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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for TFAP2B
Z-value: 1.15
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Transcription factors associated with TFAP2B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2B | hg38_v1_chr6_+_50818857_50818877 | 0.39 | 5.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2B
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_64206663 Show fit | 2.06 |
ENST00000544997.5
ENST00000345728.10 ENST00000279227.9 |
fermitin family member 3 |
|
| chr3_-_158732442 Show fit | 2.06 |
ENST00000479756.1
ENST00000237696.10 |
retinoic acid receptor responder 1 |
|
| chr22_-_35622521 Show fit | 1.69 |
ENST00000419229.1
ENST00000406324.5 |
myoglobin |
|
| chr11_+_69641146 Show fit | 1.67 |
ENST00000227507.3
ENST00000536559.1 |
cyclin D1 |
|
| chr9_+_114155526 Show fit | 1.58 |
ENST00000356083.8
|
collagen type XXVII alpha 1 chain |
|
| chr5_+_132073782 Show fit | 1.53 |
ENST00000296871.4
|
colony stimulating factor 2 |
|
| chr1_+_65147830 Show fit | 1.53 |
ENST00000395334.6
|
adenylate kinase 4 |
|
| chr1_+_65148169 Show fit | 1.45 |
ENST00000327299.8
|
adenylate kinase 4 |
|
| chr11_-_7673485 Show fit | 1.36 |
ENST00000299498.11
|
cytochrome b5 reductase 2 |
|
| chr11_-_7674206 Show fit | 1.35 |
ENST00000533558.5
ENST00000527542.5 |
cytochrome b5 reductase 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.3 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.0 | 2.7 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.9 | 2.6 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.3 | 2.6 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.2 | 2.1 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
| 0.4 | 2.0 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 1.9 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.0 | 1.9 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.1 | 1.7 | GO:0070141 | response to UV-A(GO:0070141) |
| 0.3 | 1.6 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 2.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 1.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 1.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 1.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.2 | 1.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.3 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.2 | 2.7 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.7 | 2.6 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.2 | 2.0 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 1.8 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 1.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.6 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 1.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.6 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.1 | 1.3 | GO:0035252 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 2.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 1.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.6 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.1 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.1 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.1 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 2.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 2.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.7 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 1.5 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 1.5 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 1.3 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 1.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 1.2 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 1.1 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |