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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for TBX2
Z-value: 1.15
Motif logo
Transcription factors associated with TBX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TBX2
|
ENSG00000121068.14 | TBX2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX2 | hg38_v1_chr17_+_61399835_61399851 | 0.43 | 3.3e-02 | Click! |
Activity profile of TBX2 motif
Sorted Z-values of TBX2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.4 | GO:1903282 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 1.0 | 3.1 | GO:0006393 | termination of mitochondrial transcription(GO:0006393) |
| 1.0 | 2.9 | GO:2000007 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.9 | 2.8 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.8 | 3.0 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.6 | 1.9 | GO:0003129 | heart induction(GO:0003129) |
| 0.5 | 1.5 | GO:0032827 | natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714) |
| 0.5 | 1.5 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.5 | 0.5 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) |
| 0.4 | 1.3 | GO:0031550 | positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550) |
| 0.4 | 1.3 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.4 | 1.3 | GO:0060032 | notochord regression(GO:0060032) |
| 0.4 | 1.3 | GO:0016103 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) |
| 0.4 | 1.6 | GO:0045226 | extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) |
| 0.4 | 2.0 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.4 | 2.2 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.4 | 2.5 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 0.3 | 1.0 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.3 | 1.0 | GO:0010933 | macrophage tolerance induction(GO:0010931) regulation of macrophage tolerance induction(GO:0010932) positive regulation of macrophage tolerance induction(GO:0010933) |
| 0.3 | 2.0 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
| 0.3 | 1.3 | GO:1902617 | response to fluoride(GO:1902617) |
| 0.3 | 2.2 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.3 | 6.1 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.3 | 1.6 | GO:0021966 | corticospinal neuron axon guidance(GO:0021966) |
| 0.3 | 6.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 0.9 | GO:0048319 | axial mesoderm morphogenesis(GO:0048319) |
| 0.2 | 1.1 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.2 | 1.1 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.2 | 0.6 | GO:0098758 | response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) |
| 0.2 | 0.6 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.2 | 0.8 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.2 | 0.6 | GO:0031247 | actin rod assembly(GO:0031247) |
| 0.2 | 1.8 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.2 | 4.4 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.2 | 2.2 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.2 | 2.7 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
| 0.2 | 0.5 | GO:0046603 | negative regulation of mitotic centrosome separation(GO:0046603) |
| 0.2 | 0.5 | GO:0061580 | colon epithelial cell migration(GO:0061580) |
| 0.2 | 2.0 | GO:0042492 | gamma-delta T cell differentiation(GO:0042492) |
| 0.1 | 0.7 | GO:0044856 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 0.1 | 5.7 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.6 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.1 | 0.6 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.1 | 0.5 | GO:1903786 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 0.1 | 0.7 | GO:0032632 | interleukin-3 production(GO:0032632) |
| 0.1 | 4.0 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.1 | 0.4 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 0.1 | 0.6 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 0.6 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.1 | 0.8 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.1 | 0.6 | GO:0001757 | somite specification(GO:0001757) |
| 0.1 | 1.0 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.1 | 0.7 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.1 | 0.8 | GO:0071386 | cellular response to corticosterone stimulus(GO:0071386) |
| 0.1 | 2.5 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.1 | 0.3 | GO:1901253 | negative regulation of intracellular transport of viral material(GO:1901253) |
| 0.1 | 0.9 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.1 | 2.3 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 1.6 | GO:0015871 | choline transport(GO:0015871) |
| 0.1 | 0.6 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.1 | 1.0 | GO:0030473 | nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 0.4 | GO:0018032 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 0.1 | 0.6 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.3 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.1 | 0.6 | GO:1904098 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.1 | 2.4 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 1.9 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.1 | 1.7 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.1 | 1.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 0.3 | GO:0033306 | phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173) |
| 0.1 | 0.2 | GO:0044778 | meiotic DNA integrity checkpoint(GO:0044778) |
| 0.1 | 0.4 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.1 | 0.4 | GO:0061760 | antifungal innate immune response(GO:0061760) |
| 0.1 | 0.3 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.1 | 0.5 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.5 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.1 | 0.4 | GO:0014057 | positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) |
| 0.1 | 0.7 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.1 | 0.6 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 2.2 | GO:0006677 | glycosylceramide metabolic process(GO:0006677) |
| 0.1 | 0.9 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.1 | 0.2 | GO:0006743 | ubiquinone metabolic process(GO:0006743) |
| 0.1 | 0.2 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 0.1 | 0.3 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 0.1 | 1.0 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 0.4 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.1 | 0.5 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 0.3 | GO:0003408 | optic cup formation involved in camera-type eye development(GO:0003408) |
| 0.1 | 0.4 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.1 | 0.2 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
| 0.1 | 0.6 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.1 | 0.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 1.3 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.0 | 0.5 | GO:0007379 | segment specification(GO:0007379) |
| 0.0 | 0.4 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.0 | 1.0 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.0 | 1.8 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.0 | 1.1 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.0 | 0.4 | GO:0006689 | ganglioside catabolic process(GO:0006689) glycosphingolipid catabolic process(GO:0046479) |
| 0.0 | 0.4 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.0 | 0.5 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.0 | 0.2 | GO:1903904 | negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107) |
| 0.0 | 0.4 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.0 | 0.4 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.0 | 0.5 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.0 | 0.3 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
| 0.0 | 0.2 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) |
| 0.0 | 2.1 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 0.7 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.0 | 1.1 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 0.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.2 | GO:0009972 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.0 | 1.4 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.2 | GO:0035965 | cardiolipin acyl-chain remodeling(GO:0035965) |
| 0.0 | 0.3 | GO:0040031 | snRNA modification(GO:0040031) |
| 0.0 | 1.0 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.0 | 0.5 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
| 0.0 | 0.2 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) |
| 0.0 | 0.5 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.0 | 0.4 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.0 | 1.2 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 2.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 1.0 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.5 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 0.4 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 0.8 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.0 | 0.1 | GO:0046778 | modification by virus of host mRNA processing(GO:0046778) |
| 0.0 | 0.8 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.1 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.0 | 0.7 | GO:0097201 | negative regulation of inclusion body assembly(GO:0090084) negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.0 | 0.5 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.7 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.0 | 0.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.0 | 0.3 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.0 | 0.3 | GO:0002860 | positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.0 | 0.4 | GO:0042355 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.5 | GO:1900078 | positive regulation of cellular response to insulin stimulus(GO:1900078) |
| 0.0 | 0.2 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.0 | 0.1 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.0 | 7.2 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 1.0 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.3 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.5 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) positive regulation of chromatin binding(GO:0035563) |
| 0.0 | 0.1 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.0 | 0.8 | GO:0007635 | chemosensory behavior(GO:0007635) |
| 0.0 | 0.4 | GO:0061298 | retina vasculature development in camera-type eye(GO:0061298) |
| 0.0 | 0.4 | GO:0009642 | response to light intensity(GO:0009642) |
| 0.0 | 0.7 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.3 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 0.3 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.1 | GO:0045356 | toll-like receptor 7 signaling pathway(GO:0034154) positive regulation of interferon-alpha biosynthetic process(GO:0045356) |
| 0.0 | 1.9 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 0.3 | GO:0007567 | parturition(GO:0007567) |
| 0.0 | 0.5 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.0 | 0.1 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.0 | 0.2 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 0.5 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.4 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.0 | 0.1 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.0 | 0.1 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.0 | 0.9 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 0.1 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.0 | 0.3 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.0 | 0.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 2.6 | GO:0018022 | peptidyl-lysine methylation(GO:0018022) |
| 0.0 | 0.2 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.2 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 0.1 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
| 0.0 | 0.2 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.0 | 0.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.2 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.0 | 0.4 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.0 | 0.6 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.3 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
| 0.0 | 0.8 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.4 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.5 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.0 | 0.2 | GO:0001771 | immunological synapse formation(GO:0001771) |
| 0.0 | 0.1 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.4 | 4.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.2 | 1.5 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.2 | 0.5 | GO:0097545 | axonemal outer doublet(GO:0097545) |
| 0.2 | 2.6 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.2 | 0.7 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.2 | 2.7 | GO:0032039 | integrator complex(GO:0032039) |
| 0.2 | 6.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 0.8 | GO:1990393 | 3M complex(GO:1990393) |
| 0.1 | 1.4 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 0.4 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.1 | 0.3 | GO:0030678 | mitochondrial ribonuclease P complex(GO:0030678) |
| 0.1 | 0.8 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 0.6 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 0.6 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.1 | 2.7 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 1.1 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 0.7 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.1 | 1.2 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 2.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 0.6 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 0.3 | GO:0000438 | core TFIIH complex portion of holo TFIIH complex(GO:0000438) |
| 0.1 | 0.6 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 0.8 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 0.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 0.4 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 1.0 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 0.6 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 3.2 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 1.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 1.0 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 0.2 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 1.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 2.4 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.5 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 2.3 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.6 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 1.0 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 0.5 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 0.7 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 1.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.5 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.2 | GO:0060171 | stereocilium membrane(GO:0060171) |
| 0.0 | 1.1 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.0 | 1.1 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 2.3 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.3 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 1.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 2.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.3 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 8.5 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 0.1 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.0 | 1.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.5 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.9 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.4 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 0.2 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 0.2 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.0 | 1.5 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.9 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.0 | 0.7 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 1.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 4.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.6 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 1.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.1 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.0 | 0.7 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 0.3 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.2 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 1.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 1.2 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.8 | GO:0005871 | kinesin complex(GO:0005871) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.4 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.7 | 5.6 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.6 | 2.8 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.4 | 1.3 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
| 0.4 | 1.5 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.3 | 1.0 | GO:0051990 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990) |
| 0.3 | 1.3 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.3 | 4.6 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.3 | 1.6 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.3 | 1.6 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.3 | 1.3 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.2 | 2.2 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.2 | 1.5 | GO:0047238 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238) |
| 0.2 | 0.7 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.2 | 0.6 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 0.2 | 1.0 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.2 | 5.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 0.8 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
| 0.2 | 1.9 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.2 | 1.6 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.1 | 2.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.6 | GO:0050253 | retinyl-palmitate esterase activity(GO:0050253) |
| 0.1 | 0.4 | GO:0030290 | sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428) |
| 0.1 | 0.7 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 0.1 | 2.3 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.1 | 0.4 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.1 | 2.5 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 0.5 | GO:0003943 | N-acetylgalactosamine-4-sulfatase activity(GO:0003943) |
| 0.1 | 0.4 | GO:0003863 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.1 | 0.4 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.1 | 1.8 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 1.2 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 0.3 | GO:0019166 | 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.1 | 0.1 | GO:0034040 | lipid-transporting ATPase activity(GO:0034040) |
| 0.1 | 0.4 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.1 | 0.8 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 0.6 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.1 | 0.7 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 2.2 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.1 | 2.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 2.6 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 0.5 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.1 | 0.7 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 1.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 1.2 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 1.4 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.1 | 0.2 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.1 | 0.7 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 0.1 | 0.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 0.4 | GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060) |
| 0.1 | 1.3 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 2.0 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.2 | GO:0042282 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 0.1 | 0.4 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 0.2 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 2.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 1.0 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 0.4 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.1 | 0.5 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 0.9 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.0 | 0.6 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.5 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 0.7 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.0 | 1.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 1.3 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 0.2 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 0.0 | 0.3 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.4 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 0.4 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.0 | 1.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.1 | GO:0071949 | FAD binding(GO:0071949) |
| 0.0 | 0.3 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.0 | 1.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.8 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.0 | 0.8 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 2.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.3 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.0 | 3.9 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 1.2 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.3 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.0 | 0.2 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 0.3 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.2 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.0 | 0.9 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 0.3 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.3 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 0.9 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.3 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.0 | 0.1 | GO:0004923 | interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981) |
| 0.0 | 0.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.2 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 0.0 | 0.3 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 1.9 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 1.1 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.0 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.0 | 0.9 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.0 | 0.5 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 0.7 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.3 | GO:0008381 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 0.1 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.0 | 0.5 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.5 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.1 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.0 | 0.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 4.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.1 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.0 | 0.1 | GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929) |
| 0.0 | 0.1 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.0 | 0.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 5.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.5 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.2 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.1 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.0 | 0.5 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.4 | GO:0070034 | telomerase RNA binding(GO:0070034) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 5.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 6.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.9 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 3.9 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 2.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.8 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 1.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.2 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.4 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 1.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 3.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.6 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.4 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.8 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 7.9 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 2.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 2.0 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 1.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.5 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 0.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.1 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 0.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 2.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.2 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.7 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 1.0 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.8 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.0 | 1.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 1.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 1.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.8 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.1 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 1.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.4 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 2.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.3 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.0 | 0.4 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 0.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.8 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.7 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.0 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.2 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |