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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for TFDP1
Z-value: 1.79
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Transcription factors associated with TFDP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFDP1 | hg38_v1_chr13_+_113584683_113584762 | -0.66 | 3.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFDP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_225042433 Show fit | 9.88 |
ENST00000258390.12
|
dedicator of cytokinesis 10 |
|
| chr11_-_72642450 Show fit | 6.31 |
ENST00000444035.6
ENST00000544570.5 |
phosphodiesterase 2A |
|
| chr6_+_37170133 Show fit | 5.88 |
ENST00000373509.6
|
Pim-1 proto-oncogene, serine/threonine kinase |
|
| chr9_+_114155526 Show fit | 5.15 |
ENST00000356083.8
|
collagen type XXVII alpha 1 chain |
|
| chr11_-_72642407 Show fit | 5.15 |
ENST00000376450.7
|
phosphodiesterase 2A |
|
| chr1_-_184974477 Show fit | 4.76 |
ENST00000367511.4
|
niban apoptosis regulator 1 |
|
| chr17_+_38705482 Show fit | 3.77 |
ENST00000620609.4
|
MLLT6, PHD finger containing |
|
| chr10_-_99620401 Show fit | 3.26 |
ENST00000370495.6
|
solute carrier family 25 member 28 |
|
| chr1_+_169106681 Show fit | 3.06 |
ENST00000367815.9
|
ATPase Na+/K+ transporting subunit beta 1 |
|
| chr6_-_128520358 Show fit | 2.86 |
ENST00000368215.7
ENST00000532331.5 ENST00000368213.9 ENST00000368207.7 ENST00000525459.1 ENST00000368226.9 ENST00000368210.7 |
protein tyrosine phosphatase receptor type K |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 11.5 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.6 | 9.6 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 7.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 1.7 | 6.8 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 1.7 | 6.7 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 0.5 | 6.4 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
| 1.0 | 6.3 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
| 0.2 | 5.1 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.4 | 5.0 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.0 | 5.0 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 11.6 | GO:0016605 | PML body(GO:0016605) |
| 0.6 | 10.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 9.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 8.7 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 6.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 6.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 5.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 5.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.4 | 5.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 11.9 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.1 | 8.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 7.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 7.1 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 7.1 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.3 | 6.4 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 6.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 5.9 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 5.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 5.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 12.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 10.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 8.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 7.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 6.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 5.7 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 5.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 5.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 4.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 9.9 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 9.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 6.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 6.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 6.4 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 6.3 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 6.2 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.1 | 5.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 4.8 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |