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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for ZBTB33_CHD2
Z-value: 1.13
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB33 | hg38_v1_chrX_+_120250752_120250866 | 0.23 | 2.7e-01 | Click! |
| CHD2 | hg38_v1_chr15_+_92904447_92904473 | -0.14 | 5.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.1 | 3.2 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 3.1 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 2.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 2.4 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.3 | 2.3 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.0 | 2.3 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.4 | 2.2 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.2 | 2.2 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.4 | 1.9 | GO:0043504 | mitochondrial DNA repair(GO:0043504) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 2.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 2.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.2 | 2.5 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.2 | 2.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.3 | 2.0 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 1.7 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 1.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 1.6 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 1.4 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 3.2 | GO:0002039 | p53 binding(GO:0002039) |
| 0.1 | 2.6 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 2.3 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 2.2 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.2 | 2.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 2.1 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 2.0 | GO:0008297 | single-stranded DNA exodeoxyribonuclease activity(GO:0008297) |
| 0.1 | 1.6 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 1.5 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 2.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.4 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.6 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.6 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 2.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 1.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 1.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.4 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.8 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 0.8 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.8 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.8 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |