Project
Inflammatory response time course, HUVEC (Wada, 2009)
Navigation
Downloads
Results for SIX5_SMARCC2_HCFC1
Z-value: 2.38
Motif logo
Transcription factors associated with SIX5_SMARCC2_HCFC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC2 | hg38_v1_chr12_-_56189459_56189509 | 0.71 | 8.3e-05 | Click! |
| HCFC1 | hg38_v1_chrX_-_153971169_153971233, hg38_v1_chrX_-_153971810_153971844 | -0.29 | 1.7e-01 | Click! |
| SIX5 | hg38_v1_chr19_-_45768627_45768745 | -0.15 | 4.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.9 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.5 | 14.6 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.2 | 12.9 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 1.4 | 12.2 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 1.9 | 11.3 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.7 | 10.3 | GO:0036481 | intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481) |
| 3.1 | 9.3 | GO:1905053 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.8 | 8.3 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 2.7 | 8.2 | GO:0032887 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 2.6 | 7.8 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 20.3 | GO:0032039 | integrator complex(GO:0032039) |
| 2.9 | 14.6 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 13.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 13.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 2.4 | 12.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 1.2 | 9.5 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.1 | 8.7 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.2 | 8.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 2.7 | 8.2 | GO:0055028 | cortical microtubule(GO:0055028) |
| 1.0 | 7.8 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 68.8 | GO:0003677 | DNA binding(GO:0003677) |
| 2.9 | 14.6 | GO:0003920 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 4.1 | 12.2 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.0 | 11.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.7 | 9.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.4 | 8.7 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.2 | 8.0 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 7.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 7.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.5 | 6.1 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 12.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 11.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 8.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 3.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 2.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 2.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.0 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.6 | 14.6 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.5 | 8.2 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 8.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 7.9 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 7.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 7.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 4.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 3.7 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 3.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |