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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SOX21

Z-value: 0.32

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.6 SOX21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg38_v1_chr13_-_94712505_94712553-0.039.0e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_71305986 0.51 ENST00000647614.1
FOXP1
forkhead box P1
chrX_+_51710512 0.33 ENST00000602548.2
CENPVL1
centromere protein V like 1
chrX_-_51682831 0.33 ENST00000634648.1
CENPVL2
centromere protein V like 2
chr6_+_131573219 0.30 ENST00000356962.2
ENST00000368087.8
ENST00000673427.1
ENST00000640973.1
ARG1
arginase 1
chr1_+_152908538 0.30 ENST00000368764.4
IVL
involucrin
chr2_+_102142738 0.24 ENST00000410023.6
ENST00000409288.5
IL1R1
interleukin 1 receptor type 1
chr3_-_142028597 0.24 ENST00000467667.5
TFDP2
transcription factor Dp-2
chr3_-_71306012 0.23 ENST00000649431.1
ENST00000610810.5
FOXP1
forkhead box P1
chr10_-_13234329 0.22 ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr6_+_29396555 0.19 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr2_+_89851723 0.19 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr10_-_13234368 0.18 ENST00000378681.8
UCMA
upper zone of growth plate and cartilage matrix associated
chr9_-_101487120 0.17 ENST00000374848.8
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chr15_-_79971164 0.16 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2A1
BCL2 related protein A1
chr8_+_100158576 0.15 ENST00000388798.7
SPAG1
sperm associated antigen 1
chr19_-_7040179 0.15 ENST00000381394.9
MBD3L4
methyl-CpG binding domain protein 3 like 4
chr10_-_69409275 0.14 ENST00000373307.5
TACR2
tachykinin receptor 2
chr8_-_141367276 0.14 ENST00000377741.4
GPR20
G protein-coupled receptor 20
chr9_-_101487091 0.14 ENST00000374847.5
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chr9_+_96928310 0.13 ENST00000354649.7
NUTM2G
NUT family member 2G
chr3_+_141384790 0.13 ENST00000507722.5
ZBTB38
zinc finger and BTB domain containing 38
chr17_-_8799365 0.12 ENST00000329805.6
MFSD6L
major facilitator superfamily domain containing 6 like
chrX_+_11760087 0.11 ENST00000649271.1
MSL3
MSL complex subunit 3
chrX_-_48835553 0.11 ENST00000218230.6
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr6_+_31403553 0.11 ENST00000449934.7
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chrX_+_11760035 0.11 ENST00000482871.6
ENST00000648013.1
MSL3
MSL complex subunit 3
chr11_+_118077067 0.10 ENST00000522307.5
ENST00000523251.5
ENST00000437212.8
ENST00000522824.5
ENST00000522151.5
TMPRSS4
transmembrane serine protease 4
chr11_-_8263858 0.10 ENST00000534484.1
ENST00000335790.8
LMO1
LIM domain only 1
chr1_+_207325629 0.10 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr3_-_155806260 0.09 ENST00000534941.2
ENST00000340171.7
C3orf33
chromosome 3 open reading frame 33
chr6_+_151494007 0.09 ENST00000239374.8
CCDC170
coiled-coil domain containing 170
chr9_+_102995308 0.09 ENST00000612124.4
ENST00000374798.8
ENST00000487798.5
CYLC2
cylicin 2
chr3_+_98463201 0.09 ENST00000642057.1
OR5K1
olfactory receptor family 5 subfamily K member 1
chr7_-_87220567 0.09 ENST00000433078.5
TMEM243
transmembrane protein 243
chr14_-_106470788 0.09 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr1_+_203795614 0.09 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr3_+_186570663 0.09 ENST00000265028.8
DNAJB11
DnaJ heat shock protein family (Hsp40) member B11
chr18_+_32190015 0.08 ENST00000581447.1
MEP1B
meprin A subunit beta
chr18_+_32190033 0.08 ENST00000269202.11
MEP1B
meprin A subunit beta
chr17_+_68259164 0.08 ENST00000448504.6
ARSG
arylsulfatase G
chr1_-_26067622 0.08 ENST00000374272.4
TRIM63
tripartite motif containing 63
chr1_-_217076889 0.07 ENST00000493748.5
ENST00000463665.5
ESRRG
estrogen related receptor gamma
chrX_+_3066833 0.07 ENST00000359361.2
ARSF
arylsulfatase F
chr12_-_10807286 0.07 ENST00000240615.3
TAS2R8
taste 2 receptor member 8
chr3_+_38496467 0.07 ENST00000453767.1
EXOG
exo/endonuclease G
chr6_+_131637296 0.07 ENST00000358229.6
ENST00000357639.8
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chrX_+_66164210 0.07 ENST00000343002.7
ENST00000336279.9
HEPH
hephaestin
chr8_-_86069662 0.07 ENST00000276616.3
PSKH2
protein serine kinase H2
chr6_-_53061740 0.07 ENST00000350082.10
ENST00000356971.3
ENST00000676107.1
CILK1
ciliogenesis associated kinase 1
chr3_-_155854375 0.06 ENST00000643144.2
ENST00000359479.7
ENST00000646424.1
SLC33A1
solute carrier family 33 member 1
chr1_+_151198536 0.06 ENST00000349792.9
ENST00000409426.5
ENST00000368888.9
ENST00000441902.6
ENST00000368890.8
ENST00000424999.1
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
chr7_-_73719629 0.06 ENST00000395155.3
ENST00000395154.7
ENST00000395156.7
ENST00000222812.8
STX1A
syntaxin 1A
chr3_+_38496329 0.06 ENST00000287675.10
ENST00000630638.1
ENST00000422077.6
EXOG
exo/endonuclease G
chr4_-_102825526 0.05 ENST00000504211.5
ENST00000508476.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr1_+_158931539 0.05 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
PYHIN1
pyrin and HIN domain family member 1
chr8_-_142879820 0.05 ENST00000377675.3
ENST00000517471.5
ENST00000292427.10
CYP11B1
cytochrome P450 family 11 subfamily B member 1
chr5_+_176448363 0.05 ENST00000261942.7
FAF2
Fas associated factor family member 2
chr1_+_147242654 0.05 ENST00000652587.1
ENST00000361293.10
ENST00000369258.8
ENST00000369259.4
ENST00000650714.1
ENST00000639534.1
CHD1L
chromodomain helicase DNA binding protein 1 like
chr13_+_105466216 0.05 ENST00000375936.8
ENST00000329625.9
ENST00000595812.2
ENST00000618629.1
DAOA
D-amino acid oxidase activator
chr14_+_22226711 0.05 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr10_-_12042771 0.05 ENST00000357604.10
UPF2
UPF2 regulator of nonsense mediated mRNA decay
chr12_-_949519 0.04 ENST00000397230.6
ENST00000542785.5
ENST00000544742.5
ENST00000536177.5
ENST00000541619.1
RAD52
RAD52 homolog, DNA repair protein
chr4_-_102825767 0.04 ENST00000505207.5
ENST00000502404.5
ENST00000507845.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr12_-_89352395 0.04 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr19_-_2783308 0.04 ENST00000677562.1
ENST00000677754.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr3_-_142028617 0.04 ENST00000477292.5
ENST00000478006.5
ENST00000495310.5
ENST00000486111.5
TFDP2
transcription factor Dp-2
chr8_-_19602484 0.04 ENST00000454498.6
ENST00000520003.5
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr2_+_216498831 0.04 ENST00000491306.6
ENST00000600880.5
ENST00000446558.5
RPL37A
ribosomal protein L37a
chr19_-_2783241 0.04 ENST00000676943.1
ENST00000589251.5
ENST00000221566.7
ENST00000676984.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr14_+_21030201 0.04 ENST00000321760.11
ENST00000460647.6
ENST00000530140.6
ENST00000472458.5
TPPP2
tubulin polymerization promoting protein family member 2
chr4_-_102825854 0.03 ENST00000350435.11
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr6_-_112254647 0.03 ENST00000455073.1
ENST00000522006.5
ENST00000519932.5
LAMA4
laminin subunit alpha 4
chr7_+_138076453 0.03 ENST00000242375.8
ENST00000411726.6
AKR1D1
aldo-keto reductase family 1 member D1
chr12_-_89352487 0.03 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr14_+_21941122 0.03 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr2_+_3658193 0.03 ENST00000252505.4
ALLC
allantoicase
chr3_-_45915698 0.03 ENST00000539217.5
LZTFL1
leucine zipper transcription factor like 1
chrX_-_139642518 0.03 ENST00000370573.8
ENST00000338585.6
MCF2
MCF.2 cell line derived transforming sequence
chr11_+_118077009 0.03 ENST00000616579.4
ENST00000534111.5
TMPRSS4
transmembrane serine protease 4
chr18_+_11857440 0.03 ENST00000602628.1
GNAL
G protein subunit alpha L
chr12_+_122527229 0.03 ENST00000450485.6
ENST00000333479.12
KNTC1
kinetochore associated 1
chr11_+_35180279 0.02 ENST00000531873.5
CD44
CD44 molecule (Indian blood group)
chr7_-_16421524 0.02 ENST00000407010.7
CRPPA
CDP-L-ribitol pyrophosphorylase A
chr12_-_10172117 0.02 ENST00000545927.5
ENST00000309539.8
ENST00000432556.6
ENST00000544577.5
OLR1
oxidized low density lipoprotein receptor 1
chr19_+_18571730 0.02 ENST00000596304.5
ENST00000430157.6
ENST00000596273.5
ENST00000442744.7
ENST00000595683.5
ENST00000599256.5
ENST00000595158.5
ENST00000598780.5
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr14_+_103529163 0.02 ENST00000389749.9
TRMT61A
tRNA methyltransferase 61A
chr11_+_5389377 0.02 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr7_-_14903319 0.02 ENST00000403951.6
DGKB
diacylglycerol kinase beta
chr11_-_35360050 0.02 ENST00000644868.1
ENST00000643454.1
ENST00000646080.1
SLC1A2
solute carrier family 1 member 2
chr3_-_36993103 0.02 ENST00000322716.8
EPM2AIP1
EPM2A interacting protein 1
chr18_+_35241027 0.01 ENST00000330501.12
ENST00000601719.1
ENST00000591206.5
ENST00000261333.10
ENST00000355632.8
ENST00000585800.1
ZNF397
zinc finger protein 397
chr1_+_149583865 0.01 ENST00000585245.2
PPIAL4C
peptidylprolyl isomerase A like 4C
chr22_+_38957522 0.01 ENST00000618553.1
ENST00000249116.7
APOBEC3A
apolipoprotein B mRNA editing enzyme catalytic subunit 3A
chr5_-_179618032 0.01 ENST00000519033.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr4_-_176269213 0.01 ENST00000296525.7
ASB5
ankyrin repeat and SOCS box containing 5
chr1_+_200027605 0.01 ENST00000236914.7
NR5A2
nuclear receptor subfamily 5 group A member 2
chr20_+_44715360 0.01 ENST00000190983.5
CCN5
cellular communication network factor 5
chr16_-_18433412 0.01 ENST00000620440.4
NOMO2
NODAL modulator 2
chr12_+_101280093 0.01 ENST00000261637.5
UTP20
UTP20 small subunit processome component
chr3_+_58008350 0.01 ENST00000490882.5
ENST00000358537.7
ENST00000429972.6
ENST00000682871.1
ENST00000295956.9
FLNB
filamin B
chr1_-_37514743 0.00 ENST00000448519.2
ENST00000373075.6
ENST00000373073.8
ENST00000296214.10
MEAF6
MYST/Esa1 associated factor 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.1 0.3 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.1 0.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.7 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0035106 operant conditioning(GO:0035106)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.0 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.0 GO:0030573 bile acid catabolic process(GO:0030573)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.1 GO:0016497 substance K receptor activity(GO:0016497)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.1 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.0 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)