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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for TBX20

Z-value: 0.57

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Transcription factors associated with TBX20

Gene Symbol Gene ID Gene Info
TBX20
ENSG00000164532.11 TBX20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX20hg38_v1_chr7_-_35254074_35254106-0.232.6e-01Click!

Activity profile of TBX20 motif

Sorted Z-values of TBX20 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX20

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_57628507 9.23 ENST00000456916.5
ENST00000567154.5
ENST00000388813.9
ENST00000562558.6
ENST00000566271.6
ENST00000563374.5
ENST00000673126.2
ENST00000562631.7
ENST00000568234.5
ENST00000565770.5
ENST00000566164.5
ADGRG1
adhesion G protein-coupled receptor G1
chr16_+_57628684 6.35 ENST00000567397.5
ENST00000568979.5
ENST00000672974.1
ADGRG1
adhesion G protein-coupled receptor G1
chr16_+_31033513 1.40 ENST00000313843.8
STX4
syntaxin 4
chr10_+_112376193 1.16 ENST00000433418.6
ENST00000356116.6
ENST00000354273.5
ACSL5
acyl-CoA synthetase long chain family member 5
chr10_+_112375196 1.15 ENST00000393081.6
ACSL5
acyl-CoA synthetase long chain family member 5
chr19_+_56404314 0.65 ENST00000333201.13
ENST00000391778.3
ZNF583
zinc finger protein 583
chr20_+_33217325 0.53 ENST00000375452.3
ENST00000375454.8
BPIFA3
BPI fold containing family A member 3
chr6_-_136466858 0.51 ENST00000544465.5
MAP7
microtubule associated protein 7
chr5_+_162067500 0.49 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr2_-_218270099 0.49 ENST00000248450.9
ENST00000444053.5
AAMP
angio associated migratory cell protein
chr1_-_11058839 0.44 ENST00000465788.1
SRM
spermidine synthase
chr5_+_162067458 0.44 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr5_+_134525649 0.42 ENST00000282605.8
ENST00000681547.2
ENST00000361895.6
ENST00000402835.5
JADE2
jade family PHD finger 2
chr3_-_131502946 0.40 ENST00000512877.1
ENST00000264995.8
ENST00000511168.5
ENST00000425847.6
MRPL3
mitochondrial ribosomal protein L3
chr11_+_6259806 0.36 ENST00000532715.5
ENST00000334619.7
ENST00000525014.1
ENST00000531712.5
ENST00000525462.1
CCKBR
cholecystokinin B receptor
chr2_+_153871909 0.36 ENST00000392825.8
ENST00000434213.1
GALNT13
polypeptide N-acetylgalactosaminyltransferase 13
chr12_-_121039204 0.35 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr5_+_6448832 0.33 ENST00000399816.4
UBE2QL1
ubiquitin conjugating enzyme E2 Q family like 1
chr2_-_218269619 0.32 ENST00000447885.1
ENST00000420660.5
AAMP
angio associated migratory cell protein
chr12_-_121039236 0.31 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr12_-_121039156 0.28 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr12_-_84912783 0.28 ENST00000680892.1
ENST00000266682.10
ENST00000680714.1
ENST00000552192.5
SLC6A15
solute carrier family 6 member 15
chr9_+_107306459 0.27 ENST00000457811.1
RAD23B
RAD23 homolog B, nucleotide excision repair protein
chr1_-_204307391 0.25 ENST00000637508.1
PLEKHA6
pleckstrin homology domain containing A6
chrX_+_52369014 0.25 ENST00000286049.3
XAGE2
X antigen family member 2
chr19_-_39320839 0.25 ENST00000248668.5
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr11_-_64935882 0.25 ENST00000532246.1
ENST00000279168.7
GPHA2
glycoprotein hormone subunit alpha 2
chr6_-_32407123 0.24 ENST00000374993.4
ENST00000544175.2
ENST00000454136.7
ENST00000446536.2
BTNL2
butyrophilin like 2
chr11_+_15114912 0.23 ENST00000379556.8
INSC
INSC spindle orientation adaptor protein
chr7_-_33100886 0.23 ENST00000448915.1
RP9
RP9 pre-mRNA splicing factor
chr16_+_31033781 0.22 ENST00000613541.1
STX4
syntaxin 4
chr7_+_114414997 0.22 ENST00000462331.5
ENST00000393491.7
ENST00000403559.8
ENST00000408937.7
ENST00000393498.6
ENST00000393495.7
ENST00000378237.7
FOXP2
forkhead box P2
chr22_-_42649332 0.21 ENST00000352397.10
CYB5R3
cytochrome b5 reductase 3
chr19_-_40714641 0.21 ENST00000678467.1
COQ8B
coenzyme Q8B
chr12_-_121038967 0.21 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr3_-_50359480 0.20 ENST00000266025.4
TMEM115
transmembrane protein 115
chr7_+_114414809 0.20 ENST00000350908.9
FOXP2
forkhead box P2
chr5_+_136059151 0.18 ENST00000503087.1
TGFBI
transforming growth factor beta induced
chr22_+_41560973 0.18 ENST00000306149.12
CSDC2
cold shock domain containing C2
chr20_+_45881218 0.16 ENST00000372523.1
ZSWIM1
zinc finger SWIM-type containing 1
chr5_-_90529511 0.13 ENST00000500869.6
ENST00000315948.11
ENST00000509384.5
LYSMD3
LysM domain containing 3
chr3_-_139678011 0.13 ENST00000646611.1
ENST00000645290.1
ENST00000647257.1
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr15_+_75724034 0.12 ENST00000332145.3
ODF3L1
outer dense fiber of sperm tails 3 like 1
chr2_+_63840982 0.12 ENST00000480679.5
ENST00000613823.2
ENST00000677841.1
UGP2
UDP-glucose pyrophosphorylase 2
chr2_+_63840944 0.11 ENST00000484142.2
ENST00000482668.5
ENST00000467648.6
ENST00000394417.7
UGP2
UDP-glucose pyrophosphorylase 2
chr7_+_30145789 0.10 ENST00000324489.5
MTURN
maturin, neural progenitor differentiation regulator homolog
chr3_-_139677718 0.10 ENST00000514703.5
ENST00000511444.5
ENST00000642987.1
ENST00000296202.11
ENST00000509291.5
ENST00000413939.6
ENST00000643695.2
ENST00000339837.9
ENST00000512391.5
ENST00000645507.1
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr10_-_54801262 0.09 ENST00000373965.6
ENST00000616114.4
ENST00000621708.4
ENST00000495484.5
ENST00000395440.5
ENST00000395442.5
ENST00000617271.4
ENST00000395446.5
ENST00000409834.5
ENST00000361849.7
ENST00000373957.7
ENST00000395430.5
ENST00000395433.5
ENST00000437009.5
PCDH15
protocadherin related 15
chr19_+_45668191 0.09 ENST00000652180.1
ENST00000590918.6
ENST00000263281.7
ENST00000304207.12
GIPR
gastric inhibitory polypeptide receptor
chr8_+_27325516 0.07 ENST00000346049.10
ENST00000420218.3
PTK2B
protein tyrosine kinase 2 beta
chr3_+_40387175 0.06 ENST00000301825.8
ENTPD3
ectonucleoside triphosphate diphosphohydrolase 3
chrX_+_78945332 0.05 ENST00000544091.1
ENST00000171757.3
P2RY10
P2Y receptor family member 10
chr3_-_183555696 0.04 ENST00000341319.8
KLHL6
kelch like family member 6
chr8_-_108443409 0.02 ENST00000678023.1
ENST00000679198.1
ENST00000678881.1
ENST00000677084.1
ENST00000676663.1
ENST00000677614.1
ENST00000677040.1
ENST00000676487.1
ENST00000677409.1
ENST00000678797.1
ENST00000678334.1
EIF3E
eukaryotic translation initiation factor 3 subunit E
chr12_+_64780465 0.02 ENST00000542120.6
TBC1D30
TBC1 domain family member 30
chr1_-_158330957 0.01 ENST00000451207.5
CD1B
CD1b molecule
chr12_+_15322480 0.01 ENST00000674188.1
ENST00000281171.9
ENST00000543886.6
PTPRO
protein tyrosine phosphatase receptor type O
chrX_+_55089052 0.00 ENST00000374965.5
ENST00000449097.1
PAGE2
PAGE family member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 15.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.4 1.6 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.1 0.4 GO:0021758 caudate nucleus development(GO:0021757) putamen development(GO:0021758)
0.1 0.4 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 2.3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 0.2 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.2 GO:0019255 UDP-glucuronate biosynthetic process(GO:0006065) glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.3 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.1 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.4 GO:0001696 gastric acid secretion(GO:0001696)
0.0 1.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 15.6 GO:0097451 glial limiting end-foot(GO:0097451)
0.1 1.6 GO:0000322 storage vacuole(GO:0000322)
0.1 0.3 GO:0071942 XPC complex(GO:0071942)
0.0 0.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.2 15.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.4 GO:0004766 spermidine synthase activity(GO:0004766)
0.1 2.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.2 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.1 0.2 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.1 0.2 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.1 0.9 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.3 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling