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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SIX1_SIX3_SIX2

Z-value: 0.68

Motif logo

Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
ENSG00000126778.12 SIX1
ENSG00000138083.5 SIX3
ENSG00000170577.8 SIX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX2hg38_v1_chr2_-_45009401_450094570.203.5e-01Click!
SIX1hg38_v1_chr14_-_60649449_606494900.174.1e-01Click!
SIX3hg38_v1_chr2_+_44941695_44941708-0.029.2e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_89198868 3.23 ENST00000355754.7
guanylate binding protein 4
chr6_-_159745186 2.57 ENST00000537657.5
superoxide dismutase 2
chr5_+_126423122 2.45 ENST00000515200.5
GRAM domain containing 2B
chr5_+_126423363 2.41 ENST00000285689.8
GRAM domain containing 2B
chr5_+_126423176 2.40 ENST00000542322.5
ENST00000544396.5
GRAM domain containing 2B
chr6_-_154430495 2.05 ENST00000424998.3
CNKSR family member 3
chr3_-_128052166 1.88 ENST00000648300.1
monoglyceride lipase
chr21_+_25639272 1.85 ENST00000400532.5
ENST00000312957.9
junctional adhesion molecule 2
chr21_+_25639251 1.70 ENST00000480456.6
junctional adhesion molecule 2
chr10_-_48652493 1.60 ENST00000435790.6
Rho GTPase activating protein 22
chr1_-_7940825 1.31 ENST00000377507.8
TNF receptor superfamily member 9
chr11_-_126062782 1.20 ENST00000531738.6
cell adhesion associated, oncogene regulated
chr6_-_136525961 1.14 ENST00000438100.6
microtubule associated protein 7
chr19_-_55738374 1.06 ENST00000590200.1
ENST00000332836.7
NLR family pyrin domain containing 9
chr6_+_29100609 0.90 ENST00000377171.3
olfactory receptor family 2 subfamily J member 1
chr15_-_55270383 0.89 ENST00000396307.6
RAB27A, member RAS oncogene family
chr1_-_13201409 0.88 ENST00000625019.3
PRAME family member 13
chr11_+_34632464 0.87 ENST00000531794.5
ETS homologous factor
chr6_-_136526654 0.85 ENST00000611373.1
microtubule associated protein 7
chr13_-_46105009 0.82 ENST00000439329.5
ENST00000674625.1
ENST00000181383.10
carboxypeptidase B2
chr14_+_50560137 0.80 ENST00000358385.12
atlastin GTPase 1
chr6_+_4706133 0.75 ENST00000328908.9
chromodomain Y like
chr3_-_11643871 0.71 ENST00000430365.7
vestigial like family member 4
chr8_+_103298433 0.68 ENST00000522566.5
frizzled class receptor 6
chr6_-_136526472 0.65 ENST00000454590.5
ENST00000432797.6
microtubule associated protein 7
chr1_+_12857086 0.65 ENST00000240189.2
PRAME family member 2
chr5_-_16742221 0.60 ENST00000505695.5
myosin X
chr6_-_136526177 0.60 ENST00000617204.4
microtubule associated protein 7
chr3_+_42809439 0.59 ENST00000422265.6
ENST00000487368.4
atypical chemokine receptor 2
novel transcript
chr4_+_139015751 0.57 ENST00000280614.4
nocturnin
chr12_-_89526253 0.56 ENST00000547474.1
POC1B-GALNT4 readthrough
chr20_+_36236433 0.56 ENST00000397286.7
ENST00000679519.1
ENST00000679667.1
ENST00000680933.1
ENST00000680247.1
ENST00000320849.9
ENST00000680811.1
ENST00000373932.3
AAR2 splicing factor
chr18_+_58149314 0.56 ENST00000435432.6
ENST00000357895.9
ENST00000586263.5
NEDD4 like E3 ubiquitin protein ligase
chr19_+_11346556 0.55 ENST00000587531.5
coiled-coil domain containing 159
chr14_-_24146596 0.54 ENST00000560410.5
ENST00000216802.10
ENST00000615264.4
ENST00000630027.1
proteasome activator subunit 2
chr8_-_133060347 0.53 ENST00000427060.6
Src like adaptor
chr4_+_88378733 0.53 ENST00000273960.7
ENST00000380265.9
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr1_+_26410809 0.52 ENST00000254231.4
ENST00000326279.11
lin-28 homolog A
chr12_-_89526164 0.52 ENST00000548729.5
POC1B-GALNT4 readthrough
chr1_+_169368175 0.51 ENST00000367808.8
ENST00000426663.1
basic leucine zipper nuclear factor 1
chr6_+_31587002 0.50 ENST00000376090.6
leukocyte specific transcript 1
chr1_-_46616804 0.49 ENST00000531769.6
ENST00000319928.8
MAPK interacting serine/threonine kinase 1
MOB kinase activator 3C
chr6_-_138107412 0.49 ENST00000421351.4
p53 apoptosis effector related to PMP22
chr4_+_88378842 0.47 ENST00000264346.12
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr8_+_98117285 0.47 ENST00000401707.7
ENST00000522319.5
POP1 homolog, ribonuclease P/MRP subunit
chr16_+_31108294 0.47 ENST00000287507.7
ENST00000394950.7
ENST00000219794.11
ENST00000561755.1
branched chain keto acid dehydrogenase kinase
chr16_+_57976435 0.47 ENST00000290871.10
ENST00000441824.4
testis, prostate and placenta expressed
chr3_+_38282294 0.46 ENST00000466887.5
ENST00000448498.6
solute carrier family 22 member 14
chr22_+_30409097 0.46 ENST00000439838.5
ENST00000439023.3
novel SEC14-like 2 (S. cerevisiae) (SEC14L2) and mitochondrial protein 18 kDa (MTP18) protein
chr11_-_34511710 0.45 ENST00000620316.4
ENST00000312319.6
E74 like ETS transcription factor 5
chr1_-_51325924 0.43 ENST00000532836.5
ENST00000422925.6
tetratricopeptide repeat domain 39A
chr6_+_31587185 0.43 ENST00000376092.7
ENST00000376086.7
ENST00000303757.12
ENST00000376093.6
leukocyte specific transcript 1
chr12_-_121274510 0.43 ENST00000392474.6
calcium/calmodulin dependent protein kinase kinase 2
chr11_+_64555684 0.43 ENST00000377585.7
solute carrier family 22 member 11
chr11_+_64555956 0.43 ENST00000377581.7
solute carrier family 22 member 11
chr11_+_64555924 0.43 ENST00000301891.9
solute carrier family 22 member 11
chr9_+_12693327 0.42 ENST00000388918.10
tyrosinase related protein 1
chr3_+_42091316 0.41 ENST00000327628.10
trafficking kinesin protein 1
chr2_+_161136901 0.41 ENST00000259075.6
ENST00000432002.5
TRAF family member associated NFKB activator
chr1_-_13285154 0.38 ENST00000357367.6
ENST00000614831.1
PRAME family member 8
chr16_-_75495396 0.38 ENST00000332272.9
carbohydrate sulfotransferase 6
chr17_+_7561899 0.38 ENST00000321337.12
SUMO specific peptidase 3
chr4_+_70050431 0.38 ENST00000511674.5
ENST00000246896.8
histatin 1
chr1_+_12791397 0.38 ENST00000332296.7
PRAME family member 1
chr2_-_89213917 0.38 ENST00000498435.1
immunoglobulin kappa variable 1-27
chr3_-_157533594 0.37 ENST00000487753.5
ENST00000489602.1
ENST00000461299.5
ENST00000479987.5
ventricular zone expressed PH domain containing 1
chr6_+_31587268 0.36 ENST00000396101.7
ENST00000490742.5
leukocyte specific transcript 1
chr15_+_73994667 0.36 ENST00000395135.7
PML nuclear body scaffold
chr6_+_31587049 0.36 ENST00000376089.6
ENST00000396112.6
leukocyte specific transcript 1
chr1_-_108200849 0.34 ENST00000569674.1
solute carrier family 25 member 24
chr6_+_31586680 0.34 ENST00000339530.8
leukocyte specific transcript 1
chr3_+_149474688 0.34 ENST00000305354.5
ENST00000465758.1
transmembrane 4 L six family member 4
chr11_+_55827219 0.33 ENST00000378397.1
olfactory receptor family 5 subfamily L member 2
chr15_+_75198866 0.33 ENST00000562637.1
ENST00000360639.6
chromosome 15 open reading frame 39
chr13_+_38349822 0.33 ENST00000379649.5
ENST00000239878.9
ubiquitin fold modifier 1
chr1_+_50106265 0.33 ENST00000357083.8
ELAV like RNA binding protein 4
chr3_+_128052390 0.33 ENST00000481210.5
ENST00000243253.8
SEC61 translocon subunit alpha 1
chr11_-_82901594 0.33 ENST00000679623.1
prolylcarboxypeptidase
chr17_+_48107549 0.32 ENST00000580219.5
ENST00000452859.6
ENST00000393405.6
sorting nexin 11
chr7_-_75823355 0.32 ENST00000416943.1
C-C motif chemokine ligand 24
chr4_-_152411734 0.32 ENST00000603841.1
F-box and WD repeat domain containing 7
chr2_+_167187364 0.31 ENST00000672671.1
xin actin binding repeat containing 2
chr20_-_56525925 0.31 ENST00000243913.8
glucosaminyl (N-acetyl) transferase family member 7
chr12_-_54984667 0.31 ENST00000524668.5
ENST00000533607.1
ENST00000449076.6
thymocyte expressed, positive selection associated 1
chr5_+_70025534 0.30 ENST00000515588.1
small EDRK-rich factor 1B
chr2_+_89884740 0.30 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr11_-_82901623 0.30 ENST00000681637.1
ENST00000679387.1
prolylcarboxypeptidase
chr5_-_132737518 0.30 ENST00000403231.6
ENST00000378735.5
ENST00000618515.4
ENST00000378746.8
kinesin family member 3A
chr11_+_70398404 0.30 ENST00000346329.7
ENST00000301843.13
ENST00000376561.7
cortactin
chr2_+_167187283 0.30 ENST00000409605.1
ENST00000409273.6
xin actin binding repeat containing 2
chr12_+_48727431 0.29 ENST00000548380.6
testis expressed 49
chr11_-_58731936 0.29 ENST00000344743.8
glycine-N-acyltransferase
chr21_+_34364003 0.29 ENST00000290310.4
potassium voltage-gated channel subfamily E regulatory subunit 2
chr9_-_114806031 0.29 ENST00000374045.5
TNF superfamily member 15
chr14_+_34993240 0.29 ENST00000677647.1
signal recognition particle 54
chr19_+_48606732 0.29 ENST00000321762.3
sperm acrosome associated 4
chr10_-_67665642 0.28 ENST00000682945.1
ENST00000330298.6
ENST00000682758.1
catenin alpha 3
chr2_-_89297785 0.28 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr6_-_43687774 0.27 ENST00000372133.8
ENST00000372116.5
ENST00000427312.1
mitochondrial ribosomal protein S18A
chr14_+_58244821 0.27 ENST00000216455.9
ENST00000412908.6
ENST00000557508.5
proteasome 20S subunit alpha 3
chrX_-_72875974 0.27 ENST00000595412.5
DMRT like family C1
chr12_-_89526011 0.26 ENST00000313546.8
POC1 centriolar protein B
chr19_-_10928585 0.26 ENST00000590329.5
ENST00000587943.5
ENST00000586748.6
ENST00000585858.1
ENST00000586575.5
ENST00000253031.6
Yip1 domain family member 2
chr10_+_112375196 0.26 ENST00000393081.6
acyl-CoA synthetase long chain family member 5
chr3_+_119147375 0.25 ENST00000490594.2
novel chromosome 3 open reading frame 30 (C3orf30) and uroplakin 1B (UPK1B)
chr20_+_833781 0.25 ENST00000381939.1
family with sequence similarity 110 member A
chr2_-_222320124 0.25 ENST00000678139.1
novel protein, ortholog of Gm2102 (M. musculus)
chr6_+_41053194 0.25 ENST00000244669.3
apolipoprotein B mRNA editing enzyme catalytic subunit 2
chr3_+_111998739 0.24 ENST00000393917.6
ENST00000273368.8
transgelin 3
chr7_+_75882044 0.24 ENST00000428119.1
rhomboid domain containing 2
chr11_-_32430811 0.24 ENST00000379079.8
ENST00000530998.5
WT1 transcription factor
chr11_+_55262152 0.23 ENST00000417545.5
tripartite motif containing 48
chr11_-_5343524 0.23 ENST00000300773.3
olfactory receptor family 51 subfamily B member 5
chr3_+_111999189 0.23 ENST00000455401.6
transgelin 3
chr6_+_31586835 0.23 ENST00000211921.11
leukocyte specific transcript 1
chr12_-_51083582 0.23 ENST00000548206.1
ENST00000546935.5
ENST00000228515.6
ENST00000548981.5
cysteine and serine rich nuclear protein 2
chr7_+_117611617 0.23 ENST00000468795.1
CF transmembrane conductance regulator
chr3_+_111998915 0.22 ENST00000478951.6
transgelin 3
chr15_-_72231583 0.22 ENST00000566809.1
ENST00000567087.5
ENST00000569050.1
ENST00000568883.5
pyruvate kinase M1/2
chr17_+_39628496 0.22 ENST00000394265.5
ENST00000394267.2
protein phosphatase 1 regulatory inhibitor subunit 1B
chr2_-_74465162 0.22 ENST00000649854.1
ENST00000650523.1
ENST00000649601.1
ENST00000448666.7
ENST00000409065.5
ENST00000414701.1
ENST00000452063.7
ENST00000649075.1
ENST00000648810.1
ENST00000462443.2
mannosyl-oligosaccharide glucosidase
chrX_-_66040072 0.22 ENST00000374737.9
V-set and immunoglobulin domain containing 4
chr19_+_57584131 0.22 ENST00000536878.6
ENST00000597219.1
ENST00000598689.1
ENST00000597850.2
zinc finger protein interacting with K protein 1
chrX_-_66040057 0.22 ENST00000412866.2
V-set and immunoglobulin domain containing 4
chr19_+_10928777 0.22 ENST00000270502.7
translocase of inner mitochondrial membrane 29
chr8_-_51809414 0.21 ENST00000356297.5
peroxidasin like
chrX_-_66040107 0.21 ENST00000455586.6
V-set and immunoglobulin domain containing 4
chr10_-_94362925 0.20 ENST00000371361.3
NOC3 like DNA replication regulator
chr3_+_178536205 0.20 ENST00000420517.6
potassium calcium-activated channel subfamily M regulatory beta subunit 2
chr5_-_161548124 0.20 ENST00000520240.5
ENST00000517901.5
ENST00000353437.10
gamma-aminobutyric acid type A receptor subunit beta2
chr17_+_7627963 0.20 ENST00000575729.5
ENST00000340624.9
sex hormone binding globulin
chr16_+_84768246 0.20 ENST00000569925.1
ENST00000567526.1
ubiquitin specific peptidase 10
chr22_-_37844308 0.20 ENST00000411961.6
ENST00000434930.1
ENST00000215941.9
ankyrin repeat domain 54
chr19_-_42917837 0.20 ENST00000292125.6
ENST00000402603.8
ENST00000594375.1
ENST00000187910.7
pregnancy specific beta-1-glycoprotein 6
chr19_-_57935353 0.19 ENST00000595569.1
ENST00000599852.1
ENST00000425570.7
ENST00000601593.5
ENST00000396147.6
zinc finger protein 418
chr1_+_169367934 0.19 ENST00000367807.7
ENST00000329281.6
ENST00000420531.1
basic leucine zipper nuclear factor 1
chr4_-_121381007 0.19 ENST00000394427.3
pyroglutamylated RFamide peptide receptor
chr14_+_21825453 0.19 ENST00000390432.2
T cell receptor alpha variable 10
chr19_+_2867327 0.19 ENST00000586426.5
ENST00000307635.3
zinc finger protein 556
chr19_-_38229714 0.19 ENST00000416611.5
double PHD fingers 1
chr3_-_48188356 0.19 ENST00000351231.7
ENST00000437972.1
ENST00000302506.8
cell division cycle 25A
chr18_+_21612274 0.19 ENST00000579618.1
ENST00000300413.10
ENST00000582475.1
small nuclear ribonucleoprotein D1 polypeptide
chr20_+_18507520 0.19 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23 homolog B, COPII coat complex component
chr2_-_208190001 0.18 ENST00000451346.5
ENST00000341287.9
chromosome 2 open reading frame 80
chr19_-_1848452 0.17 ENST00000170168.9
RNA exonuclease 1 homolog
chr11_-_62653285 0.17 ENST00000330574.2
integrator complex subunit 5
chr4_+_182448995 0.17 ENST00000510504.1
teneurin transmembrane protein 3
chr1_+_149475045 0.17 ENST00000651566.2
NBPF member 19
chr6_-_35688907 0.17 ENST00000539068.5
ENST00000357266.9
FKBP prolyl isomerase 5
chr6_-_31541937 0.17 ENST00000456662.5
ENST00000431908.5
ENST00000456976.5
ENST00000428450.5
ENST00000418897.5
ENST00000396172.6
ENST00000419020.1
ENST00000428098.5
DExD-box helicase 39B
chr10_+_133394094 0.17 ENST00000477902.6
mitochondrial ribosome associated GTPase 1
chr15_+_62561361 0.17 ENST00000561311.5
talin 2
chr15_+_81134257 0.17 ENST00000286732.5
cilia and flagella associated protein 161
chr1_+_27726005 0.17 ENST00000530324.5
ENST00000234549.11
ENST00000373949.5
ENST00000010299.10
family with sequence similarity 76 member A
chr17_+_7012417 0.17 ENST00000548577.5
ribonuclease K
chr19_+_14440254 0.17 ENST00000342216.8
protein kinase N1
chr1_+_171512032 0.17 ENST00000426496.6
proline rich coiled-coil 2C
chr12_-_54364467 0.17 ENST00000267015.4
ENST00000551809.1
G protein-coupled receptor 84
chr12_+_57488059 0.16 ENST00000628866.2
ENST00000262027.10
methionyl-tRNA synthetase 1
chr3_+_44712634 0.16 ENST00000449836.5
ENST00000296091.8
ENST00000436624.7
ENST00000411443.1
zinc finger protein 502
chr11_-_62754141 0.16 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
zinc finger and BTB domain containing 3
chr2_-_113756604 0.16 ENST00000409342.1
solute carrier family 35 member F5
chr11_-_58731968 0.16 ENST00000278400.3
glycine-N-acyltransferase
chr19_+_18612848 0.16 ENST00000262817.8
transmembrane protein 59 like
chr1_+_13254212 0.16 ENST00000622421.2
PRAME family member 5
chr6_+_31586859 0.15 ENST00000433492.5
leukocyte specific transcript 1
chr16_-_67833842 0.15 ENST00000566758.5
ENST00000626059.2
ENST00000564817.5
centromere protein T
chr1_+_119507203 0.15 ENST00000369413.8
ENST00000528909.1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr19_-_54063905 0.15 ENST00000645936.1
ENST00000376626.5
ENST00000366170.6
ENST00000425006.3
V-set and transmembrane domain containing 1
chr8_+_18391276 0.15 ENST00000286479.4
ENST00000520116.1
N-acetyltransferase 2
chr4_-_867162 0.15 ENST00000511980.5
ENST00000510799.1
cyclin G associated kinase
chr3_+_35680994 0.15 ENST00000441454.5
cAMP regulated phosphoprotein 21
chr15_+_89088417 0.15 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
abhydrolase domain containing 2, acylglycerol lipase
chr19_+_11346499 0.15 ENST00000458408.6
ENST00000586451.5
ENST00000588592.5
coiled-coil domain containing 159
chr3_-_119463606 0.15 ENST00000319172.10
ENST00000491685.5
ENST00000461654.1
transmembrane protein 39A
chr21_-_34511243 0.14 ENST00000399284.1
potassium voltage-gated channel subfamily E regulatory subunit 1
chr16_+_21684429 0.14 ENST00000388956.8
otoancorin
chr11_+_89924064 0.14 ENST00000623787.3
tripartite motif containing 49D2
chr6_-_49636832 0.14 ENST00000371175.10
ENST00000646272.1
ENST00000646939.1
ENST00000618248.3
ENST00000229810.9
ENST00000646963.1
Rh associated glycoprotein
chr10_-_101843920 0.14 ENST00000358038.7
potassium voltage-gated channel interacting protein 2
chr19_+_46297032 0.14 ENST00000377670.9
hypoxia inducible factor 3 subunit alpha
chr1_+_156786875 0.14 ENST00000526188.5
ENST00000454659.1
proline rich mitotic checkpoint control factor
chr2_-_218671975 0.14 ENST00000295704.7
ring finger protein 25
chr1_-_12947580 0.14 ENST00000376189.5
PRAME family member 6
chr1_-_154178174 0.14 ENST00000302206.9
tropomyosin 3
chr10_+_46375721 0.13 ENST00000616785.1
ENST00000611655.1
ENST00000619162.5
novel transcript
annexin A8 like 1
chr1_+_209686173 0.13 ENST00000615289.4
ENST00000367028.6
ENST00000261465.5
hydroxysteroid 11-beta dehydrogenase 1
chr12_-_9760893 0.13 ENST00000228434.7
ENST00000536709.1
CD69 molecule
chrX_+_76173010 0.13 ENST00000373357.3
ENST00000373358.8
polysaccharide biosynthesis domain containing 1
chr7_-_44159278 0.13 ENST00000345378.7
glucokinase
chr15_+_80441229 0.13 ENST00000533983.5
ENST00000527771.5
ENST00000525103.1
aryl hydrocarbon receptor nuclear translocator 2
chr19_+_36115439 0.13 ENST00000629269.2
ENST00000221855.8
ENST00000651435.1
ENST00000589996.5
ENST00000591296.1
tubulin folding cofactor B
chr8_+_117135259 0.13 ENST00000519688.5
solute carrier family 30 member 8
chr8_-_24956604 0.13 ENST00000610854.2
neurofilament light
chr16_-_4752565 0.13 ENST00000588099.1
ENST00000588942.1
novel transcript
zinc finger protein 500
chr16_+_27203480 0.13 ENST00000286096.9
lysine demethylase 8
chr19_+_55947832 0.13 ENST00000291971.7
ENST00000590542.1
NLR family pyrin domain containing 8
chr6_-_31542339 0.12 ENST00000458640.5
DExD-box helicase 39B
chr10_-_73096850 0.12 ENST00000307116.6
ENST00000373008.6
ENST00000394890.7
prolyl 4-hydroxylase subunit alpha 1
chr19_+_57487711 0.12 ENST00000354197.8
ENST00000426954.6
ENST00000523882.5
ENST00000520540.5
ENST00000519310.1
ENST00000442920.6
ENST00000523312.1
ENST00000424930.6
zinc finger protein 419

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0003069 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.2 1.3 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.2 1.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.8 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2 0.7 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.5 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.1 1.3 GO:0015747 urate transport(GO:0015747)
0.1 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.4 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 0.3 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 1.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.3 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.6 GO:0002254 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 0.5 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.3 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 0.4 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 0.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.5 GO:0001705 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.1 2.1 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 0.2 GO:0072299 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.1 0.2 GO:0090301 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1 0.3 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.3 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.2 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:1903937 response to acrylamide(GO:1903937)
0.0 0.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.2 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.0 0.5 GO:0002934 desmosome organization(GO:0002934)
0.0 0.1 GO:0048058 compound eye corneal lens development(GO:0048058)
0.0 0.1 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.0 0.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.4 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.4 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.1 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.0 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.2 GO:0015840 urea transport(GO:0015840)
0.0 0.2 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.4 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.1 GO:0002357 defense response to tumor cell(GO:0002357)
0.0 0.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.1 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.3 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 2.7 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.3 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.0 GO:0070409 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.0 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.0 0.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 1.6 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.0 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.0 GO:1900005 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.0 0.0 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.3 GO:0016939 kinesin II complex(GO:0016939)
0.1 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 6.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.5 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.2 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 3.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.0 GO:0097441 basilar dendrite(GO:0097441)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 2.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.4 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.2 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.1 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.6 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 0.2 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 1.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.0 0.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.0 0.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.4 GO:0032183 SUMO binding(GO:0032183)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.5 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.0 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.0 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.0 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.5 PID FOXO PATHWAY FoxO family signaling
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 1.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 3.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 3.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.2 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 0.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.2 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis