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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for TFEC_MITF_ARNTL_BHLHE41
Z-value: 0.70
Motif logo
Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TFEC
|
ENSG00000105967.16 | TFEC |
|
MITF
|
ENSG00000187098.17 | MITF |
|
ARNTL
|
ENSG00000133794.20 | ARNTL |
|
BHLHE41
|
ENSG00000123095.6 | BHLHE41 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MITF | hg38_v1_chr3_+_69763549_69763560 | 0.26 | 2.1e-01 | Click! |
| BHLHE41 | hg38_v1_chr12_-_26125023_26125047 | -0.15 | 4.9e-01 | Click! |
| TFEC | hg38_v1_chr7_-_116030750_116030813, hg38_v1_chr7_-_115968302_115968319 | 0.08 | 7.2e-01 | Click! |
| ARNTL | hg38_v1_chr11_+_13277639_13277877 | 0.02 | 9.4e-01 | Click! |
Activity profile of TFEC_MITF_ARNTL_BHLHE41 motif
Sorted Z-values of TFEC_MITF_ARNTL_BHLHE41 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TFEC_MITF_ARNTL_BHLHE41
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.1 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.5 | 3.6 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.4 | 1.3 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.4 | 1.5 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.4 | 1.1 | GO:0060435 | bronchiole development(GO:0060435) |
| 0.2 | 0.7 | GO:0090149 | mitochondrial membrane fission(GO:0090149) |
| 0.2 | 0.8 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.2 | 0.6 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
| 0.2 | 0.2 | GO:2000506 | negative regulation of energy homeostasis(GO:2000506) |
| 0.2 | 0.5 | GO:0072429 | response to intra-S DNA damage checkpoint signaling(GO:0072429) |
| 0.1 | 0.4 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.1 | 0.9 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.1 | 0.6 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.1 | 1.7 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.1 | 0.4 | GO:1902490 | regulation of sperm capacitation(GO:1902490) |
| 0.1 | 0.4 | GO:0006864 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 0.1 | 0.6 | GO:0038170 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.1 | 0.1 | GO:0051695 | actin filament uncapping(GO:0051695) |
| 0.1 | 0.4 | GO:0032707 | negative regulation of interleukin-23 production(GO:0032707) |
| 0.1 | 0.3 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.1 | 0.3 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.1 | 1.3 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.1 | 0.7 | GO:0045627 | positive regulation of T-helper 1 cell differentiation(GO:0045627) |
| 0.1 | 0.3 | GO:1904172 | regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172) |
| 0.1 | 0.5 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.1 | 0.5 | GO:2000813 | negative regulation of barbed-end actin filament capping(GO:2000813) |
| 0.1 | 1.2 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.1 | 0.3 | GO:1903567 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.1 | 0.1 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
| 0.1 | 0.5 | GO:1901526 | positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925) |
| 0.1 | 0.4 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.1 | 0.3 | GO:1900063 | regulation of peroxisome organization(GO:1900063) |
| 0.1 | 0.2 | GO:0014057 | positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) |
| 0.1 | 0.7 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.1 | 0.2 | GO:2000004 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.1 | 0.4 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.1 | 0.4 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 0.1 | 0.3 | GO:0031052 | mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685) |
| 0.1 | 2.1 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 0.3 | GO:0060621 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.1 | 0.6 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 0.8 | GO:0045617 | negative regulation of keratinocyte differentiation(GO:0045617) |
| 0.1 | 0.3 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.1 | 0.1 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.1 | 0.3 | GO:0051029 | rRNA transport(GO:0051029) |
| 0.1 | 0.2 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.1 | 0.3 | GO:0006175 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) |
| 0.1 | 0.2 | GO:0060623 | regulation of chromosome condensation(GO:0060623) cellular response to iron(III) ion(GO:0071283) |
| 0.1 | 0.8 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
| 0.1 | 0.4 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.1 | 0.4 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.1 | 0.5 | GO:0006489 | dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465) |
| 0.1 | 0.2 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.1 | 0.2 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.1 | 0.1 | GO:0072268 | pattern specification involved in metanephros development(GO:0072268) |
| 0.1 | 1.3 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.1 | 0.7 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 0.2 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.1 | 0.6 | GO:0034625 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.2 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.1 | 0.2 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.1 | 0.3 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.0 | 0.1 | GO:0006059 | hexitol metabolic process(GO:0006059) |
| 0.0 | 0.5 | GO:0090306 | polar body extrusion after meiotic divisions(GO:0040038) spindle assembly involved in meiosis(GO:0090306) |
| 0.0 | 1.1 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.0 | 0.5 | GO:0008343 | adult feeding behavior(GO:0008343) positive regulation of feeding behavior(GO:2000253) |
| 0.0 | 0.1 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.0 | 0.3 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.0 | 0.1 | GO:0036233 | glycine import(GO:0036233) |
| 0.0 | 0.1 | GO:0040009 | regulation of growth rate(GO:0040009) |
| 0.0 | 0.9 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 0.1 | GO:0019427 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542) |
| 0.0 | 0.6 | GO:0007379 | segment specification(GO:0007379) |
| 0.0 | 2.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.2 | GO:0005986 | sucrose biosynthetic process(GO:0005986) |
| 0.0 | 0.8 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.0 | 0.2 | GO:0021546 | rhombomere development(GO:0021546) |
| 0.0 | 1.8 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 0.1 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.0 | 0.1 | GO:1904761 | negative regulation of myofibroblast differentiation(GO:1904761) |
| 0.0 | 0.1 | GO:1900195 | positive regulation of oocyte maturation(GO:1900195) |
| 0.0 | 0.2 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.2 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.0 | 0.9 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.0 | 0.5 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.0 | 0.2 | GO:0000711 | meiotic DNA repair synthesis(GO:0000711) |
| 0.0 | 0.3 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.0 | 0.3 | GO:0030242 | pexophagy(GO:0030242) |
| 0.0 | 0.0 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.0 | 0.2 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.0 | 0.1 | GO:2000176 | regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.0 | 0.3 | GO:0033129 | positive regulation of histone phosphorylation(GO:0033129) |
| 0.0 | 0.1 | GO:0016999 | antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) |
| 0.0 | 3.2 | GO:0002011 | morphogenesis of an epithelial sheet(GO:0002011) |
| 0.0 | 1.2 | GO:0070987 | error-free translesion synthesis(GO:0070987) |
| 0.0 | 0.8 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.0 | 0.6 | GO:0042754 | negative regulation of circadian rhythm(GO:0042754) |
| 0.0 | 0.5 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.0 | 0.9 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.2 | GO:0044789 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.0 | 0.1 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 0.0 | 0.4 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 0.4 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 0.7 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 0.1 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
| 0.0 | 0.9 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.4 | GO:1903441 | protein localization to ciliary membrane(GO:1903441) |
| 0.0 | 0.4 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.0 | GO:0072003 | kidney rudiment formation(GO:0072003) |
| 0.0 | 0.1 | GO:0038108 | negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) |
| 0.0 | 0.2 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.0 | 0.1 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 0.0 | 0.1 | GO:0045645 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.0 | 0.5 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.0 | 0.1 | GO:1904379 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 0.2 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.0 | 0.1 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.0 | 0.1 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
| 0.0 | 0.1 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.0 | 0.2 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.1 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.0 | 0.1 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.0 | 0.1 | GO:0019464 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.0 | 0.1 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 0.0 | 0.2 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.0 | 0.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.5 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 0.0 | 0.6 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 0.4 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.0 | 0.2 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.0 | 0.7 | GO:0061318 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) |
| 0.0 | 0.1 | GO:1902024 | histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024) |
| 0.0 | 0.2 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 0.0 | 0.2 | GO:0071907 | determination of digestive tract left/right asymmetry(GO:0071907) |
| 0.0 | 0.2 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.0 | 0.1 | GO:2001245 | regulation of phosphatidylcholine biosynthetic process(GO:2001245) |
| 0.0 | 0.2 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.0 | 0.1 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
| 0.0 | 0.3 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.0 | 0.6 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 2.2 | GO:0043297 | apical junction assembly(GO:0043297) |
| 0.0 | 0.0 | GO:0010041 | response to iron(III) ion(GO:0010041) |
| 0.0 | 0.1 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.0 | 0.2 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
| 0.0 | 0.2 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.0 | 0.1 | GO:1990834 | response to odorant(GO:1990834) |
| 0.0 | 0.1 | GO:0097029 | mature conventional dendritic cell differentiation(GO:0097029) |
| 0.0 | 0.0 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 0.0 | 0.3 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
| 0.0 | 0.1 | GO:2000234 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.0 | 0.1 | GO:0033306 | phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173) |
| 0.0 | 0.3 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.5 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.0 | 0.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 0.1 | GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 0.0 | 0.1 | GO:1904021 | negative regulation of G-protein coupled receptor internalization(GO:1904021) |
| 0.0 | 0.2 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 0.3 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 0.0 | 0.5 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 0.1 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.0 | 0.3 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.0 | 0.1 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.0 | 0.2 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.0 | 0.7 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 0.0 | 0.2 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.0 | 0.0 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.0 | 0.4 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) |
| 0.0 | 0.0 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.0 | 0.4 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.4 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.0 | 0.0 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.0 | 0.6 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.0 | 0.3 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.6 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 0.1 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.0 | 0.2 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 0.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 1.2 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.1 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 0.1 | GO:0046061 | dATP catabolic process(GO:0046061) |
| 0.0 | 0.0 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
| 0.0 | 0.0 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.0 | 0.1 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731) |
| 0.0 | 0.8 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.5 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.0 | 0.1 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.0 | 0.1 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.0 | 0.1 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.0 | 0.7 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.6 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.1 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.0 | 0.4 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.0 | 0.0 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.0 | 0.2 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.0 | 0.2 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 0.0 | 0.1 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.0 | 0.4 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.1 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 0.0 | 0.3 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.0 | 0.1 | GO:0033216 | ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.0 | 0.2 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.0 | 0.1 | GO:0061624 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.0 | 0.0 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
| 0.0 | 0.1 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.0 | 0.0 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
| 0.0 | 0.0 | GO:0002644 | negative regulation of tolerance induction(GO:0002644) |
| 0.0 | 0.1 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.0 | 0.4 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.0 | 0.1 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.0 | 0.5 | GO:1990090 | cellular response to nerve growth factor stimulus(GO:1990090) |
| 0.0 | 0.2 | GO:0045955 | negative regulation of calcium ion-dependent exocytosis(GO:0045955) |
| 0.0 | 0.1 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.0 | 0.8 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.3 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.0 | 0.0 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.0 | GO:0021836 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925) |
| 0.0 | 0.0 | GO:1902594 | viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594) |
| 0.0 | 0.1 | GO:1902455 | negative regulation of stem cell population maintenance(GO:1902455) |
| 0.0 | 0.0 | GO:0019859 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 0.0 | 0.1 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 0.1 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.0 | 0.0 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.7 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.4 | 1.3 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.3 | 1.0 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.2 | 1.7 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.1 | 1.8 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.1 | 0.9 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 1.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.1 | 0.5 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.1 | 1.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.1 | 0.3 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
| 0.1 | 0.4 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.1 | 1.4 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 0.9 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 0.8 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 0.5 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.1 | 0.3 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 0.5 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 0.9 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 0.2 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 3.3 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 0.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 0.2 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.1 | 1.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 0.4 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 0.2 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 0.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.2 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.0 | 0.3 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 0.9 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.4 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.2 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 0.0 | 0.6 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 0.2 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 0.6 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.0 | 0.6 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.2 | GO:0044308 | axonal spine(GO:0044308) |
| 0.0 | 0.2 | GO:0035841 | new growing cell tip(GO:0035841) |
| 0.0 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.3 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.5 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.1 | GO:0005960 | glycine cleavage complex(GO:0005960) |
| 0.0 | 0.1 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.0 | 0.2 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 0.2 | GO:0000801 | central element(GO:0000801) |
| 0.0 | 0.4 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 1.6 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.1 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 0.2 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.0 | 0.1 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.0 | 0.0 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.3 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 0.4 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 0.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.1 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 0.2 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.2 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.1 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.0 | 0.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.3 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 0.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 0.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 1.3 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.0 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.0 | 0.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.1 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.0 | 0.1 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.1 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.1 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.0 | 0.1 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 0.2 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.0 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.1 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.0 | 0.5 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.3 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.1 | GO:0097452 | GAIT complex(GO:0097452) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.5 | 3.7 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.2 | 1.3 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.2 | 0.5 | GO:0008746 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.2 | 2.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.7 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 0.4 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 1.3 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 0.4 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 0.1 | 0.6 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.1 | 0.4 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 0.4 | GO:1990189 | peptide-serine-N-acetyltransferase activity(GO:1990189) |
| 0.1 | 0.3 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 0.1 | 0.4 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 0.6 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.1 | 0.4 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.1 | 0.6 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.1 | 0.9 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 0.4 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 0.1 | 0.3 | GO:0035501 | MH1 domain binding(GO:0035501) |
| 0.1 | 1.4 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 0.1 | 0.7 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.1 | 0.3 | GO:0005119 | smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108) |
| 0.1 | 0.3 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.1 | 0.5 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.1 | 0.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.1 | 0.3 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 0.2 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.1 | 0.2 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 0.5 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 0.6 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 0.2 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.1 | 0.1 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 0.0 | 0.1 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.0 | 0.1 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 0.2 | GO:0004773 | steryl-sulfatase activity(GO:0004773) |
| 0.0 | 1.1 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.1 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
| 0.0 | 0.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 1.1 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.2 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.0 | 0.1 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.0 | 0.2 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 0.9 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.2 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.0 | 0.7 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.4 | GO:0019158 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.1 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.0 | 0.1 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 0.0 | 0.2 | GO:0003867 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
| 0.0 | 0.5 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.2 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.0 | 0.2 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.0 | 0.1 | GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798) |
| 0.0 | 0.1 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 0.0 | 0.2 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 0.0 | 0.1 | GO:0036219 | GTP diphosphatase activity(GO:0036219) 2-hydroxy-adenosine triphosphate pyrophosphatase activity(GO:0044713) 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity(GO:0044714) ATP diphosphatase activity(GO:0047693) |
| 0.0 | 0.1 | GO:0004963 | follicle-stimulating hormone receptor activity(GO:0004963) |
| 0.0 | 0.4 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.0 | 0.3 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.0 | 0.3 | GO:0051998 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.0 | 1.2 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.1 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.0 | 0.1 | GO:0019777 | Atg12 transferase activity(GO:0019777) |
| 0.0 | 0.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.2 | GO:0004802 | transketolase activity(GO:0004802) |
| 0.0 | 0.1 | GO:0035605 | peptidyl-cysteine S-nitrosylase activity(GO:0035605) |
| 0.0 | 1.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.4 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.6 | GO:0005072 | transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072) |
| 0.0 | 0.1 | GO:0070336 | flap-structured DNA binding(GO:0070336) |
| 0.0 | 0.1 | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 0.0 | 0.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.0 | 2.3 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.1 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.0 | 0.1 | GO:0046577 | long-chain-alcohol oxidase activity(GO:0046577) |
| 0.0 | 0.4 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 0.1 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.0 | 0.5 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.1 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 0.1 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.0 | 0.9 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 0.2 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.0 | 0.1 | GO:0004980 | melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.0 | 0.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 0.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.1 | GO:0090541 | MIT domain binding(GO:0090541) |
| 0.0 | 0.1 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 0.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.1 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.0 | 0.4 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.1 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.0 | 0.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.5 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.1 | GO:0015526 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.0 | 0.2 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.0 | 0.1 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.0 | 0.1 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.0 | 0.1 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.0 | 0.0 | GO:0001601 | peptide YY receptor activity(GO:0001601) |
| 0.0 | 0.1 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.0 | 0.0 | GO:0004618 | copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682) |
| 0.0 | 1.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.0 | 0.1 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.0 | 0.0 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.0 | 0.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.2 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.0 | GO:0072590 | N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) |
| 0.0 | 1.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.2 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.1 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.0 | 0.1 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) |
| 0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.1 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.0 | 0.1 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.0 | 0.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.1 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.2 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.3 | GO:0002162 | dystroglycan binding(GO:0002162) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 3.6 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.3 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.8 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID P53 REGULATION PATHWAY | p53 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | REACTOME ORC1 REMOVAL FROM CHROMATIN | Genes involved in Orc1 removal from chromatin |
| 0.1 | 4.1 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 1.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.2 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.8 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.1 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.4 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 0.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.5 | REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.0 | 1.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 2.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.9 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.2 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 2.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.5 | REACTOME AQUAPORIN MEDIATED TRANSPORT | Genes involved in Aquaporin-mediated transport |
| 0.0 | 0.7 | REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.4 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.1 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.3 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.3 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 0.3 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.4 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |