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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SOX7

Z-value: 0.34

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.8 SOX7
PINX1
ENSG00000258724.1 PINX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PINX1hg38_v1_chr8_-_10839818_10839855-0.501.2e-02Click!
SOX7hg38_v1_chr8_-_10730498_10730525-0.481.5e-02Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_35880350 1.10 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
CCL5
C-C motif chemokine ligand 5
chr12_-_10998304 0.55 ENST00000538986.2
TAS2R20
taste 2 receptor member 20
chr4_+_76074701 0.34 ENST00000355810.9
ENST00000349321.7
ART3
ADP-ribosyltransferase 3 (inactive)
chr6_+_116399395 0.30 ENST00000644499.1
ENSG00000285446.1
novel protein
chr5_+_162067764 0.30 ENST00000639213.2
ENST00000414552.6
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr12_-_89656093 0.29 ENST00000359142.7
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr3_-_122564577 0.29 ENST00000477522.6
ENST00000360356.6
PARP9
poly(ADP-ribose) polymerase family member 9
chr1_+_222928415 0.28 ENST00000284476.7
DISP1
dispatched RND transporter family member 1
chr5_+_162067858 0.28 ENST00000361925.9
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr5_+_162067500 0.27 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr12_-_89656051 0.27 ENST00000261173.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr1_-_158426237 0.27 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr10_+_94683771 0.25 ENST00000339022.6
CYP2C18
cytochrome P450 family 2 subfamily C member 18
chr5_+_162067458 0.25 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr19_+_34926892 0.25 ENST00000303586.11
ENST00000601142.2
ENST00000439785.5
ENST00000601540.5
ENST00000601957.5
ZNF30
zinc finger protein 30
chr6_+_143843316 0.23 ENST00000367576.6
LTV1
LTV1 ribosome biogenesis factor
chr7_-_138755892 0.22 ENST00000644341.1
ENST00000478480.2
ATP6V0A4
ATPase H+ transporting V0 subunit a4
chr3_+_107599309 0.22 ENST00000406780.5
BBX
BBX high mobility group box domain containing
chr16_-_20352707 0.21 ENST00000396134.6
ENST00000573567.5
ENST00000570757.5
ENST00000396138.9
ENST00000571174.5
ENST00000576688.2
UMOD
uromodulin
chr4_+_74308463 0.20 ENST00000413830.6
EPGN
epithelial mitogen
chr13_-_37059432 0.20 ENST00000464744.5
SUPT20H
SPT20 homolog, SAGA complex component
chr13_+_94601830 0.20 ENST00000376958.5
GPR180
G protein-coupled receptor 180
chr4_-_122456725 0.20 ENST00000226730.5
IL2
interleukin 2
chr6_-_111483700 0.18 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr12_+_63779894 0.18 ENST00000261234.11
RXYLT1
ribitol xylosyltransferase 1
chr18_+_35241027 0.17 ENST00000330501.12
ENST00000601719.1
ENST00000591206.5
ENST00000261333.10
ENST00000355632.8
ENST00000585800.1
ZNF397
zinc finger protein 397
chr1_+_100133135 0.17 ENST00000370143.5
ENST00000370141.7
TRMT13
tRNA methyltransferase 13 homolog
chr4_-_47981535 0.15 ENST00000402813.9
CNGA1
cyclic nucleotide gated channel subunit alpha 1
chr11_+_7597182 0.13 ENST00000528883.5
PPFIBP2
PPFIA binding protein 2
chr4_+_68447453 0.11 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr10_-_12042771 0.10 ENST00000357604.10
UPF2
UPF2 regulator of nonsense mediated mRNA decay
chr1_-_206003385 0.10 ENST00000617070.5
RAB7B
RAB7B, member RAS oncogene family
chr11_+_35186820 0.09 ENST00000531110.6
ENST00000525685.6
CD44
CD44 molecule (Indian blood group)
chr16_+_28292485 0.09 ENST00000341901.5
SBK1
SH3 domain binding kinase 1
chr3_-_36993103 0.09 ENST00000322716.8
EPM2AIP1
EPM2A interacting protein 1
chr14_-_106117159 0.08 ENST00000390601.3
IGHV3-11
immunoglobulin heavy variable 3-11
chr21_-_14546297 0.08 ENST00000400566.6
ENST00000400564.5
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_+_42563981 0.08 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr1_-_206003442 0.08 ENST00000623893.1
RAB7B
RAB7B, member RAS oncogene family
chrX_+_131083706 0.06 ENST00000370921.1
ARHGAP36
Rho GTPase activating protein 36
chr8_-_86069662 0.06 ENST00000276616.3
PSKH2
protein serine kinase H2
chr8_+_28338640 0.06 ENST00000522209.1
PNOC
prepronociceptin
chr10_+_4963406 0.04 ENST00000380872.9
ENST00000442997.5
AKR1C1
aldo-keto reductase family 1 member C1
chr5_+_141182369 0.03 ENST00000609684.3
ENST00000625044.1
ENST00000623407.1
ENST00000623884.1
PCDHB16
ENSG00000279068.1
protocadherin beta 16
novel transcript
chr16_+_33009175 0.02 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr15_+_43826961 0.02 ENST00000381246.6
ENST00000452115.1
ENST00000263795.11
WDR76
WD repeat domain 76
chr19_-_38426195 0.02 ENST00000615439.5
ENST00000614135.4
ENST00000622174.4
ENST00000587753.5
ENST00000454404.6
ENST00000617966.4
ENST00000618320.4
ENST00000293062.13
ENST00000433821.6
ENST00000426920.6
RASGRP4
RAS guanyl releasing protein 4
chr17_-_41467386 0.02 ENST00000225899.4
KRT32
keratin 32
chrX_-_135781729 0.01 ENST00000617203.1
CT45A5
cancer/testis antigen family 45 member A5
chr11_-_62707413 0.01 ENST00000360796.10
ENST00000449636.6
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr3_+_98463201 0.01 ENST00000642057.1
OR5K1
olfactory receptor family 5 subfamily K member 1
chr11_+_56176618 0.01 ENST00000312298.1
OR5J2
olfactory receptor family 5 subfamily J member 2
chr16_-_33845229 0.00 ENST00000569103.2
IGHV3OR16-17
immunoglobulin heavy variable 3/OR16-17 (non-functional)

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.3 GO:0035638 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.1 0.2 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.6 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.0 0.2 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 1.1 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.2 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.2 GO:0034448 EGO complex(GO:0034448)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0031726 receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
0.1 1.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.3 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.0 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics