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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for VAX2_RHOXF2

Z-value: 0.41

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Transcription factors associated with VAX2_RHOXF2

Gene Symbol Gene ID Gene Info
ENSG00000116035.4 VAX2
ENSG00000131721.6 RHOXF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RHOXF2hg38_v1_chrX_+_120158600_120158624-0.144.9e-01Click!
VAX2hg38_v1_chr2_+_70900546_709006170.067.9e-01Click!

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr12_+_26195647 1.05 ENST00000535504.1
sarcospan
chr6_+_26402237 0.76 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
butyrophilin subfamily 3 member A1
chr6_+_26440472 0.68 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
butyrophilin subfamily 3 member A3
chr3_-_191282383 0.64 ENST00000427544.6
urotensin 2B
chr6_+_26365159 0.51 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
butyrophilin subfamily 3 member A2
chr11_-_117877463 0.50 ENST00000527717.5
FXYD domain containing ion transport regulator 6
chr11_-_117876719 0.47 ENST00000529335.6
ENST00000260282.8
FXYD domain containing ion transport regulator 6
chr11_-_117876892 0.45 ENST00000539526.5
FXYD domain containing ion transport regulator 6
chr12_+_26195313 0.44 ENST00000422622.3
sarcospan
chr6_+_26365176 0.44 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr1_-_56579555 0.43 ENST00000371250.4
phospholipid phosphatase 3
chr6_+_26365215 0.42 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr21_-_36542600 0.41 ENST00000399136.5
claudin 14
chr17_-_42185452 0.40 ENST00000293330.1
hypocretin neuropeptide precursor
chr12_+_26195543 0.39 ENST00000242729.7
sarcospan
chr5_+_132873660 0.26 ENST00000296877.3
liver enriched antimicrobial peptide 2
chr15_-_89211803 0.25 ENST00000563254.1
retinaldehyde binding protein 1
chr7_+_138460238 0.24 ENST00000343526.9
tripartite motif containing 24
chr19_-_3557563 0.23 ENST00000389395.7
ENST00000355415.7
major facilitator superfamily domain containing 12
chr18_+_58341038 0.22 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chr9_+_122370523 0.21 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr2_+_89884740 0.20 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr2_-_89297785 0.20 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr3_-_142029108 0.19 ENST00000497579.5
transcription factor Dp-2
chr5_-_20575850 0.19 ENST00000507958.5
cadherin 18
chr6_+_26402289 0.19 ENST00000414912.2
butyrophilin subfamily 3 member A1
chr11_+_72189528 0.19 ENST00000312293.9
folate receptor alpha
chr11_+_72189659 0.18 ENST00000393681.6
folate receptor alpha
chr20_-_31390483 0.18 ENST00000376315.2
defensin beta 119
chr12_+_130953898 0.17 ENST00000261654.10
adhesion G protein-coupled receptor D1
chr3_+_178419123 0.16 ENST00000614557.1
ENST00000455307.5
ENST00000436432.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2-IT1 - KCNMB2 readthrough transcript)
long intergenic non-protein coding RNA 1014
chr4_+_94974984 0.16 ENST00000672698.1
bone morphogenetic protein receptor type 1B
chr16_-_28597042 0.16 ENST00000533150.5
ENST00000335715.9
sulfotransferase family 1A member 2
chr11_+_24496988 0.15 ENST00000336930.11
leucine zipper protein 2
chr11_-_35419098 0.15 ENST00000606205.6
ENST00000645303.1
solute carrier family 1 member 2
chr11_-_35419213 0.14 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
solute carrier family 1 member 2
chr4_+_87832917 0.14 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr8_-_100649660 0.14 ENST00000311812.7
sorting nexin 31
chr4_+_87650277 0.13 ENST00000339673.11
ENST00000282479.8
dentin matrix acidic phosphoprotein 1
chr1_+_159204860 0.13 ENST00000368122.4
ENST00000368121.6
atypical chemokine receptor 1 (Duffy blood group)
chr14_+_32329256 0.12 ENST00000280979.9
A-kinase anchoring protein 6
chr5_+_129748091 0.11 ENST00000564719.2
membrane integral NOTCH2 associated receptor 2
chr20_+_33217325 0.11 ENST00000375452.3
ENST00000375454.8
BPI fold containing family A member 3
chr4_+_87975667 0.11 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
secreted phosphoprotein 1
chr20_+_57561103 0.11 ENST00000319441.6
phosphoenolpyruvate carboxykinase 1
chr3_+_157436842 0.11 ENST00000295927.4
pentraxin 3
chr14_+_103385450 0.11 ENST00000416682.6
microtubule affinity regulating kinase 3
chr13_+_108629605 0.11 ENST00000457511.7
myosin XVI
chr15_+_58138368 0.10 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr2_+_90220727 0.10 ENST00000471857.2
immunoglobulin kappa variable 1D-8
chr4_+_87975829 0.10 ENST00000614857.5
secreted phosphoprotein 1
chr12_+_80716906 0.10 ENST00000228644.4
myogenic factor 5
chr14_-_52791597 0.10 ENST00000216410.8
ENST00000557604.1
glucosamine-phosphate N-acetyltransferase 1
chr14_+_32329341 0.10 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
A-kinase anchoring protein 6
chr4_+_75556048 0.10 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
odontogenesis associated phosphoprotein
chr8_+_91249307 0.09 ENST00000309536.6
ENST00000276609.8
solute carrier family 26 member 7
chr1_-_92486916 0.09 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr7_-_44541318 0.09 ENST00000381160.8
NPC1 like intracellular cholesterol transporter 1
chr11_+_33039996 0.09 ENST00000432887.5
ENST00000528898.1
ENST00000531632.6
t-complex 11 like 1
chr10_+_18400562 0.09 ENST00000377315.5
ENST00000650685.1
calcium voltage-gated channel auxiliary subunit beta 2
chr10_+_18260715 0.09 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
calcium voltage-gated channel auxiliary subunit beta 2
chr2_-_74392025 0.09 ENST00000440727.1
ENST00000409240.5
dynactin subunit 1
chr14_-_55191534 0.09 ENST00000395425.6
ENST00000247191.7
DLG associated protein 5
chr9_-_134068012 0.09 ENST00000303407.12
bromodomain containing 3
chr2_-_189179754 0.09 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr19_-_14979848 0.08 ENST00000594383.2
solute carrier family 1 member 6
chr9_+_122371036 0.08 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
prostaglandin-endoperoxide synthase 1
chr5_+_67004618 0.08 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr6_+_29550407 0.08 ENST00000641137.1
olfactory receptor family 2 subfamily I member 1 pseudogene
chr1_-_211134135 0.08 ENST00000638983.1
ENST00000271751.10
ENST00000639952.1
novel protein
potassium voltage-gated channel subfamily H member 1
chr3_+_42979281 0.08 ENST00000488863.5
ENST00000430121.3
golgi associated kinase 1A
chr8_-_33567118 0.08 ENST00000256257.2
ring finger protein 122
chr10_+_70052582 0.08 ENST00000676699.1
macroH2A.2 histone
chr17_-_41047267 0.07 ENST00000542137.1
ENST00000391419.3
keratin associated protein 2-1
chr5_+_172641241 0.07 ENST00000369800.6
ENST00000520919.5
ENST00000522853.5
neuralized E3 ubiquitin protein ligase 1B
chr6_-_82247697 0.07 ENST00000306270.12
ENST00000610980.4
inhibitor of Bruton tyrosine kinase
chrX_+_73563190 0.07 ENST00000373504.10
ENST00000373502.9
cysteine rich hydrophobic domain 1
chr7_-_44082464 0.07 ENST00000335195.10
ENST00000395831.7
ENST00000414235.5
ENST00000242248.10
ENST00000452049.1
DNA polymerase mu
chrX_+_136648138 0.07 ENST00000370629.7
CD40 ligand
chr11_+_124183219 0.07 ENST00000641351.2
olfactory receptor family 10 subfamily D member 3
chr17_-_10469558 0.06 ENST00000255381.2
myosin heavy chain 4
chr1_-_211134061 0.06 ENST00000639602.1
ENST00000638498.1
ENST00000367007.5
novel protein
potassium voltage-gated channel subfamily H member 1
chr14_+_103385374 0.06 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
microtubule affinity regulating kinase 3
chr2_-_74391837 0.06 ENST00000417090.1
ENST00000409868.5
ENST00000680606.1
dynactin subunit 1
chr16_+_69311339 0.06 ENST00000254950.13
vacuolar protein sorting 4 homolog A
chr19_+_15728024 0.06 ENST00000305899.5
olfactory receptor family 10 subfamily H member 2
chr7_+_71132123 0.06 ENST00000333538.10
polypeptide N-acetylgalactosaminyltransferase 17
chr2_-_213151590 0.06 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKAROS family zinc finger 2
chr14_+_64549950 0.06 ENST00000298705.6
protein phosphatase 1 regulatory subunit 36
chr1_-_152414256 0.06 ENST00000271835.3
cornulin
chr18_+_34976928 0.06 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
microtubule associated protein RP/EB family member 2
chr4_+_168497044 0.05 ENST00000505667.6
palladin, cytoskeletal associated protein
chr15_-_49620747 0.05 ENST00000559905.5
ENST00000560246.1
ENST00000299338.11
ENST00000558594.5
family with sequence similarity 227 member B
chr8_-_96261579 0.05 ENST00000517720.1
ENST00000523821.5
ENST00000287025.4
mitochondrial transcription termination factor 3
chr1_+_174700413 0.05 ENST00000529145.6
ENST00000325589.9
RAB GTPase activating protein 1 like
chr9_+_12693327 0.05 ENST00000388918.10
tyrosinase related protein 1
chrX_+_136648214 0.05 ENST00000370628.2
CD40 ligand
chr8_-_39838250 0.05 ENST00000622267.1
ADAM metallopeptidase domain 2
chr4_+_168497066 0.04 ENST00000261509.10
palladin, cytoskeletal associated protein
chr1_-_113871665 0.04 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
protein tyrosine phosphatase non-receptor type 22
chr18_-_69956924 0.04 ENST00000581982.5
ENST00000280200.8
CD226 molecule
chr6_+_54018910 0.04 ENST00000514921.5
ENST00000274897.9
ENST00000370877.6
muscular LMNA interacting protein
chr19_-_45584769 0.04 ENST00000263275.5
outer mitochondrial membrane lipid metabolism regulator OPA3
chr6_+_29099490 0.04 ENST00000641659.2
olfactory receptor family 2 subfamily J member 1
chr20_+_15196834 0.04 ENST00000402914.5
mono-ADP ribosylhydrolase 2
chr20_-_52105644 0.04 ENST00000371523.8
ZFP64 zinc finger protein
chr4_-_159035226 0.04 ENST00000434826.3
chromosome 4 open reading frame 45
chr4_-_145180496 0.04 ENST00000447906.8
OTU deubiquitinase 4
chr12_-_118359639 0.04 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr5_+_177384430 0.04 ENST00000512593.5
ENST00000324417.6
solute carrier family 34 member 1
chr3_-_151316795 0.03 ENST00000260843.5
G protein-coupled receptor 87
chr5_+_121961955 0.03 ENST00000339397.5
serum response factor binding protein 1
chr8_-_39838201 0.03 ENST00000347580.8
ENST00000379853.6
ENST00000265708.9
ENST00000521880.5
ADAM metallopeptidase domain 2
chr15_+_49170237 0.03 ENST00000560031.6
ENST00000558145.5
ENST00000544523.5
ENST00000560138.5
galactokinase 2
chr16_+_7303245 0.03 ENST00000674626.1
RNA binding fox-1 homolog 1
chr11_-_7941708 0.02 ENST00000642047.1
olfactory receptor family 10 subfamily A member 3
chr20_-_51802509 0.02 ENST00000371539.7
ENST00000217086.9
spalt like transcription factor 4
chr4_+_150582119 0.02 ENST00000317605.6
mab-21 like 2
chr14_+_71933116 0.02 ENST00000553530.5
ENST00000556437.5
regulator of G protein signaling 6
chr8_-_90082871 0.02 ENST00000265431.7
calbindin 1
chr1_+_75134382 0.02 ENST00000356261.4
LIM homeobox 8
chr7_-_44541262 0.02 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1 like intracellular cholesterol transporter 1
chr10_-_97445850 0.02 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
exosome component 1
chr10_+_97446137 0.02 ENST00000370854.7
ENST00000393760.6
ENST00000414567.5
zinc finger DHHC-type palmitoyltransferase 16
chr5_+_90474879 0.02 ENST00000504930.5
ENST00000514483.5
RNA polymerase III subunit G
chr7_+_73830988 0.02 ENST00000340958.4
claudin 4
chr11_-_111923722 0.02 ENST00000527950.5
crystallin alpha B
chr10_+_72893734 0.01 ENST00000334011.10
oncoprotein induced transcript 3
chr19_+_41262480 0.01 ENST00000352456.7
ENST00000595018.5
ENST00000597725.5
heterogeneous nuclear ribonucleoprotein U like 1
chr5_+_90474848 0.01 ENST00000651687.1
RNA polymerase III subunit G
chr17_+_45161070 0.01 ENST00000593138.6
ENST00000586681.6
HEXIM P-TEFb complex subunit 2
chr10_+_97446194 0.01 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
zinc finger DHHC-type palmitoyltransferase 16
chr9_-_34895722 0.01 ENST00000603640.6
ENST00000603592.1
ENST00000340783.11
family with sequence similarity 205 member C
chr11_-_107858777 0.01 ENST00000525815.6
solute carrier family 35 member F2
chr4_-_73620629 0.01 ENST00000342081.7
Ras association domain family member 6
chr7_-_111392915 0.01 ENST00000450877.5
inner mitochondrial membrane peptidase subunit 2
chr20_-_51802433 0.01 ENST00000395997.3
spalt like transcription factor 4
chr17_+_7407838 0.01 ENST00000302926.7
neuroligin 2
chr12_-_10802627 0.01 ENST00000240687.2
taste 2 receptor member 7
chr14_+_56117702 0.01 ENST00000559044.5
pellino E3 ubiquitin protein ligase family member 2
chr7_-_101217569 0.01 ENST00000223127.8
procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
chr11_-_5301946 0.00 ENST00000380224.2
olfactory receptor family 51 subfamily B member 4
chr17_-_40665121 0.00 ENST00000394052.5
keratin 222
chr17_+_50746534 0.00 ENST00000511974.5
LUC7 like 3 pre-mRNA splicing factor
chr7_-_100119840 0.00 ENST00000437822.6
TATA-box binding protein associated factor 6
chr6_+_106360668 0.00 ENST00000633556.3
crystallin beta-gamma domain containing 1
chrX_-_155071064 0.00 ENST00000369484.8
ENST00000369476.8
C-X9-C motif containing 4
mature T cell proliferation 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 2.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.4 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.2 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.1 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 0.1 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.4 GO:0008354 germ cell migration(GO:0008354)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:0015855 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.2 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.4 GO:0098712 L-glutamate import across plasma membrane(GO:0098712)
0.0 0.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 1.4 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.0 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.0 GO:0097187 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.9 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.4 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 1.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)