Project

Inflammatory response time course, HUVEC (Wada, 2009)

Navigation
Downloads

Results for RFX5

Z-value: 1.15

Motif logo

logo of

Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.18 RFX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg38_v1_chr1_-_151346806_1513468280.536.5e-03Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_32854179 9.03 ENST00000374859.3
PSMB9
proteasome 20S subunit beta 9
chr6_+_32844789 8.07 ENST00000414474.5
PSMB9
proteasome 20S subunit beta 9
chr6_-_32853618 7.88 ENST00000354258.5
TAP1
transporter 1, ATP binding cassette subfamily B member
chr6_-_32853813 7.79 ENST00000643049.2
TAP1
transporter 1, ATP binding cassette subfamily B member
chr6_+_26402237 3.83 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
BTN3A1
butyrophilin subfamily 3 member A1
chr6_+_26440472 3.64 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr6_+_26383176 3.42 ENST00000416795.6
ENST00000494184.1
BTN2A2
butyrophilin subfamily 2 member A2
chr6_-_32844643 3.26 ENST00000374881.3
PSMB8
proteasome 20S subunit beta 8
chr6_+_26383090 2.98 ENST00000469230.5
ENST00000490025.5
ENST00000352867.6
ENST00000356709.9
ENST00000493275.5
ENST00000472507.5
ENST00000482536.5
ENST00000432533.6
ENST00000482842.1
BTN2A2
butyrophilin subfamily 2 member A2
chr6_+_26457904 2.42 ENST00000541522.5
BTN2A1
butyrophilin subfamily 2 member A1
chr6_-_31357171 2.30 ENST00000412585.7
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr5_-_60488055 2.13 ENST00000505507.6
ENST00000515835.2
ENST00000502484.6
PDE4D
phosphodiesterase 4D
chr19_+_49527988 1.94 ENST00000270645.8
RCN3
reticulocalbin 3
chr6_+_26457941 1.84 ENST00000493173.1
ENST00000312541.10
ENST00000429381.5
ENST00000469185.5
BTN2A1
butyrophilin subfamily 2 member A1
chr9_+_130172343 1.74 ENST00000372398.6
NCS1
neuronal calcium sensor 1
chr6_+_26365159 1.72 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
BTN3A2
butyrophilin subfamily 3 member A2
chr10_-_25062279 1.67 ENST00000615958.4
ENKUR
enkurin, TRPC channel interacting protein
chr6_+_26402289 1.53 ENST00000414912.2
BTN3A1
butyrophilin subfamily 3 member A1
chr6_+_26365215 1.44 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
BTN3A2
butyrophilin subfamily 3 member A2
chr6_+_26365176 1.43 ENST00000377708.7
BTN3A2
butyrophilin subfamily 3 member A2
chr17_+_39980799 1.29 ENST00000264639.9
PSMD3
proteasome 26S subunit, non-ATPase 3
chr11_-_72722302 1.28 ENST00000334211.12
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_-_32816910 1.09 ENST00000447394.1
ENST00000438763.7
HLA-DOB
major histocompatibility complex, class II, DO beta
chr6_+_30489501 1.08 ENST00000376630.5
HLA-E
major histocompatibility complex, class I, E
chrX_-_40735476 1.07 ENST00000324817.6
MED14
mediator complex subunit 14
chr11_-_85719045 1.04 ENST00000533057.6
ENST00000533892.5
SYTL2
synaptotagmin like 2
chr11_+_24496988 1.00 ENST00000336930.11
LUZP2
leucine zipper protein 2
chr11_+_24497155 0.97 ENST00000529015.5
ENST00000533227.5
LUZP2
leucine zipper protein 2
chr16_+_67347391 0.96 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr16_+_67347358 0.83 ENST00000563189.5
LRRC36
leucine rich repeat containing 36
chr6_-_30690968 0.82 ENST00000376420.9
ENST00000376421.7
NRM
nurim
chr11_+_45847406 0.77 ENST00000443527.6
ENST00000616623.4
ENST00000616080.2
CRY2
cryptochrome circadian regulator 2
chr11_+_57667974 0.76 ENST00000528177.5
ENST00000287169.8
ZDHHC5
zinc finger DHHC-type palmitoyltransferase 5
chr1_+_85062304 0.70 ENST00000326813.12
ENST00000528899.5
ENST00000294664.11
DNAI3
dynein axonemal intermediate chain 3
chrX_+_19343893 0.67 ENST00000540249.5
ENST00000545074.5
ENST00000379806.9
ENST00000423505.5
ENST00000422285.7
ENST00000417819.5
ENST00000355808.9
ENST00000379805.3
PDHA1
pyruvate dehydrogenase E1 subunit alpha 1
chr20_+_44247298 0.65 ENST00000342560.10
ENST00000438466.5
ENST00000372952.7
GDAP1L1
ganglioside induced differentiation associated protein 1 like 1
chr20_+_44247252 0.62 ENST00000537864.5
ENST00000612599.4
GDAP1L1
ganglioside induced differentiation associated protein 1 like 1
chr17_-_19362669 0.59 ENST00000268841.10
ENST00000663089.1
ENST00000675510.1
ENST00000647252.1
ENST00000477683.5
ENST00000575478.7
ENST00000261499.10
B9D1
B9 domain containing 1
chr12_-_52652207 0.54 ENST00000309680.4
KRT2
keratin 2
chr4_-_121952014 0.53 ENST00000379645.8
TRPC3
transient receptor potential cation channel subfamily C member 3
chr9_+_83980757 0.50 ENST00000325875.7
ENST00000445877.6
RMI1
RecQ mediated genome instability 1
chr17_-_19362542 0.49 ENST00000440841.1
ENST00000671102.1
ENST00000461069.6
B9D1
B9 domain containing 1
chr3_+_196739839 0.45 ENST00000327134.7
PAK2
p21 (RAC1) activated kinase 2
chr6_-_32530268 0.45 ENST00000374975.4
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr4_-_142305826 0.44 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr19_+_3933581 0.43 ENST00000593949.1
NMRK2
nicotinamide riboside kinase 2
chr7_+_726682 0.40 ENST00000297440.11
DNAAF5
dynein axonemal assembly factor 5
chr6_-_30213379 0.40 ENST00000418026.1
ENST00000454678.7
ENST00000416596.5
ENST00000453195.5
TRIM26
tripartite motif containing 26
chr19_+_44914702 0.40 ENST00000592885.5
ENST00000589781.1
APOC1
apolipoprotein C1
chr11_+_111514772 0.39 ENST00000375618.9
ENST00000529167.5
ENST00000332814.6
HOATZ
HOATZ cilia and flagella associated protein
chr11_+_7987314 0.39 ENST00000531572.2
ENST00000651655.1
EIF3F
eukaryotic translation initiation factor 3 subunit F
chr16_-_57971121 0.34 ENST00000251102.13
CNGB1
cyclic nucleotide gated channel subunit beta 1
chr1_+_181033887 0.34 ENST00000684662.1
ENST00000434571.7
ENST00000367580.6
ENST00000617803.5
ENST00000683652.1
ENST00000367579.7
ENST00000282990.10
MR1
major histocompatibility complex, class I-related
chr1_-_8878018 0.33 ENST00000646660.1
ENST00000646906.1
ENO1
enolase 1
chr4_-_99290975 0.32 ENST00000209668.3
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr19_+_44914833 0.32 ENST00000589078.1
ENST00000586638.5
APOC1
apolipoprotein C1
chr19_-_48615050 0.31 ENST00000263266.4
FAM83E
family with sequence similarity 83 member E
chr17_-_19362732 0.30 ENST00000395616.7
B9D1
B9 domain containing 1
chr6_-_24666591 0.30 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr12_-_110403657 0.27 ENST00000455511.9
ENST00000450008.3
ANAPC7
anaphase promoting complex subunit 7
chr3_+_66220984 0.27 ENST00000354883.11
ENST00000336733.10
SLC25A26
solute carrier family 25 member 26
chr8_+_100158029 0.25 ENST00000251809.4
SPAG1
sperm associated antigen 1
chr8_-_97277890 0.23 ENST00000322128.5
TSPYL5
TSPY like 5
chr5_+_120464236 0.23 ENST00000407149.7
ENST00000379551.2
PRR16
proline rich 16
chr9_+_133061981 0.22 ENST00000372080.8
CEL
carboxyl ester lipase
chr6_-_32941018 0.20 ENST00000418107.3
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_+_126819720 0.20 ENST00000371125.4
PRR32
proline rich 32
chr6_-_24666854 0.19 ENST00000378198.9
TDP2
tyrosyl-DNA phosphodiesterase 2
chr8_+_100158576 0.17 ENST00000388798.7
SPAG1
sperm associated antigen 1
chr5_-_150412743 0.17 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74
CD74 molecule
chr4_-_142305935 0.16 ENST00000511838.5
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr22_-_23751080 0.16 ENST00000341976.5
ZNF70
zinc finger protein 70
chr8_-_132321509 0.15 ENST00000638588.1
KCNQ3
potassium voltage-gated channel subfamily Q member 3
chr19_+_49766962 0.13 ENST00000354293.10
ENST00000359032.9
AP2A1
adaptor related protein complex 2 subunit alpha 1
chr1_-_53142617 0.12 ENST00000371491.4
ENST00000371494.9
SLC1A7
solute carrier family 1 member 7
chr1_-_53142577 0.12 ENST00000620347.5
ENST00000611397.5
SLC1A7
solute carrier family 1 member 7
chr9_-_34895722 0.09 ENST00000603640.6
ENST00000603592.1
ENST00000340783.11
FAM205C
family with sequence similarity 205 member C
chr1_+_248838211 0.08 ENST00000306562.8
ZNF672
zinc finger protein 672
chr1_-_208244375 0.06 ENST00000367033.4
PLXNA2
plexin A2
chr1_+_36084079 0.06 ENST00000207457.8
TEKT2
tektin 2
chr10_+_80356754 0.06 ENST00000616870.4
ENST00000411538.5
ENST00000256039.3
DYDC2
DPY30 domain containing 2
chr6_-_32589833 0.01 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.4 6.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.4 1.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.4 1.1 GO:2000566 protection from natural killer cell mediated cytotoxicity(GO:0042270) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.3 9.9 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 1.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.3 0.8 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.2 2.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 21.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.2 0.7 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.2 0.5 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.1 0.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.4 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 1.0 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 0.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.2 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.0 0.3 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.2 GO:2001188 regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001188)
0.0 0.3 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 3.6 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.5 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.9 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.3 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.4 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.4 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.3 GO:0032620 interleukin-17 production(GO:0032620)
0.0 0.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 1.7 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 0.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 1.3 GO:0006749 glutathione metabolic process(GO:0006749)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 20.4 GO:1990111 spermatoproteasome complex(GO:1990111)
2.2 15.7 GO:0042825 TAP complex(GO:0042825)
0.2 1.1 GO:0070847 core mediator complex(GO:0070847)
0.1 1.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.1 1.4 GO:0036038 MKS complex(GO:0036038)
0.1 0.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 1.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 15.7 GO:0023029 peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029) TAP2 binding(GO:0046979)
0.7 20.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.4 GO:0008158 hedgehog receptor activity(GO:0008158)
0.2 0.7 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 0.5 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 1.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.4 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 0.6 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 2.1 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.1 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.7 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 0.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 1.9 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.1 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.8 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.3 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 1.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 15.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 15.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 21.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 2.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation