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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for SPIC
Z-value: 0.87
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Transcription factors associated with SPIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIC | hg38_v1_chr12_+_101475319_101475340 | 0.01 | 9.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_131270493 Show fit | 1.91 |
ENST00000372269.7
ENST00000464831.1 |
family with sequence similarity 78 member A |
|
| chr4_+_155666963 Show fit | 1.58 |
ENST00000455639.6
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155666718 Show fit | 1.57 |
ENST00000621234.4
ENST00000511108.5 |
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155667198 Show fit | 1.57 |
ENST00000296518.11
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155667096 Show fit | 1.57 |
ENST00000393832.7
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr7_+_1044542 Show fit | 1.32 |
ENST00000444847.2
|
G protein-coupled receptor 146 |
|
| chr10_-_129964240 Show fit | 1.29 |
ENST00000440978.2
ENST00000355311.10 |
EBF transcription factor 3 |
|
| chrX_+_55452119 Show fit | 1.28 |
ENST00000342972.3
|
MAGE family member H1 |
|
| chr17_+_41226648 Show fit | 1.25 |
ENST00000377721.3
|
keratin associated protein 9-2 |
|
| chr4_+_155666827 Show fit | 1.21 |
ENST00000511507.5
ENST00000506455.6 |
guanylate cyclase 1 soluble subunit alpha 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.8 | GO:0018317 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.4 | 2.7 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.5 | 2.1 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.0 | 2.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 2.0 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
| 0.0 | 2.0 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
| 0.2 | 1.9 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.4 | 1.8 | GO:1902559 | 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559) |
| 0.0 | 1.5 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.1 | 1.3 | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 2.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.9 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 1.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.3 | 1.5 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 1.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.2 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 1.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 0.9 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 0.9 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.2 | 2.7 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.3 | 2.1 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.1 | 2.0 | GO:0015923 | mannosidase activity(GO:0015923) |
| 0.5 | 1.9 | GO:0061769 | ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769) |
| 0.4 | 1.8 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
| 0.1 | 1.7 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.3 | 1.5 | GO:0003920 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.0 | 1.5 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 1.3 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 1.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 1.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 0.8 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.2 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 2.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.3 | REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | Genes involved in Cleavage of Growing Transcript in the Termination Region |
| 0.0 | 1.2 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.0 | 1.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.0 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |