ISMARA results: TBP

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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for TBP

Z-value: 2.09

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Transcription factors associated with TBP

Gene Symbol	Gene ID	Gene Info
TBP Ensembl NCBI GeneCards UniProt	ENSG00000112592.14	TBP

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBP	hg38_v1_chr6_+_170554333_170554396	-0.23	2.8e-01	Click!

Activity profile of TBP motif

Sorted Z-values of TBP motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBP

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr1_-_169734064 Show fit	22.29	ENST00000333360.12	SELE Ensembl NCBI GeneCards UniProt Show fit	selectin E
chr19_+_10271093 Show fit	18.48	ENST00000423829.2 ENST00000588645.1 ENST00000264832.8	ICAM1 Ensembl NCBI GeneCards UniProt Show fit	intercellular adhesion molecule 1
chr16_+_57372465 Show fit	17.47	ENST00000563383.1	CX3CL1 Ensembl NCBI GeneCards UniProt Show fit	C-X3-C motif chemokine ligand 1
chr16_+_57372481 Show fit	17.23	ENST00000006053.7	CX3CL1 Ensembl NCBI GeneCards UniProt Show fit	C-X3-C motif chemokine ligand 1
chr11_-_102780620 Show fit	14.85	ENST00000279441.9 ENST00000539681.1	MMP10 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 10
chr4_+_73740541 Show fit	10.94	ENST00000401931.1 ENST00000307407.8	CXCL8 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 8
chr1_-_40862354 Show fit	8.84	ENST00000372638.4	CITED4 Ensembl NCBI GeneCards UniProt Show fit	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
chr2_+_151357583 Show fit	8.81	ENST00000243347.5	TNFAIP6 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 6
chr4_+_73836667 Show fit	7.92	ENST00000226317.10	CXCL6 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 6
chr4_-_74038681 Show fit	7.44	ENST00000296026.4	CXCL3 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine ligand 3

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	38.3	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
11.6	34.7	GO:0051040	regulation of calcium-independent cell-cell adhesion(GO:0051040)
1.1	24.3	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.8	21.0	GO:0071294	cellular response to zinc ion(GO:0071294)
3.7	18.5	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
3.6	14.6	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.8	11.3	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.4	11.2	GO:0003351	epithelial cilium movement(GO:0003351)
0.2	11.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	10.9	GO:0030574	collagen catabolic process(GO:0030574)

Showing 1 to 10 of 229 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	38.0	GO:0009986	cell surface(GO:0009986)
0.0	30.4	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.2	23.1	GO:0005901	caveola(GO:0005901)
0.3	21.0	GO:0001772	immunological synapse(GO:0001772)
0.0	18.5	GO:0005615	extracellular space(GO:0005615)
0.4	14.6	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	14.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
2.8	11.2	GO:0097229	sperm end piece(GO:0097229)
0.1	10.2	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	9.4	GO:0005874	microtubule(GO:0005874)

Showing 1 to 10 of 102 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	46.8	GO:0008009	chemokine activity(GO:0008009)
3.0	45.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	27.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.9	22.3	GO:0033691	sialic acid binding(GO:0033691)
0.1	17.9	GO:0001618	virus receptor activity(GO:0001618)
0.0	15.3	GO:0003924	GTPase activity(GO:0003924)
0.0	15.3	GO:0008270	zinc ion binding(GO:0008270)
0.0	11.2	GO:0017124	SH3 domain binding(GO:0017124)
0.1	11.1	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.2	8.2	GO:0005540	hyaluronic acid binding(GO:0005540)

Showing 1 to 10 of 159 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	98.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	40.8	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.1	21.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	10.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	5.5	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	5.2	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.3	5.0	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	4.5	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0	3.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	3.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	76.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	17.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	15.2	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.3	12.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	10.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.4	10.5	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.4	7.4	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2	6.9	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.2	5.7	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	5.6	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Showing 1 to 10 of 65 entries

Results for TBP

Z-value: 2.09

Motif logo

Transcription factors associated with TBP

Activity-expression correlation:

Activity profile of TBP motif

Sorted Z-values of TBP motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBP

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: