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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ZBTB14
Z-value: 2.08
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Transcription factors associated with ZBTB14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB14 | hg38_v1_chr18_-_5296139_5296195 | 0.43 | 3.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB14
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 19.7 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
| 4.7 | 18.9 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 3.1 | 15.4 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.9 | 11.4 | GO:0042492 | gamma-delta T cell differentiation(GO:0042492) |
| 1.3 | 10.0 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 2.0 | 9.9 | GO:0032484 | Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485) |
| 3.2 | 9.7 | GO:0021793 | chemorepulsion of branchiomotor axon(GO:0021793) |
| 1.3 | 9.2 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
| 0.6 | 7.9 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 1.1 | 7.5 | GO:0018211 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 18.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 16.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 14.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 12.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 11.6 | GO:0000145 | exocyst(GO:0000145) |
| 0.7 | 9.3 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 8.7 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 8.6 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.3 | 7.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 6.8 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 4.9 | 19.7 | GO:0061769 | ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769) |
| 1.9 | 17.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 13.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 12.2 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 11.7 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.5 | 10.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.4 | 9.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.5 | 9.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 9.3 | GO:0008022 | protein C-terminus binding(GO:0008022) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.7 | 17.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 10.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 7.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 7.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 7.0 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 6.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 6.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 5.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 23.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.4 | 22.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 10.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.6 | 10.4 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 7.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 7.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 7.0 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.2 | 5.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 5.0 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.3 | 4.9 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |