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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for STAT4

Z-value: 1.17

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Transcription factors associated with STAT4

Gene Symbol Gene ID Gene Info
STAT4
ENSG00000138378.19 STAT4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT4hg38_v1_chr2_-_191150971_191151017,
hg38_v1_chr2_-_191151568_191151596		-0.717.3e-05Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_-_76036060 9.99 ENST00000306621.8
CXCL11
C-X-C motif chemokine ligand 11
chr6_+_32854179 7.42 ENST00000374859.3
PSMB9
proteasome 20S subunit beta 9
chr15_+_67166019 6.79 ENST00000537194.6
SMAD3
SMAD family member 3
chr6_-_32853618 6.69 ENST00000354258.5
TAP1
transporter 1, ATP binding cassette subfamily B member
chr6_-_32853813 6.62 ENST00000643049.2
TAP1
transporter 1, ATP binding cassette subfamily B member
chr5_+_132073782 6.23 ENST00000296871.4
CSF2
colony stimulating factor 2
chr3_-_79767987 5.76 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr1_-_7940825 5.35 ENST00000377507.8
TNFRSF9
TNF receptor superfamily member 9
chr17_-_35880350 4.99 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
CCL5
C-C motif chemokine ligand 5
chr5_-_122078249 4.36 ENST00000231004.5
LOX
lysyl oxidase
chr11_+_20022550 4.28 ENST00000533917.5
NAV2
neuron navigator 2
chr1_-_120100688 4.24 ENST00000652264.1
NOTCH2
notch receptor 2
chr3_+_122680802 4.11 ENST00000474629.7
PARP14
poly(ADP-ribose) polymerase family member 14
chr19_+_10086787 3.87 ENST00000590378.5
ENST00000397881.7
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chr7_-_116030735 3.09 ENST00000393485.5
TFEC
transcription factor EC
chr19_+_10086305 2.80 ENST00000253110.16
ENST00000591813.5
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chrX_-_155334580 2.73 ENST00000369449.7
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr2_-_201698040 2.60 ENST00000396886.7
ENST00000409143.5
MPP4
membrane palmitoylated protein 4
chr14_+_24161257 2.60 ENST00000396864.8
ENST00000557894.5
ENST00000559284.5
ENST00000560275.5
IRF9
interferon regulatory factor 9
chr6_+_36676455 2.53 ENST00000615513.4
CDKN1A
cyclin dependent kinase inhibitor 1A
chr22_+_35648438 2.51 ENST00000409652.5
APOL6
apolipoprotein L6
chr6_+_36676489 2.49 ENST00000448526.6
CDKN1A
cyclin dependent kinase inhibitor 1A
chr6_+_36678699 2.43 ENST00000405375.5
ENST00000244741.10
ENST00000373711.3
CDKN1A
cyclin dependent kinase inhibitor 1A
chr7_-_116030750 2.36 ENST00000265440.12
ENST00000320239.11
TFEC
transcription factor EC
chr2_-_201698628 2.34 ENST00000602867.1
ENST00000409474.8
MPP4
membrane palmitoylated protein 4
chr19_+_56595279 2.33 ENST00000328070.10
ENST00000599599.7
ENST00000650950.1
ZNF71
ZIM2-AS1
zinc finger protein 71
ZIM2 antisense RNA 1
chr2_-_201698692 2.27 ENST00000315506.11
ENST00000359962.9
ENST00000620095.4
MPP4
membrane palmitoylated protein 4
chr15_+_66453418 2.09 ENST00000566326.1
MAP2K1
mitogen-activated protein kinase kinase 1
chr3_-_71064915 2.06 ENST00000614176.5
ENST00000485326.7
FOXP1
forkhead box P1
chr16_+_4624811 2.00 ENST00000415496.5
ENST00000262370.12
ENST00000587747.5
ENST00000399577.9
ENST00000588994.5
ENST00000586183.5
MGRN1
mahogunin ring finger 1
chr3_-_71064964 1.82 ENST00000650387.1
FOXP1
forkhead box P1
chr6_-_32843994 1.79 ENST00000395339.7
ENST00000374882.8
PSMB8
proteasome 20S subunit beta 8
chrX_+_150693360 1.70 ENST00000370390.7
ENST00000490316.6
ENST00000542156.5
ENST00000445323.7
MTMR1
myotubularin related protein 1
chr3_-_165196369 1.67 ENST00000475390.2
SLITRK3
SLIT and NTRK like family member 3
chr2_+_74206384 1.59 ENST00000678623.1
ENST00000678731.1
MTHFD2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr12_+_20695323 1.47 ENST00000266509.7
SLCO1C1
solute carrier organic anion transporter family member 1C1
chr2_-_189179754 1.38 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr4_+_145619371 1.28 ENST00000649156.2
ENST00000648388.1
MMAA
metabolism of cobalamin associated A
chr2_+_102187015 1.19 ENST00000441515.3
ENST00000264257.7
IL1RL2
interleukin 1 receptor like 2
chr3_+_171843337 1.19 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
TMEM212
transmembrane protein 212
chr17_+_7455571 1.17 ENST00000575379.1
CHRNB1
cholinergic receptor nicotinic beta 1 subunit
chr17_+_42980547 1.15 ENST00000361677.5
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr1_+_202462730 1.13 ENST00000290419.9
ENST00000491336.5
PPP1R12B
protein phosphatase 1 regulatory subunit 12B
chr3_+_38138478 1.12 ENST00000396334.8
ENST00000417037.8
ENST00000652213.1
ENST00000650112.2
ENST00000651800.2
ENST00000421516.3
ENST00000650905.2
MYD88
MYD88 innate immune signal transduction adaptor
chr1_-_230869564 1.11 ENST00000470540.5
C1orf198
chromosome 1 open reading frame 198
chr1_+_15684284 1.11 ENST00000375799.8
ENST00000375793.2
PLEKHM2
pleckstrin homology and RUN domain containing M2
chr5_+_157731400 1.10 ENST00000231198.12
THG1L
tRNA-histidine guanylyltransferase 1 like
chr17_-_51120855 1.06 ENST00000618113.4
ENST00000357122.8
ENST00000262013.12
SPAG9
sperm associated antigen 9
chr2_+_68734773 1.04 ENST00000409202.8
ARHGAP25
Rho GTPase activating protein 25
chr19_+_49642188 1.00 ENST00000360565.8
SCAF1
SR-related CTD associated factor 1
chr17_-_79950828 0.98 ENST00000572862.5
ENST00000573782.5
ENST00000574427.1
ENST00000570373.5
ENST00000340848.11
ENST00000576768.5
TBC1D16
TBC1 domain family member 16
chr5_-_161546671 0.82 ENST00000517547.5
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr17_-_42980393 0.81 ENST00000409446.8
ENST00000409399.6
ENST00000421990.7
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 like
PTGES3L-AARSD1 readthrough
chr5_-_161546970 0.80 ENST00000675303.1
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr4_-_139556199 0.80 ENST00000274031.8
ENST00000506866.6
SETD7
SET domain containing 7, histone lysine methyltransferase
chr9_-_83267230 0.79 ENST00000328788.5
FRMD3
FERM domain containing 3
chr5_+_137867852 0.78 ENST00000421631.6
ENST00000239926.9
MYOT
myotilin
chr8_-_109334112 0.78 ENST00000678094.1
NUDCD1
NudC domain containing 1
chr3_+_111542178 0.77 ENST00000283285.10
ENST00000352690.9
CD96
CD96 molecule
chr8_-_109334074 0.76 ENST00000239690.9
NUDCD1
NudC domain containing 1
chr12_-_51009264 0.75 ENST00000545993.7
SLC11A2
solute carrier family 11 member 2
chr7_+_117480011 0.74 ENST00000649406.1
ENST00000648260.1
ENST00000003084.11
CFTR
CF transmembrane conductance regulator
chr11_-_120138104 0.74 ENST00000341846.10
TRIM29
tripartite motif containing 29
chr11_+_117200188 0.73 ENST00000529792.5
TAGLN
transgelin
chr4_-_186555567 0.73 ENST00000307161.5
MTNR1A
melatonin receptor 1A
chr22_-_31140494 0.72 ENST00000215885.4
PLA2G3
phospholipase A2 group III
chr18_-_27990256 0.72 ENST00000675173.1
CDH2
cadherin 2
chr1_+_17580474 0.69 ENST00000375415.5
ARHGEF10L
Rho guanine nucleotide exchange factor 10 like
chr1_-_28058087 0.66 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr15_-_100341899 0.65 ENST00000568565.2
ENST00000268070.9
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif 17
chr15_+_63048535 0.65 ENST00000560959.5
TPM1
tropomyosin 1
chr19_+_50025714 0.60 ENST00000598809.5
ENST00000595661.5
ENST00000391821.6
ZNF473
zinc finger protein 473
chr15_+_63048436 0.59 ENST00000334895.10
ENST00000404484.9
ENST00000558910.3
ENST00000317516.12
TPM1
tropomyosin 1
chr3_+_77039836 0.59 ENST00000461745.5
ROBO2
roundabout guidance receptor 2
chr16_+_67227105 0.59 ENST00000563953.5
ENST00000304800.14
ENST00000565201.1
TMEM208
transmembrane protein 208
chr20_+_8132138 0.59 ENST00000378641.7
ENST00000338037.11
ENST00000629992.2
PLCB1
phospholipase C beta 1
chr1_+_50106265 0.58 ENST00000357083.8
ELAVL4
ELAV like RNA binding protein 4
chr1_-_1273617 0.57 ENST00000360466.6
UBE2J2
ubiquitin conjugating enzyme E2 J2
chr21_+_34364003 0.55 ENST00000290310.4
KCNE2
potassium voltage-gated channel subfamily E regulatory subunit 2
chr1_+_50105666 0.54 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr5_-_161546708 0.52 ENST00000393959.6
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr3_+_156120572 0.52 ENST00000389636.9
ENST00000490337.6
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr12_-_6635938 0.52 ENST00000329858.9
LPAR5
lysophosphatidic acid receptor 5
chr19_+_50025989 0.50 ENST00000445728.7
ENST00000270617.8
ENST00000601364.5
ZNF473
zinc finger protein 473
chr3_+_111542134 0.50 ENST00000438817.6
CD96
CD96 molecule
chr17_+_2056073 0.50 ENST00000576444.1
ENST00000322941.3
HIC1
HIC ZBTB transcriptional repressor 1
chr19_-_34677157 0.49 ENST00000601241.6
SCGB2B2
secretoglobin family 2B member 2
chr3_-_108953870 0.48 ENST00000261047.8
GUCA1C
guanylate cyclase activator 1C
chr1_+_9239835 0.47 ENST00000602477.1
H6PD
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
chr3_+_188153271 0.47 ENST00000448637.5
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_+_95165784 0.46 ENST00000622059.4
ENST00000614034.5
ENST00000611147.1
ZNF2
zinc finger protein 2
chr2_+_68734861 0.46 ENST00000467265.5
ARHGAP25
Rho GTPase activating protein 25
chr7_+_129502517 0.45 ENST00000462322.3
SMKR1
small lysine rich protein 1
chr7_-_93226449 0.45 ENST00000394468.7
ENST00000453812.2
HEPACAM2
HEPACAM family member 2
chr20_+_9069076 0.43 ENST00000378473.9
PLCB4
phospholipase C beta 4
chr2_+_108377947 0.41 ENST00000272452.7
SULT1C4
sulfotransferase family 1C member 4
chr20_+_37744630 0.41 ENST00000373473.5
CTNNBL1
catenin beta like 1
chr12_+_26011713 0.41 ENST00000542004.5
RASSF8
Ras association domain family member 8
chr2_+_27537380 0.40 ENST00000447166.2
C2orf16
chromosome 2 open reading frame 16
chr4_-_154590735 0.40 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
FGA
fibrinogen alpha chain
chr3_+_45388555 0.39 ENST00000650792.2
ENST00000414984.5
ENST00000645846.2
LARS2
leucyl-tRNA synthetase 2, mitochondrial
chr12_-_9999176 0.39 ENST00000298527.10
ENST00000348658.4
CLEC1B
C-type lectin domain family 1 member B
chr14_+_73490926 0.39 ENST00000304061.8
RIOX1
ribosomal oxygenase 1
chr4_+_157220691 0.39 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr2_-_96035974 0.38 ENST00000434632.5
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr15_+_63048576 0.38 ENST00000559281.6
TPM1
tropomyosin 1
chr1_-_161367872 0.37 ENST00000367974.2
CFAP126
cilia and flagella associated protein 126
chr15_+_63048658 0.37 ENST00000560615.5
ENST00000651577.1
TPM1
tropomyosin 1
chr10_+_102644990 0.37 ENST00000645961.1
TRIM8
tripartite motif containing 8
chr11_-_133845495 0.37 ENST00000299140.8
ENST00000532889.1
SPATA19
spermatogenesis associated 19
chr11_-_85627268 0.37 ENST00000650630.1
DLG2
discs large MAGUK scaffold protein 2
chrX_+_108045050 0.36 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr7_+_117480052 0.36 ENST00000426809.5
ENST00000649781.1
CFTR
CF transmembrane conductance regulator
chr1_+_192636121 0.36 ENST00000543215.5
ENST00000391995.7
RGS13
regulator of G protein signaling 13
chr12_-_11022620 0.35 ENST00000390673.2
TAS2R19
taste 2 receptor member 19
chr12_-_11092313 0.35 ENST00000531678.1
TAS2R43
taste 2 receptor member 43
chr3_+_130345516 0.34 ENST00000265379.10
COL6A5
collagen type VI alpha 5 chain
chr4_+_157220654 0.34 ENST00000393815.6
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr5_+_40909490 0.33 ENST00000313164.10
C7
complement C7
chr1_-_161309961 0.33 ENST00000533357.5
ENST00000672602.2
ENST00000526189.3
MPZ
myelin protein zero
chr11_-_62984957 0.33 ENST00000377871.7
ENST00000360421.9
SLC22A6
solute carrier family 22 member 6
chr3_-_108953762 0.32 ENST00000393963.7
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr13_-_26221703 0.32 ENST00000381570.7
ENST00000346166.7
RNF6
ring finger protein 6
chr9_-_114074969 0.31 ENST00000466610.6
AMBP
alpha-1-microglobulin/bikunin precursor
chr3_-_149221811 0.31 ENST00000455472.3
ENST00000264613.11
CP
ceruloplasmin
chr17_+_34356472 0.31 ENST00000225844.7
CCL13
C-C motif chemokine ligand 13
chr16_-_20327426 0.31 ENST00000575582.5
ENST00000341642.9
ENST00000381362.8
ENST00000572347.5
ENST00000572478.5
ENST00000302555.10
GP2
glycoprotein 2
chr2_+_113127588 0.30 ENST00000409930.4
IL1RN
interleukin 1 receptor antagonist
chr17_-_40054391 0.30 ENST00000394127.6
ENST00000356271.7
ENST00000394128.7
ENST00000535071.6
ENST00000580885.5
ENST00000543759.6
ENST00000537674.6
ENST00000580517.5
ENST00000578161.2
MED24
mediator complex subunit 24
chr4_-_46124046 0.29 ENST00000295452.5
GABRG1
gamma-aminobutyric acid type A receptor subunit gamma1
chr16_-_18926408 0.28 ENST00000446231.7
SMG1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr6_+_108656346 0.28 ENST00000540898.1
FOXO3
forkhead box O3
chr6_+_31571957 0.28 ENST00000454783.5
LTA
lymphotoxin alpha
chr12_+_57745017 0.27 ENST00000547992.5
ENST00000552816.5
ENST00000257910.8
ENST00000547472.5
TSPAN31
tetraspanin 31
chr6_-_49744378 0.27 ENST00000371159.8
ENST00000263045.9
CRISP3
cysteine rich secretory protein 3
chr16_+_78022538 0.26 ENST00000651443.1
ENST00000299642.10
CLEC3A
C-type lectin domain family 3 member A
chr11_+_64924673 0.26 ENST00000164133.7
ENST00000532850.1
PPP2R5B
protein phosphatase 2 regulatory subunit B'beta
chr12_+_100357068 0.26 ENST00000323346.10
SLC17A8
solute carrier family 17 member 8
chr4_-_139084289 0.26 ENST00000510408.5
ENST00000379549.7
ENST00000358635.7
ELF2
E74 like ETS transcription factor 2
chr12_-_10986912 0.25 ENST00000506868.1
TAS2R50
taste 2 receptor member 50
chr5_-_16508990 0.25 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chrX_+_108044967 0.25 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr20_+_31739260 0.25 ENST00000340513.4
ENST00000300403.11
TPX2
TPX2 microtubule nucleation factor
chr18_+_63476927 0.25 ENST00000489441.5
ENST00000382771.9
ENST00000424602.1
SERPINB5
serpin family B member 5
chr12_-_91004965 0.25 ENST00000261172.8
EPYC
epiphycan
chrX_-_138711663 0.25 ENST00000315930.11
FGF13
fibroblast growth factor 13
chr10_+_17752185 0.24 ENST00000377495.2
TMEM236
transmembrane protein 236
chr13_-_40982880 0.23 ENST00000635415.1
ELF1
E74 like ETS transcription factor 1
chr6_+_46793379 0.23 ENST00000230588.9
ENST00000611727.2
MEP1A
meprin A subunit alpha
chr6_-_25874212 0.23 ENST00000361703.10
ENST00000397060.8
SLC17A3
solute carrier family 17 member 3
chr5_-_16508951 0.23 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr19_-_51372686 0.23 ENST00000595217.1
NKG7
natural killer cell granule protein 7
chr3_+_15427551 0.23 ENST00000396842.7
EAF1
ELL associated factor 1
chr1_-_230745574 0.23 ENST00000681269.1
AGT
angiotensinogen
chr5_-_16508858 0.22 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr1_+_15236509 0.22 ENST00000683790.1
FHAD1
forkhead associated phosphopeptide binding domain 1
chr19_-_56393430 0.21 ENST00000589895.1
ENST00000589143.5
ENST00000301310.8
ENST00000586929.5
ZNF582
zinc finger protein 582
chr3_-_196515315 0.21 ENST00000397537.3
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr1_-_33036840 0.21 ENST00000548033.5
ENST00000487289.1
ENST00000626911.1
ENST00000673291.1
ENST00000480134.5
ENST00000373449.7
ENST00000672715.1
ENST00000467905.5
ENST00000629371.2
AK2
adenylate kinase 2
chr12_-_48852153 0.19 ENST00000308025.8
DDX23
DEAD-box helicase 23
chr6_-_123636979 0.19 ENST00000662930.1
TRDN
triadin
chr16_-_46748337 0.18 ENST00000394809.9
MYLK3
myosin light chain kinase 3
chr6_+_31572279 0.18 ENST00000418386.3
LTA
lymphotoxin alpha
chr19_-_54159696 0.17 ENST00000222224.4
LENG1
leukocyte receptor cluster member 1
chr16_+_85899121 0.16 ENST00000268638.10
ENST00000565552.1
IRF8
interferon regulatory factor 8
chr6_-_123636923 0.16 ENST00000334268.9
TRDN
triadin
chr6_-_56851888 0.16 ENST00000312431.10
ENST00000520645.5
DST
dystonin
chr10_+_104269163 0.16 ENST00000338595.7
GSTO2
glutathione S-transferase omega 2
chrX_+_106802660 0.15 ENST00000357242.10
ENST00000310452.6
ENST00000481617.6
ENST00000276175.7
TBC1D8B
TBC1 domain family member 8B
chr12_+_5432101 0.15 ENST00000423158.4
NTF3
neurotrophin 3
chr1_+_115976488 0.14 ENST00000369503.9
SLC22A15
solute carrier family 22 member 15
chr11_+_73292755 0.14 ENST00000680955.1
ENST00000538328.2
P2RY6
pyrimidinergic receptor P2Y6
chr6_+_139028680 0.14 ENST00000367660.4
ABRACL
ABRA C-terminal like
chr1_-_33036927 0.14 ENST00000354858.11
AK2
adenylate kinase 2
chr5_+_141343818 0.13 ENST00000619750.1
ENST00000253812.8
PCDHGA3
protocadherin gamma subfamily A, 3
chr11_-_120128831 0.13 ENST00000529044.5
TRIM29
tripartite motif containing 29
chr11_-_118176576 0.13 ENST00000278947.6
SCN2B
sodium voltage-gated channel beta subunit 2
chr14_+_96256194 0.13 ENST00000216629.11
ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr6_+_52186373 0.13 ENST00000648244.1
IL17A
interleukin 17A
chr19_-_50025936 0.13 ENST00000596445.5
ENST00000599538.5
VRK3
VRK serine/threonine kinase 3
chr5_-_65481907 0.12 ENST00000381055.8
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif 6
chr5_-_128339191 0.12 ENST00000507835.5
FBN2
fibrillin 2
chr19_-_44448435 0.12 ENST00000588655.1
ENST00000592308.1
ENST00000614049.5
ENST00000613197.4
ENSG00000267188.1
ZNF229
novel transcript
zinc finger protein 229
chrX_-_66033664 0.12 ENST00000427538.5
VSIG4
V-set and immunoglobulin domain containing 4
chr1_-_205422050 0.12 ENST00000367153.9
LEMD1
LEM domain containing 1
chr5_-_16508812 0.12 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr15_+_57706670 0.11 ENST00000299638.8
POLR2M
RNA polymerase II subunit M
chr2_+_231056845 0.11 ENST00000677230.1
ENST00000677259.1
ENST00000677180.1
ENST00000409643.6
ENST00000619128.5
ENST00000678679.1
ENST00000676740.1
ENST00000308696.11
ENST00000440838.5
ENST00000373635.9
PSMD1
proteasome 26S subunit, non-ATPase 1
chr10_+_102644887 0.11 ENST00000462202.3
TRIM8
tripartite motif containing 8
chr5_+_90899183 0.10 ENST00000640815.1
ADGRV1
adhesion G protein-coupled receptor V1
chr3_-_15427497 0.09 ENST00000443029.5
ENST00000383789.9
ENST00000450816.6
ENST00000383790.8
METTL6
methyltransferase like 6
chr6_+_83512501 0.08 ENST00000369700.4
PRSS35
serine protease 35
chr2_-_201769759 0.08 ENST00000680163.1
ENST00000680188.1
ENST00000679550.1
ALS2
alsin Rho guanine nucleotide exchange factor ALS2
chr13_+_111115303 0.08 ENST00000646102.2
ENST00000449979.5
ARHGEF7
Rho guanine nucleotide exchange factor 7
chr6_+_25754699 0.08 ENST00000439485.6
ENST00000377905.9
SLC17A4
solute carrier family 17 member 4
chr19_+_44113385 0.07 ENST00000262894.11
ENST00000588926.5
ENST00000592780.5
ZNF225
zinc finger protein 225
chr6_+_133889105 0.06 ENST00000367882.5
TCF21
transcription factor 21
chr5_-_131945658 0.05 ENST00000442687.6
ENST00000616644.2
MEIKIN
meiotic kinetochore factor
chr10_+_113553039 0.04 ENST00000351270.4
HABP2
hyaluronan binding protein 2
chr3_+_186581995 0.03 ENST00000418776.1
ENSG00000283149.1
novel protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.3 GO:0046967 cytosol to ER transport(GO:0046967)
1.6 6.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.5 7.5 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
1.2 5.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.1 6.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.9 10.0 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.9 5.3 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.8 7.5 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.7 4.3 GO:0021564 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.5 1.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 1.3 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.4 1.7 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.4 2.0 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.4 4.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 1.3 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.3 2.1 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.2 4.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.2 3.9 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 1.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.2 2.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 3.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 0.5 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.2 1.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 0.8 GO:0015692 lead ion transport(GO:0015692)
0.1 0.6 GO:0090427 activation of meiosis(GO:0090427)
0.1 1.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.3 GO:1905237 response to cyclosporin A(GO:1905237)
0.1 0.8 GO:0061709 reticulophagy(GO:0061709)
0.1 0.4 GO:0030961 peptidyl-arginine hydroxylation(GO:0030961)
0.1 1.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.3 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 1.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.3 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 0.2 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.7 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1 2.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 8.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.2 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1 0.3 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.1 1.5 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.1 0.2 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 0.3 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 0.7 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 1.5 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.8 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 1.6 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.4 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 1.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.3 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.1 GO:0060435 bronchiole development(GO:0060435)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.5 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.4 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 4.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.5 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.0 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 2.8 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.5 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.5 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 1.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.4 GO:0030220 platelet formation(GO:0030220)
0.0 2.8 GO:0042157 lipoprotein metabolic process(GO:0042157)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 13.3 GO:0042825 TAP complex(GO:0042825)
1.5 7.5 GO:0070557 PCNA-p21 complex(GO:0070557)
1.2 9.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.8 6.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 1.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.2 4.3 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.1 2.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.3 GO:0097441 basilar dendrite(GO:0097441)
0.1 2.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 4.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.7 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.8 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 1.3 GO:0015030 Cajal body(GO:0015030)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 10.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.7 13.3 GO:0015440 peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029) TAP2 binding(GO:0046979)
1.5 7.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.1 6.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
1.0 5.0 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
0.7 4.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.6 6.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 4.2 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.4 1.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.4 1.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.3 8.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 1.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.3 1.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.2 0.7 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 2.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.2 0.5 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.2 1.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 5.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 0.8 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.3 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 1.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 3.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.4 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 2.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.3 GO:0019862 IgA binding(GO:0019862)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 2.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 4.3 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.6 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.6 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 6.2 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 0.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.1 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0045174 glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0 1.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 2.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.4 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 4.1 GO:0004386 helicase activity(GO:0004386)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 5.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 2.6 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 6.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 6.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 9.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 6.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 6.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 13.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 4.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 5.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 4.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 3.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.6 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 ST ADRENERGIC Adrenergic Pathway
0.0 0.8 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 7.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 4.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 5.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 14.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 7.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 6.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 8.5 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 1.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.1 1.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 2.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 2.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules