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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SOX30

Z-value: 0.53

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Transcription factors associated with SOX30

Gene Symbol Gene ID Gene Info
SOX30
ENSG00000039600.11 SOX30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX30hg38_v1_chr5_-_157652364_157652385,
hg38_v1_chr5_-_157652432_157652443		0.058.2e-01Click!

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_125919296 1.60 ENST00000444128.2
NCOA7
nuclear receptor coactivator 7
chr6_+_125919210 1.59 ENST00000438495.6
NCOA7
nuclear receptor coactivator 7
chr2_-_37672448 0.79 ENST00000611976.1
CDC42EP3
CDC42 effector protein 3
chr2_-_37672178 0.74 ENST00000457889.1
CDC42EP3
CDC42 effector protein 3
chr3_-_122564577 0.71 ENST00000477522.6
ENST00000360356.6
PARP9
poly(ADP-ribose) polymerase family member 9
chr2_-_37671633 0.69 ENST00000295324.4
CDC42EP3
CDC42 effector protein 3
chr5_-_147081428 0.68 ENST00000394413.7
PPP2R2B
protein phosphatase 2 regulatory subunit Bbeta
chr3_-_71306012 0.66 ENST00000649431.1
ENST00000610810.5
FOXP1
forkhead box P1
chr2_+_27496830 0.63 ENST00000264717.7
GCKR
glucokinase regulator
chr7_+_101127095 0.59 ENST00000223095.5
SERPINE1
serpin family E member 1
chr3_-_71305986 0.56 ENST00000647614.1
FOXP1
forkhead box P1
chr11_-_85719160 0.54 ENST00000389958.7
ENST00000527794.5
SYTL2
synaptotagmin like 2
chr11_-_85719045 0.51 ENST00000533057.6
ENST00000533892.5
SYTL2
synaptotagmin like 2
chr17_+_4948252 0.48 ENST00000520221.5
ENO3
enolase 3
chr5_-_147081462 0.46 ENST00000508267.5
ENST00000504198.5
PPP2R2B
protein phosphatase 2 regulatory subunit Bbeta
chr7_+_144000320 0.45 ENST00000641698.1
OR6B1
olfactory receptor family 6 subfamily B member 1
chr11_-_85719111 0.45 ENST00000529581.5
ENST00000533577.1
SYTL2
synaptotagmin like 2
chr11_-_35419462 0.42 ENST00000643522.1
SLC1A2
solute carrier family 1 member 2
chr11_-_35420050 0.42 ENST00000395753.6
ENST00000395750.6
ENST00000645634.1
SLC1A2
solute carrier family 1 member 2
chr6_-_89217339 0.41 ENST00000454853.7
GABRR1
gamma-aminobutyric acid type A receptor subunit rho1
chr11_-_35419213 0.40 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
SLC1A2
solute carrier family 1 member 2
chr6_-_139291987 0.40 ENST00000358430.8
TXLNB
taxilin beta
chr3_-_8644782 0.40 ENST00000544814.6
SSUH2
ssu-2 homolog
chr14_-_50561119 0.39 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr11_-_35420017 0.39 ENST00000643000.1
ENST00000646099.1
ENST00000647372.1
ENST00000642578.1
SLC1A2
solute carrier family 1 member 2
chr15_-_48963912 0.38 ENST00000332408.9
SHC4
SHC adaptor protein 4
chr20_+_38962299 0.37 ENST00000373325.6
ENST00000373323.8
ENST00000252011.8
ENST00000615559.1
DHX35
ENSG00000277581.1
DEAH-box helicase 35
novel transcript, sense intronic to DHX35
chr12_+_92702983 0.37 ENST00000344636.6
ENST00000544406.2
PLEKHG7
pleckstrin homology and RhoGEF domain containing G7
chr12_+_92702843 0.36 ENST00000397833.3
PLEKHG7
pleckstrin homology and RhoGEF domain containing G7
chr12_-_11395556 0.35 ENST00000565533.1
ENST00000389362.6
ENST00000546254.3
PRB2
PRB1
proline rich protein BstNI subfamily 2
proline rich protein BstNI subfamily 1
chr11_+_54706832 0.35 ENST00000319760.8
OR4A5
olfactory receptor family 4 subfamily A member 5
chr7_+_26152188 0.35 ENST00000056233.4
NFE2L3
nuclear factor, erythroid 2 like 3
chr9_-_71768386 0.35 ENST00000377066.9
ENST00000377044.9
CEMIP2
cell migration inducing hyaluronidase 2
chr11_+_128694052 0.34 ENST00000527786.7
ENST00000534087.3
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr11_+_128693887 0.31 ENST00000281428.12
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr8_-_81112055 0.30 ENST00000220597.4
PAG1
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
chr3_-_11643871 0.30 ENST00000430365.7
VGLL4
vestigial like family member 4
chr16_+_3654683 0.29 ENST00000246949.10
DNASE1
deoxyribonuclease 1
chr15_+_76336755 0.28 ENST00000290759.9
ISL2
ISL LIM homeobox 2
chr5_+_141359970 0.27 ENST00000522605.2
ENST00000622527.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr5_+_141392616 0.26 ENST00000398604.3
PCDHGA8
protocadherin gamma subfamily A, 8
chr12_-_49187369 0.26 ENST00000547939.6
TUBA1A
tubulin alpha 1a
chr11_-_35419899 0.25 ENST00000646847.1
ENST00000449068.2
ENST00000643401.1
ENST00000645966.1
ENST00000647104.1
SLC1A2
solute carrier family 1 member 2
chr1_-_167914089 0.24 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr6_+_131637296 0.24 ENST00000358229.6
ENST00000357639.8
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr3_-_167474026 0.23 ENST00000466903.1
ENST00000264677.8
SERPINI2
serpin family I member 2
chr8_+_24294044 0.23 ENST00000265769.9
ADAM28
ADAM metallopeptidase domain 28
chr12_-_10098940 0.23 ENST00000420265.2
CLEC1A
C-type lectin domain family 1 member A
chr6_-_134318097 0.23 ENST00000367858.10
ENST00000533224.1
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_10098977 0.23 ENST00000315330.8
ENST00000457018.6
CLEC1A
C-type lectin domain family 1 member A
chr17_-_676348 0.23 ENST00000681510.1
ENST00000679680.1
VPS53
VPS53 subunit of GARP complex
chr5_-_160852200 0.22 ENST00000327245.10
ATP10B
ATPase phospholipid transporting 10B (putative)
chr1_-_201507116 0.22 ENST00000340006.7
ENST00000526256.5
ENST00000526723.5
ENST00000524951.5
CSRP1
cysteine and glycine rich protein 1
chr4_-_175812746 0.22 ENST00000393658.6
GPM6A
glycoprotein M6A
chr2_-_165204042 0.22 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr2_-_157325808 0.21 ENST00000410096.6
ENST00000420719.6
ENST00000409216.5
ENST00000419116.2
ERMN
ermin
chr12_-_98894830 0.21 ENST00000549797.5
ENST00000333732.11
ENST00000341752.11
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chrX_+_41333342 0.21 ENST00000629496.3
ENST00000625837.2
ENST00000626301.2
DDX3X
DEAD-box helicase 3 X-linked
chr16_+_4495852 0.21 ENST00000575129.5
ENST00000398595.7
ENST00000414777.5
HMOX2
heme oxygenase 2
chr6_-_11778781 0.21 ENST00000414691.8
ENST00000229583.9
ADTRP
androgen dependent TFPI regulating protein
chr1_+_180928133 0.20 ENST00000367587.1
KIAA1614
KIAA1614
chr11_+_196761 0.20 ENST00000325113.9
ODF3
outer dense fiber of sperm tails 3
chr5_+_140855882 0.19 ENST00000562220.2
ENST00000307360.6
ENST00000506939.6
PCDHA10
protocadherin alpha 10
chr2_-_165203870 0.18 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr3_+_181711915 0.18 ENST00000325404.3
SOX2
SRY-box transcription factor 2
chr7_-_93226449 0.18 ENST00000394468.7
ENST00000453812.2
HEPACAM2
HEPACAM family member 2
chr6_-_127900958 0.17 ENST00000434358.3
ENST00000630369.2
ENST00000368248.4
THEMIS
thymocyte selection associated
chr14_+_51989609 0.17 ENST00000556760.5
RTRAF
RNA transcription, translation and transport factor
chr13_-_85799400 0.15 ENST00000647374.2
SLITRK6
SLIT and NTRK like family member 6
chr17_-_75153826 0.15 ENST00000481647.5
ENST00000470924.5
JPT1
Jupiter microtubule associated homolog 1
chr8_-_33567118 0.15 ENST00000256257.2
RNF122
ring finger protein 122
chr7_-_83162899 0.15 ENST00000423517.6
PCLO
piccolo presynaptic cytomatrix protein
chr17_-_40665121 0.14 ENST00000394052.5
KRT222
keratin 222
chr7_+_144070313 0.14 ENST00000641441.1
OR2A25
olfactory receptor family 2 subfamily A member 25
chr5_+_141408000 0.14 ENST00000616430.1
PCDHGB6
protocadherin gamma subfamily B, 6
chr3_+_19947074 0.14 ENST00000273047.9
RAB5A
RAB5A, member RAS oncogene family
chr11_-_35419542 0.14 ENST00000643305.1
ENST00000644351.1
ENST00000278379.9
ENST00000644779.1
SLC1A2
solute carrier family 1 member 2
chr12_-_11310420 0.13 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
PRB4
proline rich protein BstNI subfamily 4
chr5_+_141408032 0.12 ENST00000520790.1
PCDHGB6
protocadherin gamma subfamily B, 6
chr14_+_51989508 0.12 ENST00000261700.8
RTRAF
RNA transcription, translation and transport factor
chr11_+_63369779 0.12 ENST00000279178.4
SLC22A9
solute carrier family 22 member 9
chr12_-_95217373 0.12 ENST00000549499.1
ENST00000546711.5
ENST00000343958.9
FGD6
FYVE, RhoGEF and PH domain containing 6
chr9_+_100473140 0.11 ENST00000374879.5
TMEFF1
transmembrane protein with EGF like and two follistatin like domains 1
chr2_+_222671651 0.11 ENST00000446656.4
MOGAT1
monoacylglycerol O-acyltransferase 1
chr7_-_44189428 0.11 ENST00000673284.1
ENST00000403799.8
ENST00000671824.1
GCK
glucokinase
chr1_+_74235377 0.11 ENST00000326637.8
TNNI3K
TNNI3 interacting kinase
chrX_+_71283186 0.11 ENST00000535149.5
NONO
non-POU domain containing octamer binding
chr8_+_24294107 0.10 ENST00000437154.6
ADAM28
ADAM metallopeptidase domain 28
chr19_-_43935234 0.10 ENST00000269973.10
ZNF45
zinc finger protein 45
chrX_+_71283577 0.10 ENST00000420903.6
ENST00000373856.8
ENST00000678437.1
ENST00000678830.1
ENST00000677879.1
ENST00000373841.5
ENST00000276079.13
ENST00000676797.1
ENST00000678660.1
ENST00000678231.1
ENST00000677612.1
ENST00000413858.5
ENST00000450092.6
NONO
non-POU domain containing octamer binding
chr7_+_142670734 0.09 ENST00000390398.3
TRBV25-1
T cell receptor beta variable 25-1
chr22_+_50170720 0.09 ENST00000159647.9
ENST00000395842.3
PANX2
pannexin 2
chrX_-_143636094 0.09 ENST00000356928.2
SLITRK4
SLIT and NTRK like family member 4
chr5_+_66958870 0.08 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr9_-_83267230 0.08 ENST00000328788.5
FRMD3
FERM domain containing 3
chr2_+_29113989 0.08 ENST00000404424.5
CLIP4
CAP-Gly domain containing linker protein family member 4
chr8_+_104339796 0.08 ENST00000622554.1
ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr8_+_7836433 0.08 ENST00000314265.3
DEFB104A
defensin beta 104A
chr2_+_167135901 0.07 ENST00000628543.2
XIRP2
xin actin binding repeat containing 2
chrX_+_70444827 0.07 ENST00000374360.8
DLG3
discs large MAGUK scaffold protein 3
chr4_+_70592253 0.07 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr8_-_140800535 0.07 ENST00000521986.5
ENST00000523539.5
PTK2
protein tyrosine kinase 2
chr2_+_99337364 0.07 ENST00000617677.1
ENST00000289371.11
EIF5B
eukaryotic translation initiation factor 5B
chr7_+_102285125 0.07 ENST00000536178.3
SH2B2
SH2B adaptor protein 2
chrX_-_15854743 0.07 ENST00000450644.2
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr1_+_154429315 0.07 ENST00000476006.5
IL6R
interleukin 6 receptor
chr20_-_51768327 0.07 ENST00000311637.9
ENST00000338821.6
ATP9A
ATPase phospholipid transporting 9A (putative)
chr4_+_70592295 0.06 ENST00000449493.2
AMBN
ameloblastin
chr2_+_231708511 0.06 ENST00000341369.11
ENST00000409115.8
ENST00000409683.5
PTMA
prothymosin alpha
chrX_+_80420466 0.05 ENST00000308293.5
TENT5D
terminal nucleotidyltransferase 5D
chr12_-_68225806 0.05 ENST00000229134.5
IL26
interleukin 26
chr12_-_11269805 0.05 ENST00000538488.2
PRB3
proline rich protein BstNI subfamily 3
chr12_-_11269696 0.04 ENST00000381842.7
PRB3
proline rich protein BstNI subfamily 3
chr16_-_2787550 0.04 ENST00000682474.1
PRSS33
serine protease 33
chr1_-_118989504 0.03 ENST00000207157.7
TBX15
T-box transcription factor 15
chr10_+_68721012 0.03 ENST00000536391.5
ENST00000630771.2
CCAR1
cell division cycle and apoptosis regulator 1
chr1_+_240091866 0.03 ENST00000319653.14
FMN2
formin 2
chr12_+_95217792 0.03 ENST00000436874.6
ENST00000551472.5
ENST00000552821.5
VEZT
vezatin, adherens junctions transmembrane protein
chr11_-_102705737 0.02 ENST00000260229.5
MMP27
matrix metallopeptidase 27
chr1_+_244835616 0.02 ENST00000366528.3
ENST00000411948.7
COX20
cytochrome c oxidase assembly factor COX20
chr1_+_185045515 0.01 ENST00000367509.8
ENST00000367510.8
RNF2
ring finger protein 2
chr11_-_18526885 0.01 ENST00000251968.4
ENST00000536719.5
TSG101
tumor susceptibility 101
chr12_+_10929229 0.01 ENST00000381847.7
ENST00000396400.4
PRH2
proline rich protein HaeIII subfamily 2
chr7_-_149028452 0.01 ENST00000413966.1
ENST00000652332.1
PDIA4
protein disulfide isomerase family A member 4
chr7_-_14903319 0.00 ENST00000403951.6
DGKB
diacylglycerol kinase beta

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0001300 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 3.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 2.0 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 2.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.5 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 0.3 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.2 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.6 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 1.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.2 GO:0006788 heme oxidation(GO:0006788)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0034241 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.0 0.2 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.4 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 2.0 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 0.6 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 2.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.2 GO:0043273 CTPase activity(GO:0043273)
0.0 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.2 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 3.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.7 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 1.2 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID ATR PATHWAY ATR signaling pathway
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.7 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression