Project
Inflammatory response time course, HUVEC (Wada, 2009)
Navigation
Downloads
Results for SMAD4
Z-value: 1.07
Motif logo
Transcription factors associated with SMAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD4 | hg38_v1_chr18_+_51030100_51030270 | -0.29 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_99646025 Show fit | 4.03 |
ENST00000263174.9
ENST00000605497.5 ENST00000615664.1 |
palmdelphin |
|
| chr4_+_155667096 Show fit | 1.98 |
ENST00000393832.7
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155667198 Show fit | 1.98 |
ENST00000296518.11
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155666963 Show fit | 1.98 |
ENST00000455639.6
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr20_+_32010429 Show fit | 1.65 |
ENST00000452892.3
ENST00000262659.12 |
CCM2 like scaffold protein |
|
| chr4_+_155666827 Show fit | 1.60 |
ENST00000511507.5
ENST00000506455.6 |
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_54657918 Show fit | 1.54 |
ENST00000412167.6
ENST00000288135.6 |
KIT proto-oncogene, receptor tyrosine kinase |
|
| chr9_-_14321948 Show fit | 1.53 |
ENST00000635877.1
ENST00000636432.1 ENST00000646622.1 |
nuclear factor I B |
|
| chr1_+_61404076 Show fit | 1.52 |
ENST00000357977.5
|
nuclear factor I A |
|
| chr17_+_63484840 Show fit | 1.50 |
ENST00000290863.10
ENST00000413513.7 |
angiotensin I converting enzyme |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 3.2 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.0 | 2.9 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.1 | 2.4 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 2.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.2 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.0 | 2.0 | GO:0071470 | cellular response to osmotic stress(GO:0071470) |
| 0.0 | 1.9 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.5 | 1.6 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.2 | 1.6 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 3.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 2.9 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 2.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 2.1 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 2.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.9 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.0 | 1.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.3 | 1.6 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.3 | 1.5 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 3.3 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 2.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.2 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 2.1 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 2.0 | GO:1901567 | icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567) |
| 0.4 | 1.9 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.0 | 1.8 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 1.7 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.1 | 1.7 | GO:0019992 | diacylglycerol binding(GO:0019992) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 3.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.8 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.1 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.6 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.6 | PID ENDOTHELIN PATHWAY | Endothelins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 1.9 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 1.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 1.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 1.8 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.3 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |