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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for TEAD3_TEAD1
Z-value: 2.30
Motif logo
Transcription factors associated with TEAD3_TEAD1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TEAD3
|
ENSG00000007866.22 | TEAD3 |
|
TEAD1
|
ENSG00000187079.20 | TEAD1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD1 | hg38_v1_chr11_+_12674397_12674442 | 0.84 | 1.5e-07 | Click! |
| TEAD3 | hg38_v1_chr6_-_35497042_35497117 | 0.08 | 7.1e-01 | Click! |
Activity profile of TEAD3_TEAD1 motif
Sorted Z-values of TEAD3_TEAD1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD3_TEAD1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 15.3 | GO:0035026 | leading edge cell differentiation(GO:0035026) |
| 3.2 | 12.8 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 1.9 | 20.6 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.7 | 5.1 | GO:0044335 | canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335) |
| 1.2 | 7.1 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 1.0 | 15.1 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 1.0 | 9.0 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 1.0 | 3.0 | GO:0010752 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.9 | 2.8 | GO:0060003 | copper ion export(GO:0060003) |
| 0.9 | 3.8 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.8 | 2.5 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
| 0.8 | 4.7 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.8 | 2.3 | GO:2000830 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.7 | 29.0 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.7 | 5.0 | GO:0090191 | negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191) |
| 0.7 | 3.4 | GO:0048865 | stem cell fate commitment(GO:0048865) |
| 0.7 | 2.0 | GO:0006711 | estrogen catabolic process(GO:0006711) |
| 0.7 | 2.0 | GO:0060957 | endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445) |
| 0.7 | 2.0 | GO:0061386 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.6 | 1.8 | GO:2000646 | positive regulation of receptor catabolic process(GO:2000646) |
| 0.6 | 1.8 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.6 | 16.0 | GO:0072189 | ureter development(GO:0072189) |
| 0.5 | 3.3 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.5 | 2.3 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.5 | 1.4 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.5 | 1.4 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.4 | 1.6 | GO:0048073 | regulation of eye pigmentation(GO:0048073) |
| 0.4 | 0.8 | GO:1901376 | mycotoxin metabolic process(GO:0043385) aflatoxin metabolic process(GO:0046222) organic heteropentacyclic compound metabolic process(GO:1901376) |
| 0.4 | 1.2 | GO:1903926 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 0.4 | 1.6 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.4 | 4.6 | GO:0072307 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.4 | 3.4 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.4 | 2.2 | GO:0010166 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.4 | 1.8 | GO:0046668 | negative regulation of photoreceptor cell differentiation(GO:0046533) regulation of retinal cell programmed cell death(GO:0046668) |
| 0.4 | 3.3 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.4 | 21.9 | GO:0000305 | response to oxygen radical(GO:0000305) |
| 0.3 | 1.7 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.3 | 3.8 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.3 | 1.8 | GO:2000504 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504) |
| 0.3 | 0.9 | GO:1902948 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.3 | 0.9 | GO:1905053 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.3 | 1.1 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 0.3 | 4.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.3 | 1.4 | GO:0070278 | extracellular matrix constituent secretion(GO:0070278) |
| 0.3 | 0.8 | GO:0071206 | establishment of protein localization to juxtaparanode region of axon(GO:0071206) |
| 0.3 | 6.0 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
| 0.3 | 1.4 | GO:0061107 | seminal vesicle development(GO:0061107) |
| 0.3 | 0.8 | GO:0038162 | erythropoietin-mediated signaling pathway(GO:0038162) |
| 0.3 | 1.5 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.3 | 12.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.3 | 4.0 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.3 | 0.8 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.2 | 1.2 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.2 | 4.8 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.2 | 0.9 | GO:0060596 | mammary placode formation(GO:0060596) |
| 0.2 | 12.1 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.2 | 3.4 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.2 | 3.2 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.2 | 1.2 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.2 | 1.4 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.2 | 2.0 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.2 | 0.6 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) |
| 0.2 | 0.8 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.2 | 8.3 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.2 | 1.4 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
| 0.2 | 0.9 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.2 | 0.7 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) |
| 0.2 | 0.7 | GO:0048850 | hypophysis morphogenesis(GO:0048850) |
| 0.2 | 0.8 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.2 | 1.1 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.2 | 1.6 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.2 | 5.4 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.2 | 1.8 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.2 | 4.5 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.2 | 4.8 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.2 | 2.6 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.1 | 0.4 | GO:0006059 | hexitol metabolic process(GO:0006059) |
| 0.1 | 1.5 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 0.8 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.1 | 2.0 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 0.1 | 2.5 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 0.4 | GO:0097698 | telomere maintenance via base-excision repair(GO:0097698) |
| 0.1 | 0.5 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.1 | 1.7 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.1 | 0.4 | GO:0022012 | subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875) |
| 0.1 | 0.7 | GO:0021553 | olfactory nerve development(GO:0021553) |
| 0.1 | 2.6 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.1 | 1.0 | GO:2000580 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.1 | 0.7 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.1 | 0.2 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.1 | 1.8 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.6 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
| 0.1 | 2.0 | GO:0034391 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.1 | 2.3 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.1 | 0.3 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.1 | 2.4 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 0.6 | GO:0006696 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.1 | 1.0 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 1.2 | GO:0015727 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) |
| 0.1 | 0.5 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.1 | 1.3 | GO:0035089 | establishment of apical/basal cell polarity(GO:0035089) |
| 0.1 | 1.4 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.1 | 0.6 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.1 | 0.5 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.1 | 6.1 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.1 | 0.4 | GO:0006127 | glycerophosphate shuttle(GO:0006127) |
| 0.1 | 0.3 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.6 | GO:0030885 | regulation of myeloid dendritic cell activation(GO:0030885) |
| 0.1 | 1.0 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949) |
| 0.1 | 0.6 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
| 0.1 | 1.2 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.1 | 0.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.2 | GO:0050976 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) |
| 0.1 | 0.7 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.1 | 0.4 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 0.1 | 0.9 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 0.9 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.1 | 14.4 | GO:0007286 | spermatid development(GO:0007286) |
| 0.1 | 2.7 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.1 | 2.0 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.1 | 0.4 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) |
| 0.1 | 0.8 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.1 | 0.9 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.1 | 2.7 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 2.4 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.1 | 0.7 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 2.2 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.1 | 0.4 | GO:0015705 | iodide transport(GO:0015705) |
| 0.1 | 4.4 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.1 | 0.4 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 1.2 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.1 | 0.4 | GO:0038183 | bile acid signaling pathway(GO:0038183) |
| 0.1 | 0.3 | GO:0019556 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.1 | 1.2 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 0.1 | 0.5 | GO:2000394 | positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.1 | 0.2 | GO:0010710 | regulation of collagen catabolic process(GO:0010710) |
| 0.1 | 0.2 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.1 | 0.3 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 0.1 | 1.0 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.1 | 15.5 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 1.7 | GO:0060065 | uterus development(GO:0060065) |
| 0.1 | 0.7 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.1 | 0.7 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 0.8 | GO:0046716 | muscle cell cellular homeostasis(GO:0046716) |
| 0.0 | 0.6 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.0 | 0.1 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.0 | 0.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.0 | 0.4 | GO:0030242 | pexophagy(GO:0030242) |
| 0.0 | 1.9 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 1.0 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 0.2 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) |
| 0.0 | 0.1 | GO:0018057 | peptidyl-lysine oxidation(GO:0018057) negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 0.0 | 1.4 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 0.9 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.6 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.0 | 3.7 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.2 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
| 0.0 | 2.8 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 0.5 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.0 | 0.2 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.0 | 0.8 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.0 | 1.2 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.0 | 0.2 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.0 | 0.7 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.0 | 8.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 0.5 | GO:0090109 | regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109) |
| 0.0 | 0.5 | GO:1901626 | regulation of postsynaptic membrane organization(GO:1901626) |
| 0.0 | 0.9 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.0 | 0.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.9 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
| 0.0 | 0.6 | GO:0098743 | cell aggregation(GO:0098743) |
| 0.0 | 0.0 | GO:1902688 | regulation of NAD metabolic process(GO:1902688) |
| 0.0 | 0.5 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.0 | 2.2 | GO:1903557 | positive regulation of tumor necrosis factor production(GO:0032760) positive regulation of tumor necrosis factor superfamily cytokine production(GO:1903557) |
| 0.0 | 2.6 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 3.7 | GO:0090090 | negative regulation of canonical Wnt signaling pathway(GO:0090090) |
| 0.0 | 0.3 | GO:0043586 | tongue development(GO:0043586) |
| 0.0 | 1.5 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.0 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.0 | 0.1 | GO:0052148 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 0.0 | 0.4 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.6 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 0.8 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.0 | 1.2 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.0 | 1.6 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.2 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 1.8 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.7 | GO:0007143 | female meiotic division(GO:0007143) |
| 0.0 | 0.2 | GO:0001946 | lymphangiogenesis(GO:0001946) |
| 0.0 | 0.3 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.0 | 0.3 | GO:0098903 | regulation of membrane repolarization during action potential(GO:0098903) |
| 0.0 | 1.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.1 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.6 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.0 | 0.5 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.0 | 0.1 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
| 0.0 | 0.2 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 0.0 | 0.1 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.0 | 0.1 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.5 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.1 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.0 | 0.7 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.0 | 0.2 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.2 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.0 | 2.4 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.3 | GO:0031290 | retinal ganglion cell axon guidance(GO:0031290) |
| 0.0 | 1.4 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.3 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.0 | 0.1 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 2.0 | GO:0006275 | regulation of DNA replication(GO:0006275) |
| 0.0 | 0.7 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 0.1 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.0 | 0.2 | GO:0036148 | phosphatidylglycerol acyl-chain remodeling(GO:0036148) |
| 0.0 | 0.1 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 0.0 | 0.2 | GO:0042135 | neurotransmitter catabolic process(GO:0042135) |
| 0.0 | 0.2 | GO:0097435 | fibril organization(GO:0097435) |
| 0.0 | 0.4 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.1 | GO:0072553 | terminal button organization(GO:0072553) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 15.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 1.3 | 5.1 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.9 | 2.7 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.8 | 20.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.7 | 3.3 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.7 | 2.0 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.6 | 2.6 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.6 | 1.9 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.5 | 1.4 | GO:0036027 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
| 0.4 | 1.8 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.4 | 1.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.4 | 2.0 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.4 | 14.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.4 | 11.2 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.4 | 1.1 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.3 | 1.0 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.3 | 0.9 | GO:0097545 | axonemal outer doublet(GO:0097545) |
| 0.3 | 5.3 | GO:0008091 | spectrin(GO:0008091) |
| 0.3 | 3.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 5.3 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.2 | 1.4 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.2 | 0.6 | GO:0097135 | X chromosome(GO:0000805) cyclin E2-CDK2 complex(GO:0097135) |
| 0.2 | 2.6 | GO:0060091 | kinocilium(GO:0060091) |
| 0.2 | 1.0 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.2 | 5.0 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 1.4 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.2 | 2.4 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 11.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 2.5 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 0.4 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.1 | 1.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 3.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 3.9 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 1.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.4 | GO:1990879 | CST complex(GO:1990879) |
| 0.1 | 1.0 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 1.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 5.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 0.4 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.1 | 23.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 0.2 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.1 | 0.8 | GO:0099634 | postsynaptic specialization membrane(GO:0099634) |
| 0.1 | 0.5 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.3 | GO:0032798 | Swi5-Sfr1 complex(GO:0032798) |
| 0.1 | 0.4 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.1 | 2.2 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 15.0 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 0.2 | GO:0034677 | integrin alpha7-beta1 complex(GO:0034677) |
| 0.1 | 29.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 1.0 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.1 | 0.6 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 4.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 1.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 0.9 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 3.1 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 1.6 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 1.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.9 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.4 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.3 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 2.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 19.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 2.8 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.8 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 0.6 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.2 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.4 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 1.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 3.7 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 3.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.5 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.3 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.9 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 4.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 1.5 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 1.7 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 0.1 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 0.9 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 2.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.5 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 1.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 5.2 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 8.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 1.1 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 0.1 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.0 | 4.2 | GO:0043235 | receptor complex(GO:0043235) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.1 | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928) |
| 1.5 | 9.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 1.4 | 8.3 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 1.4 | 21.9 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 1.1 | 3.3 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 1.0 | 3.0 | GO:0070052 | collagen V binding(GO:0070052) |
| 1.0 | 3.9 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.9 | 2.8 | GO:0043682 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 0.9 | 28.1 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.8 | 7.1 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.7 | 2.7 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.7 | 2.0 | GO:0005128 | erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135) |
| 0.6 | 15.3 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.6 | 1.9 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.5 | 1.9 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.5 | 1.4 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.4 | 2.2 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.4 | 1.2 | GO:0080023 | 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023) |
| 0.4 | 2.0 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.4 | 2.3 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.4 | 7.9 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.4 | 1.8 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.3 | 1.4 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.3 | 2.0 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.3 | 1.6 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.3 | 1.2 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.3 | 2.0 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.3 | 1.7 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.3 | 1.4 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.3 | 2.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.2 | 0.7 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.2 | 2.6 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.2 | 3.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 1.8 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.2 | 3.8 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.2 | 1.3 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.2 | 0.6 | GO:0038181 | bile acid receptor activity(GO:0038181) |
| 0.2 | 11.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.2 | 2.0 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.2 | 14.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.2 | 0.9 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.2 | 1.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.2 | 6.1 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 0.5 | GO:0004639 | phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 0.2 | 1.5 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.1 | 1.5 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 2.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 0.3 | GO:0031762 | alpha-1A adrenergic receptor binding(GO:0031691) follicle-stimulating hormone receptor binding(GO:0031762) |
| 0.1 | 1.5 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 0.4 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.1 | 0.8 | GO:0039552 | RIG-I binding(GO:0039552) |
| 0.1 | 2.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.8 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.1 | 4.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 0.5 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 1.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 2.3 | GO:0005024 | transforming growth factor beta-activated receptor activity(GO:0005024) |
| 0.1 | 0.4 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.1 | 0.4 | GO:0004335 | galactokinase activity(GO:0004335) |
| 0.1 | 3.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 0.4 | GO:0052590 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.1 | 4.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 0.5 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 1.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 1.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 48.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 0.4 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.1 | 1.0 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.1 | 1.9 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 0.6 | GO:0004310 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.1 | 0.8 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.1 | 0.9 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.1 | 0.4 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 0.7 | GO:0010340 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.1 | 0.5 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.1 | 2.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.4 | GO:0016429 | tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.1 | 2.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.0 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 2.6 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.7 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 6.3 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.1 | 0.7 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 0.2 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 0.9 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 0.9 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.9 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.1 | 0.6 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.2 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 1.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 0.3 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.0 | 0.5 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.2 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
| 0.0 | 1.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.9 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.7 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.3 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.0 | 0.2 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.8 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 1.0 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 1.0 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 3.7 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 1.0 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.8 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.5 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.0 | 4.1 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.8 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 20.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 1.6 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 2.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.7 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 1.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 6.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.5 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 0.7 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.6 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.8 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.2 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.0 | 6.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.4 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 5.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.2 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 0.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.5 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.5 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 7.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.3 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 0.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.1 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.0 | 0.3 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.8 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 9.9 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.3 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.8 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.2 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 25.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 2.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 5.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 7.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 4.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 10.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 6.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 2.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 5.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 4.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 10.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.3 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 6.5 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 2.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 0.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 5.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 1.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 0.2 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 6.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 0.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 2.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 6.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.8 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 3.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.8 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.2 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.0 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 1.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.7 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.4 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 14.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.5 | 19.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.3 | 4.8 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.2 | 8.6 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 8.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 3.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 6.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 2.7 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.2 | 11.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 9.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.4 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.1 | 7.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 3.6 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 3.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 1.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 2.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 4.5 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 6.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 2.6 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 2.0 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 3.6 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 0.4 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 0.4 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.1 | 1.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.2 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 1.2 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 1.5 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 1.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 1.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 1.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 2.0 | REACTOME PI3K AKT ACTIVATION | Genes involved in PI3K/AKT activation |
| 0.1 | 5.3 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.1 | 1.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 2.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 4.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 2.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 6.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 3.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.8 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 2.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.1 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 1.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.2 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.7 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.3 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 1.0 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.0 | 0.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.8 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 0.6 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 1.1 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.4 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.2 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.8 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |