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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SREBF2

Z-value: 0.67

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.12 SREBF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg38_v1_chr22_+_41833079_418331420.629.0e-04Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_11089446 2.28 ENST00000557933.5
ENST00000455727.6
ENST00000535915.5
ENST00000545707.5
ENST00000558518.6
ENST00000558013.5
LDLR
low density lipoprotein receptor
chr10_-_114684457 1.59 ENST00000392955.7
ABLIM1
actin binding LIM protein 1
chr20_+_34876603 1.56 ENST00000360596.7
ENST00000253382.5
ACSS2
acyl-CoA synthetase short chain family member 2
chr8_+_11802667 1.45 ENST00000443614.6
ENST00000220584.9
ENST00000525900.5
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr10_-_114684612 1.44 ENST00000533213.6
ENST00000369252.8
ABLIM1
actin binding LIM protein 1
chr8_+_11802611 1.41 ENST00000623368.3
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr5_+_160229499 1.26 ENST00000402432.4
FABP6
fatty acid binding protein 6
chr8_-_17722217 1.25 ENST00000381861.7
MTUS1
microtubule associated scaffold protein 1
chr5_-_43313473 1.14 ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr5_-_43313403 1.10 ENST00000325110.11
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr5_-_39424966 0.95 ENST00000515700.5
ENST00000320816.11
ENST00000339788.10
DAB2
DAB adaptor protein 2
chr15_+_47184076 0.92 ENST00000558014.5
SEMA6D
semaphorin 6D
chr11_-_119340816 0.86 ENST00000528368.3
C1QTNF5
C1q and TNF related 5
chr17_-_82098187 0.85 ENST00000634990.1
FASN
fatty acid synthase
chr6_-_52995170 0.85 ENST00000370959.1
ENST00000370963.9
GSTA4
glutathione S-transferase alpha 4
chr18_+_79395942 0.83 ENST00000397790.6
NFATC1
nuclear factor of activated T cells 1
chr15_-_72783611 0.80 ENST00000563907.5
ADPGK
ADP dependent glucokinase
chr10_-_50623897 0.75 ENST00000361781.7
ENST00000429490.5
ENST00000619438.4
SGMS1
sphingomyelin synthase 1
chr17_+_81103998 0.72 ENST00000572498.1
BAIAP2
BAR/IMD domain containing adaptor protein 2
chr8_+_123416766 0.65 ENST00000287387.7
ENST00000650311.1
ENST00000523356.1
NTAQ1
N-terminal glutamine amidase 1
chr8_+_123416718 0.64 ENST00000523984.5
NTAQ1
N-terminal glutamine amidase 1
chr2_-_55923775 0.62 ENST00000438672.5
ENST00000355426.8
ENST00000440439.5
ENST00000429909.5
ENST00000424207.5
ENST00000452337.5
ENST00000439193.5
ENST00000421664.1
EFEMP1
EGF containing fibulin extracellular matrix protein 1
chr6_-_32184227 0.59 ENST00000450110.5
ENST00000375067.7
ENST00000375056.6
AGER
advanced glycosylation end-product specific receptor
chr17_-_41918966 0.54 ENST00000537919.5
ENST00000353196.5
ENST00000393896.6
ACLY
ATP citrate lyase
chr2_-_25982471 0.54 ENST00000264712.8
KIF3C
kinesin family member 3C
chr5_-_150155828 0.53 ENST00000261799.9
PDGFRB
platelet derived growth factor receptor beta
chr10_-_3785179 0.51 ENST00000469435.1
KLF6
Kruppel like factor 6
chr19_-_18281612 0.50 ENST00000252818.5
JUND
JunD proto-oncogene, AP-1 transcription factor subunit
chr8_+_123416735 0.49 ENST00000524254.5
NTAQ1
N-terminal glutamine amidase 1
chr22_+_41833079 0.48 ENST00000612482.4
ENST00000361204.9
SREBF2
sterol regulatory element binding transcription factor 2
chr5_-_108367860 0.48 ENST00000496714.2
FBXL17
F-box and leucine rich repeat protein 17
chr11_-_73598067 0.47 ENST00000450446.6
ENST00000356467.5
FAM168A
family with sequence similarity 168 member A
chr11_-_6655788 0.46 ENST00000299441.5
DCHS1
dachsous cadherin-related 1
chr6_-_32184287 0.42 ENST00000375069.7
ENST00000375070.7
ENST00000438221.6
ENST00000620802.4
ENST00000538695.2
AGER
advanced glycosylation end-product specific receptor
chr17_-_41918944 0.42 ENST00000352035.7
ENST00000590770.5
ENST00000590151.5
ACLY
ATP citrate lyase
chr11_-_73598183 0.41 ENST00000064778.8
FAM168A
family with sequence similarity 168 member A
chr15_-_72783685 0.40 ENST00000456471.3
ENST00000311669.12
ADPGK
ADP dependent glucokinase
chr6_-_32184243 0.39 ENST00000375055.6
ENST00000375076.9
AGER
advanced glycosylation end-product specific receptor
chr8_-_123416327 0.38 ENST00000521903.5
ATAD2
ATPase family AAA domain containing 2
chr12_-_48004467 0.35 ENST00000380518.8
COL2A1
collagen type II alpha 1 chain
chr10_-_3785197 0.34 ENST00000497571.6
KLF6
Kruppel like factor 6
chr16_+_2033264 0.34 ENST00000565855.5
ENST00000566198.1
SLC9A3R2
SLC9A3 regulator 2
chr3_-_56683218 0.31 ENST00000355628.9
ENST00000683822.1
TASOR
transcription activation suppressor
chr10_-_3785225 0.31 ENST00000542957.1
KLF6
Kruppel like factor 6
chr12_-_48004496 0.29 ENST00000337299.7
COL2A1
collagen type II alpha 1 chain
chr16_+_66880503 0.29 ENST00000568869.1
ENST00000311765.4
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr3_+_183253795 0.28 ENST00000460419.1
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr6_+_41637005 0.26 ENST00000419164.6
ENST00000373051.6
MDFI
MyoD family inhibitor
chrX_-_112840815 0.26 ENST00000304758.5
ENST00000371959.9
AMOT
angiomotin
chr3_+_50269140 0.24 ENST00000616701.5
ENST00000433753.4
ENST00000611067.4
SEMA3B
semaphorin 3B
chr6_+_78867524 0.24 ENST00000369940.7
IRAK1BP1
interleukin 1 receptor associated kinase 1 binding protein 1
chr11_+_64291992 0.23 ENST00000394525.6
KCNK4
potassium two pore domain channel subfamily K member 4
chr8_+_26577843 0.23 ENST00000311151.9
DPYSL2
dihydropyrimidinase like 2
chr6_+_151239951 0.22 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chr3_-_160399512 0.21 ENST00000498409.5
ENST00000475677.5
ENST00000478536.1
IFT80
intraflagellar transport 80
chr16_+_31214088 0.21 ENST00000613872.1
TRIM72
tripartite motif containing 72
chr16_+_31214111 0.20 ENST00000322122.8
TRIM72
tripartite motif containing 72
chr2_+_119759875 0.18 ENST00000263708.7
PTPN4
protein tyrosine phosphatase non-receptor type 4
chr15_+_78264552 0.16 ENST00000394852.8
ENST00000343789.7
DNAJA4
DnaJ heat shock protein family (Hsp40) member A4
chr12_-_57846686 0.16 ENST00000548823.1
ENST00000398073.7
CTDSP2
CTD small phosphatase 2
chr1_+_55039511 0.14 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr1_+_32753991 0.12 ENST00000373481.7
KIAA1522
KIAA1522
chr14_-_74493275 0.10 ENST00000541064.5
NPC2
NPC intracellular cholesterol transporter 2
chr19_+_55080363 0.09 ENST00000588359.5
ENST00000245618.5
EPS8L1
EPS8 like 1
chr14_-_74493291 0.09 ENST00000238633.6
ENST00000555619.6
ENST00000434013.6
NPC2
NPC intracellular cholesterol transporter 2
chr14_-_74493322 0.08 ENST00000553490.5
ENST00000557510.5
NPC2
NPC intracellular cholesterol transporter 2
chr11_+_22666604 0.08 ENST00000454584.6
GAS2
growth arrest specific 2
chr11_+_2902258 0.06 ENST00000649076.2
ENST00000449793.6
SLC22A18
solute carrier family 22 member 18
chr9_+_128689201 0.06 ENST00000322030.13
SET
SET nuclear proto-oncogene
chr11_+_2902388 0.06 ENST00000380574.5
SLC22A18
solute carrier family 22 member 18
chr1_+_197268222 0.06 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
CRB1
crumbs cell polarity complex component 1
chr17_-_41118369 0.05 ENST00000391413.4
KRTAP4-11
keratin associated protein 4-11
chr12_+_49950733 0.05 ENST00000199280.4
ENST00000550862.1
AQP2
aquaporin 2
chr2_-_219060914 0.04 ENST00000295731.7
IHH
Indian hedgehog signaling molecule
chr18_-_23586422 0.02 ENST00000269228.10
NPC1
NPC intracellular cholesterol transporter 1
chr2_+_231707650 0.02 ENST00000409321.5
PTMA
prothymosin alpha
chr9_+_128689948 0.02 ENST00000372688.8
ENST00000372686.5
SET
SET nuclear proto-oncogene
chr19_-_13938371 0.02 ENST00000588872.3
ENST00000339560.10
PODNL1
podocan like 1
chr19_-_45782388 0.01 ENST00000458663.6
DMPK
DM1 protein kinase
chr11_+_65711991 0.01 ENST00000377046.7
ENST00000352980.8
KAT5
lysine acetyltransferase 5
chr1_+_197268204 0.01 ENST00000535699.5
ENST00000538660.5
CRB1
crumbs cell polarity complex component 1
chr3_+_160399630 0.00 ENST00000465903.5
ENST00000485645.5
ENST00000472991.5
ENST00000467468.5
ENST00000469762.5
ENST00000357388.8
ENST00000489573.5
ENST00000462787.5
ENST00000490207.5
ENST00000485867.5
SMC4
structural maintenance of chromosomes 4
chr19_-_11197516 0.00 ENST00000592903.5
ENST00000586659.6
ENST00000589359.5
ENST00000588724.5
KANK2
KN motif and ankyrin repeat domains 2
chr11_+_65615755 0.00 ENST00000355703.4
PCNX3
pecanex 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.5 1.6 GO:0019542 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.5 2.9 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.5 1.4 GO:1904597 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.3 1.0 GO:0035026 leading edge cell differentiation(GO:0035026)
0.3 0.9 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.2 0.5 GO:0072275 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.2 0.5 GO:0003192 mitral valve formation(GO:0003192)
0.1 2.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.5 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.7 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.1 0.2 GO:0050976 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.1 0.9 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 1.0 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.3 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.6 GO:0060174 limb bud formation(GO:0060174)
0.0 0.0 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 1.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.8 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.0 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 1.2 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 2.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.3 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 0.3 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.8 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.9 GO:0070206 protein trimerization(GO:0070206)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.2 1.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.9 GO:0042587 glycogen granule(GO:0042587)
0.1 0.8 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.5 GO:0035976 AP1 complex(GO:0035976)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 3.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.6 GO:0001650 fibrillar center(GO:0001650)
0.0 0.8 GO:0097542 ciliary tip(GO:0097542)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.5 2.9 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.5 1.4 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.4 1.6 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 2.3 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.3 0.9 GO:0016420 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.2 1.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 0.8 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 0.5 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2 0.5 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.2 0.6 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.1 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 0.8 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 0.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.2 GO:0097604 temperature-gated cation channel activity(GO:0097604)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.3 GO:0032052 bile acid binding(GO:0032052)
0.1 0.3 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 0.2 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.0 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 3.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 0.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.9 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels