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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for YY1_YY2
Z-value: 1.05
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Transcription factors associated with YY1_YY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY1 | hg38_v1_chr14_+_100239121_100239196 | 0.60 | 1.6e-03 | Click! |
| YY2 | hg38_v1_chrX_+_21855987_21855987 | 0.02 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.3 | 4.0 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.4 | 4.0 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.0 | 3.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 3.4 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.1 | 3.3 | GO:0072720 | response to dithiothreitol(GO:0072720) |
| 1.0 | 2.9 | GO:0099557 | trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557) |
| 0.7 | 2.8 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 0.5 | 2.8 | GO:0038016 | insulin receptor internalization(GO:0038016) |
| 0.6 | 2.6 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 4.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.5 | 4.0 | GO:1903439 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.1 | 3.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 3.4 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 3.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 2.8 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 2.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 2.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 2.7 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 6.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 4.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 4.1 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.8 | 4.0 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.5 | 4.0 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 0.1 | 3.7 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.2 | 3.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 3.3 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.1 | 3.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 3.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.7 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 2.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 2.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 5.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 4.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 3.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 3.2 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.1 | 2.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.3 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |