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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for SRF

Z-value: 1.54

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.8 SRF

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg38_v1_chr6_+_43171260_431712810.213.0e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_138465472 32.30 ENST00000239938.5
EGR1
early growth response 1
chr10_-_62816341 18.02 ENST00000242480.4
ENST00000637191.1
EGR2
early growth response 2
chr10_-_62816309 17.57 ENST00000411732.3
EGR2
early growth response 2
chr8_-_22693469 10.11 ENST00000317216.3
EGR3
early growth response 3
chr4_+_87006988 9.43 ENST00000307808.10
AFF1
AF4/FMR2 family member 1
chr10_-_129964240 9.03 ENST00000440978.2
ENST00000355311.10
EBF3
EBF transcription factor 3
chr19_+_45467988 7.84 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FOSB
FosB proto-oncogene, AP-1 transcription factor subunit
chr4_+_87006736 6.42 ENST00000544085.6
AFF1
AF4/FMR2 family member 1
chr19_+_2476118 5.91 ENST00000215631.9
ENST00000587345.1
GADD45B
growth arrest and DNA damage inducible beta
chr7_-_27143672 4.77 ENST00000222726.4
HOXA5
homeobox A5
chr2_-_105438503 4.75 ENST00000393352.7
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr2_-_105398978 4.68 ENST00000408995.5
ENST00000530340.6
ENST00000393353.7
ENST00000322142.13
ENST00000344213.9
ENST00000358129.8
FHL2
four and a half LIM domains 2
chr12_+_52051402 4.52 ENST00000243050.5
ENST00000550763.1
ENST00000394825.6
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4 group A member 1
chr10_+_110497898 4.32 ENST00000369583.4
DUSP5
dual specificity phosphatase 5
chr19_+_13151975 4.26 ENST00000588173.1
IER2
immediate early response 2
chr14_+_75278820 3.79 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr6_-_16761447 3.24 ENST00000244769.8
ENST00000436367.6
ATXN1
ataxin 1
chr2_-_73293538 3.03 ENST00000436467.4
ENST00000545030.1
EGR4
early growth response 4
chr1_-_207911384 2.57 ENST00000356522.4
CD34
CD34 molecule
chr19_-_17245889 2.56 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chr1_-_207911027 2.53 ENST00000310833.12
CD34
CD34 molecule
chr14_-_73760259 2.51 ENST00000286523.9
ENST00000435371.1
MIDEAS
mitotic deacetylase associated SANT domain protein
chr15_+_83107572 2.38 ENST00000379390.10
ENST00000322019.14
ENST00000565774.5
ENST00000565982.1
TM6SF1
transmembrane 6 superfamily member 1
chr19_+_1026566 2.33 ENST00000562015.5
ENST00000263097.9
ENST00000348419.7
ENST00000565096.6
ENST00000562958.6
ENST00000568865.3
ENST00000606983.5
ENST00000562075.6
ENST00000607102.1
CNN2
calponin 2
chr14_-_89417148 2.28 ENST00000557258.6
FOXN3
forkhead box N3
chr1_+_76074698 2.24 ENST00000328299.4
ST6GALNAC3
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr2_-_208254232 2.23 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
IDH1
isocitrate dehydrogenase (NADP(+)) 1
chr3_+_48989876 2.10 ENST00000343546.8
P4HTM
prolyl 4-hydroxylase, transmembrane
chr9_+_128882502 2.08 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 VRAC subunit A
chr20_-_35147285 2.07 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr17_+_3475959 1.69 ENST00000263080.3
ASPA
aspartoacylase
chr15_+_96330691 1.62 ENST00000394166.8
NR2F2
nuclear receptor subfamily 2 group F member 2
chr9_-_76906090 1.61 ENST00000376718.8
PRUNE2
prune homolog 2 with BCH domain
chr17_+_44557476 1.55 ENST00000315323.5
FZD2
frizzled class receptor 2
chr3_+_143971784 1.51 ENST00000315691.8
DIPK2A
divergent protein kinase domain 2A
chr9_-_76906041 1.50 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
PRUNE2
prune homolog 2 with BCH domain
chr11_-_57514876 1.49 ENST00000528450.5
SLC43A1
solute carrier family 43 member 1
chr4_+_80197493 1.42 ENST00000415738.3
PRDM8
PR/SET domain 8
chr7_+_5879827 1.41 ENST00000416608.5
OCM
oncomodulin
chr5_-_54310545 1.36 ENST00000504924.6
ENST00000620747.4
ENST00000507646.2
ENST00000502271.5
ARL15
ADP ribosylation factor like GTPase 15
chr2_+_190927649 1.35 ENST00000409428.5
ENST00000409215.5
GLS
glutaminase
chr1_+_15758768 1.32 ENST00000483633.6
ENST00000502739.5
ENST00000375766.8
ENST00000431771.6
FBLIM1
filamin binding LIM protein 1
chrX_-_32412220 1.32 ENST00000619831.5
DMD
dystrophin
chr8_+_2045058 1.28 ENST00000523438.1
MYOM2
myomesin 2
chr6_-_3751703 1.16 ENST00000380283.5
PXDC1
PX domain containing 1
chr8_+_96584920 1.12 ENST00000521590.5
SDC2
syndecan 2
chr12_+_59596010 1.05 ENST00000547379.6
ENST00000552432.5
SLC16A7
solute carrier family 16 member 7
chr6_+_151239951 1.04 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chr5_-_177496845 0.95 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7
chr12_-_14951106 0.94 ENST00000541644.5
ENST00000545895.5
ARHGDIB
Rho GDP dissociation inhibitor beta
chr12_-_6663136 0.93 ENST00000396807.8
ENST00000619641.4
ENST00000446105.6
ING4
inhibitor of growth family member 4
chr12_-_6663083 0.90 ENST00000467678.5
ENST00000493873.1
ENST00000412586.6
ENST00000423703.6
ENST00000444704.5
ENST00000341550.9
ING4
inhibitor of growth family member 4
chr7_+_94656325 0.90 ENST00000482108.1
ENST00000488574.5
ENST00000612748.1
ENST00000613043.1
PEG10
paternally expressed 10
chr5_-_177496802 0.88 ENST00000506161.5
PDLIM7
PDZ and LIM domain 7
chr8_+_2045037 0.83 ENST00000262113.9
MYOM2
myomesin 2
chr2_-_171231314 0.82 ENST00000521943.5
TLK1
tousled like kinase 1
chr2_-_127675459 0.81 ENST00000355119.9
LIMS2
LIM zinc finger domain containing 2
chr7_-_44141074 0.80 ENST00000457314.5
ENST00000447951.1
ENST00000431007.1
MYL7
myosin light chain 7
chr2_-_127675065 0.80 ENST00000545738.6
ENST00000409808.6
LIMS2
LIM zinc finger domain containing 2
chr7_-_108003122 0.80 ENST00000393559.2
ENST00000222399.11
ENST00000676777.1
ENST00000439976.6
ENST00000393560.5
ENST00000677793.1
ENST00000679244.1
LAMB1
laminin subunit beta 1
chr17_+_75456618 0.73 ENST00000314256.12
ENST00000582186.5
ENST00000582455.5
ENST00000581252.5
ENST00000579208.5
TMEM94
transmembrane protein 94
chr1_+_223701582 0.71 ENST00000433674.6
CAPN2
calpain 2
chr12_+_18242955 0.70 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr1_-_91021996 0.68 ENST00000337393.10
ZNF644
zinc finger protein 644
chr1_-_168137430 0.67 ENST00000546300.5
ENST00000271357.9
ENST00000367835.1
ENST00000537209.5
GPR161
G protein-coupled receptor 161
chr11_-_2141238 0.66 ENST00000434045.6
IGF2
insulin like growth factor 2
chr20_+_36541484 0.62 ENST00000346786.2
MYL9
myosin light chain 9
chr11_-_2140967 0.60 ENST00000381389.5
IGF2
insulin like growth factor 2
chr12_-_50222694 0.60 ENST00000552783.5
LIMA1
LIM domain and actin binding 1
chr6_-_159045010 0.59 ENST00000338313.5
TAGAP
T cell activation RhoGTPase activating protein
chr7_-_94655993 0.59 ENST00000647110.1
ENST00000647048.1
ENST00000643020.1
ENST00000644682.1
ENST00000646119.1
ENST00000646265.1
ENST00000645445.1
ENST00000647334.1
ENST00000645262.1
ENST00000428696.7
ENST00000647096.1
ENST00000642394.1
ENST00000645725.1
ENST00000647351.1
ENST00000646943.1
ENST00000648936.2
ENST00000642707.1
ENST00000645109.1
ENST00000646489.1
ENST00000642933.1
ENST00000643128.1
ENST00000445866.7
ENST00000645101.1
ENST00000644116.1
ENST00000642441.1
ENST00000646879.1
ENST00000647018.1
SGCE
sarcoglycan epsilon
chr7_-_94656197 0.57 ENST00000643903.1
ENST00000644122.1
ENST00000447873.6
ENST00000644816.1
ENST00000644375.1
SGCE
sarcoglycan epsilon
chr12_-_50222348 0.56 ENST00000552823.5
ENST00000552909.5
LIMA1
LIM domain and actin binding 1
chr16_-_11281322 0.55 ENST00000312511.4
PRM1
protamine 1
chr7_-_94656160 0.54 ENST00000644609.1
ENST00000643272.1
ENST00000646137.1
ENST00000646098.1
ENST00000643193.1
ENST00000437425.7
ENST00000644551.1
ENST00000415788.3
SGCE
sarcoglycan epsilon
chr2_-_160200289 0.50 ENST00000409872.1
ITGB6
integrin subunit beta 6
chr3_+_9793074 0.49 ENST00000397261.8
ENST00000485273.1
ENST00000433034.1
ENST00000397256.5
ARPC4
ARPC4-TTLL3
actin related protein 2/3 complex subunit 4
ARPC4-TTLL3 readthrough
chr6_+_151240368 0.49 ENST00000253332.5
AKAP12
A-kinase anchoring protein 12
chr18_+_56651335 0.47 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chr19_+_13023958 0.47 ENST00000587760.5
ENST00000585575.5
NFIX
nuclear factor I X
chr18_+_56651385 0.46 ENST00000615645.4
WDR7
WD repeat domain 7
chr15_-_65067938 0.45 ENST00000421977.7
ENST00000220062.9
RASL12
RAS like family 12
chr19_-_47471847 0.45 ENST00000594353.1
ENST00000542837.2
SLC8A2
solute carrier family 8 member A2
chr17_-_81512671 0.45 ENST00000679480.1
ENST00000644774.2
ENST00000571721.6
ENST00000575842.5
ENST00000575087.5
ENST00000573283.7
ENST00000571691.6
ENST00000570382.2
ACTG1
actin gamma 1
chr1_-_248755754 0.40 ENST00000590317.4
LYPD8
LY6/PLAUR domain containing 8
chr5_-_179623659 0.38 ENST00000519056.5
ENST00000506721.5
ENST00000503105.5
ENST00000504348.5
ENST00000508103.5
ENST00000510431.5
ENST00000515158.5
ENST00000393432.8
ENST00000442819.6
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr1_+_11934651 0.37 ENST00000449038.5
ENST00000196061.5
ENST00000429000.6
PLOD1
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
chr13_+_42040036 0.36 ENST00000379274.6
DGKH
diacylglycerol kinase eta
chr10_-_16817443 0.35 ENST00000602389.1
RSU1
Ras suppressor protein 1
chr10_-_16817362 0.33 ENST00000377921.7
ENST00000345264.10
RSU1
Ras suppressor protein 1
chr3_-_9792404 0.33 ENST00000301964.7
TADA3
transcriptional adaptor 3
chr7_-_44141285 0.33 ENST00000458240.5
ENST00000223364.7
MYL7
myosin light chain 7
chr19_+_57389839 0.31 ENST00000366197.9
ENST00000336128.12
ENST00000596282.5
ENST00000597400.5
ENST00000598895.5
ENST00000596617.5
ZNF548
ENSG00000269533.5
zinc finger protein 548
novel transcript
chr17_-_10657302 0.31 ENST00000583535.6
MYH3
myosin heavy chain 3
chr19_-_4518465 0.30 ENST00000633942.1
PLIN4
perilipin 4
chr20_+_36541511 0.27 ENST00000279022.7
MYL9
myosin light chain 9
chr17_-_48593748 0.24 ENST00000239151.6
HOXB5
homeobox B5
chr10_+_86668501 0.24 ENST00000623056.4
ENST00000263066.11
ENST00000429277.7
ENST00000361373.9
ENST00000372066.8
ENST00000372056.8
ENST00000623007.3
LDB3
LIM domain binding 3
chr3_+_188212931 0.24 ENST00000618621.4
ENST00000640853.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_226063466 0.21 ENST00000666609.1
ENST00000661429.1
H3-3A
H3.3 histone A
chr17_-_4987624 0.20 ENST00000572543.5
ENST00000381311.9
ENST00000348066.8
CAMTA2
calmodulin binding transcription activator 2
chr17_-_4987354 0.19 ENST00000361571.9
CAMTA2
calmodulin binding transcription activator 2
chr2_+_73892967 0.19 ENST00000409731.7
ENST00000409918.5
ENST00000442912.5
ENST00000345517.8
ENST00000409624.1
ACTG2
actin gamma 2, smooth muscle
chr1_+_223701607 0.19 ENST00000434648.5
CAPN2
calpain 2
chr7_-_122304738 0.17 ENST00000442488.7
FEZF1
FEZ family zinc finger 1
chr1_-_85578345 0.16 ENST00000426972.8
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_+_138501753 0.15 ENST00000280098.9
SPOPL
speckle type BTB/POZ protein like
chr1_+_219173861 0.15 ENST00000366927.3
ENST00000366928.10
LYPLAL1
lysophospholipase like 1
chr6_+_43171260 0.12 ENST00000265354.6
SRF
serum response factor
chr8_+_85438850 0.12 ENST00000285381.3
CA3
carbonic anhydrase 3
chr2_+_206159884 0.12 ENST00000392222.7
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr17_-_74361860 0.11 ENST00000375366.4
BTBD17
BTB domain containing 17
chr20_+_4721901 0.10 ENST00000305817.3
PRND
prion like protein doppel
chr4_-_108166715 0.10 ENST00000510624.5
LEF1
lymphoid enhancer binding factor 1
chr19_-_47471886 0.08 ENST00000236877.11
ENST00000597014.1
SLC8A2
solute carrier family 8 member A2
chr14_+_103928432 0.07 ENST00000409874.9
TDRD9
tudor domain containing 9
chr8_+_74320832 0.07 ENST00000676377.1
GDAP1
ganglioside induced differentiation associated protein 1
chr2_-_96145431 0.06 ENST00000288943.5
DUSP2
dual specificity phosphatase 2
chr10_-_17617235 0.05 ENST00000466335.1
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr12_-_11310420 0.04 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
PRB4
proline rich protein BstNI subfamily 4
chr11_+_17260353 0.03 ENST00000530527.5
NUCB2
nucleobindin 2
chr13_+_27251545 0.03 ENST00000311549.11
RPL21
ribosomal protein L21
chr17_+_35147807 0.02 ENST00000394570.7
ENST00000268876.9
UNC45B
unc-45 myosin chaperone B
chr10_-_17617326 0.01 ENST00000326961.6
ENST00000361271.8
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr2_+_206159580 0.00 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
EEF1B2
eukaryotic translation elongation factor 1 beta 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.9 35.6 GO:0021593 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
10.8 32.3 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182)
2.4 9.4 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
1.7 5.1 GO:0071657 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
1.6 4.8 GO:0060435 bronchiole development(GO:0060435)
1.3 10.1 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.7 2.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.7 2.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.6 1.7 GO:0006533 aspartate catabolic process(GO:0006533)
0.5 4.5 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.4 3.8 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 1.6 GO:0009956 radial pattern formation(GO:0009956)
0.3 4.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.3 2.1 GO:0002329 pre-B cell differentiation(GO:0002329)
0.2 7.1 GO:0051412 response to corticosterone(GO:0051412)
0.2 1.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.1 GO:0008218 bioluminescence(GO:0008218)
0.2 1.6 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.2 1.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 1.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.2 0.9 GO:0071461 cellular response to redox state(GO:0071461)
0.1 3.8 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 1.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 1.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.8 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 1.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 1.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.5 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.4 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 2.6 GO:0050961 entrainment of circadian clock by photoperiod(GO:0043153) detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 2.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 2.2 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.1 0.8 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.9 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.7 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.3 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 2.1 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.2 GO:0043697 forebrain anterior/posterior pattern specification(GO:0021797) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 3.9 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.8 GO:0022030 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.7 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 1.2 GO:0031529 ruffle organization(GO:0031529)
0.0 1.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.5 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.9 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 0.8 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 3.2 GO:0051168 nuclear export(GO:0051168)
0.0 0.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.5 3.8 GO:0035976 AP1 complex(GO:0035976)
0.3 0.8 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.2 5.1 GO:0046930 pore complex(GO:0046930)
0.2 15.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 7.8 GO:0031430 M band(GO:0031430)
0.1 1.3 GO:0016013 syntrophin complex(GO:0016013)
0.1 2.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 3.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 1.6 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.2 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.6 GO:0001650 fibrillar center(GO:0001650)
0.0 0.5 GO:0031672 A band(GO:0031672)
0.0 1.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 70.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 1.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0071547 piP-body(GO:0071547)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 32.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.0 35.6 GO:0071837 HMG box domain binding(GO:0071837)
0.7 2.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.5 5.1 GO:0043199 sulfate binding(GO:0043199)
0.5 3.2 GO:0034046 poly(G) binding(GO:0034046)
0.4 1.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.3 4.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 2.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 2.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 1.4 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.7 GO:0004046 aminoacylase activity(GO:0004046)
0.1 2.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 2.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.5 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.1 0.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 8.8 GO:0050681 androgen receptor binding(GO:0050681)
0.1 1.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 2.1 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 6.0 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 3.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.3 GO:0031005 filamin binding(GO:0031005)
0.0 1.3 GO:0017166 vinculin binding(GO:0017166)
0.0 18.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 7.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
0.0 23.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 81.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.3 3.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 9.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 4.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 6.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 5.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 37.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 29.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 4.5 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 2.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 4.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 5.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 2.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)