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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for RFX3_RFX2
Z-value: 1.42
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Transcription factors associated with RFX3_RFX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX2 | hg38_v1_chr19_-_6110463_6110541 | 0.20 | 3.5e-01 | Click! |
| RFX3 | hg38_v1_chr9_-_3525968_3526017 | -0.16 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX3_RFX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 24.2 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.0 | 3.8 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.1 | 3.2 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.2 | 2.9 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.1 | 2.6 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.0 | 2.4 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 2.2 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.3 | 2.0 | GO:0010731 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.1 | 2.0 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.1 | 1.7 | GO:1901978 | positive regulation of cell cycle checkpoint(GO:1901978) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 4.1 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 3.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.4 | 3.0 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.6 | 2.6 | GO:0097123 | cyclin A1-CDK2 complex(GO:0097123) |
| 0.1 | 2.6 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 2.2 | GO:0005858 | axonemal dynein complex(GO:0005858) |
| 0.1 | 1.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 24.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 3.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 2.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 2.3 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 2.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 1.9 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 1.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 1.8 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 1.6 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 24.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.8 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.3 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.1 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.0 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.9 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 25.1 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 2.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 2.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 1.8 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.2 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 1.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.2 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 1.2 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |