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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for RHOXF1
Z-value: 2.00
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Transcription factors associated with RHOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RHOXF1 | hg38_v1_chrX_-_120115909_120115916 | 0.66 | 3.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RHOXF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_120914549 Show fit | 13.44 |
ENST00000546084.5
|
TNF receptor associated factor 1 |
|
| chr11_-_102780620 Show fit | 12.71 |
ENST00000279441.9
ENST00000539681.1 |
matrix metallopeptidase 10 |
|
| chr8_+_53851786 Show fit | 10.50 |
ENST00000297313.8
ENST00000344277.10 |
regulator of G protein signaling 20 |
|
| chr1_-_173050931 Show fit | 8.16 |
ENST00000404377.5
|
TNF superfamily member 18 |
|
| chr1_-_184974477 Show fit | 7.42 |
ENST00000367511.4
|
niban apoptosis regulator 1 |
|
| chr16_-_67936808 Show fit | 6.80 |
ENST00000358514.9
|
proteasome 20S subunit beta 10 |
|
| chr14_+_21070273 Show fit | 6.10 |
ENST00000555038.5
ENST00000298694.9 |
Rho guanine nucleotide exchange factor 40 |
|
| chr2_+_230759918 Show fit | 5.91 |
ENST00000614925.1
|
calcium binding protein 39 |
|
| chr4_+_73836667 Show fit | 5.63 |
ENST00000226317.10
|
C-X-C motif chemokine ligand 6 |
|
| chr4_+_73740541 Show fit | 5.47 |
ENST00000401931.1
ENST00000307407.8 |
C-X-C motif chemokine ligand 8 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 15.1 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.1 | 12.4 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.1 | 12.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 11.6 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.1 | 10.7 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 1.8 | 10.5 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.1 | 9.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.6 | 8.8 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 2.0 | 8.0 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 2.6 | 7.7 | GO:0034769 | basement membrane disassembly(GO:0034769) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.1 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 13.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.6 | 12.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 1.2 | 10.5 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 10.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.3 | 9.2 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.5 | 7.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.9 | 6.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 6.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 6.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.8 | 15.0 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.4 | 13.9 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 13.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.8 | 12.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 11.4 | GO:0042805 | actinin binding(GO:0042805) |
| 1.8 | 10.5 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.7 | 9.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 7.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 7.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 31.7 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.2 | 23.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 21.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 20.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 17.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 11.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 8.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 7.7 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 7.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 6.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 15.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.4 | 12.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.3 | 11.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 10.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 10.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 9.5 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.2 | 8.2 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 7.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.7 | 7.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 7.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |