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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 2.96
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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000065978.19 | YBX1 | |
| ENSG00000170345.10 | FOS | |
| ENSG00000066136.20 | NFYC | |
| ENSG00000001167.15 | NFYA | |
| ENSG00000120837.8 | NFYB | |
| ENSG00000115816.15 | CEBPZ |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFYC | hg38_v1_chr1_+_40738834_40738874 | 0.57 | 2.9e-03 | Click! |
| NFYB | hg38_v1_chr12_-_104138007_104138035 | 0.34 | 1.0e-01 | Click! |
| FOS | hg38_v1_chr14_+_75279637_75279670 | 0.26 | 2.0e-01 | Click! |
| YBX1 | hg38_v1_chr1_+_42682388_42682440 | -0.06 | 7.6e-01 | Click! |
| CEBPZ | hg38_v1_chr2_-_37231549_37231603 | 0.04 | 8.3e-01 | Click! |
| NFYA | hg38_v1_chr6_+_41072939_41072984 | -0.02 | 9.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_159761991 Show fit | 8.31 |
ENST00000367048.5
|
acetyl-CoA acetyltransferase 2 |
|
| chr1_+_220879434 Show fit | 7.52 |
ENST00000366903.8
|
H2.0 like homeobox |
|
| chr19_+_45469841 Show fit | 7.25 |
ENST00000592811.5
ENST00000586615.5 |
FosB proto-oncogene, AP-1 transcription factor subunit |
|
| chr17_-_49764123 Show fit | 6.37 |
ENST00000240364.7
ENST00000506156.1 |
family with sequence similarity 117 member A |
|
| chr14_+_52552830 Show fit | 6.29 |
ENST00000321662.11
|
G protein-coupled receptor 137C |
|
| chr5_+_75337261 Show fit | 6.17 |
ENST00000680940.1
|
3-hydroxy-3-methylglutaryl-CoA reductase |
|
| chr5_+_75337192 Show fit | 6.03 |
ENST00000680160.1
|
3-hydroxy-3-methylglutaryl-CoA reductase |
|
| chr5_+_75337348 Show fit | 6.00 |
ENST00000681271.1
|
3-hydroxy-3-methylglutaryl-CoA reductase |
|
| chr5_+_75337211 Show fit | 5.93 |
ENST00000287936.9
ENST00000343975.9 |
3-hydroxy-3-methylglutaryl-CoA reductase |
|
| chr11_+_95789965 Show fit | 5.27 |
ENST00000537677.5
|
centrosomal protein 57 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 28.9 | GO:0006695 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 1.7 | 24.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.7 | 17.6 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 2.1 | 17.2 | GO:0016129 | phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129) |
| 0.1 | 11.5 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.2 | 9.3 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.3 | 8.9 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.5 | 7.7 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.5 | 7.6 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 1.1 | 7.5 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 32.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 20.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 11.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.6 | 8.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 7.9 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 7.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 7.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 7.0 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 7.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 6.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 24.1 | GO:0004420 | hydroxymethylglutaryl-CoA reductase (NADPH) activity(GO:0004420) hydroxymethylglutaryl-CoA reductase activity(GO:0042282) |
| 0.0 | 12.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.9 | 11.6 | GO:0004310 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.0 | 10.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 9.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.5 | 9.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 1.1 | 8.8 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.2 | 8.6 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 2.1 | 8.2 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.2 | 8.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 10.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 7.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 7.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 7.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 6.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 6.8 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.3 | 5.9 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 5.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 5.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 87.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 9.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 9.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 9.4 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 8.5 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.5 | 7.8 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.4 | 7.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.3 | 7.4 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.2 | 7.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 6.1 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |