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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SMAD2

Z-value: 0.63

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.16 SMAD2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg38_v1_chr18_-_47931107_47931146-0.301.4e-01Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_99646025 4.26 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
PALMD
palmdelphin
chr12_+_53050179 4.04 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
TNS2
tensin 2
chr18_+_23135452 2.34 ENST00000580153.5
ENST00000256925.12
CABLES1
Cdk5 and Abl enzyme substrate 1
chr12_+_53050014 2.06 ENST00000314250.11
TNS2
tensin 2
chr11_-_33892010 1.57 ENST00000257818.3
LMO2
LIM domain only 2
chr21_+_44600597 1.43 ENST00000609664.2
KRTAP10-7
keratin associated protein 10-7
chr1_+_185734362 1.37 ENST00000271588.9
HMCN1
hemicentin 1
chr10_-_124093582 1.27 ENST00000462406.1
ENST00000435907.6
CHST15
carbohydrate sulfotransferase 15
chr8_+_94895763 1.16 ENST00000523378.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr22_+_19718390 1.11 ENST00000383045.7
ENST00000438754.6
SEPTIN5
septin 5
chrX_-_63754664 0.86 ENST00000677315.1
ENST00000636392.1
ENST00000637040.1
ENST00000637178.1
ENST00000637557.1
ENST00000636048.1
ENST00000638021.1
ENST00000672513.1
ENSG00000288661.1
ARHGEF9
novel protein
Cdc42 guanine nucleotide exchange factor 9
chr3_+_194685874 0.77 ENST00000329759.6
FAM43A
family with sequence similarity 43 member A
chr21_+_44573724 0.77 ENST00000622352.3
ENST00000400374.4
ENST00000616689.2
KRTAP10-4
keratin associated protein 10-4
chr11_+_68312542 0.77 ENST00000294304.12
LRP5
LDL receptor related protein 5
chr20_+_32010429 0.77 ENST00000452892.3
ENST00000262659.12
CCM2L
CCM2 like scaffold protein
chr11_+_59755427 0.76 ENST00000529177.5
STX3
syntaxin 3
chr20_-_23086316 0.73 ENST00000246006.5
CD93
CD93 molecule
chr4_-_113761441 0.71 ENST00000394524.7
CAMK2D
calcium/calmodulin dependent protein kinase II delta
chr17_+_7888783 0.69 ENST00000330494.12
ENST00000358181.8
CHD3
chromodomain helicase DNA binding protein 3
chr19_+_735026 0.69 ENST00000592155.5
ENST00000590161.2
PALM
paralemmin
chr5_-_88731827 0.68 ENST00000627170.2
MEF2C
myocyte enhancer factor 2C
chr3_+_52495330 0.66 ENST00000321725.10
STAB1
stabilin 1
chr22_+_31122923 0.61 ENST00000620191.4
ENST00000412277.6
ENST00000412985.5
ENST00000331075.10
ENST00000420017.5
ENST00000400294.6
ENST00000405300.5
ENST00000404390.7
INPP5J
inositol polyphosphate-5-phosphatase J
chr1_-_58784035 0.58 ENST00000371222.4
JUN
Jun proto-oncogene, AP-1 transcription factor subunit
chr6_+_32164586 0.57 ENST00000333845.11
ENST00000395512.5
ENST00000432129.1
EGFL8
EGF like domain multiple 8
chr4_-_113761724 0.57 ENST00000511664.6
CAMK2D
calcium/calmodulin dependent protein kinase II delta
chr15_+_96332432 0.57 ENST00000559679.1
ENST00000394171.6
NR2F2
nuclear receptor subfamily 2 group F member 2
chr1_+_2050387 0.55 ENST00000378567.8
PRKCZ
protein kinase C zeta
chr22_+_50089879 0.54 ENST00000545383.5
ENST00000262794.10
MOV10L1
Mov10 like RISC complex RNA helicase 1
chr3_+_111674654 0.53 ENST00000636933.1
ENST00000393934.7
ENST00000477665.2
PLCXD2
phosphatidylinositol specific phospholipase C X domain containing 2
chr1_-_94121105 0.53 ENST00000649773.1
ENST00000370225.4
ABCA4
ATP binding cassette subfamily A member 4
chr7_-_130441136 0.53 ENST00000675596.1
ENST00000676312.1
CEP41
centrosomal protein 41
chr5_-_74640575 0.52 ENST00000651128.1
ENC1
ectodermal-neural cortex 1
chrX_+_153494970 0.51 ENST00000331595.9
ENST00000431891.1
BGN
biglycan
chr3_+_124094663 0.50 ENST00000460856.5
ENST00000240874.7
KALRN
kalirin RhoGEF kinase
chr9_+_125747345 0.49 ENST00000342287.9
ENST00000373489.10
ENST00000373487.8
PBX3
PBX homeobox 3
chr1_+_37474572 0.47 ENST00000373087.7
ZC3H12A
zinc finger CCCH-type containing 12A
chr19_+_49591170 0.47 ENST00000418929.7
PRR12
proline rich 12
chr1_+_26159071 0.46 ENST00000374268.5
FAM110D
family with sequence similarity 110 member D
chr22_+_22822658 0.44 ENST00000620395.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr4_-_113761068 0.41 ENST00000342666.9
ENST00000514328.5
ENST00000515496.5
ENST00000508738.5
ENST00000379773.6
CAMK2D
calcium/calmodulin dependent protein kinase II delta
chr11_-_5441514 0.41 ENST00000380211.1
OR51I1
olfactory receptor family 51 subfamily I member 1
chr19_+_48624952 0.41 ENST00000599748.5
ENST00000599029.2
SPHK2
sphingosine kinase 2
chr2_-_240682879 0.40 ENST00000407834.4
ENST00000621682.4
AQP12B
aquaporin 12B
chr11_+_66857056 0.40 ENST00000309602.5
ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr21_+_44697172 0.40 ENST00000400365.3
KRTAP10-12
keratin associated protein 10-12
chr1_-_206003385 0.40 ENST00000617070.5
RAB7B
RAB7B, member RAS oncogene family
chr19_+_49513154 0.40 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr22_-_38455199 0.39 ENST00000303592.3
KCNJ4
potassium inwardly rectifying channel subfamily J member 4
chr22_+_37560472 0.39 ENST00000430687.1
ENST00000249014.5
CDC42EP1
CDC42 effector protein 1
chr14_-_104978360 0.39 ENST00000333244.6
AHNAK2
AHNAK nucleoprotein 2
chr22_-_20016807 0.38 ENST00000263207.8
ARVCF
ARVCF delta catenin family member
chr17_-_78925376 0.38 ENST00000262768.11
TIMP2
TIMP metallopeptidase inhibitor 2
chr3_+_124094696 0.38 ENST00000360013.7
ENST00000684186.1
ENST00000684276.1
KALRN
kalirin RhoGEF kinase
chr1_+_43946905 0.37 ENST00000372343.8
IPO13
importin 13
chr20_+_58651785 0.36 ENST00000358029.8
STX16
syntaxin 16
chr12_-_12266769 0.36 ENST00000543091.1
LRP6
LDL receptor related protein 6
chr16_+_55479188 0.36 ENST00000219070.9
MMP2
matrix metallopeptidase 2
chr19_-_41353904 0.35 ENST00000221930.6
TGFB1
transforming growth factor beta 1
chr11_+_9573633 0.35 ENST00000450114.7
WEE1
WEE1 G2 checkpoint kinase
chr5_-_151686908 0.35 ENST00000231061.9
SPARC
secreted protein acidic and cysteine rich
chr9_+_122519141 0.31 ENST00000340750.1
OR1J4
olfactory receptor family 1 subfamily J member 4
chr1_-_44031352 0.31 ENST00000372306.7
ENST00000475075.6
SLC6A9
solute carrier family 6 member 9
chr1_-_234479131 0.30 ENST00000040877.2
TARBP1
TAR (HIV-1) RNA binding protein 1
chr12_-_55712402 0.30 ENST00000452168.6
ITGA7
integrin subunit alpha 7
chr17_-_41424583 0.29 ENST00000225550.4
KRT37
keratin 37
chr5_+_43603163 0.29 ENST00000660752.1
ENST00000654405.1
ENST00000344920.9
ENST00000657172.1
ENST00000512996.6
ENST00000671668.1
NNT
nicotinamide nucleotide transhydrogenase
chr6_+_43132472 0.29 ENST00000489707.5
PTK7
protein tyrosine kinase 7 (inactive)
chr12_+_103930600 0.29 ENST00000680316.1
ENST00000679861.1
HSP90B1
heat shock protein 90 beta family member 1
chr1_-_154961720 0.29 ENST00000368457.3
PYGO2
pygopus family PHD finger 2
chr2_-_20225433 0.28 ENST00000381150.5
SDC1
syndecan 1
chr1_-_2801717 0.28 ENST00000401095.8
TTC34
tetratricopeptide repeat domain 34
chrX_+_153764178 0.28 ENST00000538966.5
PLXNB3
plexin B3
chr13_-_41961078 0.28 ENST00000379310.8
ENST00000281496.6
VWA8
von Willebrand factor A domain containing 8
chrX_-_107775740 0.27 ENST00000372383.9
TSC22D3
TSC22 domain family member 3
chrX_+_153764233 0.27 ENST00000361971.10
PLXNB3
plexin B3
chr21_-_46285608 0.27 ENST00000291688.6
MCM3AP
minichromosome maintenance complex component 3 associated protein
chr16_+_53130921 0.27 ENST00000564845.5
CHD9
chromodomain helicase DNA binding protein 9
chr3_-_195876635 0.26 ENST00000672669.1
ENST00000672886.1
ENST00000672098.1
ENST00000671767.1
ENST00000672548.1
TNK2
tyrosine kinase non receptor 2
chr9_+_122264603 0.26 ENST00000297908.7
MRRF
mitochondrial ribosome recycling factor
chr6_-_159045010 0.25 ENST00000338313.5
TAGAP
T cell activation RhoGTPase activating protein
chr22_+_22327298 0.24 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr14_-_106038355 0.23 ENST00000390597.3
IGHV2-5
immunoglobulin heavy variable 2-5
chr6_+_34514853 0.22 ENST00000538621.2
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr19_-_49362376 0.22 ENST00000601519.5
ENST00000593945.6
ENST00000539846.5
ENST00000596757.1
ENST00000311227.6
TEAD2
TEA domain transcription factor 2
chr11_-_75669028 0.22 ENST00000304771.8
MAP6
microtubule associated protein 6
chr6_-_27873525 0.22 ENST00000618305.2
H4C13
H4 clustered histone 13
chrX_-_107775951 0.22 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family member 3
chr19_-_55069488 0.22 ENST00000396247.7
ENST00000586945.5
ENST00000587026.1
RDH13
retinol dehydrogenase 13
chr17_+_68205453 0.21 ENST00000674770.2
AMZ2
archaelysin family metallopeptidase 2
chr12_+_6927946 0.21 ENST00000396684.3
ATN1
atrophin 1
chr1_-_1307861 0.21 ENST00000354700.10
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr3_-_195442977 0.21 ENST00000326793.11
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr17_+_75516514 0.21 ENST00000333213.11
ENST00000545228.3
ENST00000680999.1
TSEN54
tRNA splicing endonuclease subunit 54
chr1_-_151146611 0.21 ENST00000341697.7
ENST00000368914.8
SEMA6C
semaphorin 6C
chr10_+_103555124 0.20 ENST00000437579.1
NEURL1
neuralized E3 ubiquitin protein ligase 1
chr5_+_175871670 0.20 ENST00000514150.5
CPLX2
complexin 2
chr7_-_10940123 0.20 ENST00000339600.6
NDUFA4
NDUFA4 mitochondrial complex associated
chr6_-_56954747 0.20 ENST00000680361.1
DST
dystonin
chr7_-_150955796 0.19 ENST00000330883.9
KCNH2
potassium voltage-gated channel subfamily H member 2
chr4_-_39638893 0.19 ENST00000511809.5
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr1_-_151146643 0.19 ENST00000613223.1
SEMA6C
semaphorin 6C
chr12_-_57016517 0.19 ENST00000441881.5
ENST00000458521.7
TAC3
tachykinin precursor 3
chrX_-_135098695 0.18 ENST00000433425.4
SMIM10L2B
small integral membrane protein 10 like 2B
chr7_-_105876575 0.18 ENST00000318724.8
ENST00000419735.8
ATXN7L1
ataxin 7 like 1
chr19_+_48469354 0.18 ENST00000452733.7
ENST00000641098.1
CYTH2
cytohesin 2
chr19_+_35936360 0.17 ENST00000246529.4
LRFN3
leucine rich repeat and fibronectin type III domain containing 3
chr1_-_206946448 0.17 ENST00000356495.5
PIGR
polymeric immunoglobulin receptor
chr20_+_1895365 0.17 ENST00000358771.5
SIRPA
signal regulatory protein alpha
chr16_+_90022600 0.16 ENST00000620723.4
ENST00000268699.9
GAS8
growth arrest specific 8
chr1_-_206003442 0.16 ENST00000623893.1
RAB7B
RAB7B, member RAS oncogene family
chr3_-_168095885 0.16 ENST00000470487.6
GOLIM4
golgi integral membrane protein 4
chrX_-_30577759 0.16 ENST00000378962.4
TASL
TLR adaptor interacting with endolysosomal SLC15A4
chr16_+_57668299 0.16 ENST00000333493.9
ENST00000450388.7
ADGRG3
adhesion G protein-coupled receptor G3
chr3_-_51903341 0.16 ENST00000310914.10
IQCF1
IQ motif containing F1
chr5_-_43412323 0.16 ENST00000361115.4
CCL28
C-C motif chemokine ligand 28
chr4_-_39638846 0.16 ENST00000295958.10
SMIM14
small integral membrane protein 14
chr19_+_36140059 0.15 ENST00000246533.8
ENST00000587718.5
ENST00000592483.5
ENST00000590874.5
ENST00000588815.5
CAPNS1
calpain small subunit 1
chr6_+_32970888 0.15 ENST00000374831.8
BRD2
bromodomain containing 2
chr9_-_133131109 0.15 ENST00000372062.8
RALGDS
ral guanine nucleotide dissociation stimulator
chrX_+_102651366 0.14 ENST00000415986.5
ENST00000444152.5
ENST00000361600.9
GPRASP1
G protein-coupled receptor associated sorting protein 1
chr1_+_36306359 0.14 ENST00000453908.8
SH3D21
SH3 domain containing 21
chr20_+_64091954 0.14 ENST00000672146.2
OPRL1
opioid related nociceptin receptor 1
chr16_+_24729641 0.14 ENST00000395799.8
TNRC6A
trinucleotide repeat containing adaptor 6A
chr11_-_66317037 0.14 ENST00000311330.4
CD248
CD248 molecule
chr5_+_64768921 0.14 ENST00000381070.8
ENST00000508024.1
CWC27
CWC27 spliceosome associated cyclophilin
chr7_-_99408548 0.13 ENST00000626285.1
ENST00000350498.8
PDAP1
PDGFA associated protein 1
chr2_-_227164194 0.13 ENST00000396625.5
COL4A4
collagen type IV alpha 4 chain
chr19_-_51458448 0.13 ENST00000430817.5
ENST00000321424.7
ENST00000340550.5
SIGLEC8
sialic acid binding Ig like lectin 8
chr6_-_143450662 0.13 ENST00000237283.9
ADAT2
adenosine deaminase tRNA specific 2
chr7_-_102616692 0.13 ENST00000521076.5
ENST00000462172.5
ENST00000522801.5
ENST00000262940.12
ENST00000449970.6
RASA4
RAS p21 protein activator 4
chr19_-_14114156 0.13 ENST00000589994.6
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
chr12_+_109900518 0.13 ENST00000312777.9
ENST00000536408.2
TCHP
trichoplein keratin filament binding
chr9_+_122510802 0.12 ENST00000335302.5
OR1J2
olfactory receptor family 1 subfamily J member 2
chr18_+_13218195 0.12 ENST00000679167.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr3_-_88059042 0.12 ENST00000309534.10
CGGBP1
CGG triplet repeat binding protein 1
chr7_-_102517755 0.12 ENST00000306682.6
ENST00000465829.6
ENST00000541662.5
RASA4B
RAS p21 protein activator 4B
chr3_-_88058928 0.12 ENST00000482016.6
CGGBP1
CGG triplet repeat binding protein 1
chr9_+_79572715 0.12 ENST00000265284.10
TLE4
TLE family member 4, transcriptional corepressor
chr1_+_15456727 0.11 ENST00000359621.5
CELA2A
chymotrypsin like elastase 2A
chr17_+_7407838 0.11 ENST00000302926.7
NLGN2
neuroligin 2
chr22_+_44677044 0.11 ENST00000006251.11
PRR5
proline rich 5
chr5_+_175871570 0.11 ENST00000512824.5
ENST00000393745.8
CPLX2
complexin 2
chr11_-_117295485 0.11 ENST00000680971.1
BACE1
beta-secretase 1
chr11_+_75562056 0.11 ENST00000533603.5
SERPINH1
serpin family H member 1
chr4_+_37244735 0.11 ENST00000309447.6
NWD2
NACHT and WD repeat domain containing 2
chr19_+_16888991 0.11 ENST00000248076.4
F2RL3
F2R like thrombin or trypsin receptor 3
chr1_+_36307090 0.10 ENST00000505871.7
SH3D21
SH3 domain containing 21
chr17_-_42609356 0.10 ENST00000309428.10
RETREG3
reticulophagy regulator family member 3
chr5_+_134526176 0.10 ENST00000681820.1
ENST00000512386.6
ENST00000612830.2
JADE2
jade family PHD finger 2
chr22_+_44677077 0.10 ENST00000403581.5
PRR5
proline rich 5
chr16_+_28878382 0.10 ENST00000357084.7
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr7_-_105876477 0.10 ENST00000478915.1
ATXN7L1
ataxin 7 like 1
chr1_+_159171607 0.09 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr1_+_32362537 0.09 ENST00000373534.4
TSSK3
testis specific serine kinase 3
chr17_-_10114546 0.09 ENST00000323816.8
GAS7
growth arrest specific 7
chr9_+_79573162 0.09 ENST00000425506.5
TLE4
TLE family member 4, transcriptional corepressor
chr6_+_39792298 0.09 ENST00000633794.1
ENST00000274867.9
DAAM2
dishevelled associated activator of morphogenesis 2
chr16_-_4937064 0.08 ENST00000590782.6
ENST00000345988.7
PPL
periplakin
chr8_-_143617457 0.08 ENST00000529048.5
ENST00000529064.5
GFUS
GDP-L-fucose synthase
chr5_+_180494344 0.08 ENST00000261951.9
CNOT6
CCR4-NOT transcription complex subunit 6
chr16_+_28878480 0.08 ENST00000395503.9
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr1_-_41242106 0.07 ENST00000337495.9
ENST00000372597.5
ENST00000372596.5
SCMH1
Scm polycomb group protein homolog 1
chr19_-_35135011 0.07 ENST00000310123.8
LGI4
leucine rich repeat LGI family member 4
chr10_+_18261080 0.07 ENST00000377319.8
ENST00000377331.8
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr6_+_39792993 0.07 ENST00000538976.5
DAAM2
dishevelled associated activator of morphogenesis 2
chr16_+_2033264 0.07 ENST00000565855.5
ENST00000566198.1
SLC9A3R2
SLC9A3 regulator 2
chr7_+_102363874 0.07 ENST00000496391.5
PRKRIP1
PRKR interacting protein 1
chr7_-_155809072 0.07 ENST00000430104.5
SHH
sonic hedgehog signaling molecule
chr5_+_134526100 0.07 ENST00000395003.5
JADE2
jade family PHD finger 2
chr11_+_14643782 0.07 ENST00000282096.9
PDE3B
phosphodiesterase 3B
chr9_+_101028721 0.06 ENST00000374874.8
PLPPR1
phospholipid phosphatase related 1
chr21_-_33479914 0.06 ENST00000542230.7
TMEM50B
transmembrane protein 50B
chr8_-_144416481 0.06 ENST00000276833.9
SLC39A4
solute carrier family 39 member 4
chr9_-_98708856 0.06 ENST00000259455.4
GABBR2
gamma-aminobutyric acid type B receptor subunit 2
chr11_+_14643826 0.06 ENST00000455098.2
PDE3B
phosphodiesterase 3B
chr18_+_3448456 0.05 ENST00000549780.5
TGIF1
TGFB induced factor homeobox 1
chrX_+_48802156 0.05 ENST00000643374.1
ENST00000644068.1
ENST00000441703.6
ENST00000643934.1
ENST00000489352.5
HDAC6
histone deacetylase 6
chr22_+_24495242 0.05 ENST00000382760.2
ENST00000326010.10
UPB1
beta-ureidopropionase 1
chr6_+_39793008 0.05 ENST00000398904.6
DAAM2
dishevelled associated activator of morphogenesis 2
chr12_-_6689450 0.05 ENST00000355772.8
ENST00000417772.7
ENST00000319770.7
ENST00000396801.7
ZNF384
zinc finger protein 384
chr3_-_9792404 0.05 ENST00000301964.7
TADA3
transcriptional adaptor 3
chr18_-_3013114 0.04 ENST00000677752.1
LPIN2
lipin 2
chr14_+_35826298 0.04 ENST00000216807.12
BRMS1L
BRMS1 like transcriptional repressor
chr8_-_94895195 0.04 ENST00000308108.9
ENST00000396133.7
CCNE2
cyclin E2
chr17_-_15262537 0.04 ENST00000395936.7
ENST00000675819.1
ENST00000674707.1
ENST00000675854.1
ENST00000426385.4
ENST00000395938.7
ENST00000612492.5
ENST00000675808.1
PMP22
peripheral myelin protein 22
chr22_-_43891995 0.04 ENST00000438734.1
ENST00000597664.6
ENST00000216177.8
ENST00000593866.5
ENST00000381198.6
PNPLA5
patatin like phospholipase domain containing 5
chr22_+_37639660 0.04 ENST00000649765.2
ENST00000451997.6
SH3BP1
ENSG00000285304.1
SH3 domain binding protein 1
novel protein
chr9_-_133356448 0.04 ENST00000615505.4
ENST00000371974.8
SURF1
SURF1 cytochrome c oxidase assembly factor
chr16_-_4801301 0.04 ENST00000586504.5
ENST00000649556.1
ROGDI
ENSG00000285952.1
rogdi atypical leucine zipper
novel transcript
chr12_-_6689244 0.03 ENST00000361959.7
ENST00000436774.6
ENST00000544482.1
ZNF384
zinc finger protein 384
chrX_+_21940693 0.03 ENST00000404933.7
ENST00000379404.5
SMS
spermine synthase
chr22_-_24245059 0.03 ENST00000398292.3
ENST00000263112.11
ENST00000327365.10
ENST00000424217.1
GGT5
gamma-glutamyltransferase 5
chr12_-_6689359 0.03 ENST00000683879.1
ZNF384
zinc finger protein 384
chr19_+_11355491 0.03 ENST00000591608.1
PLPPR2
phospholipid phosphatase related 2
chr8_-_143617498 0.03 ENST00000425753.7
GFUS
GDP-L-fucose synthase
chr20_+_45469745 0.03 ENST00000372676.8
ENST00000217425.9
ENST00000339946.7
WFDC2
WAP four-disulfide core domain 2
chr19_+_11355386 0.03 ENST00000251473.9
ENST00000591329.5
ENST00000586380.5
PLPPR2
phospholipid phosphatase related 2
chr6_-_159044980 0.03 ENST00000367066.8
TAGAP
T cell activation RhoGTPase activating protein
chr5_-_64768619 0.02 ENST00000513458.9
SREK1IP1
SREK1 interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 0.6 GO:0051365 leading edge cell differentiation(GO:0035026) cellular response to potassium ion starvation(GO:0051365)
0.2 6.1 GO:0014850 response to muscle activity(GO:0014850)
0.2 0.8 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.6 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.6 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.1 0.4 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.4 GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335)
0.1 0.5 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1 0.4 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1 1.7 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.1 0.3 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.7 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.1 0.3 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.5 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.4 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.1 0.9 GO:0060125 habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125)
0.1 0.7 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.8 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.3 GO:0000451 rRNA 2'-O-methylation(GO:0000451)
0.1 0.3 GO:0048627 myoblast development(GO:0048627)
0.1 1.6 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.2 GO:0003064 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.4 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.2 GO:0031448 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.1 0.4 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.6 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.4 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 1.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:0009644 response to high light intensity(GO:0009644)
0.0 0.1 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.2 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.3 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0070846 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.3 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 4.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.0 GO:0019483 beta-alanine biosynthetic process(GO:0019483)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 2.9 GO:0031424 keratinization(GO:0031424)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 1.2 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:0002097 tRNA wobble base modification(GO:0002097)
0.0 0.2 GO:0030903 notochord development(GO:0030903)
0.0 0.1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.2 0.8 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.1 0.6 GO:0035976 AP1 complex(GO:0035976)
0.1 0.5 GO:0071546 pi-body(GO:0071546)
0.1 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 0.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.7 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.3 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 2.2 GO:0045095 keratin filament(GO:0045095)
0.0 1.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 4.2 GO:0043197 dendritic spine(GO:0043197)
0.0 0.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.0 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.2 1.3 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.2 0.5 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1 0.7 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.1 0.3 GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.3 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.6 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.6 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.4 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.0 0.8 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 1.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.0 0.1 GO:0001626 nociceptin receptor activity(GO:0001626)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 2.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.7 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.5 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 5.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 2.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.7 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 2.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)