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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for THRB

Z-value: 0.36

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.20 THRB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg38_v1_chr3_-_24495532_24495756-0.232.7e-01Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_77532100 2.00 ENST00000478255.1
AK5
adenylate kinase 5
chr20_+_38805686 1.34 ENST00000299824.6
ENST00000373331.2
PPP1R16B
protein phosphatase 1 regulatory subunit 16B
chr10_+_35167516 0.69 ENST00000361599.8
CREM
cAMP responsive element modulator
chr6_-_99394164 0.47 ENST00000254759.8
COQ3
coenzyme Q3, methyltransferase
chr10_-_13300051 0.44 ENST00000479604.1
ENST00000263038.9
PHYH
phytanoyl-CoA 2-hydroxylase
chr11_+_5596627 0.33 ENST00000380097.8
TRIM6
tripartite motif containing 6
chr7_-_38354517 0.32 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr11_+_5596745 0.29 ENST00000445329.5
TRIM6
tripartite motif containing 6
chr11_+_57542641 0.28 ENST00000527972.5
ENST00000399154.3
SMTNL1
smoothelin like 1
chr22_+_19950896 0.27 ENST00000412786.5
COMT
catechol-O-methyltransferase
chr8_-_99893622 0.27 ENST00000520271.5
ENST00000522940.5
ENST00000523016.1
ENST00000517682.6
ENST00000297564.6
COX6C
cytochrome c oxidase subunit 6C
chr4_+_113292838 0.26 ENST00000672411.1
ENST00000673231.1
ANK2
ankyrin 2
chr19_+_34994778 0.26 ENST00000599564.5
GRAMD1A
GRAM domain containing 1A
chr8_-_99893697 0.25 ENST00000518171.5
ENST00000520468.7
COX6C
cytochrome c oxidase subunit 6C
chr4_+_113292925 0.24 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ANK2
ankyrin 2
chr10_+_60778331 0.21 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr7_+_107580454 0.21 ENST00000379117.6
ENST00000473124.1
BCAP29
B cell receptor associated protein 29
chr9_-_136373613 0.20 ENST00000641290.1
ENST00000371732.10
ENST00000371734.7
CARD9
caspase recruitment domain family member 9
chr12_-_21657792 0.19 ENST00000396076.5
LDHB
lactate dehydrogenase B
chr12_-_21657831 0.19 ENST00000450584.5
ENST00000350669.5
ENST00000673047.2
LDHB
lactate dehydrogenase B
chr8_-_99893135 0.19 ENST00000524245.5
COX6C
cytochrome c oxidase subunit 6C
chr10_+_5890203 0.18 ENST00000397269.7
ENST00000362091.9
FBH1
F-box DNA helicase 1
chr11_+_5596721 0.18 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr10_+_60778490 0.18 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr5_-_113434978 0.17 ENST00000390666.4
TSSK1B
testis specific serine kinase 1B
chr11_-_18726187 0.16 ENST00000513874.6
IGSF22
immunoglobulin superfamily member 22
chr16_+_72054477 0.16 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
HP
haptoglobin
chr1_-_112956063 0.15 ENST00000538576.5
ENST00000369626.8
ENST00000458229.6
SLC16A1
solute carrier family 16 member 1
chr9_+_97307645 0.13 ENST00000529487.3
CCDC180
coiled-coil domain containing 180
chrX_+_102599168 0.12 ENST00000246174.6
ARMCX5
armadillo repeat containing X-linked 5
chr12_+_49346911 0.12 ENST00000395069.3
DNAJC22
DnaJ heat shock protein family (Hsp40) member C22
chr3_+_50569470 0.11 ENST00000455834.5
ENST00000232854.9
HEMK1
HemK methyltransferase family member 1
chr10_-_119165542 0.11 ENST00000419372.5
ENST00000369131.8
ENST00000355697.7
SFXN4
sideroflexin 4
chr15_-_100544243 0.09 ENST00000538112.6
ENST00000559639.1
ENST00000558884.6
CERS3
ceramide synthase 3
chr6_-_39322540 0.09 ENST00000425054.6
ENST00000373227.8
ENST00000373229.9
KCNK16
potassium two pore domain channel subfamily K member 16
chrX_-_135833541 0.09 ENST00000620885.1
CT45A7
cancer/testis antigen family 45 member A7
chr16_+_72063226 0.08 ENST00000540303.7
ENST00000356967.6
ENST00000561690.1
HPR
haptoglobin-related protein
chr3_+_50569145 0.08 ENST00000434410.5
HEMK1
HemK methyltransferase family member 1
chr15_-_100544341 0.08 ENST00000394113.5
CERS3
ceramide synthase 3
chrX_-_135764444 0.07 ENST00000597510.6
CT45A3
cancer/testis antigen family 45 member A3
chr9_-_21350956 0.06 ENST00000259555.5
IFNA6
interferon alpha 6
chr17_+_1742836 0.06 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
SERPINF2
serpin family F member 2
chr17_-_75844334 0.06 ENST00000592386.5
ENST00000412096.6
ENST00000586147.1
ENST00000207549.9
UNC13D
unc-13 homolog D
chr1_+_3752441 0.05 ENST00000294600.7
CCDC27
coiled-coil domain containing 27
chr7_+_103297425 0.04 ENST00000428154.5
ENST00000249269.9
PMPCB
peptidase, mitochondrial processing subunit beta
chr2_-_9423190 0.03 ENST00000497105.1
ENST00000360635.7
ENST00000359712.7
ITGB1BP1
integrin subunit beta 1 binding protein 1
chr7_-_100656384 0.03 ENST00000461605.1
ENST00000160382.10
ACTL6B
actin like 6B
chr5_-_157166262 0.02 ENST00000302938.4
FAM71B
family with sequence similarity 71 member B
chr1_+_32247212 0.02 ENST00000373582.4
FAM167B
family with sequence similarity 167 member B
chr11_-_47378391 0.02 ENST00000227163.8
SPI1
Spi-1 proto-oncogene
chrX_-_135868069 0.02 ENST00000604569.1
CT45A9
cancer/testis antigen family 45 member A9
chr12_+_49346885 0.01 ENST00000549441.7
DNAJC22
DnaJ heat shock protein family (Hsp40) member C22
chrX_-_135850791 0.01 ENST00000611438.1
CT45A8
cancer/testis antigen family 45 member A8
chr19_-_52139904 0.01 ENST00000597013.5
ENST00000596290.5
ENST00000600228.6
ZNF616
zinc finger protein 616
chr11_+_73787853 0.00 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
MRPL48
mitochondrial ribosomal protein L48
chr11_-_47378494 0.00 ENST00000533030.1
SPI1
Spi-1 proto-oncogene

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0009183 ADP biosynthetic process(GO:0006172) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183)
0.4 1.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.4 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.1 0.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.1 0.6 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.5 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.4 GO:0014038 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
0.0 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.5 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.2 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.0 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 2.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0008198 ferrous iron binding(GO:0008198) L-ascorbic acid binding(GO:0031418)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.5 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism