ISMARA results: WRNIP1

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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for WRNIP1

Z-value: 1.89

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Transcription factors associated with WRNIP1

Gene Symbol	Gene ID	Gene Info
WRNIP1 Ensembl NCBI GeneCards UniProt	ENSG00000124535.16	WRNIP1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
WRNIP1	hg38_v1_chr6_+_2765361_2765563	-0.70	1.1e-04	Click!

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

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Promoter	Score	Transcript	Gene	Gene Info
chr6_-_29628038 Show fit	12.50	ENST00000355973.7 ENST00000377012.8	GABBR1 Ensembl NCBI GeneCards UniProt Show fit	gamma-aminobutyric acid type B receptor subunit 1
chr6_-_31582415 Show fit	9.56	ENST00000429299.3 ENST00000446745.2	LTB Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin beta
chr15_+_88638947 Show fit	9.30	ENST00000559876.2	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20
chr15_+_88639009 Show fit	8.04	ENST00000306072.10	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20
chr6_-_33314386 Show fit	8.00	ENST00000456592.3	TAPBP Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein
chr16_-_11587162 Show fit	7.19	ENST00000570904.5 ENST00000574701.5	LITAF Ensembl NCBI GeneCards UniProt Show fit	lipopolysaccharide induced TNF factor
chr9_-_120926752 Show fit	7.17	ENST00000373887.8	TRAF1 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor associated factor 1
chr19_+_45001430 Show fit	6.95	ENST00000625761.2 ENST00000505236.1 ENST00000221452.13	RELB Ensembl NCBI GeneCards UniProt Show fit	RELB proto-oncogene, NF-kB subunit
chr2_+_227813834 Show fit	6.77	ENST00000358813.5 ENST00000409189.7	CCL20 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 20
chr19_+_50649445 Show fit	6.60	ENST00000425202.6	C19orf81 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 81

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	24.6	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.2	23.8	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
1.7	18.8	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.4	17.7	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
4.4	17.4	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
1.1	16.8	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.2	16.3	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.3	15.9	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
5.1	15.3	GO:2000755	regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755)
0.4	14.8	GO:1902624	positive regulation of neutrophil migration(GO:1902624)

Showing 1 to 10 of 1,291 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	94.4	GO:0005615	extracellular space(GO:0005615)
0.0	37.9	GO:0005887	integral component of plasma membrane(GO:0005887)
3.1	22.0	GO:0042825	TAP complex(GO:0042825)
2.7	21.9	GO:0098559	cytoplasmic side of early endosome membrane(GO:0098559)
0.1	19.8	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.3	18.7	GO:0015030	Cajal body(GO:0015030)
0.3	17.8	GO:0030673	axolemma(GO:0030673)
0.1	17.7	GO:0035578	azurophil granule lumen(GO:0035578)
0.2	15.6	GO:0005581	collagen trimer(GO:0005581)
1.9	15.2	GO:0097451	glial limiting end-foot(GO:0097451)

Showing 1 to 10 of 445 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	31.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	30.6	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	24.5	GO:0045296	cadherin binding(GO:0045296)
0.2	20.9	GO:0005518	collagen binding(GO:0005518)
0.1	18.1	GO:0005125	cytokine activity(GO:0005125)
0.7	17.9	GO:0048020	CCR chemokine receptor binding(GO:0048020)
1.2	17.7	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
5.8	17.3	GO:0008859	exoribonuclease II activity(GO:0008859)
0.5	15.7	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3	15.4	GO:0035035	histone acetyltransferase binding(GO:0035035)

Showing 1 to 10 of 703 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	65.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.7	48.5	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2	26.9	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.5	24.1	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.3	23.4	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.3	22.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	20.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	19.4	PID P73PATHWAY	p73 transcription factor network
0.4	19.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.4	19.0	ST G ALPHA I PATHWAY	G alpha i Pathway

Showing 1 to 10 of 130 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	43.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	24.0	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.5	23.9	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.7	21.9	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	21.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.4	19.5	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.3	18.9	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	17.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.5	17.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.2	17.3	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters

Showing 1 to 10 of 197 entries

Results for WRNIP1

Z-value: 1.89

Motif logo

Transcription factors associated with WRNIP1

Activity-expression correlation:

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: