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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for THRA_RXRB

Z-value: 0.79

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Transcription factors associated with THRA_RXRB

Gene Symbol Gene ID Gene Info
ENSG00000126351.13 THRA
ENSG00000204231.11 RXRB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRAhg38_v1_chr17_+_40062810_400629010.331.1e-01Click!
RXRBhg38_v1_chr6_-_33200614_332006800.001.0e+00Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr8_+_62248591 1.63 ENST00000519049.6
sodium/potassium transporting ATPase interacting 3
chr4_-_148444674 1.09 ENST00000344721.8
nuclear receptor subfamily 3 group C member 2
chr19_+_1248553 0.99 ENST00000586757.5
ENST00000300952.6
ENST00000682408.1
midnolin
chr9_-_33402551 0.79 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
aquaporin 7
chr2_-_55232158 0.77 ENST00000407122.5
ENST00000401408.6
clathrin heavy chain linker domain containing 1
chr12_+_78863962 0.76 ENST00000393240.7
synaptotagmin 1
chr9_+_27109393 0.74 ENST00000406359.8
TEK receptor tyrosine kinase
chr14_+_88385643 0.72 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
spermatogenesis associated 7
chr14_+_88385714 0.72 ENST00000045347.11
spermatogenesis associated 7
chr11_+_7513966 0.67 ENST00000299492.9
PPFIA binding protein 2
chr1_+_163069353 0.66 ENST00000531057.5
ENST00000527809.5
ENST00000367908.8
ENST00000367909.11
regulator of G protein signaling 4
chr1_+_32362537 0.63 ENST00000373534.4
testis specific serine kinase 3
chr11_-_27700472 0.61 ENST00000418212.5
ENST00000533246.5
brain derived neurotrophic factor
chr11_-_27700447 0.60 ENST00000356660.9
brain derived neurotrophic factor
chr9_-_33402449 0.60 ENST00000377425.8
aquaporin 7
chr2_-_182522703 0.58 ENST00000410103.1
phosphodiesterase 1A
chr19_-_51723968 0.57 ENST00000222115.5
ENST00000540069.7
hyaluronan synthase 1
chr1_+_160177386 0.56 ENST00000470705.1
ATPase Na+/K+ transporting subunit alpha 4
chr22_+_22822658 0.52 ENST00000620395.2
immunoglobulin lambda variable 2-8
chr12_-_95116967 0.51 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr14_-_105588322 0.51 ENST00000497872.4
ENST00000390539.2
immunoglobulin heavy constant alpha 2 (A2m marker)
chr1_+_185734362 0.51 ENST00000271588.9
hemicentin 1
chr5_-_163460067 0.51 ENST00000302764.9
NudC domain containing 2
chr14_-_76826229 0.50 ENST00000557497.1
angel homolog 1
chr17_-_41060109 0.49 ENST00000391418.3
keratin associated protein 2-3
chr12_+_57583101 0.47 ENST00000674858.1
ENST00000675433.1
ENST00000674980.1
kinesin family member 5A
chr12_-_52601458 0.43 ENST00000537672.6
ENST00000293745.7
keratin 72
chrX_-_133753681 0.43 ENST00000406757.2
glypican 3
chr5_-_163460048 0.42 ENST00000517501.1
NudC domain containing 2
chr12_-_52601507 0.42 ENST00000354310.4
keratin 72
chr15_-_79923647 0.42 ENST00000485386.1
ENST00000479961.1
ENST00000494999.1
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr21_+_44353607 0.41 ENST00000397928.6
transient receptor potential cation channel subfamily M member 2
chr3_+_37861926 0.40 ENST00000443503.6
CTD small phosphatase like
chr22_-_21227637 0.40 ENST00000401924.5
gamma-glutamyltransferase 2
chr22_+_22594528 0.40 ENST00000390303.3
immunoglobulin lambda variable 3-32 (non-functional)
chr10_-_70376779 0.39 ENST00000395011.5
leucine rich repeat containing 20
chr14_+_22495890 0.38 ENST00000390494.1
T cell receptor alpha joining 43
chr22_+_22922594 0.38 ENST00000390331.3
immunoglobulin lambda constant 7
chr22_+_22792485 0.37 ENST00000390314.2
immunoglobulin lambda variable 2-11
chr7_+_121328991 0.37 ENST00000222462.3
Wnt family member 16
chr22_+_22758698 0.36 ENST00000390312.2
immunoglobulin lambda variable 2-14
chr3_+_184337591 0.36 ENST00000383847.7
family with sequence similarity 131 member A
chr17_+_45844875 0.36 ENST00000329196.7
signal peptide peptidase like 2C
chr10_-_96357155 0.35 ENST00000536387.5
oligodendrocytic myelin paranodal and inner loop protein
chr22_+_30881674 0.35 ENST00000454145.5
ENST00000453621.5
ENST00000431368.5
ENST00000535268.5
oxysterol binding protein 2
chr6_+_139135063 0.34 ENST00000367658.3
hdc homolog, cell cycle regulator
chr21_+_44353633 0.34 ENST00000397932.6
ENST00000300481.13
transient receptor potential cation channel subfamily M member 2
chr22_+_28742024 0.33 ENST00000216027.8
ENST00000398941.6
HscB mitochondrial iron-sulfur cluster cochaperone
chr12_+_102120172 0.33 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARP1 binding protein
chr11_+_64340191 0.33 ENST00000356786.10
coiled-coil domain containing 88B
chr2_-_74552616 0.33 ENST00000409249.5
lysyl oxidase like 3
chr7_-_92246045 0.33 ENST00000394507.5
ENST00000458177.6
ENST00000340022.6
ENST00000444960.5
KRIT1 ankyrin repeat containing
chr12_-_95790755 0.32 ENST00000343702.9
ENST00000344911.8
netrin 4
chr2_-_182522556 0.31 ENST00000435564.5
phosphodiesterase 1A
chrX_-_111410420 0.31 ENST00000371993.7
ENST00000680476.1
doublecortin
chr13_-_33185994 0.31 ENST00000255486.8
StAR related lipid transfer domain containing 13
chr22_+_22327298 0.30 ENST00000390291.2
immunoglobulin lambda variable 1-50 (non-functional)
chr7_-_92245795 0.30 ENST00000412043.6
ENST00000430102.5
ENST00000425073.1
ENST00000394505.7
ENST00000394503.6
ENST00000454017.5
ENST00000440209.5
ENST00000413688.5
ENST00000452773.5
ENST00000433016.5
ENST00000422347.5
ENST00000458493.5
ENST00000425919.5
ENST00000650585.1
KRIT1 ankyrin repeat containing
novel protein
chr1_+_70411180 0.30 ENST00000411986.6
cystathionine gamma-lyase
chr14_+_74084947 0.30 ENST00000674221.1
ENST00000554938.2
lin-52 DREAM MuvB core complex component
chr2_-_69643152 0.29 ENST00000606389.7
AP2 associated kinase 1
chr5_+_170861990 0.29 ENST00000523189.6
RAN binding protein 17
chr22_-_37484505 0.29 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_-_150720842 0.28 ENST00000442853.5
ENST00000368995.8
ENST00000322343.11
ENST00000361824.7
HORMA domain containing 1
chr17_-_2025289 0.28 ENST00000331238.7
reticulon 4 receptor like 1
chr17_+_46851580 0.27 ENST00000290015.7
ENST00000393461.2
Wnt family member 9B
chr12_-_111488538 0.27 ENST00000389154.7
ataxin 2
chr8_-_18808837 0.27 ENST00000286485.12
pleckstrin and Sec7 domain containing 3
chr9_-_101487120 0.27 ENST00000374848.8
post-GPI attachment to proteins GalNAc transferase 4
chr14_-_105708627 0.27 ENST00000641837.1
ENST00000390547.3
immunoglobulin heavy constant alpha 1
chr3_+_40477107 0.27 ENST00000314686.9
ENST00000447116.6
ENST00000429348.6
ENST00000432264.4
ENST00000456778.5
zinc finger protein 619
chr3_-_50303565 0.26 ENST00000266031.8
ENST00000395143.6
ENST00000457214.6
ENST00000447605.2
ENST00000395144.7
ENST00000418723.1
hyaluronidase 1
chr11_-_71928624 0.26 ENST00000533047.5
ENST00000529844.5
novel protein similar to transient receptor potential cation channel, subfamily C, member 2 TRPC2
chr13_-_75537805 0.26 ENST00000626103.1
ENST00000682242.1
ENST00000355801.4
COMM domain containing 6
chr22_+_22162155 0.26 ENST00000390284.2
immunoglobulin lambda variable 4-60
chr17_-_5234801 0.26 ENST00000571800.5
ENST00000574081.6
ENST00000399600.8
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr15_-_51622738 0.25 ENST00000560891.6
Dmx like 2
chr3_-_49689053 0.25 ENST00000449682.2
macrophage stimulating 1
chr1_+_70411241 0.25 ENST00000370938.8
ENST00000346806.2
cystathionine gamma-lyase
chr9_-_101487091 0.25 ENST00000374847.5
post-GPI attachment to proteins GalNAc transferase 4
chr19_-_57974527 0.25 ENST00000314391.3
chromosome 19 open reading frame 18
chr17_+_29043124 0.25 ENST00000323372.9
pipecolic acid and sarcosine oxidase
chr12_+_119593758 0.25 ENST00000426426.3
transmembrane protein 233
chr20_-_37527862 0.25 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP apoptosis inducing factor
chr1_+_28438104 0.24 ENST00000633167.1
ENST00000373836.4
phosphatase and actin regulator 4
chr15_-_34337462 0.24 ENST00000676379.1
solute carrier family 12 member 6
chr6_-_88963573 0.24 ENST00000369485.9
RNA guanylyltransferase and 5'-phosphatase
chr14_-_105601728 0.24 ENST00000641420.1
ENST00000390541.2
immunoglobulin heavy constant epsilon
chr15_-_56733473 0.24 ENST00000558320.5
ENST00000267807.12
zinc finger protein 280D
chr1_-_110606009 0.23 ENST00000640774.2
ENST00000638616.2
potassium voltage-gated channel subfamily A member 2
chr15_-_45129857 0.23 ENST00000267803.8
ENST00000613425.4
ENST00000559014.5
ENST00000558851.1
ENST00000559988.5
ENST00000558996.5
ENST00000558422.5
ENST00000559226.5
ENST00000560572.6
ENST00000558326.5
ENST00000558377.5
ENST00000559644.5
dual oxidase maturation factor 1
chr22_+_22871478 0.23 ENST00000390318.2
immunoglobulin lambda variable 4-3
chr4_+_89901979 0.23 ENST00000508372.1
multimerin 1
chr3_+_12287859 0.23 ENST00000309576.11
ENST00000397015.7
peroxisome proliferator activated receptor gamma
chr1_+_178513103 0.23 ENST00000319416.7
ENST00000367643.7
ENST00000367642.3
ENST00000367641.7
ENST00000367639.1
testis expressed 35
chr17_-_60392333 0.23 ENST00000590133.5
ubiquitin specific peptidase 32
chr19_+_19528861 0.23 ENST00000436027.9
YjeF N-terminal domain containing 3
chr3_+_12287962 0.22 ENST00000643197.2
ENST00000644622.2
peroxisome proliferator activated receptor gamma
chr3_+_10026409 0.22 ENST00000287647.7
ENST00000676013.1
ENST00000675286.1
ENST00000419585.5
FA complementation group D2
chr3_+_12287899 0.22 ENST00000643888.2
peroxisome proliferator activated receptor gamma
chr12_+_56007484 0.22 ENST00000262032.9
IKAROS family zinc finger 4
chr2_-_74553934 0.22 ENST00000264094.8
ENST00000393937.6
ENST00000409986.5
lysyl oxidase like 3
chr19_+_19528901 0.22 ENST00000514277.6
YjeF N-terminal domain containing 3
chr10_-_118046574 0.21 ENST00000369199.5
RAB11 family interacting protein 2
chr17_+_60422483 0.21 ENST00000269127.5
chromosome 17 open reading frame 64
chrX_-_10833643 0.21 ENST00000380785.5
ENST00000380787.5
midline 1
chr1_-_173917281 0.21 ENST00000367698.4
serpin family C member 1
chr17_-_7179544 0.20 ENST00000619926.4
asialoglycoprotein receptor 1
chr17_+_66964638 0.20 ENST00000262138.4
calcium voltage-gated channel auxiliary subunit gamma 4
chr6_+_13272709 0.20 ENST00000379335.8
phosphatase and actin regulator 1
chr10_-_118046922 0.20 ENST00000355624.8
RAB11 family interacting protein 2
chr17_+_49969178 0.20 ENST00000240306.5
distal-less homeobox 4
chr11_-_77411883 0.19 ENST00000528203.5
ENST00000528592.5
ENST00000528633.1
ENST00000529248.5
p21 (RAC1) activated kinase 1
chr8_-_98942557 0.19 ENST00000523601.5
serine/threonine kinase 3
chr1_+_154327737 0.19 ENST00000672630.1
ATPase phospholipid transporting 8B2
chr12_-_6556034 0.19 ENST00000619571.5
ENST00000336604.8
ENST00000396840.6
ENST00000356896.8
intermediate filament family orphan 1
chr16_+_28863812 0.19 ENST00000684370.1
SH2B adaptor protein 1
chr22_-_37188281 0.19 ENST00000397110.6
C1q and TNF related 6
chr16_-_58295019 0.19 ENST00000567164.6
ENST00000219301.8
ENST00000569727.1
serine protease 54
chr7_+_77122609 0.19 ENST00000285871.5
coiled-coil domain containing 146
chr12_-_52553139 0.18 ENST00000267119.6
keratin 71
chr17_+_39738317 0.18 ENST00000394211.7
growth factor receptor bound protein 7
chr1_+_17308194 0.18 ENST00000375453.5
ENST00000375448.4
peptidyl arginine deiminase 4
chr19_-_37207074 0.18 ENST00000588873.1
novel protein
chr7_-_151736304 0.18 ENST00000492843.6
protein kinase AMP-activated non-catalytic subunit gamma 2
chr2_+_172821575 0.18 ENST00000397087.7
Rap guanine nucleotide exchange factor 4
chr5_+_148312416 0.18 ENST00000274565.5
serine peptidase inhibitor Kazal type 7
chr7_+_143284930 0.18 ENST00000409244.5
ENST00000409541.5
ENST00000410004.1
ENST00000359333.8
transmembrane protein 139
chrX_+_48786578 0.18 ENST00000376670.9
GATA binding protein 1
chr16_-_2329687 0.18 ENST00000567910.1
ATP binding cassette subfamily A member 3
chr14_-_70188967 0.18 ENST00000381269.6
ENST00000357887.7
solute carrier family 8 member A3
chr15_-_82647503 0.18 ENST00000567678.1
ENST00000620182.4
cytoplasmic polyadenylation element binding protein 1
chr11_-_59810750 0.18 ENST00000300151.5
mitochondrial ribosomal protein L16
chr9_+_17579059 0.18 ENST00000380607.5
SH3 domain containing GRB2 like 2, endophilin A1
chr2_+_218880844 0.18 ENST00000258411.8
Wnt family member 10A
chr2_+_148021083 0.18 ENST00000642680.2
methyl-CpG binding domain protein 5
chr15_-_51622798 0.17 ENST00000251076.9
Dmx like 2
chr12_+_65169546 0.17 ENST00000308330.3
LEM domain containing 3
chrX_-_136780925 0.17 ENST00000250617.7
Rac/Cdc42 guanine nucleotide exchange factor 6
chr20_+_18145083 0.17 ENST00000489634.2
lysine acetyltransferase 14
chr8_+_102551583 0.17 ENST00000285402.4
outer dense fiber of sperm tails 1
chr2_+_148021001 0.17 ENST00000407073.5
methyl-CpG binding domain protein 5
chrX_-_130165699 0.17 ENST00000676328.1
ENST00000675857.1
ENST00000675427.1
ENST00000675092.1
apoptosis inducing factor mitochondria associated 1
chr5_+_113513674 0.17 ENST00000161863.9
ENST00000515883.5
YTH domain containing 2
chr14_+_22883220 0.17 ENST00000536884.1
ENST00000267396.9
RRAD and GEM like GTPase 2
chr2_+_74513441 0.17 ENST00000621092.1
T cell leukemia homeobox 2
chr1_-_242449478 0.17 ENST00000427495.5
phospholipase D family member 5
chr7_+_94907584 0.17 ENST00000433360.6
ENST00000340694.8
ENST00000424654.5
protein phosphatase 1 regulatory subunit 9A
chr16_+_67666770 0.16 ENST00000403458.9
ENST00000602365.1
chromosome 16 open reading frame 86
chr4_-_53591477 0.16 ENST00000263925.8
ligand of numb-protein X 1
chr2_+_61162185 0.16 ENST00000432605.3
ENST00000488469.4
chromosome 2 open reading frame 74
chr1_-_155911340 0.16 ENST00000368323.8
Ras like without CAAX 1
chr14_-_70188937 0.16 ENST00000356921.7
solute carrier family 8 member A3
chr3_-_197298558 0.16 ENST00000656944.1
ENST00000346964.6
ENST00000448528.6
ENST00000655488.1
ENST00000357674.9
ENST00000667157.1
ENST00000661336.1
ENST00000654737.1
ENST00000659716.1
ENST00000657381.1
discs large MAGUK scaffold protein 1
chr9_+_27109200 0.15 ENST00000380036.10
TEK receptor tyrosine kinase
chr17_+_37491464 0.15 ENST00000613659.1
dual specificity phosphatase 14
chr1_-_243843226 0.15 ENST00000336199.9
AKT serine/threonine kinase 3
chr5_+_163460623 0.15 ENST00000393915.9
ENST00000432118.6
hyaluronan mediated motility receptor
chr3_+_12288838 0.15 ENST00000455517.6
ENST00000681982.1
peroxisome proliferator activated receptor gamma
chr16_-_67666692 0.15 ENST00000602644.5
ENST00000243878.9
enkurin domain containing 1
chr12_+_102120240 0.15 ENST00000537257.5
ENST00000392911.6
PARP1 binding protein
chr2_+_230996115 0.15 ENST00000424440.5
ENST00000452881.5
ENST00000433428.6
ENST00000455816.1
ENST00000440792.5
ENST00000423134.1
spermatogenesis associated 3
chr1_+_93079234 0.15 ENST00000540243.5
ENST00000545708.5
metal response element binding transcription factor 2
chr20_+_48921701 0.15 ENST00000371917.5
ADP ribosylation factor guanine nucleotide exchange factor 2
chr13_+_48303709 0.15 ENST00000646097.1
ENST00000650461.1
ENST00000267163.6
RB transcriptional corepressor 1
chr2_-_99489955 0.15 ENST00000393445.7
ENST00000258428.8
REV1 DNA directed polymerase
chr13_+_114281577 0.15 ENST00000375299.8
ENST00000492270.1
ENST00000351487.5
UPF3A regulator of nonsense mediated mRNA decay
chr16_-_58294976 0.15 ENST00000543437.5
ENST00000569079.1
serine protease 54
chr11_+_1834804 0.15 ENST00000341958.3
synaptotagmin 8
chr2_-_191151568 0.15 ENST00000358470.8
ENST00000432798.1
ENST00000450994.1
signal transducer and activator of transcription 4
chr22_+_22734577 0.15 ENST00000390310.3
immunoglobulin lambda variable 2-18
chr15_+_86079863 0.15 ENST00000614907.3
ENST00000441037.7
ATP/GTP binding protein like 1
chr6_-_31777319 0.14 ENST00000375688.5
von Willebrand factor A domain containing 7
chr9_+_88535101 0.14 ENST00000618633.1
ENST00000375854.7
ENST00000375855.3
nucleoredoxin like 2
chr19_-_40690553 0.14 ENST00000598779.5
NUMB like endocytic adaptor protein
chr22_+_22409755 0.14 ENST00000390299.2
immunoglobulin lambda variable 1-40
chr1_+_241652275 0.14 ENST00000366552.6
ENST00000437684.7
WD repeat domain 64
chr1_+_39081316 0.14 ENST00000484793.5
microtubule actin crosslinking factor 1
chr19_+_40611863 0.14 ENST00000601032.5
latent transforming growth factor beta binding protein 4
chr9_-_86282061 0.14 ENST00000311534.6
iron-sulfur cluster assembly 1
chr19_-_45322867 0.14 ENST00000221476.4
creatine kinase, M-type
chr7_-_56092932 0.14 ENST00000446428.5
ENST00000432123.5
ENST00000297373.7
phosphorylase kinase catalytic subunit gamma 1
chr7_-_56092974 0.13 ENST00000452681.6
ENST00000537360.5
phosphorylase kinase catalytic subunit gamma 1
chr11_+_1834415 0.13 ENST00000381968.7
ENST00000381978.7
synaptotagmin 8
chr9_+_27109135 0.13 ENST00000519097.5
ENST00000615002.4
TEK receptor tyrosine kinase
chr3_-_183555696 0.13 ENST00000341319.8
kelch like family member 6
chr6_-_127519191 0.13 ENST00000525778.5
SOGA family member 3
chr9_-_86282511 0.13 ENST00000375991.9
ENST00000326094.4
iron-sulfur cluster assembly 1
chr12_+_10212867 0.13 ENST00000545047.5
ENST00000266458.10
ENST00000629504.1
ENST00000543602.5
ENST00000545887.1
GABA type A receptor associated protein like 1
chr15_+_78266181 0.13 ENST00000446172.2
DnaJ heat shock protein family (Hsp40) member A4
chr17_-_46192767 0.13 ENST00000262419.10
KAT8 regulatory NSL complex subunit 1
chr22_-_37188233 0.13 ENST00000434784.1
ENST00000337843.7
C1q and TNF related 6
chr7_-_73738831 0.13 ENST00000395147.9
ENST00000437775.7
abhydrolase domain containing 11
chr4_+_7192519 0.13 ENST00000507866.6
sortilin related VPS10 domain containing receptor 2
chr17_-_60392113 0.13 ENST00000300896.9
ENST00000589335.5
ubiquitin specific peptidase 32
chr8_-_130016395 0.13 ENST00000523509.5
CYFIP related Rac1 interactor B
chr3_+_12289061 0.13 ENST00000652522.1
ENST00000652431.1
ENST00000652098.1
ENST00000651735.1
ENST00000397026.7
peroxisome proliferator activated receptor gamma
chr2_-_229921963 0.13 ENST00000343290.5
ENST00000389044.8
ENST00000675453.1
ENST00000675903.1
ENST00000283943.9
thyroid hormone receptor interactor 12
chr15_-_34337772 0.13 ENST00000354181.8
solute carrier family 12 member 6
chr1_+_93079264 0.13 ENST00000370298.9
ENST00000370303.4
metal response element binding transcription factor 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.3 0.8 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2 0.5 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 0.5 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.2 1.4 GO:0015793 glycerol transport(GO:0015793)
0.1 0.6 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 1.0 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 1.4 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.1 1.0 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 1.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.4 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.1 0.7 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.1 0.5 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.1 0.3 GO:0030221 basophil differentiation(GO:0030221)
0.1 0.4 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 0.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 0.6 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.2 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.3 GO:1904045 cellular response to aldosterone(GO:1904045)
0.1 0.7 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.1 0.3 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.3 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.1 0.3 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.2 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.1 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.3 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.1 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.0 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.2 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.3 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:1903565 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:0061052 negative regulation of cell proliferation involved in contact inhibition(GO:0060244) negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.0 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.1 GO:0035822 release from viral latency(GO:0019046) gene conversion(GO:0035822) regulation of DNA strand elongation(GO:0060382)
0.0 0.2 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.1 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.0 0.1 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.4 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.1 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.1 GO:1900114 positive regulation of methylation-dependent chromatin silencing(GO:0090309) positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.1 GO:1904719 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.1 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 0.2 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.0 0.5 GO:2000352 negative regulation of endothelial cell apoptotic process(GO:2000352)
0.0 0.2 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 2.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.0 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0006203 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.0 0.2 GO:1903286 regulation of potassium ion import(GO:1903286)
0.0 0.0 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:0060083 cellular potassium ion homeostasis(GO:0030007) smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.2 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.1 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.0 GO:0042335 cuticle development(GO:0042335)
0.0 0.7 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 1.3 GO:0002028 regulation of sodium ion transport(GO:0002028)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0071752 dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752)
0.2 0.8 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.3 GO:0036117 hyaluranon cable(GO:0036117)
0.1 0.4 GO:0043291 RAVE complex(GO:0043291)
0.1 0.2 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.4 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 1.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.2 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.3 GO:0033010 paranodal junction(GO:0033010)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.3 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.2 1.4 GO:0015254 glycerol channel activity(GO:0015254)
0.2 0.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.9 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.4 GO:0052857 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.1 0.4 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.1 0.4 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.8 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.4 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.1 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.0 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.1 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.1 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.0 0.3 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0047693 GTP diphosphatase activity(GO:0036219) 2-hydroxy-adenosine triphosphate pyrophosphatase activity(GO:0044713) 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity(GO:0044714) ATP diphosphatase activity(GO:0047693)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 1.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.7 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.3 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 1.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.0 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID SHP2 PATHWAY SHP2 signaling
0.0 1.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.8 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME AQUAPORIN MEDIATED TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis