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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for SRF
Z-value: 1.54
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg38_v1_chr6_+_43171260_43171281 | 0.21 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_138465472 Show fit | 32.30 |
ENST00000239938.5
|
early growth response 1 |
|
| chr10_-_62816341 Show fit | 18.02 |
ENST00000242480.4
ENST00000637191.1 |
early growth response 2 |
|
| chr10_-_62816309 Show fit | 17.57 |
ENST00000411732.3
|
early growth response 2 |
|
| chr8_-_22693469 Show fit | 10.11 |
ENST00000317216.3
|
early growth response 3 |
|
| chr4_+_87006988 Show fit | 9.43 |
ENST00000307808.10
|
AF4/FMR2 family member 1 |
|
| chr10_-_129964240 Show fit | 9.03 |
ENST00000440978.2
ENST00000355311.10 |
EBF transcription factor 3 |
|
| chr19_+_45467988 Show fit | 7.84 |
ENST00000615753.4
ENST00000585836.5 ENST00000417353.6 ENST00000591858.5 ENST00000443841.6 ENST00000590335.1 ENST00000353609.8 |
FosB proto-oncogene, AP-1 transcription factor subunit |
|
| chr4_+_87006736 Show fit | 6.42 |
ENST00000544085.6
|
AF4/FMR2 family member 1 |
|
| chr19_+_2476118 Show fit | 5.91 |
ENST00000215631.9
ENST00000587345.1 |
growth arrest and DNA damage inducible beta |
|
| chr7_-_27143672 Show fit | 4.77 |
ENST00000222726.4
|
homeobox A5 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.9 | 35.6 | GO:0021593 | rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658) |
| 10.8 | 32.3 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182) |
| 1.3 | 10.1 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 2.4 | 9.4 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.2 | 7.1 | GO:0051412 | response to corticosterone(GO:0051412) |
| 1.7 | 5.1 | GO:0071657 | mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258) |
| 1.6 | 4.8 | GO:0060435 | bronchiole development(GO:0060435) |
| 0.5 | 4.5 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.3 | 4.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 3.9 | GO:0071774 | response to fibroblast growth factor(GO:0071774) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 70.0 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.2 | 15.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 7.8 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 5.1 | GO:0046930 | pore complex(GO:0046930) |
| 0.5 | 3.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 3.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.5 | 3.2 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.1 | 2.1 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 1.8 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.2 | 1.7 | GO:0016012 | sarcoglycan complex(GO:0016012) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 35.6 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 5.4 | 32.3 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.0 | 23.1 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 18.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 8.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 7.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 6.0 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.5 | 5.1 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.3 | 4.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 3.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 81.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.2 | 9.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 6.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 5.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 4.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.3 | 3.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 3.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 37.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 29.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 5.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 4.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 4.5 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.1 | 3.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 2.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.2 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.2 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.1 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |