8
ENST00000371560.4
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr17_-_3398410 0.34 ENST00000322608.2
OR1E1
olfactory receptor family 1 subfamily E member 1
chr14_-_51095066 0.34 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr9_+_137139139 0.34 ENST00000371561.8
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr5_-_176610104 0.33 ENST00000303991.5
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr2_-_51032091 0.33 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
NRXN1
neurexin 1
chr6_+_154039102 0.33 ENST00000360422.8
ENST00000330432.12
OPRM1
opioid receptor mu 1
chr3_+_9703826 0.33 ENST00000613455.4
ENST00000383831.7
ENST00000383832.8
CPNE9
copine family member 9
chr3_-_132035004 0.33 ENST00000429747.6
CPNE4
copine 4
chr2_-_51032536 0.32 ENST00000626899.1
ENST00000406316.6
NRXN1
neurexin 1
chr9_-_101594995 0.32 ENST00000636434.1
PPP3R2
protein phosphatase 3 regulatory subunit B, beta
chr14_+_92923143 0.31 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr10_+_87659839 0.30 ENST00000456849.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr3_-_48662877 0.30 ENST00000164024.5
CELSR3
cadherin EGF LAG seven-pass G-type receptor 3
chr20_-_63653413 0.30 ENST00000370053.3
STMN3
stathmin 3
chr3_+_62318983 0.29 ENST00000232519.9
ENST00000462069.6
ENST00000465142.5
C3orf14
chromosome 3 open reading frame 14
chr9_-_101594918 0.29 ENST00000374806.2
PPP3R2
protein phosphatase 3 regulatory subunit B, beta
chr15_-_72320149 0.28 ENST00000287202.10
CELF6
CUGBP Elav-like family member 6
chr4_+_157220691 0.28 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr11_-_125903190 0.28 ENST00000227474.8
ENST00000613398.4
ENST00000534158.5
ENST00000529801.1
PUS3
pseudouridine synthase 3
chr8_-_90082871 0.27 ENST00000265431.7
CALB1
calbindin 1
chr3_+_62319037 0.27 ENST00000494481.5
C3orf14
chromosome 3 open reading frame 14
chr2_-_51032390 0.27 ENST00000404971.5
NRXN1
neurexin 1
chr12_+_113358542 0.27 ENST00000545182.6
ENST00000280800.5
PLBD2
phospholipase B domain containing 2
chr10_-_44385043 0.26 ENST00000374426.6
ENST00000395794.2
ENST00000374429.6
ENST00000395793.7
ENST00000343575.10
ENST00000395795.5
CXCL12
C-X-C motif chemokine ligand 12
chr9_-_128275987 0.26 ENST00000490628.2
ENST00000421699.7
ENST00000611957.4
ENST00000450617.6
GOLGA2
golgin A2
chr5_+_175871570 0.25 ENST00000512824.5
ENST00000393745.8
CPLX2
complexin 2
chr14_-_94293071 0.25 ENST00000554723.5
SERPINA10
serpin family A member 10
chr14_-_94293024 0.24 ENST00000393096.5
SERPINA10
serpin family A member 10
chr19_-_55180104 0.23 ENST00000537500.5
SYT5
synaptotagmin 5
chr6_+_109978297 0.23 ENST00000275169.5
GPR6
G protein-coupled receptor 6
chr4_+_157220654 0.23 ENST00000393815.6
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr9_-_128275935 0.23 ENST00000610329.4
GOLGA2
golgin A2
chr14_-_94293260 0.23 ENST00000261994.9
SERPINA10
serpin family A member 10
chr11_+_637244 0.21 ENST00000176183.6
DRD4
dopamine receptor D4
chr6_+_138404206 0.21 ENST00000607197.6
ENST00000367697.7
HEBP2
heme binding protein 2
chr5_+_64505981 0.21 ENST00000334025.3
RGS7BP
regulator of G protein signaling 7 binding protein
chr17_+_44308573 0.21 ENST00000590941.5
ENST00000225441.11
ENST00000426726.8
RUNDC3A
RUN domain containing 3A
chr6_+_109978256 0.20 ENST00000414000.3
GPR6
G protein-coupled receptor 6
chr1_-_101996919 0.20 ENST00000370103.9
OLFM3
olfactomedin 3
chr9_-_121050264 0.19 ENST00000223642.3
C5
complement C5
chr10_-_101031095 0.18 ENST00000645349.1
ENST00000619208.6
ENST00000644782.1
ENST00000370215.7
ENST00000646029.1
PDZD7
PDZ domain containing 7
chr20_+_37383648 0.18 ENST00000373567.6
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
chr18_-_5197241 0.17 ENST00000434239.4
AKAIN1
A-kinase anchor inhibitor 1
chr12_-_57478070 0.17 ENST00000549602.1
ENST00000430041.6
ARHGAP9
Rho GTPase activating protein 9
chr19_-_55180242 0.17 ENST00000592470.1
ENST00000354308.8
SYT5
synaptotagmin 5
chr17_-_29005913 0.17 ENST00000442608.7
ENST00000317338.17
ENST00000335960.10
SEZ6
seizure related 6 homolog
chr13_-_110561668 0.16 ENST00000267328.5
RAB20
RAB20, member RAS oncogene family
chr17_-_7315084 0.16 ENST00000570780.5
GPS2
G protein pathway suppressor 2
chr1_+_37793865 0.16 ENST00000397631.7
MANEAL
mannosidase endo-alpha like
chr7_+_8433602 0.15 ENST00000405863.6
NXPH1
neurexophilin 1
chr1_+_154567770 0.15 ENST00000368476.4
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr1_+_37793787 0.15 ENST00000373045.11
MANEAL
mannosidase endo-alpha like
chr1_-_153544997 0.14 ENST00000368715.5
S100A4
S100 calcium binding protein A4
chr9_+_114329869 0.14 ENST00000431067.4
ORM2
orosomucoid 2
chr11_-_93197932 0.14 ENST00000326402.9
SLC36A4
solute carrier family 36 member 4
chr11_+_45885625 0.13 ENST00000241014.6
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr17_+_58148384 0.13 ENST00000268912.6
ENST00000641449.1
OR4D1
olfactory receptor family 4 subfamily D member 1
chr2_+_130756291 0.13 ENST00000458606.5
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr1_+_171781635 0.13 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr12_+_71439789 0.13 ENST00000266674.10
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr2_+_225399684 0.12 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr15_-_21742799 0.12 ENST00000622410.2
ENSG00000278263.2
novel protein, identical to IGHV4-4
chr3_-_42701513 0.12 ENST00000310417.9
HHATL
hedgehog acyltransferase like
chr6_+_25652272 0.12 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr2_-_47570905 0.11 ENST00000327876.5
KCNK12
potassium two pore domain channel subfamily K member 12
chr17_-_29006145 0.10 ENST00000360295.13
SEZ6
seizure related 6 homolog
chrX_-_47619850 0.10 ENST00000295987.13
ENST00000340666.5
SYN1
synapsin I
chr16_+_4958289 0.10 ENST00000251170.12
SEC14L5
SEC14 like lipid binding 5
chr10_-_77638369 0.06 ENST00000372443.6
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr3_-_114178698 0.03 ENST00000467632.5
DRD3
dopamine receptor D3
chr10_+_26216766 0.03 ENST00000376261.8
GAD2
glutamate decarboxylase 2
chr19_-_51342130 0.02 ENST00000335624.5
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr12_+_118981531 0.02 ENST00000267260.5
SRRM4
serine/arginine repetitive matrix 4
chr2_+_114442616 0.01 ENST00000410059.6
DPP10
dipeptidyl peptidase like 10
chr1_+_154567820 0.00 ENST00000637900.1
CHRNB2
cholinergic receptor nicotinic beta 2 subunit

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.3 4.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 0.7 GO:0008355 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
0.2 0.7 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.2 1.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 0.6 GO:0019046 release from viral latency(GO:0019046)
0.2 1.3 GO:1902731 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.2 0.5 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 2.0 GO:0032782 bile acid secretion(GO:0032782)
0.2 1.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 2.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 1.0 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.7 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
0.1 0.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.3 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.7 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 1.2 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.1 0.5 GO:0090166 Golgi disassembly(GO:0090166)
0.1 0.3 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 0.4 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.7 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.0 0.3 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 1.0 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 1.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.4 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.4 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.4 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.7 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.1 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 0.5 GO:0032127 dense core granule membrane(GO:0032127)
0.1 1.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 2.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.8 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.6 GO:0032280 symmetric synapse(GO:0032280)
0.1 1.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.5 GO:0033391 chromatoid body(GO:0033391)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.3 1.4 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.6 GO:0008430 selenium binding(GO:0008430)
0.1 0.7 GO:0004966 galanin receptor activity(GO:0004966)
0.1 1.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.5 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.7 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 2.1 GO:0097109 acetylcholine receptor binding(GO:0033130) neuroligin family protein binding(GO:0097109)
0.1 1.0 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 2.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.6 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1