ISMARA results: SP1

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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SP1

Z-value: 1.74

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Transcription factors associated with SP1

Gene Symbol	Gene ID	Gene Info
SP1 Ensembl NCBI GeneCards UniProt	ENSG00000185591.10	SP1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP1	hg38_v1_chr12_+_53380639_53380874, hg38_v1_chr12_+_53380141_53380210	0.17	4.2e-01	Click!

Activity profile of SP1 motif

Sorted Z-values of SP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SP1

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Promoter	Score	Transcript	Gene	Gene Info
chr1_+_25616780 Show fit	10.85	ENST00000374332.9	MAN1C1 Ensembl NCBI GeneCards UniProt Show fit	mannosidase alpha class 1C member 1
chr10_-_79445617 Show fit	8.80	ENST00000372336.4	ZCCHC24 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCHC-type containing 24
chr20_+_43914801 Show fit	8.76	ENST00000341197.9	TOX2 Ensembl NCBI GeneCards UniProt Show fit	TOX high mobility group box family member 2
chr1_+_164559173 Show fit	8.38	ENST00000420696.7	PBX1 Ensembl NCBI GeneCards UniProt Show fit	PBX homeobox 1
chr14_-_91060113 Show fit	8.33	ENST00000536315.6	RPS6KA5 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase A5
chr4_+_41360759 Show fit	8.08	ENST00000508501.5 ENST00000512946.5 ENST00000313860.11 ENST00000512632.5 ENST00000512820.5	LIMCH1 Ensembl NCBI GeneCards UniProt Show fit	LIM and calponin homology domains 1
chr4_+_125314918 Show fit	8.00	ENST00000674496.2 ENST00000394329.9	FAT4 Ensembl NCBI GeneCards UniProt Show fit	FAT atypical cadherin 4
chr3_+_37861849 Show fit	7.46	ENST00000273179.10	CTDSPL Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like
chr14_-_91060578 Show fit	6.44	ENST00000418736.6 ENST00000614987.5	RPS6KA5 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase A5
chr20_-_40689228 Show fit	6.43	ENST00000373313.3	MAFB Ensembl NCBI GeneCards UniProt Show fit	MAF bZIP transcription factor B

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.0	GO:0006367	transcription initiation from RNA polymerase II promoter(GO:0006367)
1.8	20.1	GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
5.0	19.8	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
1.1	15.6	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
3.8	15.2	GO:1904428	negative regulation of tubulin deacetylation(GO:1904428)
0.4	15.1	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
2.9	14.6	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
1.4	13.5	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.5	13.4	GO:0072189	ureter development(GO:0072189)
3.3	13.2	GO:1904381	Golgi apparatus mannose trimming(GO:1904381)

Showing 1 to 10 of 1,076 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	26.2	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	22.7	GO:0005667	transcription factor complex(GO:0005667)
1.7	19.1	GO:0005955	calcineurin complex(GO:0005955)
0.3	17.2	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.2	16.2	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.6	15.4	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.2	14.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.3	13.4	GO:0016514	SWI/SNF complex(GO:0016514)
0.3	13.4	GO:0034451	centriolar satellite(GO:0034451)
0.3	12.8	GO:0099738	cell cortex region(GO:0099738)

Showing 1 to 10 of 318 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	33.6	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.0	26.5	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0	26.4	GO:0005509	calcium ion binding(GO:0005509)
0.2	16.7	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.9	15.8	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	13.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.4	13.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.6	12.3	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.5	12.1	GO:0052832	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
1.3	12.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)

Showing 1 to 10 of 649 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	41.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.7	37.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.3	33.5	PID E2F PATHWAY	E2F transcription factor network
0.6	24.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	19.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.7	17.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	12.4	PID BMP PATHWAY	BMP receptor signaling
0.2	11.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	9.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.2	8.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Showing 1 to 10 of 92 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	25.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.5	23.3	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.2	22.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.6	21.5	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.6	19.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.6	18.7	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	16.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	15.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.5	11.5	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	11.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK

Showing 1 to 10 of 164 entries

Results for SP1

Z-value: 1.74

Motif logo

Transcription factors associated with SP1

Activity-expression correlation:

Activity profile of SP1 motif

Sorted Z-values of SP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SP1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: