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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for SP3
Z-value: 1.15
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg38_v1_chr2_-_173965356_173965380 | 0.45 | 2.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.5 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.2 | 14.5 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 2.7 | 13.7 | GO:0003070 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.9 | 10.5 | GO:0030578 | PML body organization(GO:0030578) |
| 0.3 | 10.1 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.1 | 9.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.5 | 9.1 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.4 | 8.9 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.3 | 8.5 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 1.1 | 8.4 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.7 | 12.0 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 1.5 | 11.9 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.1 | 10.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 9.1 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 8.6 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.1 | 8.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.5 | 7.7 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.8 | 7.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 7.0 | GO:0035770 | ribonucleoprotein granule(GO:0035770) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 18.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.4 | 14.1 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.7 | 13.2 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 11.1 | GO:0008026 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
| 0.1 | 11.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 10.9 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.1 | 10.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.2 | 9.7 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.2 | 9.4 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 15.4 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 14.6 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.2 | 14.5 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 12.0 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 11.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 9.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 7.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 6.9 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 6.5 | PID P53 REGULATION PATHWAY | p53 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 19.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 13.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.3 | 10.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 10.1 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.3 | 9.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 8.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 7.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 7.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.4 | 7.1 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |