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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for SP4_PML
Z-value: 1.56
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Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP4 | hg38_v1_chr7_+_21428184_21428227 | -0.34 | 9.5e-02 | Click! |
| PML | hg38_v1_chr15_+_73994667_73994678 | -0.34 | 9.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.2 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.3 | 13.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 3.2 | 12.6 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.2 | 12.3 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.3 | 12.1 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.9 | 10.4 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 9.3 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 1.3 | 9.2 | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641) |
| 2.9 | 8.7 | GO:0060086 | circadian temperature homeostasis(GO:0060086) |
| 1.2 | 8.5 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 23.8 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 17.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 17.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 16.8 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.1 | 14.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 13.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.2 | 12.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 11.4 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.0 | 11.2 | GO:0005955 | calcineurin complex(GO:0005955) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 25.4 | GO:0002020 | protease binding(GO:0002020) |
| 2.9 | 20.6 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.0 | 15.1 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.8 | 12.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 12.4 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 1.3 | 11.8 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.4 | 11.0 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.3 | 9.0 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.2 | 8.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 41.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.4 | 22.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 21.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 17.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 13.9 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 13.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 12.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 10.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 9.5 | PID EPO PATHWAY | EPO signaling pathway |
| 0.3 | 8.9 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 18.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.4 | 14.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 14.3 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.3 | 13.3 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.3 | 11.6 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 10.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 9.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 9.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 8.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |