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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for TP73

Z-value: 0.39

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.15 TP73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg38_v1_chr1_+_3682306_3682366-0.554.8e-03Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_71527267 0.95 ENST00000398536.6
KRTAP5-7
keratin associated protein 5-7
chr14_+_75279637 0.61 ENST00000555686.1
ENST00000555672.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr14_+_75278820 0.57 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr10_-_103452384 0.51 ENST00000369788.7
CALHM2
calcium homeostasis modulator family member 2
chr10_-_103452356 0.50 ENST00000260743.10
CALHM2
calcium homeostasis modulator family member 2
chrX_+_9912434 0.42 ENST00000418909.6
SHROOM2
shroom family member 2
chr10_-_103479240 0.41 ENST00000369783.4
CALHM3
calcium homeostasis modulator 3
chr3_+_20040437 0.40 ENST00000263754.5
KAT2B
lysine acetyltransferase 2B
chr4_+_6269869 0.39 ENST00000506362.2
WFS1
wolframin ER transmembrane glycoprotein
chr12_+_82358496 0.33 ENST00000248306.8
ENST00000548200.5
METTL25
methyltransferase like 25
chr8_+_37796850 0.31 ENST00000412232.3
ADGRA2
adhesion G protein-coupled receptor A2
chr8_+_37796906 0.30 ENST00000315215.11
ADGRA2
adhesion G protein-coupled receptor A2
chr20_-_50636887 0.29 ENST00000045083.6
RIPOR3
RIPOR family member 3
chr3_-_48898813 0.28 ENST00000319017.5
ENST00000430379.5
SLC25A20
solute carrier family 25 member 20
chr19_-_291132 0.27 ENST00000327790.7
PLPP2
phospholipid phosphatase 2
chr11_-_236821 0.27 ENST00000529382.5
ENST00000528469.1
SIRT3
sirtuin 3
chr1_+_64745089 0.26 ENST00000294428.7
ENST00000371072.8
RAVER2
ribonucleoprotein, PTB binding 2
chr3_-_66038537 0.22 ENST00000483466.5
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr20_+_59940362 0.22 ENST00000360816.8
FAM217B
family with sequence similarity 217 member B
chr19_+_44777860 0.22 ENST00000341505.4
ENST00000647358.2
CBLC
Cbl proto-oncogene C
chr8_+_62248591 0.21 ENST00000519049.6
NKAIN3
sodium/potassium transporting ATPase interacting 3
chr2_-_165794190 0.21 ENST00000392701.8
ENST00000422973.1
GALNT3
polypeptide N-acetylgalactosaminyltransferase 3
chr2_+_74002685 0.21 ENST00000305799.8
TET3
tet methylcytosine dioxygenase 3
chr19_+_12995554 0.20 ENST00000397661.6
NFIX
nuclear factor I X
chr9_-_20382461 0.20 ENST00000380321.5
ENST00000629733.3
MLLT3
MLLT3 super elongation complex subunit
chr17_+_67825664 0.20 ENST00000321892.8
BPTF
bromodomain PHD finger transcription factor
chr2_-_26641363 0.19 ENST00000288861.5
CIB4
calcium and integrin binding family member 4
chr17_-_82101850 0.17 ENST00000583053.1
CCDC57
coiled-coil domain containing 57
chr17_+_67825494 0.17 ENST00000306378.11
ENST00000544778.6
BPTF
bromodomain PHD finger transcription factor
chr19_-_35490456 0.16 ENST00000338897.4
ENST00000484218.6
KRTDAP
keratinocyte differentiation associated protein
chr11_+_63681444 0.16 ENST00000341307.6
ENST00000356000.7
ENST00000542238.5
RTN3
reticulon 3
chr4_+_109560219 0.16 ENST00000394650.7
MCUB
mitochondrial calcium uniporter dominant negative subunit beta
chr19_+_41350911 0.16 ENST00000539627.5
TMEM91
transmembrane protein 91
chr6_+_155216637 0.16 ENST00000275246.11
TIAM2
TIAM Rac1 associated GEF 2
chr11_+_63681483 0.15 ENST00000339997.8
ENST00000540798.5
ENST00000545432.5
ENST00000543552.5
ENST00000377819.10
ENST00000537981.5
RTN3
reticulon 3
chr1_-_153615858 0.15 ENST00000476873.5
S100A14
S100 calcium binding protein A14
chr19_+_35351552 0.15 ENST00000246553.3
FFAR1
free fatty acid receptor 1
chr11_+_119149029 0.13 ENST00000619701.5
ABCG4
ATP binding cassette subfamily G member 4
chr2_+_219572304 0.13 ENST00000243786.3
INHA
inhibin subunit alpha
chr11_+_60429595 0.13 ENST00000528905.1
ENST00000528093.1
MS4A5
membrane spanning 4-domains A5
chr11_+_111977300 0.12 ENST00000615255.1
DIXDC1
DIX domain containing 1
chr14_+_103100328 0.12 ENST00000559116.1
EXOC3L4
exocyst complex component 3 like 4
chr11_+_63681573 0.12 ENST00000354497.4
RTN3
reticulon 3
chr4_-_20984011 0.11 ENST00000382149.9
KCNIP4
potassium voltage-gated channel interacting protein 4
chr8_-_143942524 0.11 ENST00000357649.6
PLEC
plectin
chr12_-_91179472 0.11 ENST00000550099.5
ENST00000546391.5
DCN
decorin
chr14_+_52314280 0.11 ENST00000557436.1
ENST00000245457.6
PTGER2
prostaglandin E receptor 2
chr14_+_22086401 0.11 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr16_-_14630200 0.11 ENST00000650990.1
ENST00000651049.1
ENST00000652727.1
ENST00000652501.1
ENST00000539279.5
ENST00000651634.1
ENST00000651027.1
ENST00000420015.6
ENST00000651865.1
ENST00000437198.7
ENST00000341484.11
ENST00000650960.1
PARN
poly(A)-specific ribonuclease
chr3_-_185821092 0.11 ENST00000421047.3
IGF2BP2
insulin like growth factor 2 mRNA binding protein 2
chr7_-_128405930 0.10 ENST00000470772.5
ENST00000480861.5
ENST00000496200.5
IMPDH1
inosine monophosphate dehydrogenase 1
chr17_+_7888783 0.10 ENST00000330494.12
ENST00000358181.8
CHD3
chromodomain helicase DNA binding protein 3
chr20_+_36876119 0.10 ENST00000602922.5
ENST00000217320.8
TLDC2
TBC/LysM-associated domain containing 2
chr17_+_39200275 0.10 ENST00000225430.9
RPL19
ribosomal protein L19
chr17_+_75754618 0.10 ENST00000584939.1
ITGB4
integrin subunit beta 4
chr17_+_39200334 0.10 ENST00000579260.5
ENST00000582193.5
RPL19
ribosomal protein L19
chr22_-_37580075 0.09 ENST00000215886.6
LGALS2
galectin 2
chr19_+_35106510 0.09 ENST00000648240.1
ENSG00000285526.1
novel protein
chr19_-_38735405 0.09 ENST00000597987.5
ENST00000595177.1
CAPN12
calpain 12
chr17_+_39200302 0.09 ENST00000579374.5
RPL19
ribosomal protein L19
chr4_-_156970903 0.09 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr19_-_35742431 0.09 ENST00000592537.5
ENST00000246532.6
ENST00000588992.5
IGFLR1
IGF like family receptor 1
chr8_+_119873710 0.09 ENST00000523492.5
ENST00000286234.6
DEPTOR
DEP domain containing MTOR interacting protein
chr17_-_76027212 0.09 ENST00000586740.1
EVPL
envoplakin
chr1_-_51878799 0.08 ENST00000354831.11
ENST00000544028.5
NRDC
nardilysin convertase
chr14_+_103100144 0.08 ENST00000380069.7
EXOC3L4
exocyst complex component 3 like 4
chr1_+_27959943 0.08 ENST00000675575.1
ENST00000373884.6
XKR8
XK related 8
chr17_+_74431338 0.08 ENST00000342648.9
ENST00000652232.1
ENST00000481232.2
GPRC5C
G protein-coupled receptor class C group 5 member C
chr1_-_51878711 0.08 ENST00000352171.12
NRDC
nardilysin convertase
chr19_+_41860236 0.08 ENST00000601492.5
ENST00000600467.6
ENST00000598742.6
ENST00000221975.6
ENST00000598261.2
RPS19
ribosomal protein S19
chr12_-_31729010 0.07 ENST00000537562.5
ENST00000537960.5
ENST00000281471.11
ENST00000536761.5
ENST00000542781.5
ENST00000457428.6
AMN1
antagonist of mitotic exit network 1 homolog
chr17_+_39200507 0.07 ENST00000678573.1
RPL19
ribosomal protein L19
chr16_+_84145256 0.07 ENST00000378553.10
DNAAF1
dynein axonemal assembly factor 1
chr1_+_16043736 0.07 ENST00000619181.4
CLCNKB
chloride voltage-gated channel Kb
chr2_+_113406368 0.07 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr12_+_43758936 0.06 ENST00000440781.6
ENST00000431837.5
ENST00000550616.5
ENST00000613694.5
ENST00000551736.5
IRAK4
interleukin 1 receptor associated kinase 4
chr13_+_50910018 0.06 ENST00000645990.1
ENST00000642995.1
ENST00000636524.2
ENST00000643159.1
ENST00000645618.1
ENST00000611510.5
ENST00000642454.1
ENST00000646709.1
RNASEH2B
ribonuclease H2 subunit B
chr7_+_69967464 0.06 ENST00000664521.1
AUTS2
activator of transcription and developmental regulator AUTS2
chr1_+_26159071 0.06 ENST00000374268.5
FAM110D
family with sequence similarity 110 member D
chr14_-_89954659 0.06 ENST00000555070.1
ENST00000316738.12
ENST00000538485.6
ENST00000556609.5
ENSG00000259053.1
EFCAB11
novel transcript
EF-hand calcium binding domain 11
chr11_+_66466745 0.06 ENST00000349459.10
ENST00000320740.12
ENST00000524466.5
ENST00000526296.5
PELI3
pellino E3 ubiquitin protein ligase family member 3
chr2_+_69741974 0.06 ENST00000409920.5
ANXA4
annexin A4
chr1_-_68232539 0.06 ENST00000370976.7
ENST00000354777.6
WLS
Wnt ligand secretion mediator
chr19_+_43716095 0.06 ENST00000596627.1
IRGC
immunity related GTPase cinema
chr3_+_136957948 0.06 ENST00000329582.9
IL20RB
interleukin 20 receptor subunit beta
chr19_+_19516216 0.05 ENST00000507754.9
ENST00000503283.5
ENST00000428459.6
ENST00000555938.1
NDUFA13
ENSG00000258674.5
NADH:ubiquinone oxidoreductase subunit A13
novel protein
chr2_+_219418369 0.05 ENST00000373960.4
DES
desmin
chr10_-_89535575 0.05 ENST00000371790.5
SLC16A12
solute carrier family 16 member 12
chr1_+_155173787 0.05 ENST00000392451.6
ENST00000545012.5
ENST00000334634.9
ENST00000368385.8
ENST00000543729.5
ENST00000368383.7
ENST00000368382.5
TRIM46
tripartite motif containing 46
chr20_+_41136944 0.05 ENST00000244007.7
PLCG1
phospholipase C gamma 1
chr17_-_76027296 0.05 ENST00000301607.8
EVPL
envoplakin
chr1_-_68232514 0.04 ENST00000262348.9
ENST00000370973.2
ENST00000370971.1
WLS
Wnt ligand secretion mediator
chr6_-_33289189 0.04 ENST00000374617.9
WDR46
WD repeat domain 46
chr1_-_236065079 0.04 ENST00000264187.7
ENST00000366595.7
NID1
nidogen 1
chr2_-_38602626 0.04 ENST00000378915.7
HNRNPLL
heterogeneous nuclear ribonucleoprotein L like
chr17_+_56153458 0.04 ENST00000318698.6
ENST00000682825.1
ENST00000566473.6
ANKFN1
ankyrin repeat and fibronectin type III domain containing 1
chrX_-_139642518 0.04 ENST00000370573.8
ENST00000338585.6
MCF2
MCF.2 cell line derived transforming sequence
chr5_+_38258373 0.04 ENST00000354891.7
EGFLAM
EGF like, fibronectin type III and laminin G domains
chr19_+_41114430 0.04 ENST00000331105.7
CYP2F1
cytochrome P450 family 2 subfamily F member 1
chr5_+_38258551 0.04 ENST00000322350.10
EGFLAM
EGF like, fibronectin type III and laminin G domains
chr17_+_32928126 0.03 ENST00000579849.6
ENST00000578289.5
ENST00000439138.5
TMEM98
transmembrane protein 98
chr17_-_44123628 0.03 ENST00000587135.1
ENST00000225983.10
ENST00000682912.1
ENST00000588703.5
HDAC5
histone deacetylase 5
chr1_-_34859717 0.03 ENST00000423898.1
ENST00000521580.3
ENST00000456842.1
SMIM12
small integral membrane protein 12
chr1_+_156815633 0.03 ENST00000392302.7
ENST00000674537.1
NTRK1
neurotrophic receptor tyrosine kinase 1
chr17_+_45241067 0.03 ENST00000587489.5
FMNL1
formin like 1
chr17_-_40867200 0.03 ENST00000647902.1
ENST00000251643.5
KRT12
keratin 12
chr3_-_48088824 0.03 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
MAP4
microtubule associated protein 4
chr10_-_31928864 0.03 ENST00000375245.8
ENST00000396144.8
ARHGAP12
Rho GTPase activating protein 12
chr18_-_55586092 0.03 ENST00000563888.6
ENST00000540999.5
ENST00000627685.2
TCF4
transcription factor 4
chr12_+_113057687 0.02 ENST00000257600.3
DTX1
deltex E3 ubiquitin ligase 1
chr11_+_60429567 0.02 ENST00000300190.7
MS4A5
membrane spanning 4-domains A5
chr10_-_95441015 0.02 ENST00000371241.5
ENST00000354106.7
ENST00000371239.5
ENST00000361941.7
ENST00000277982.9
ENST00000371245.7
SORBS1
sorbin and SH3 domain containing 1
chr16_-_636270 0.02 ENST00000397665.6
ENST00000397666.6
ENST00000301686.13
ENST00000338401.8
ENST00000397664.8
ENST00000568830.1
ENST00000614890.4
METTL26
methyltransferase like 26
chr15_+_74174403 0.02 ENST00000560862.1
ENST00000395118.1
ISLR
immunoglobulin superfamily containing leucine rich repeat
chr22_+_39570753 0.02 ENST00000407673.5
ENST00000401624.5
ENST00000404898.5
ENST00000402142.4
CACNA1I
calcium voltage-gated channel subunit alpha1 I
chr16_+_74999003 0.02 ENST00000335325.9
ENST00000320619.10
ZNRF1
zinc and ring finger 1
chr20_-_59940289 0.02 ENST00000370996.5
PPP1R3D
protein phosphatase 1 regulatory subunit 3D
chrX_+_73447042 0.01 ENST00000373514.3
CDX4
caudal type homeobox 4
chr4_+_105710809 0.01 ENST00000360505.9
ENST00000510865.5
ENST00000509336.5
GSTCD
glutathione S-transferase C-terminal domain containing
chr10_-_31928790 0.01 ENST00000375250.9
ENST00000344936.7
ARHGAP12
Rho GTPase activating protein 12
chr18_-_4455257 0.01 ENST00000581527.5
DLGAP1
DLG associated protein 1
chr16_-_8797624 0.01 ENST00000333050.7
TMEM186
transmembrane protein 186
chr9_+_35673917 0.01 ENST00000617161.1
ENST00000378357.9
CA9
carbonic anhydrase 9
chr3_-_69386079 0.01 ENST00000398540.8
FRMD4B
FERM domain containing 4B
chr8_+_144504131 0.01 ENST00000394955.3
GPT
glutamic--pyruvic transaminase
chr5_+_139561159 0.01 ENST00000505007.5
UBE2D2
ubiquitin conjugating enzyme E2 D2
chr3_+_48440246 0.01 ENST00000438607.2
TMA7
translation machinery associated 7 homolog
chr12_-_56488153 0.00 ENST00000311966.9
GLS2
glutaminase 2
chr20_-_54173516 0.00 ENST00000395955.7
CYP24A1
cytochrome P450 family 24 subfamily A member 1
chrX_-_139642889 0.00 ENST00000370576.9
MCF2
MCF.2 cell line derived transforming sequence
chr11_+_237016 0.00 ENST00000352303.9
PSMD13
proteasome 26S subunit, non-ATPase 13
chr2_+_89884740 0.00 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr6_+_31547560 0.00 ENST00000376148.9
ENST00000376145.8
NFKBIL1
NFKB inhibitor like 1
chr1_-_182672882 0.00 ENST00000367557.8
ENST00000258302.8
RGS8
regulator of G protein signaling 8
chr16_+_89918855 0.00 ENST00000555147.2
MC1R
melanocortin 1 receptor
chrX_-_139642835 0.00 ENST00000536274.5
MCF2
MCF.2 cell line derived transforming sequence
chr14_+_21749163 0.00 ENST00000390427.3
TRAV5
T cell receptor alpha variable 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.4 GO:1903892 negative regulation of ATF6-mediated unfolded protein response(GO:1903892)
0.1 0.6 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.1 0.4 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.2 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
0.1 0.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.4 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0046882 negative regulation of B cell differentiation(GO:0045578) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.4 GO:0045176 apical protein localization(GO:0045176)
0.0 0.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.1 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.3 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.4 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.3 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.3 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones