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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for TAL1
Z-value: 1.79
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Transcription factors associated with TAL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAL1 | hg38_v1_chr1_-_47231715_47231786 | -0.43 | 3.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_7940825 Show fit | 3.71 |
ENST00000377507.8
|
TNF receptor superfamily member 9 |
|
| chr3_-_127736329 Show fit | 3.44 |
ENST00000398101.7
|
monoglyceride lipase |
|
| chr4_-_80073170 Show fit | 3.26 |
ENST00000403729.7
|
ANTXR cell adhesion molecule 2 |
|
| chr12_+_112978386 Show fit | 3.25 |
ENST00000342315.8
|
2'-5'-oligoadenylate synthetase 2 |
|
| chr6_+_32844789 Show fit | 2.96 |
ENST00000414474.5
|
proteasome 20S subunit beta 9 |
|
| chr4_-_80073057 Show fit | 2.93 |
ENST00000681710.1
|
ANTXR cell adhesion molecule 2 |
|
| chr12_-_55842950 Show fit | 2.91 |
ENST00000548629.5
|
matrix metallopeptidase 19 |
|
| chr10_-_5978022 Show fit | 2.90 |
ENST00000525219.6
|
interleukin 15 receptor subunit alpha |
|
| chr12_+_121132869 Show fit | 2.66 |
ENST00000328963.10
|
purinergic receptor P2X 7 |
|
| chr17_-_41124178 Show fit | 2.59 |
ENST00000394014.2
|
keratin associated protein 4-12 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.2 | 10.6 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 10.6 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.6 | 7.8 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.7 | 6.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 6.6 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 0.7 | 6.1 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 5.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 5.0 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.1 | 4.8 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 10.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 8.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 7.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 5.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 5.2 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 5.1 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.5 | 4.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 4.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 3.7 | GO:0032059 | bleb(GO:0032059) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 16.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 9.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 8.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 7.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 7.3 | GO:0005518 | collagen binding(GO:0005518) |
| 2.3 | 7.0 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 6.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 6.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 4.7 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.7 | 4.6 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 5.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 5.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.5 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 4.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.9 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 2.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 32.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 9.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 8.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 5.8 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 5.6 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 5.6 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 0.2 | 5.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 5.2 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 4.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 4.7 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |