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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for RORC

Z-value: 0.28

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.19 RORC

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg38_v1_chr1_-_151826085_151826108,
hg38_v1_chr1_-_151831768_151831833		0.145.1e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_7061206 0.33 ENST00000423384.5
ENST00000413211.5
C1S
complement C1s
chr3_-_165196369 0.31 ENST00000475390.2
SLITRK3
SLIT and NTRK like family member 3
chr3_-_165196689 0.31 ENST00000241274.3
SLITRK3
SLIT and NTRK like family member 3
chr12_+_7060676 0.29 ENST00000617865.4
ENST00000402681.7
ENST00000360817.10
C1S
complement C1s
chr7_+_102285125 0.26 ENST00000536178.3
SH2B2
SH2B adaptor protein 2
chr8_+_66043413 0.26 ENST00000522619.1
DNAJC5B
DnaJ heat shock protein family (Hsp40) member C5 beta
chr12_-_81758641 0.18 ENST00000552948.5
ENST00000548586.5
PPFIA2
PTPRF interacting protein alpha 2
chr1_-_149936816 0.18 ENST00000439741.4
MTMR11
myotubularin related protein 11
chr16_-_9943182 0.14 ENST00000535259.6
GRIN2A
glutamate ionotropic receptor NMDA type subunit 2A
chr6_-_119078642 0.13 ENST00000621231.4
ENST00000338891.12
FAM184A
family with sequence similarity 184 member A
chr16_-_69351778 0.12 ENST00000288025.4
TMED6
transmembrane p24 trafficking protein 6
chr16_+_1782940 0.09 ENST00000262302.14
ENST00000563136.5
ENST00000565987.5
ENST00000568287.5
ENST00000565134.5
NUBP2
nucleotide binding protein 2
chr8_+_39913881 0.09 ENST00000518237.6
IDO1
indoleamine 2,3-dioxygenase 1
chr18_-_26091175 0.08 ENST00000579061.5
ENST00000542420.6
SS18
SS18 subunit of BAF chromatin remodeling complex
chr1_+_171841466 0.08 ENST00000367733.6
ENST00000627582.3
ENST00000355305.9
ENST00000367731.5
DNM3
dynamin 3
chr2_+_118942188 0.08 ENST00000327097.5
MARCO
macrophage receptor with collagenous structure
chr1_+_67166448 0.08 ENST00000347310.10
IL23R
interleukin 23 receptor
chr10_-_119536533 0.08 ENST00000392865.5
RGS10
regulator of G protein signaling 10
chr11_+_13277639 0.07 ENST00000527998.5
ENST00000529388.6
ENST00000401424.6
ENST00000403510.8
ENST00000403290.6
ENST00000533520.5
ENST00000389707.8
ENST00000673817.1
ARNTL
aryl hydrocarbon receptor nuclear translocator like
chr19_+_39268394 0.07 ENST00000331982.6
IFNL2
interferon lambda 2
chr19_-_7633713 0.07 ENST00000311069.6
PCP2
Purkinje cell protein 2
chr8_-_94436926 0.07 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr2_-_29921580 0.07 ENST00000389048.8
ALK
ALK receptor tyrosine kinase
chr10_-_104085847 0.07 ENST00000648076.2
COL17A1
collagen type XVII alpha 1 chain
chr4_-_119322128 0.07 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr6_+_43770707 0.06 ENST00000324450.11
ENST00000417285.7
ENST00000413642.8
ENST00000372055.9
ENST00000482630.7
ENST00000425836.7
ENST00000372064.9
ENST00000372077.8
ENST00000519767.5
VEGFA
vascular endothelial growth factor A
chr17_-_39607876 0.06 ENST00000302584.5
NEUROD2
neuronal differentiation 2
chr6_+_43770202 0.06 ENST00000372067.8
ENST00000672860.2
VEGFA
vascular endothelial growth factor A
chr17_-_75289212 0.06 ENST00000582778.1
ENST00000581988.5
ENST00000579207.5
ENST00000583332.5
ENST00000442286.6
ENST00000580151.5
ENST00000580994.5
ENST00000584438.1
ENST00000416858.7
ENST00000320362.7
SLC25A19
solute carrier family 25 member 19
chr7_-_141841473 0.06 ENST00000350549.8
ENST00000438520.1
PRSS37
serine protease 37
chr16_+_28292485 0.06 ENST00000341901.5
SBK1
SH3 domain binding kinase 1
chr1_+_161197372 0.06 ENST00000677550.1
ENST00000676600.1
ENST00000678507.1
ENST00000677579.1
ENST00000677231.1
ENST00000678911.1
ENST00000677846.1
NDUFS2
NADH:ubiquinone oxidoreductase core subunit S2
chr12_-_81758665 0.06 ENST00000549325.5
ENST00000550584.6
PPFIA2
PTPRF interacting protein alpha 2
chr1_-_235649734 0.05 ENST00000391854.7
GNG4
G protein subunit gamma 4
chr19_-_42423100 0.05 ENST00000597001.1
LIPE
lipase E, hormone sensitive type
chr20_+_31637905 0.05 ENST00000376075.4
COX4I2
cytochrome c oxidase subunit 4I2
chrX_-_49233309 0.05 ENST00000376251.5
ENST00000323022.10
ENST00000376265.2
CACNA1F
calcium voltage-gated channel subunit alpha1 F
chr10_+_100535927 0.05 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr1_-_217137748 0.05 ENST00000493603.5
ENST00000366940.6
ESRRG
estrogen related receptor gamma
chr12_-_54258275 0.05 ENST00000552562.1
CBX5
chromobox 5
chrX_-_111412162 0.05 ENST00000637570.1
ENST00000356220.8
ENST00000636035.2
ENST00000637453.1
ENST00000635795.1
DCX
doublecortin
chr1_-_153550083 0.05 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr11_-_64759967 0.04 ENST00000377432.7
ENST00000164139.4
PYGM
glycogen phosphorylase, muscle associated
chr11_+_67605488 0.04 ENST00000533876.1
ENST00000647561.1
ENSG00000255119.1
NDUFV1
novel transcript
NADH:ubiquinone oxidoreductase core subunit V1
chr2_+_161160299 0.04 ENST00000440506.5
ENST00000429217.5
ENST00000406287.5
ENST00000402568.5
TANK
TRAF family member associated NFKB activator
chr19_-_7632971 0.04 ENST00000598935.5
PCP2
Purkinje cell protein 2
chr16_-_67481131 0.04 ENST00000290949.8
ATP6V0D1
ATPase H+ transporting V0 subunit d1
chr16_-_67481079 0.04 ENST00000565835.5
ENST00000602876.5
ENST00000540149.5
ATP6V0D1
ATPase H+ transporting V0 subunit d1
chr20_-_41317602 0.04 ENST00000559234.5
ENST00000683867.1
ZHX3
zinc fingers and homeoboxes 3
chr10_-_101818405 0.04 ENST00000357797.9
ENST00000370094.7
OGA
O-GlcNAcase
chr1_-_150234668 0.03 ENST00000616917.4
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr14_+_21317535 0.03 ENST00000382933.8
RPGRIP1
RPGR interacting protein 1
chr7_-_30550761 0.03 ENST00000598361.4
ENST00000440438.6
ENSG00000281039.1
GARS1-DT
novel protein
GARS1 divergent transcript
chr20_-_23452857 0.03 ENST00000377007.3
ENST00000377009.8
CST11
cystatin 11
chr4_+_109827963 0.03 ENST00000317735.7
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr6_+_89146046 0.02 ENST00000275072.5
PM20D2
peptidase M20 domain containing 2
chr3_-_65597886 0.02 ENST00000460329.6
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_+_161160420 0.02 ENST00000392749.7
ENST00000405852.5
TANK
TRAF family member associated NFKB activator
chr2_-_148020689 0.02 ENST00000457954.5
ENST00000392857.10
ENST00000540442.5
ENST00000535373.5
ORC4
origin recognition complex subunit 4
chr14_-_23286082 0.02 ENST00000357460.7
HOMEZ
homeobox and leucine zipper encoding
chr3_-_184378136 0.02 ENST00000445696.6
THPO
thrombopoietin
chr17_-_61863327 0.02 ENST00000584322.2
ENST00000682369.1
ENST00000683039.1
ENST00000683381.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr6_-_136526654 0.01 ENST00000611373.1
MAP7
microtubule associated protein 7
chr19_-_39245006 0.01 ENST00000413851.3
ENST00000613087.4
IFNL3
interferon lambda 3
chr1_+_103655760 0.01 ENST00000370083.9
AMY1A
amylase alpha 1A
chr19_-_48637338 0.01 ENST00000601104.1
ENST00000222122.10
DBP
D-box binding PAR bZIP transcription factor
chr17_-_49362206 0.01 ENST00000430262.3
ZNF652
zinc finger protein 652
chr1_+_154567820 0.01 ENST00000637900.1
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr10_-_101818425 0.01 ENST00000361464.8
ENST00000439817.5
OGA
O-GlcNAcase
chr2_-_148020754 0.01 ENST00000440042.1
ENST00000536575.5
ORC4
origin recognition complex subunit 4
chr2_+_148021001 0.01 ENST00000407073.5
MBD5
methyl-CpG binding domain protein 5
chr20_+_38581186 0.01 ENST00000373348.4
ENST00000537425.2
ENST00000416116.2
ADIG
adipogenin
chr1_-_185317234 0.01 ENST00000367498.8
IVNS1ABP
influenza virus NS1A binding protein
chr11_-_65662780 0.01 ENST00000534283.1
ENST00000527749.5
ENST00000533187.5
ENST00000525693.5
ENST00000534558.5
ENST00000532879.5
ENST00000406246.8
ENST00000532999.5
RELA
RELA proto-oncogene, NF-kB subunit
chr6_-_111605859 0.00 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr2_+_148021083 0.00 ENST00000642680.2
MBD5
methyl-CpG binding domain protein 5
chr1_+_159826860 0.00 ENST00000289707.10
SLAMF8
SLAM family member 8
chr3_+_185586270 0.00 ENST00000296257.10
SENP2
SUMO specific peptidase 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.2 GO:0036269 swimming behavior(GO:0036269)
0.0 0.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0033058 directional locomotion(GO:0033058)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.1 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0090422 thiamine pyrophosphate transporter activity(GO:0090422)
0.0 0.1 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators