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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for XBP1
Z-value: 1.68
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Transcription factors associated with XBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| XBP1 | hg38_v1_chr22_-_28800558_28800597 | 0.36 | 7.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_128052166 Show fit | 9.52 |
ENST00000648300.1
|
monoglyceride lipase |
|
| chr5_-_122078249 Show fit | 6.27 |
ENST00000231004.5
|
lysyl oxidase |
|
| chr9_+_35732649 Show fit | 6.06 |
ENST00000353704.3
|
cAMP responsive element binding protein 3 |
|
| chr19_+_49527988 Show fit | 4.94 |
ENST00000270645.8
|
reticulocalbin 3 |
|
| chr8_+_103372388 Show fit | 4.16 |
ENST00000520337.1
|
collagen triple helix repeat containing 1 |
|
| chr2_-_69387130 Show fit | 3.78 |
ENST00000674438.1
|
glutamine--fructose-6-phosphate transaminase 1 |
|
| chr6_+_116370938 Show fit | 3.53 |
ENST00000644252.3
ENST00000646710.1 ENST00000359564.3 |
dermatan sulfate epimerase |
|
| chr5_+_127517611 Show fit | 3.48 |
ENST00000296666.13
ENST00000442138.6 ENST00000512635.2 |
proline rich coiled-coil 1 |
|
| chr20_-_63568074 Show fit | 3.32 |
ENST00000427522.6
|
helicase with zinc finger 2 |
|
| chr3_+_105367212 Show fit | 3.26 |
ENST00000472644.6
|
activated leukocyte cell adhesion molecule |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.2 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 1.1 | 9.5 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 8.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.5 | 6.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.9 | 6.1 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.0 | 4.7 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.6 | 4.2 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.1 | 3.5 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 3.5 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.2 | 3.3 | GO:1902284 | axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 5.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 4.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 4.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 3.9 | GO:0030016 | myofibril(GO:0030016) |
| 0.1 | 3.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 3.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 3.3 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.2 | 3.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 2.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 2.4 | 9.7 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 1.0 | 6.3 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.2 | 6.1 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 5.3 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 4.9 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 4.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 4.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 3.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.9 | 3.5 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 5.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 2.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 2.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 6.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 3.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 3.3 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 3.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 2.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 2.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 2.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |