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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for SOX3_SOX2
Z-value: 2.13
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Transcription factors associated with SOX3_SOX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX3 | hg38_v1_chrX_-_140505058_140505076 | -0.35 | 8.6e-02 | Click! |
| SOX2 | hg38_v1_chr3_+_181711915_181711934 | 0.06 | 7.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX3_SOX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_10655023 Show fit | 8.27 |
ENST00000590009.5
|
interleukin enhancer binding factor 3 |
|
| chr4_+_41612892 Show fit | 6.73 |
ENST00000509454.5
ENST00000396595.7 ENST00000381753.8 |
LIM and calponin homology domains 1 |
|
| chr4_+_41612702 Show fit | 6.67 |
ENST00000509277.5
|
LIM and calponin homology domains 1 |
|
| chr1_+_99646025 Show fit | 5.87 |
ENST00000263174.9
ENST00000605497.5 ENST00000615664.1 |
palmdelphin |
|
| chr7_-_22193728 Show fit | 5.74 |
ENST00000620335.4
|
Rap guanine nucleotide exchange factor 5 |
|
| chr3_+_141386393 Show fit | 5.07 |
ENST00000503809.5
|
zinc finger and BTB domain containing 38 |
|
| chr4_+_143381939 Show fit | 5.04 |
ENST00000505913.5
|
GRB2 associated binding protein 1 |
|
| chr14_-_50561119 Show fit | 5.03 |
ENST00000555216.5
|
mitogen-activated protein kinase kinase kinase kinase 5 |
|
| chr7_-_22193824 Show fit | 4.45 |
ENST00000401957.6
|
Rap guanine nucleotide exchange factor 5 |
|
| chr4_-_158159657 Show fit | 4.28 |
ENST00000590648.5
|
golgi associated kinase 1B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.0 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 9.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.5 | 8.2 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.0 | 8.2 | GO:0007264 | small GTPase mediated signal transduction(GO:0007264) |
| 0.2 | 8.0 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.7 | 7.9 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 1.9 | 5.7 | GO:0006683 | galactosylceramide catabolic process(GO:0006683) |
| 0.4 | 5.7 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 0.4 | 5.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 1.7 | 5.0 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 7.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 7.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 7.1 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 7.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 5.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 5.5 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 5.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 4.8 | GO:0000922 | spindle pole(GO:0000922) |
| 0.2 | 4.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.8 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.3 | 9.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 8.4 | GO:0043621 | protein self-association(GO:0043621) |
| 0.2 | 7.0 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.3 | 6.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 6.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 6.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 5.8 | GO:0005525 | GTP binding(GO:0005525) |
| 1.9 | 5.7 | GO:0004336 | galactosylceramidase activity(GO:0004336) |
| 0.1 | 5.7 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.8 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.2 | 10.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 8.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 8.0 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.2 | 6.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 6.0 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 5.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 5.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 5.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 5.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.0 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 6.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 5.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 4.8 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.3 | 4.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 4.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 4.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 4.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 3.9 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |