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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for WT1_MTF1_ZBTB7B
Z-value: 1.78
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Transcription factors associated with WT1_MTF1_ZBTB7B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MTF1 | hg38_v1_chr1_-_37859583_37859609 | -0.57 | 2.9e-03 | Click! |
| WT1 | hg38_v1_chr11_-_32435360_32435419 | -0.34 | 9.4e-02 | Click! |
| ZBTB7B | hg38_v1_chr1_+_155002630_155002689 | -0.19 | 3.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of WT1_MTF1_ZBTB7B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 30.5 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.9 | 24.8 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 18.0 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.3 | 16.3 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 3.0 | 15.1 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.3 | 14.9 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 2.3 | 13.8 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 1.9 | 13.0 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
| 3.2 | 12.8 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.2 | 12.7 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 43.9 | GO:0005912 | adherens junction(GO:0005912) |
| 1.2 | 30.4 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.2 | 28.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.4 | 23.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 20.9 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.1 | 20.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.2 | 19.6 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.3 | 19.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.7 | 15.8 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 15.0 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 78.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 31.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 29.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 24.3 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 3.1 | 21.8 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 1.2 | 21.0 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.5 | 16.2 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.4 | 15.6 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.2 | 15.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 1.2 | 14.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 64.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.7 | 42.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.6 | 22.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.6 | 22.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 20.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 20.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 18.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 18.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 17.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 14.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 29.4 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.6 | 28.3 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.4 | 25.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 19.0 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.4 | 15.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 15.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 14.2 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.3 | 13.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 12.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 12.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |