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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SIX4

Z-value: 0.46

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.9 SIX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg38_v1_chr14_-_60724300_60724362-0.528.1e-03Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_35031263 1.64 ENST00000640135.1
ENST00000596348.2
SCN1B
sodium voltage-gated channel beta subunit 1
chr6_-_75363003 1.40 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr19_+_34926892 0.80 ENST00000303586.11
ENST00000601142.2
ENST00000439785.5
ENST00000601540.5
ENST00000601957.5
ZNF30
zinc finger protein 30
chr14_-_91946989 0.77 ENST00000556154.5
FBLN5
fibulin 5
chr8_+_94895763 0.76 ENST00000523378.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr13_-_77918820 0.70 ENST00000646607.2
EDNRB
endothelin receptor type B
chr16_+_590200 0.69 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr1_+_158930778 0.61 ENST00000458222.5
PYHIN1
pyrin and HIN domain family member 1
chr14_-_106349792 0.58 ENST00000438142.3
IGHV4-31
immunoglobulin heavy variable 4-31
chr3_-_93973833 0.55 ENST00000348974.5
ENST00000647936.1
ENST00000394236.9
ENST00000407433.6
PROS1
protein S
chr11_-_130314686 0.50 ENST00000525842.5
ZBTB44
zinc finger and BTB domain containing 44
chr8_+_94895837 0.47 ENST00000519136.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr2_-_113241683 0.46 ENST00000468980.3
PAX8
paired box 8
chr1_+_115641945 0.46 ENST00000355485.7
ENST00000369510.8
VANGL1
VANGL planar cell polarity protein 1
chr2_+_85584402 0.46 ENST00000306384.5
VAMP5
vesicle associated membrane protein 5
chr11_-_130314575 0.40 ENST00000397753.5
ZBTB44
zinc finger and BTB domain containing 44
chr8_+_94895813 0.36 ENST00000396113.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr1_-_247172002 0.35 ENST00000491356.5
ENST00000472531.5
ENST00000340684.10
ENST00000543802.3
ZNF124
zinc finger protein 124
chr2_-_61017174 0.34 ENST00000407787.5
ENST00000398658.2
PUS10
pseudouridine synthase 10
chr14_-_93955577 0.31 ENST00000555507.5
ASB2
ankyrin repeat and SOCS box containing 2
chr17_-_41528293 0.30 ENST00000455635.1
ENST00000361566.7
KRT19
keratin 19
chr1_+_231338242 0.28 ENST00000008440.9
ENST00000295050.12
SPRTN
SprT-like N-terminal domain
chr13_-_77918788 0.27 ENST00000626030.1
EDNRB
endothelin receptor type B
chr1_-_16352420 0.26 ENST00000375592.8
FBXO42
F-box protein 42
chr1_-_37947010 0.26 ENST00000458109.6
ENST00000373024.8
ENST00000373023.6
INPP5B
inositol polyphosphate-5-phosphatase B
chr19_-_58381022 0.26 ENST00000427624.2
ENST00000597582.2
ZNF837
zinc finger protein 837
chr20_-_54070520 0.25 ENST00000371435.6
ENST00000395961.7
BCAS1
brain enriched myelin associated protein 1
chr13_+_113122791 0.25 ENST00000375559.8
ENST00000409306.5
ENST00000375551.7
F10
coagulation factor X
chr17_-_63446260 0.24 ENST00000448884.6
ENST00000582297.5
ENST00000360793.8
ENST00000582034.5
ENST00000578072.1
CYB561
cytochrome b561
chr3_-_168095885 0.23 ENST00000470487.6
GOLIM4
golgi integral membrane protein 4
chr1_+_116754422 0.21 ENST00000369478.4
ENST00000369477.1
CD2
CD2 molecule
chr7_+_69599588 0.21 ENST00000403018.3
AUTS2
activator of transcription and developmental regulator AUTS2
chr17_+_40287861 0.20 ENST00000209728.9
ENST00000580824.5
ENST00000577249.1
ENST00000649662.1
CDC6
cell division cycle 6
chrX_-_120629936 0.19 ENST00000371313.2
ENST00000304661.6
C1GALT1C1
C1GALT1 specific chaperone 1
chr14_-_106627685 0.19 ENST00000390629.3
IGHV4-59
immunoglobulin heavy variable 4-59
chr8_-_94895195 0.19 ENST00000308108.9
ENST00000396133.7
CCNE2
cyclin E2
chr13_-_113864062 0.18 ENST00000327773.7
GAS6
growth arrest specific 6
chr9_-_92536031 0.17 ENST00000344604.9
ENST00000375540.5
ECM2
extracellular matrix protein 2
chr3_+_32685128 0.17 ENST00000331889.10
ENST00000328834.9
CNOT10
CCR4-NOT transcription complex subunit 10
chr19_-_46625037 0.15 ENST00000596260.1
ENST00000594275.1
ENST00000597185.1
ENST00000598865.5
ENST00000291294.7
PTGIR
prostaglandin I2 receptor
chr12_-_57742120 0.15 ENST00000257897.7
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_+_161153968 0.15 ENST00000368003.6
UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr6_-_41072331 0.15 ENST00000424266.7
OARD1
O-acyl-ADP-ribose deacylase 1
chr10_+_7818497 0.14 ENST00000344293.6
TAF3
TATA-box binding protein associated factor 3
chr13_-_48001265 0.14 ENST00000646932.1
ENST00000433022.1
ENST00000470760.2
ENST00000644338.1
ENST00000646602.1
SUCLA2
succinate-CoA ligase ADP-forming subunit beta
chr12_-_10130143 0.14 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
CLEC7A
C-type lectin domain containing 7A
chr12_-_10130241 0.13 ENST00000353231.9
ENST00000525605.1
CLEC7A
C-type lectin domain containing 7A
chr13_-_48001305 0.13 ENST00000643023.1
SUCLA2
succinate-CoA ligase ADP-forming subunit beta
chr11_+_7251886 0.13 ENST00000318881.11
SYT9
synaptotagmin 9
chr7_-_144403693 0.13 ENST00000645489.1
ENST00000643164.1
NOBOX
NOBOX oogenesis homeobox
chrX_+_71283186 0.12 ENST00000535149.5
NONO
non-POU domain containing octamer binding
chr1_-_77682639 0.12 ENST00000370801.8
ENST00000433749.5
ZZZ3
zinc finger ZZ-type containing 3
chr17_-_74531467 0.11 ENST00000314401.3
ENST00000392621.6
CD300LB
CD300 molecule like family member b
chr15_-_21742799 0.11 ENST00000622410.2
ENSG00000278263.2
novel protein, identical to IGHV4-4
chr19_-_474880 0.10 ENST00000382696.7
ENST00000315489.5
ODF3L2
outer dense fiber of sperm tails 3 like 2
chr5_+_79069754 0.09 ENST00000518666.5
ENST00000521567.1
ENST00000255192.8
BHMT2
betaine--homocysteine S-methyltransferase 2
chr14_+_21042352 0.09 ENST00000298690.5
RNASE7
ribonuclease A family member 7
chr11_-_113773668 0.09 ENST00000200135.8
ZW10
zw10 kinetochore protein
chr11_+_118077009 0.09 ENST00000616579.4
ENST00000534111.5
TMPRSS4
transmembrane serine protease 4
chr11_+_118077067 0.09 ENST00000522307.5
ENST00000523251.5
ENST00000437212.8
ENST00000522824.5
ENST00000522151.5
TMPRSS4
transmembrane serine protease 4
chr10_+_26216665 0.09 ENST00000259271.7
GAD2
glutamate decarboxylase 2
chr9_-_133209227 0.09 ENST00000372032.3
ENST00000372034.8
ENST00000618116.4
OBP2B
odorant binding protein 2B
chr20_-_44521989 0.09 ENST00000342374.5
ENST00000255175.5
SERINC3
serine incorporator 3
chr19_+_9140377 0.09 ENST00000360385.7
ENST00000247956.11
ZNF317
zinc finger protein 317
chr14_-_94517844 0.08 ENST00000341228.2
SERPINA12
serpin family A member 12
chr9_-_34895722 0.08 ENST00000603640.6
ENST00000603592.1
ENST00000340783.11
FAM205C
family with sequence similarity 205 member C
chr14_-_67515153 0.08 ENST00000555994.6
TMEM229B
transmembrane protein 229B
chr6_-_41072456 0.07 ENST00000463088.5
ENST00000469104.5
ENST00000486443.5
OARD1
O-acyl-ADP-ribose deacylase 1
chr7_-_99466148 0.07 ENST00000394186.3
ENST00000359832.8
ENST00000449683.5
ENST00000292475.8
ENST00000488775.5
ENST00000523680.1
ENST00000430982.1
ENST00000413834.5
ATP5MF
PTCD1
ATP5MF-PTCD1
ATP synthase membrane subunit f
pentatricopeptide repeat domain 1
ATP5MF-PTCD1 readthrough
chr11_-_14359118 0.06 ENST00000256196.9
RRAS2
RAS related 2
chr6_-_31736504 0.06 ENST00000616760.1
ENST00000375784.7
ENST00000375779.6
CLIC1
chloride intracellular channel 1
chr3_+_119147375 0.06 ENST00000490594.2
ENSG00000251012.2
novel chromosome 3 open reading frame 30 (C3orf30) and uroplakin 1B (UPK1B)
chr1_-_154961720 0.06 ENST00000368457.3
PYGO2
pygopus family PHD finger 2
chr7_+_97732046 0.06 ENST00000350485.8
ENST00000346867.4
ENST00000319273.10
TAC1
tachykinin precursor 1
chr1_+_152514474 0.06 ENST00000368790.4
CRCT1
cysteine rich C-terminal 1
chr12_-_10130082 0.06 ENST00000533022.5
CLEC7A
C-type lectin domain containing 7A
chr11_+_46936710 0.05 ENST00000378618.6
ENST00000278460.12
ENST00000395460.6
ENST00000378615.7
C11orf49
chromosome 11 open reading frame 49
chr1_-_42335189 0.05 ENST00000361776.5
ENST00000445886.5
ENST00000361346.6
FOXJ3
forkhead box J3
chr1_+_156642148 0.05 ENST00000361588.5
BCAN
brevican
chr5_-_1294989 0.05 ENST00000334602.10
ENST00000310581.10
TERT
telomerase reverse transcriptase
chr1_-_42335869 0.04 ENST00000372573.5
FOXJ3
forkhead box J3
chr14_-_106803221 0.04 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr1_+_156642108 0.04 ENST00000457777.6
ENST00000329117.10
ENST00000424639.5
BCAN
brevican
chr10_+_86654541 0.04 ENST00000241891.10
ENST00000372071.6
OPN4
opsin 4
chr14_+_96502542 0.04 ENST00000556619.5
ENST00000392990.6
PAPOLA
poly(A) polymerase alpha
chr1_+_116373233 0.03 ENST00000295598.10
ATP1A1
ATPase Na+/K+ transporting subunit alpha 1
chr12_-_57846686 0.03 ENST00000548823.1
ENST00000398073.7
CTDSP2
CTD small phosphatase 2
chrX_+_54440396 0.03 ENST00000375151.5
TSR2
TSR2 ribosome maturation factor
chr19_+_19063986 0.03 ENST00000318596.8
SLC25A42
solute carrier family 25 member 42
chr10_+_26216766 0.03 ENST00000376261.8
GAD2
glutamate decarboxylase 2
chr5_+_86617967 0.03 ENST00000515763.1
COX7C
cytochrome c oxidase subunit 7C
chr5_+_86617919 0.02 ENST00000247655.4
ENST00000509578.1
COX7C
cytochrome c oxidase subunit 7C
chr17_-_59707404 0.01 ENST00000393038.3
PTRH2
peptidyl-tRNA hydrolase 2
chr14_-_106324743 0.01 ENST00000390612.3
IGHV4-28
immunoglobulin heavy variable 4-28
chr11_+_33258304 0.01 ENST00000531504.5
ENST00000456517.2
HIPK3
homeodomain interacting protein kinase 3
chr3_-_49120785 0.00 ENST00000417901.5
ENST00000306026.5
ENST00000434032.6
USP19
ubiquitin specific peptidase 19
chr1_+_160127672 0.00 ENST00000447527.1
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.2 1.0 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
0.1 0.5 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.1 0.3 GO:0006781 succinyl-CoA pathway(GO:0006781)
0.1 0.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.2 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.1 0.2 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.8 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.2 GO:2000620 innate vocalization behavior(GO:0098582) positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 1.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0071953 elastic fiber(GO:0071953)
0.1 1.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.0 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1 1.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.3 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.1 0.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.5 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.0 0.3 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.3 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors