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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for TAF1
Z-value: 1.71
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Transcription factors associated with TAF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAF1 | hg38_v1_chrX_+_71366290_71366368 | 0.84 | 1.2e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 6.5 | GO:0019985 | translesion synthesis(GO:0019985) |
| 2.1 | 6.4 | GO:0006683 | galactosylceramide catabolic process(GO:0006683) |
| 0.3 | 6.2 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 0.1 | 5.5 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.4 | 5.4 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 1.7 | 5.1 | GO:0072720 | response to dithiothreitol(GO:0072720) |
| 0.1 | 5.0 | GO:0090181 | regulation of cholesterol metabolic process(GO:0090181) |
| 0.9 | 4.5 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.8 | 4.5 | GO:0038016 | insulin receptor internalization(GO:0038016) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.7 | 7.5 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 7.4 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.1 | 5.5 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 4.5 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.0 | 4.1 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.3 | 4.0 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.2 | 3.7 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.2 | 3.5 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.1 | 3.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.0 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 9.6 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 6.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 2.1 | 6.4 | GO:0004336 | galactosylceramidase activity(GO:0004336) |
| 0.2 | 6.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 5.0 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 5.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 4.8 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.6 | 4.5 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.1 | 4.5 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 8.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 5.9 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 4.4 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 4.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 3.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.5 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 3.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 3.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 2.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.9 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 7.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.2 | 5.9 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 5.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 4.5 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 4.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 4.1 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 3.6 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 3.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 3.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |